Physical
Sciences Inc.
VG10-182
Biomedical Optics Instrumentation
Dan Hammer, Dan Ferguson, Nick Iftimia, Dave Rosen
Physical Sciences Inc.
A Case Study for University – Industry Collaboration
presented by Mark Druy and B. David Green at the
Session on SBIR Successes
at
2010 National SBIR Beyond Phase II
Conference and Technology Showcase
15 September 2010
Physical Sciences Inc.
20 New England Business Center
Andover, MA 01810
Who we are
Physical Sciences Inc.
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A growing 37 year-old company of 180 scientists, engineers and
administrative professionals
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Headquartered in Andover, MA; operations in:
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VG10-182-1
Pleasanton, CA (PSI)
Lanham, MD and Princeton, NJ (RSI)
Bedford, MA (Q-Peak)
Dayton, OH (Faraday Technology)
College Park, MD (Maxion Technologies)
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Research Support Instruments supports the Naval Research Laboratory
and National programs
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Q-Peak manufactures lasers and optical devices
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Faraday Technology develops electrochemical processing
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Maxion Technologies develops long-wavelength (3-12 microns) infrared
semiconductor lasers
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PSI is a technologically diverse research and development
organization with revenues of $50+M
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Owned by the PSI Employee Stock Ownership Trust
Our Locations
Physical Sciences Inc.
VG10-182-2
Andover, MA
Pleasanton, CA
PSI
Space Exploration
Technologies and
Novel Electro-optic
Materials
Corporate Headquarters
PSI Main Offices
Haverhill, MA
Material Sciences and Technologies,
Optics and Laser Technologies,
Space and Atmospheric Studies,
Energy Technologies
Advanced Composite
Structures
PSI
Bedford, MA
Q-Peak
Solid State Lasers
Princeton, NJ
RSI
MEMS and Plasma
Technologies
Lanham, MD
RSI
Systems Support
and Calibration
College Park, MD
Maxion Technologies, Inc.
Quantum and Interband
Cascade Lasers
IR EO Materials and Devices
Clayton, OH
Faraday Technology, Inc.
Pulsed/Pulse Reverse
Electrochemical Engineering
for Precise Surface Modification
C-7543
Creating Value For Our Customers
Physical Sciences Inc.
VG10-182-3
 Leading edge technology invention, development,
and application
 Custom instrument development
 Prototype product development,
premanufacturing, and technology transfer
 Production of specialized instruments
 Technology and product licensing to strategic
partners and spin-outs
Army, Air Force, and NIH SBIR/STTR
Funding has led to
Physical Sciences Inc.
VG10-182-4
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Rapid assessment tool for retinal damage from laser illumination
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Tools for angiography and guided surgery in the eye
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Biomedical optical systems for ophthalmic researchers, clinicians, and
other medical personnel
– Detection of diseases
– Discovery of novel therapies
– Understanding of the body from system/organ to sub-cellular and molecular structures
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PSI (small business) creating improved diagnostic instrumentation
– Eye diseases, eye health, drug discovery
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University – Teaching hospital – Industry collaborative research
– Publications motivating additional research by many groups around world
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Sale of advanced instrumentation to leading research labs
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Licensing of technology to leading established OCT manufacturer
– Wide spread application in clinics and laboratories
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Licensing of enabling technology to several focused start up companies
– Many formed from university labs
Ophthalmic Diagnostics
Physical Sciences Inc.
VG10-182-5
 Ophthalmic Instrumentation
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TSO: Tracking, Scanning Ophthalmoscope
TOCT: Tracking Optical Coherence Tomography
LSO: Line Scanning Ophthalmoscope
AOSLO: Adaptive Optics Scanning Laser Ophthalmoscope
 Applications
– Laser illumination damage and mechanisms
– Diagnosis and surgical guidance in the eye
– Degenerative eye diseases in children and aged
• Diabetic retinopathy, macular degeneration
– Research on the cellular basis of eye diseases
Biomedical Imaging Instruments
Physical Sciences Inc.
 Line scanning ophthalmoscopy (LSO)
– Compact retinal imager to augment or guide OCT
• Autofluorescence, microperimetry
• Small animal imaging and advanced therapies
– patents
– 5 licenses with ophthalmic instrument manufacturers
 Retinal tracking (TOCT)
– High-speed, high fidelity stabilization of eye motion
– Applications: AO, SDOCT, PSOCT, hemodynamics
– Diagnostic or therapeutic beams
– > 12 systems sold to researchers
– patents
 Adaptive optics (AOSLO)
– Measurement and correction of ocular aberrations
– Ultrahigh resolution of retinal structures
– patent applications
 Real-time Fourier domain OCT processor
VG10-182-6
Collaborators
Physical Sciences Inc.
