HEALTHCARE Sarah Hemmelgarn Billy Wong Alex Wisler Jason Wattier Size and Composition Sector Weight S&P 500 Weight SIM Weight +/- 8.97% 7.50% -1.46% 12.32% 12.36% 0.04% 12.05% 10.68% -1.37% 13.70% 9.33% -4.37% 14.06% 13.58% -0.49% Consumer Discretionary Consumer Staples Energy Financials Health Care 9.79% 11.57% 1.78% 18.43% 20.19% 1.76% 3.20% 4.12% 0.92% 3.39% 3.28% -0.11% 4.10% 3.87% -0.23% 0.00% 3.53% 3.53% Industrials Information Technology Materials Telecommunication Services Utilities Cash 49 basis points underweight. SIM Weights: Health Care--13.58% Industries Pharmaceuticals is the largest, at 52.97% of the sector's market value. Industry Drug Manufacturers – Major* Biotechnology* Medical Instruments & Supplies Drug Manufacturers - Other Medical Appliances & Equipment Health Care Plans* Medical Laboratories & Research Drug Delivery Specialized Health Services* Diagnostic Substances Hospitals Drug Related Products Drugs - Generic Home Health Care Long-Term Care Facilities Medical Practitioners Market Cap ($B) Market Cap (%) 935.74 52.97% 216.35 12.25% 176.76 10.01% 141.46 8.01% 106.52 6.03% 87.77 4.97% 22.84 1.29% 15.24 0.86% 13.22 0.75% 11.61 0.66% 10.71 0.61% 10.33 0.58% 8.42 0.48% 5.02 0.28% 4.26 0.24% 0.38 0.02% TOP HEALTCARE COMPANIES BY MARKET CAP TOP 10 HEALTHCARE COMPANIES BY MARKET CAP JOHNSON AND JOHNSON $169.5 B PFIZER INC $111.2 B NOVARTIS AG ADS $100.4 B GLAXOSMITHKLINE PLC $97.0 B SANOFI-AVENTIS SA $86.4 B ABBOTT LABORATORIES 69.6 B ASTRAZZENECA PLC ADS 68.8 B MERCK 65.3 B WYETH 63.1 B AMGEN, INC $61.7 B SIM Stocks MARKET CAP AND INDUSTRY OF SIM HEALTHCARE STOCKS COMPANY MARKET CAP INDUSTRY JOHNSON & JOHNSON CO 169.5 B DRUG MANUFACTURERS, MAJOR GILEAD SCIENCES, INC 43.9 B BIOTECH ELI LILLY CO 39.9 B DRUG MANUFACTURERS, MAJOR WELLPOINT 25.5 B HEALTHCARE PLANS CARDINAL HEALTH INC 11.8 B DRUGS, WHOLESALE Economic Factors at a Glance Summary of Economic Trends Positive trends include: the aging population and the baby boomers people living longer with chronic disease obesity and diabetes epidemics technological advances the global reach of disease personalized medicine Negative trends include: a single-payer system (Medicare/U.S. government) expenditure as an increasing share of gross domestic product (GDP) the uninsured cost controls consumerism Obesity Childhood Obesity has grown over the last 30-40 years, but there is now more of an emphasis on living a healthy lifestyle. We expect the obesity rate to eventually start declining in the long run. Prevalence of Obesity* Among U.S. Children and Adolescents (Aged 2–19 Years) Survey Periods 2003– 1976–1980 1988–1994 1999–2002 2006 Ages 2 through 5 5% 7.20% 10.30% 12.40% 6 through 11 6.50% 11.30% 15.80% 17.00% 5% 10.50% 16.10% 17.60% 12 through 19 The Aging Population The baby boomers are reaching old age where much more healthcare will be needed. Healthcare Reform and Cost Controls Obama’s proposed Healthcare reform will provide the industry with much uncertainty. This could be costly to the healthcare industry which will be pressured to lower costs, but could be beneficial to the industry because more people will be insured and able to seek out medical attention. COST CONTROL Uses have exceeded sources— there will likely be pressure/ requirements for healthcare companies to reduce costs. Patent Expiration Drugs representing $63B in 2007 sales will have their patents expire by 2014 Significant because Pharmaceuticals make up the majority of the Healthcare sector BUSINESS ANALYSIS Component Industries Industry Drug Manufacturers – Major* Biotechnology* Medical Instruments & Supplies Drug Manufacturers - Other Medical Appliances & Equipment Health Care Plans* Medical Laboratories & Research Drug Delivery Specialized Health Services Diagnostic Substances Hospitals Drug Related Products