Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Oudin, M. J., O. Jonas, T. Kosciuk, L. C. Broye, B. C. Guido, J. Wyckoff, D. Riquelme, et al. “Tumor Cell-Driven Extracellular Matrix Remodeling Enables Haptotaxis During Metastatic Progression.” Cancer Discovery (January 25, 2016). As Published http://dx.doi.org/10.1158/2159-8290.CD-15-1183 Publisher American Association for Cancer Research Version Author's final manuscript Accessed Wed May 25 22:17:06 EDT 2016 Citable Link http://hdl.handle.net/1721.1/101752 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited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ownloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. 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Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Downloaded from cancerdiscovery.aacrjournals.org on March 22, 2016. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on January 25, 2016; DOI: 10.1158/2159-8290.CD-15-1183 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression Madeleine J. Oudin, Oliver Jonas, Tatsiana Kosciuk, et al. Cancer Discov Published OnlineFirst January 25, 2016. 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