VG10-182-7
Including:
Institutions:
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Bruce Stuck
Henry Hacker
Ben Rockwell
David R. Williams
Benjamin Bloom
T. Milner
Robb Webb
Ann Elsner
Steve Burns
Johannes F. de Boer
Joel Schuman
Army Medical Research Branch
Air Force Research Lab HPW, Brooks
Schepens Eye Research Institute
Mass Eye and Ear Infirmary
MIT
University of Pittsburgh
University of Rochester
University of Texas, Austin
Indiana University
Massachusetts General Hospital
Boston Medical Center
Brigham and Women’s Hospital
University of Texas Medical Branch
Representative Journal Publications
Physical Sciences Inc.
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VG10-182-8
Applied Optics: Compact Scanning
Laser Ophthalmoscope with High-Speed
Retinal Tracker
Optics Express: Image Stabilization for
Scanning Laser Ophthalmoscope
Journal of Biomedical Optics: An
Active Retinal Tracker for Clinical Optical
Coherence Tomography Systems
Optics Express: Advanced Scanning
Methods with Tracking Optical
Coherence Tomography
Journal of Biomedical Optics:Scanning
Laser Opthalmoscope
Optics Express: Wide-field
hemodynamic imaging with tracking
ophthalmoscope
Optics Express: Adaptive optics
scanning laser ophthalmoscope for
stabilized retinal imaging
Journal of the Optical Society of
America: Increased Signal and
Resolution with Adaptive Optics Spectral
Domain Optical Coherence Tomography
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Optics Express: Hybrid retinal imager
using linescanning laser ophthalmoscopy
and spectral domain optical coherence
tomography
Optics Letters: Tracking OCT
Optics Express: Dual-beam Fourier
domain optical Doppler tomography of
zebrafish
Circulation Research: Blood flow and
cardiac output measurements in
zebrafish (Danio rerio) using dual-beam
Fourier domain optical Doppler
tomography
Review Scientific Instruments: Realtime processing for Fourier domain
optical coherence tomography using a
field programmable gate array
Optics Express: Compact adaptive
optics line scanning Ophthalmoscope
Journal of the Optical Society of
America A: Adaptive optics SLO with
integrated wide-field retinal imaging and
tracking
Licenses: Tracking for Ophthalmic Office Market
Physical Sciences Inc.
VG10-182-9
 Partner with major instrument company
– Non exclusive license
– Transfer technology
– Work with development team to incorporate in
Gen 4 product
 Benefit
– Provides high contrast, wide area image of retina
– Ensures precise registration between OCT scan
and fundus image
 Adds incremental cost to product
– Significantly greater value
 Sold 5940 units in 27 months
 PSI receives modest royalty income
Custom Instrument Sales to Researchers
Physical Sciences Inc.
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Licenses to start up companies – commercial product creation
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retinal metabolic analysis
perimetry
therapeutics (pending)
small animal imaging
OCT, optical biometer
Custom ophthalmic instruments
for researchers at:
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U. Rochester
Indiana U.
U. Texas Medical Branch
U. Texas Austin
Harvard
MIT
U. Pittsburgh Medical Center
Mass General Hospital
Children’s Hospital/Boston
U. Michigan
U. Waterloo
FDA
VG10-182-10
Summary
Physical Sciences Inc.
VG10-182-12
 Under Air Force, Army, and NIH SBIR /STTR funding PSI staff has:
– Performed world class research in the understanding and diagnosis of
diseases of the eye
– Collaborated with many researchers in academia
– Published and presented results to community to spur additional research
– Obtained six patents
– Developed several generations of optical diagnostic technology
– Standardized subassemblies and process in a Prototype Manufacturing Area
– Offered specialized instruments and sold them to the research community
– Created further collaborations and advanced research by the community
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Licensing several generations of the technology to companies for
commercial products
– Established commercial company next product for wide application in clinics
– Start up companies for autofluorescence, low cost retinal screening,
image-guided therapy
• Many grow and evolve from university laboratories
University – PSI Partnerships in Last Five Years
Physical Sciences Inc.
VG10-182-13
Alfred University
Boston University
Brown University
California State University
Cornell University
Dartmouth College
Duke University
Emory University
Harvard University
Indiana University
Iowa State
Johns Hopkins University
Medical College of Wisconsin
Michigan Tech University
MIT
Northeastern University
Ohio State University
Pennsylvania State University
Princeton University
State University of New York
UMass Lowell
University of Arizona
University of Connecticut
University of Deleware
University of Denver
University of Florida
University of Illinois
University of Michigan
University of Maryland
University of New Hampshire
University of North Carolina
University of Notre Dame
University of Pittsburg
University of Rochester
University of Texas
Utah State University
Western New England College
West Virginia University
Worcester Polytechnic Institute