91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:47 AM
Page 3
Supor® EKV Membrane Filters
For cost-effective filtration of buffers, tissue culture
media, and many other biological fluids
Disposable – Reduces labor costs associated with assembling, cleaning, and testing stainless
steel filter holders.
Flexible – Encapsulated format for ease of use.
Extended life – Built-in MachV asymmetric prefilter layer for maximum flow and throughput performance.
Simplified scale-up – Membrane and housing materials are identical to those used in larger-volume
capsules and cartridges from Pall Life Sciences.
Low adsorption and high chemical compatibility – Featuring hydrophilic polyethersulfone membrane
for high compatibility over the entire pH range and low protein binding.
Presterilized – Using gamma irradiation, products are presterilized, non-pyrogenic, and non-cytotoxic
(with the exception of 47 mm disc filters).
Inherently hydrophilic – Provides a reliable integrity test.
Patented Ultipleat® technology – Offers large effective filtration and superior flow rates on AcroPak™
400, 800 and 1500 capsules.
Tested – Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>. Assessed
during manufacture to ensure product integrity.
91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:48 AM
Page 4
Pall Products Featuring Supor EKV Membrane Filters —
Designed to meet your specific application needs
47 mm Disc Filters
High throughput
Low protein binding
AcroPak 20 Filters
Designed to add convenience to small- and mediumvolume filtration
Applications
Generates twice the effective filtration area and double the
throughput/flow rate of conventional metal 47 mm reusable
filter holders
Suitable for sterile filtration of a wide range of fluids, including:
Disposable for reduced labor
Fast flow rates
Buffers
Biological fluids
Cell culture media
Ophthalmic products
Significantly reduces the cost of repeat testing when scaling
up your filtration system
Applications
Ideal for filtering aqueous solutions, cell culture media,
and serum
Small- to medium-volume sterile filtration, typically up to 1 liter
Suitable for use with fluids containing dilute proteins,
preservatives, or other critical components
Sterile filtration of media and buffers
25 mm Acrodisc® Syringe Filters
Universal life science membrane with low protein binding
to minimize sample loss
Superior flow rates and higher throughputs than
similar devices
Sterilized by gamma irradiation to eliminate potential
contamination by EtO residuals
Applications
Small-volume applications (such as liquid sterilization and
determination of product compatibility and recovery)
Ideal for typical process volume up to 100 mL
91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:47 AM
AcroPak 200 Capsules
High filtration area and compact size are ideal for upscale trials
Page 1
AcroPak 400, 800 and 1500 Capsules
Minimal hold-up volume
Encapsulated format for higher flexibility, minimized cleaning,
and low installation costs
Good wettability for reliable integrity test
Minimal hold-up volume
United States Pharmacopeia (USP) Biological Reactivity Test,
In Vivo <88>
Hydrophilic polyethersulfone membrane for low adsorption
and wide chemical compatibility
Sealed membrane and housing uses fusion technology
to eliminate potential extractables
Good wettability for a reliable integrity test
Gamma sterilized, non-pyrogenic, and provided with
a removable filling bell (except sanitary flange option)
Hydrophilic polyethersulfone membrane for low adsorption
and wide chemical compatibility
Very high flow rates and consistently higher total solution
throughputs due to superior porosity over other membranes
Patented Ultipleat technology for high area and good
flow rates
Built-in MachV asymmetric prefilter layer for long-life and low
filtration costs
Applications
Suitable for sterile filtration of a wide range of fluids, including:
Buffers
Applications
Designed to quickly process difficult-to-filter solutions within
5-21 liters, such as serum, serum-supplemented culture
media, and ascites fluid
Biological fluids
Cell culture media
Ophthalmic products
Ideal in situations where rapid filtration or short processing
times are essential
www.pall.com/lab
91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:48 AM
Page 5
Supor EKV Membrane Products —
High performance filtration for a variety of processes
47 mm Disc Filters with Supor
EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
25 mm Acrodisc Syringe Filters
with Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
AcroPak 20 Filters with
Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
Housing, Vent Plug, and
Support Material
–
Polypropylene
Polypropylene
Filling Bell
–
–
Polycarbonate
Sealing Technology
–
–
Thermal bonding without adhesives
Pore Size
0.2 µm
0.2 µm
0.2 µm
cm2
20 cm2
Specifications
Filter Media
cm2
(1.4
in.2)
(dependent on holder)
2.8
Effective Filtration Area
9.6
Dimensions
–
Length: 21 mm (0.8 in.)