Drugs - Generic Home Health Care Long-Term Care Facilities Medical Practitioners Market Cap ($B) Market Cap (%) 935.74 52.97% 216.35 12.25% 176.76 10.01% 141.46 8.01% 106.52 6.03% 87.77 4.97% 22.84 1.29% 15.24 0.86% 13.22 0.75% 11.61 0.66% 10.71 0.61% 10.33 0.58% 8.42 0.48% 5.02 0.28% 4.26 0.24% 0.38 0.02% *Industries represented in SIM Portfolio (double-check Specialized Health Services / Cardinal Health) Phase of Life Cycle Biotechnology • Health Care Sector is: • Defensive • Weighted towards maturity stage Drug Manufacturers - Major Health Care Plans Medical Appliances Medical Instruments Business Driver: Demographics • Aging population -> increase demand • Aging of baby boomers • Increasing life expectancy • Number and % of 50+ age group will rise substantially Business Driver: Demographics Business Analysis Barriers to Entry (Pharmaceuticals) Very high R&D costs Long, strict approval process by FDA Established companies in industry High capital requirements Demand Demand is generally inelastic Demand will continue to increase as population ages Business Analysis Competition and Substitution Barriers to entry retain industry concentration, especially in pharmaceuticals Competition and substitution mostly within the industry Opportunities and Threats Opportunities Very high barrier to entry Inelastic demand Aging population creates demand Threats • R&D is costly and highly uncertain • Increasing strict FDA approval process • Uncertainty regarding government controls and mandates in the future • Major patent cliff in next 5 years for Pharmaceuticals; estimated $63B erosion in sales by 2014 Financial Analysis Sector Growth and Margins 2004 2005 2006 2007 2008 Revenue Growth 16% 10% 13% 7% 10% EBITDA Margin 17.1% 17.0% 16.4% 16.7% 16.4% Profit Margin 10% 9.9% 9.4% 10.2% 10.1% Return on Equity 22.4% 22.4% 21.7% 22.1% 22.9% •EBITDA and Profit margins are stable •Return on Equity averages 22.3% over the past five years 04/01/2009 12/01/2008 08/01/2008 04/01/2008 12/01/2007 08/01/2007 04/01/2007 12/01/2006 08/01/2006 04/01/2006 12/01/2005 08/01/2005 04/01/2005 12/01/2004 08/01/2004 04/01/2004 12/01/2003 08/01/2003 04/01/2003 12/01/2002 08/01/2002 04/01/2002 12/01/2001 08/01/2001 04/01/2001 12/01/2000 08/01/2000 04/01/2000 12/01/1999 Net Profit Margin 35.00% 30.00% 25.00% 20.00% SP500 15.00% HCX BIOTK 10.00% DRUGS HCEQP 5.00% 0.00% •Health care sector net profit margins greater than S&P 500 •Biotechnology, pharmaceutical and health care equipment industries have the highest profit margins in the sector 04/01/2009 12/01/2008 08/01/2008 04/01/2008 12/01/2007 08/01/2007 04/01/2007 12/01/2006 08/01/2006 04/01/2006 12/01/2005 08/01/2005 04/01/2005 12/01/2004 08/01/2004 04/01/2004 12/01/2003 08/01/2003 04/01/2003 12/01/2002 08/01/2002 04/01/2002 12/01/2001 08/01/2001 04/01/2001 12/01/2000 08/01/2000 04/01/2000 12/01/1999 Return on Equity 60.00% 50.00% 40.00% 30.00% SP500 HCX BIOTK 20.00% DRUGS HCSVS 10.00% 0.00% •Health care sector return on equity greater than the S&P 500 •Pharmaceutical industry has highest return on equity •Biotechnology industry return on equity growing the quickest in recent years •Health care sector cash flow per share has grown steadily since 2000 •Biotechnology industry cash flow per share is the highest 04/01/2009 12/01/2008 08/01/2008 04/01/2008 12/01/2007 08/01/2007 04/01/2007 12/01/2006 08/01/2006 04/01/2006 12/01/2005 08/01/2005 04/01/2005 12/01/2004 08/01/2004 04/01/2004 12/01/2003 08/01/2003 04/01/2003 12/01/2002 08/01/2002 04/01/2002 12/01/2001 08/01/2001 04/01/2001 12/01/2000 08/01/2000 04/01/2000 12/01/1999 Cash Flow Per Share 80.00 70.00 60.00 50.00 40.00 HCX BIOTK 30.00 HCEQP HCMAN 20.00 10.00 - Valuation Analysis Valuation Analysis Absolute vs. Relative Sector Look Prognosis: HC is shows strong support for being