Title: Kinematics and Muscle Activity During Landing on a Supinating Platform in Persons with Ankle Instability Abstract Lateral ankle sprains are common injuries in athletic activity. Although most will resolve with conservative treatment, others develop chronic Ankle Instability (AI), a condition associated with persistent pain, weakness, and instability. Because of an increase in prevalence of AI, considerable attention has been directed towards understanding the underlying causes of this pathology. Despite the amount of research conducted in this area, analysis of individuals with AI during dynamic conditions is limited. A detailed kinematic and electromyographic analysis of the landing phase of a dynamic movement pattern may give greater insight into the stresses placed on the foot and ankle complex in AI subjects and how they differ from other populations. The aims of this study are to determine if differences in preparatory EMG profiles, reactive EMG profiles, and kinematics are present between the three groups (uninjured, coper, and AI) when landing on a (1) non-supinating surface and a (2) supinating surface. To address these aims, a three-dimensional motion analysis, combined with an electromyographic analysis, during a dynamic landing on a custom supinating platform will be conducted on 45 subjects. The subjects will be specifically recruited and divided for comparison into three groups: 15 subjects with chronic ankle instability (AI), 15 subjects who have a previous history of at least one lateral ankle sprains and never experienced recurrent symptoms (Copers), and 15 control subjects who are without a history of a lateral ankle sprain (Control). A range of kinetic and electromyographic variables will be extracted using techniques developed in previous studies. The variables of interest will be analyzed to determine if there are differences between each subgroup during a landing on a supinating and non-supinating platform. Accurately assessing foot and ankle mechanics, along with muscle activations, can give insight into the neuromuscular mechanism underlying ankle joint injuries, and the subsequent pathology of AI. Once determined, future intervention studies can be performed to reduce the incidence and severity of acute and chronic lateral ankle injury.