Diameter: 29 mm (1.2 in.)
Length: 83 mm (3.3 in.)
Diameter: 67 mm (2.7 in.)
Inlet/Outlet Connections
–
Female luer lock inlet,
male slip luer outlet
Stepped hose barbs, 6.4-12.7 mm
(1/4-1/2 in.) diameter with female
slip luer ID in the hose barb
Typical Hold-up Volume
(with Air Purge)
–
< 100 µL
< 2.5 mL
Maximum Operating Temperature*
–
60 ºC (140 ºF) at 2.1 bar
(210 kPa, 30 psi)
60 ºC (140 ºF) at 1.0 bar
(100 kPa, 15 psi)
Maximum Operating Pressure*
–
5.4 bar (540 kPa, 80 psi)
at ambient temperature
4.1 bar (410 kPa, 60 psi)
at 21-24 ºC (70-75 ºF)
Recommended Integrity Test
Minimum Bubble Point (Water)
–
≥ 3.32 bar (332 kPa, 48 psi)
≥ 3.32 bar (332 kPa, 48 psi)
Typical Water Flow Rate
–
–
–
Bacterial Retention
–
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
Endotoxin Level
–
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
Biological Safety
–
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Sterilization
–
Sterilized by gamma irradiation and
individually packaged
Sterilized by gamma irradiation or
sold non-sterile; if desired, autoclave
once at 125 ºC (257 ºF) for 60 minutes;
water wet capsule prior to autoclaving
*Incompatible fluids which do not soften, swell or adversely affect the filter or its materials of construction.
3
91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:48 AM
Page 6
AcroPak 200 Capsules
with Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
AcroPak 400 Capsules
with Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
AcroPak 800 Capsules
with Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
AcroPak 1500 Capsules
with Supor EKV Membrane
Supor EKV membrane
(hydrophilic polyethersulfone)
Polypropylene
Polypropylene
Polypropylene
Polypropylene
Polycarbonate
Polycarbonate
Polycarbonate
Polycarbonate
*No filling bell on sanitary option
*No filling bell on sanitary flange option
*No filling bell on sanitary flange option
*No filling bell on sanitary flange option
Thermal bonding without adhesives
Thermal bonding without adhesives
Thermal bonding without adhesives
Thermal bonding without adhesives
0.2 µm
0.2 µm
0.2 µm
0.2 µm
220
cm2
375
cm2
750
cm2
1500 cm2
Housing Length
12094: 10.5 cm (4.1 in.)
12095: 7.3 cm (2.9 in.)
Housing Diameter
5.3 cm (2.1 in.) without vent
6.7 cm (2.6 in.) with vent
Housing Length
12460: 11.7 cm (4.6 in.)
12461: 15.7 cm (6.2 in.)
Housing Diameter (including valves)
9.4 cm (3.7 in.)
Housing Length
12463: 15.7 cm (6.2 in.)
12464: 19.7 cm (7.7 in.)
Housing Diameter (including valves)
9.4 cm (3.7 in.)
Housing Length
12466: 17.4 cm (6.8 in.)
12467: 21.0 cm (8.3 in.)
Housing Diameter (including valves)
10.5 cm (4.1 in.)