underpriced on an absolute basis, but mixed to negative support for underpricing on a relative basis. Appendix – HC Industries Relative to S&P500 Sector – P/Forward E Sector – P/Book Sector – P/Sales Sector – P/CF P/CF - Abs 200.00 180.00 160.00 140.00 120.00 100.00 80.00 60.00 40.00 20.00 0.00 June-94 13.33995 9.2662 December-97 May-01 October-04 March-08 P/CF - Relative to S&P 12.00 10.00 8.00 6.00 4.00 2.00 1.26205 0.00 June-94 December-97 May-01 October-04 March-08 Sector – P/EBITDA P/EBITDA - Abs 30.00 25.00 20.00 15.00 10.78365 10.00 7.1378 5.00 0.00 June-94 December-97 May-01 October-04 March-08 P/EBITDA - Relative to S&P 2.50 2.00 1.65045 1.5036 1.50 1.00 0.50 0.00 June-94 December-97 May-01 October-04 March-08 Summary Look Health Care - Absolute Over/Under – 5 Yr Med % Trend P/Forward E Under -29% Positive P/B Under -24% Positive P/S Under -32% Positive P/CF Under -31% Positive P/EBITDA Under -34% Positive Over/Under – 5 Yr Med % Trend P/Forward E Under -31% Negative P/B Under -1% Negative P/S Over 3% Level P/CF Under -17% Level P/EBITDA Under -9% Negative Health Care - Relative RECOMMENDATION *Keep Healthcare at 49 basis points underweight (possibly decrease if better opportunities exist) REASONS: Uncertainty in the sector with proposed healthcare plan and patent expirations On a relative basis, the sector is mostly “underpriced” but experiencing negative valuation trends. If the economy starts to turn around, we expect better opportunities for returns outside of the healthcare sector Appendix – Industry Valuations Drug/Pharm P/Forward E P/B P/S P/CF P/EBITDA Over/Under Under Over Over Under Under % -29% 8% 7% -16% -6% Trend Negative Negative Level Level Negative Over/Under Under Over Over Under Under % -19% 14% 17% -9% -2% Trend Negative Negative Positive Positive Positive Over/Under Under Under Under Under Under % -38% -15% 0% -17% -14% Trend Negative Negative Negative Negative Negative Biotech P/Forward E P/B P/S P/CF P/EBITDA HC Equipment P/Forward E P/B P/S P/CF P/EBITDA Appendix – Pharm Charts P/Forward E - Relative to S&P 1.20 1.00 0.80 0.60 0.40 0.20 0.00 June-94 P/CF - Relative to S&P 2.50 0.9708 2.00 0.6862 1.50 0.50 December-97 May-01 October-04 0.00 June-94 March-08 P/Book - Relative to S&P 4.00 3.00 3.00 2.00 1.4913 1.3857 1.00 December-97 May-01 October-04 P/Sales - Relative to S&P 5.00 4.00 2.5410 2.36875 2.00 1.00 0.00 June-94 December-97 May-01 October-04 March-08 May-01 October-04 March-08 2.00 1.5509 1.4634 1.00 0.00 June-94 March-08 3.00 December-97 P/EBITDA - Relative to S&P 4.00 0.00 June-94 1.12935 0.9453 1.00 December-97 May-01 October-04 March-08 Appendix – Biotech Charts P/Forward E - Rel to S&P P/CF - Relative to S&P 4.00 5.00 3.00 4.00 3.00 2.00 1.3303 1.0723 1.00 0.00 June-94 December-97 May-01 October-04 2.00 0.00 June-94 March-08 P/Book - Relative to S&P 6.00 5.00 4.00 3.00 2.00 1.00 0.00 June-94 December-97 May-01 October-04 March-08 P/EBITDA - Relative to S&P 8.00 6.00 4.00 1.7954 1.5796 December-97 May-01 October-04 5.3035 4.5258 December-97 May-01 October-04 March-08 2.3970 2.00 0.00 June-94 March-08 P/Sales - Relative to S&P 12.00 10.00 8.00 6.00 4.00 2.00 0.00 June-94 1.6916 1.5425 1.00 December-97 May-01 October-04 March-08 Appendix – HC Equip Charts P/Forward E - Rel to S&P P/CF - Relative to S&P 2.00 1.50 1.3450 1.00 0.8377 0.50 0.00 June-94 December-97 May-01 October-04 March-08 3.00 2.50 2.00 1.50 1.00 0.50 0.00 June-94 P/Book - Relative to S&P 3.00 2.50 2.00 1.50 1.00 0.50 0.00 June-94 December-97 May-01 October-04 March-08 P/EBITDA - Relative to S&P 15.00 10.00 1.5600 1.3325 December-97 May-01 October-04 March-08 4.00 3.00 2.5229 2.00 1.00 December-97 May-01 October-04 March-08 5.00 0.00 June-94 P/Sales - Relative to S&P 0.00 June-94 1.5297 1.2671 2.0356 1.7491 December-97 May-01 October-04 March-08