12094: 6.4-12.7 mm (1/4-1/2 in.)
stepped hose barb inlet and outlet
12095: 13 mm (1/2 in.) sanitary flange
inlet and outlet
12460: 25-38 mm (1-1.5 in.) sanitary
flange inlet/outlet connection
12461: 13 mm (1/2 in.) hose barb
inlet/outlet connection
12463: 25-38 mm (1-1.5 in.) sanitary
flange inlet/outlet connection
12464: 13 mm (1/2 in.) hose barb
inlet/outlet connection
12466: 25-38 mm (1-1.5 in.) sanitary
flange inlet/outlet connection
12467: 13 mm (1/2 in.) hose barb
inlet/outlet connection
< 6 mL
–
–
–
60 ºC (140 ºF) at 2.1 bar
(210 kPa, 30 psi)
40 ºC (104 ºF) at 4.0 bar
(400 kPa, 58 psi)
40 ºC (104 ºF) at 4.0 bar
(400 kPa, 58 psi)
40 ºC (104 ºF) at 4.0 bar
(400 kPa, 58 psi)
4.1 bar (410 kPa, 60 psi)
at ambient temperature
5.2 bar (520 kPa, 75 psi)
at 20 ºC (68 ºF)
5.2 bar (520 kPa, 75 psi)
at 20 ºC (68 ºF)
5.2 bar (520 kPa, 75 psi)
at 20 ºC (68 ºF)
≥ 3.32 bar (332 kPa, 48 psi)
≥ 3.32 bar (332 kPa, 48 psi)
≥ 3.32 bar (332 kPa, 48 psi)
≥ 3.32 bar (332 kPa, 48 psi)
350 mL/min/0.1 bar (241 mL/min/psi)
700 mL/min/0.1 bar (483 mL/min/psi)
1.5 L/min/0.1 bar (1.0 L/min/psi)
3.2 L/min/0.1 bar (2.2 L/min/psi)
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
Lot samples retain a minimum of
107 cfu/cm2 of B. diminuta per modified
ASTM F838, current revision
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
< 0.25 EU/mL using Limulus
Amoebocyte Lysate (LAL) test
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Passes United States Pharmacopeia
(USP) Biological Reactivity Test,
In Vivo <88>
Sterilized by gamma irradiation and
individually packaged; if desired,
autoclave once prior to use at 131 ºC
(268 ºF) for 30 minutes; water wet
capsule prior to autoclaving
Sterilized by gamma irradiation and
individually packaged
Sterilized by gamma irradiation and
individually packaged
Sterilized by gamma irradiation and
individually packaged
www.pall.com/lab
91927-Supor EKV_SS.qxd:91927-Supor EKV_SS
12/4/09
9:47 AM
Page 2
Ordering Information
Part Number
Description
Pkg
61309
Supor EKV membrane, 47 mm disc filter
5/pkg
Part Number
12461
Description
AcroPak 400 Capsule with Supor EKV
membrane, 0.2 µm, 13 mm (1/2 in.) hose
barb inlet/outlet connection with filling bell
on outlet
Pkg
1/pkg
4902
Acrodisc Syringe Filter with Supor EKV
membrane, 0.2 µm, 25 mm
50/pkg
12246
AcroPak 20 Filter with Supor EKV
membrane, 0.2 µm, non-sterile
3/pkg
12463
AcroPak 800 Capsule with Supor EKV
membrane, 0.2 µm, 38 mm (1.5 in.)
sanitary flange inlet/outlet connection
1/pkg
12247
AcroPak 20 Filter with Supor EKV
membrane, 0.2 µm, sterilized
3/pkg
12094
AcroPak 200 Capsule with Supor EKV
membrane, 0.2 µm, tapered hose barb
inlet/tapered hose barb outlet with filling bell
3/pkg
12464
AcroPak 800 Capsule with Supor EKV
membrane, 0.2 µm, 13 mm (1/2 in.) hose
barb inlet/outlet connection with filling bell
on outlet
1/pkg
12095
AcroPak 200 Capsule with Supor EKV
membrane, 0.2 µm, 13 mm (1/2 in.)
sanitary flange inlet/outlet connection
3/pkg
12466
AcroPak 1500 Capsule with Supor EKV
membrane, 0.2 µm, 38 mm (1.5 in.) sanitary
flange inlet/outlet connection
1/pkg
12460
AcroPak 400 Capsule with Supor EKV
membrane, 0.2 µm, 1.5 in. sanitary
flange inlet/outlet connection
1/pkg
12467
AcroPak 1500 Capsule with Supor EKV
membrane, 0.2 µm, 13 mm (1/2 in.) hose
barb inlet/outlet connection with filling bell
on outlet
1/pkg
Pall's UpScaleSM Program
From drug discovery and basic research, through process development and production, Pall Life Sciences is
the single source for all of your filtration and separation needs. Our UpScale program provides you with the
scalable filtration products and support you need to bring new products to market faster. From syringe filters
to product scale, UpScale products incorporate the same membranes and identical materials of construction.
UpScale direct flow filtration products include Acrodisc syringe filters and AcroPak capsules. These products
use the same membranes in larger or smaller effective filtration areas.
Visit us on the Web at www.pall.com/lab
E-mail us at LabCustomerSupport@pall.com
Pall Life Sciences
600 South Wagner Road
Ann Arbor, MI 48103-9019 USA
800.521.1520 USA and Canada
(+)800.PALL.LIFE Outside USA and Canada
734.665.0651 phone
734.913.6114 fax
Australia – Cheltenham, VIC
Tel: 03 9584 8100
1800 635 082 (in Australia)
Fax: 1800 228 825
Austria – Wien
Tel: 00 1 49 192 0
Fax: 00 1 49 192 400
Brasil – São Paulo, SP
Tel: +55 11 5501 6000
Fax: +55 11 5501 6025
Canada – Ontario
Tel: 905-542-0330
800-263-5910 (in Canada)
Fax: 905-542-0331
Canada – Québec
Tel: 514-332-7255
800-435-6268 (in Canada)
Fax: 514-332-0996
800-808-6268 (in Canada)
China – P. R., Beijing
Tel: 86-10-6780 2288
Fax: 86-10-6780 2238
France – St. Germain-en-Laye
Tel: 01 30 61 32 32
Fax: 01 30 61 58 01
Lab-FR@pall.com
Germany – Dreieich
Tel: 06103-307 333
Fax: 06103-307 399
Lab-DE@pall.com
India – Mumbai
Tel: 91 (0) 22 67995555
Fax: 91(0) 22 67995556
Italy – Buccinasco
Tel: +3902488870.1
Fax: +39024880014
Japan – Tokyo
Tel: 03-6901-5800
Fax: 03-5322-2134
Korea – Seoul
Tel: 82-2-560-8711
Fax: 82-2-569-9095
Malaysia – Selangor
Tel: +60 3 5569 4892
Fax: +60 3 5569 4896
Poland – Warszawa
Tel: 22 510 2100
Fax: 22 510 2101
Russia – Moscow
Tel: 5 01 787 76 14
Fax: 5 01 787 76 15
Singapore
Tel: 65 6 389-6500
Fax: 65 6 389-6501
South Africa –
Johannesburg
Tel: +27-11-2662300
Fax: +27-11-3253243
Spain – Madrid
Tel: 91-657-9876
Fax: 91-657-9836
Sweden – Lund
Tel: (0)46 158400
Fax: (0)46 320781
Switzerland – Basel
Tel: 061-638 39 00
Fax: 061-638 39 40
Taiwan – Taipei
Tel: 886 2 2545 5991
Fax: 886 2 2545 5990
Thailand – Bangkok
Tel: 66 2937 1055
Fax: 66 2937 1066
United Kingdom –
Farlington
Tel: 02392 302600
Fax: 02392 302601
Lab-UK@europe.pall.com
© 2009, Pall Corporation. Pall,
, Acrodisc, AcroPak, Supor, and Ultipleat are trademarks of Pall
Corporation. ® indicates a trademark registered in the United States.
is a service mark of Pall Corporation.
10/09, 5K, AA GN09.2868
PN33564