Electronic Supplementary Material
Appendix Table 1. Total number of returned searches in NIH grant databases, type and
number of exclusions, number of grants identified, and total number of trials analyzed
Number
a
Total grant years retrieved from searches from NIH grant databases
5,810
Additional grants found in NHLBI search
18
Duplicate years of funding removed from same grant
3,315
Number of grant abstracts reviewed after removing duplicate years of funding
2,513
Duplicate sites, ancillary studies or coordinating centers from same grant
933
Abstracts excluded after review, reasons below
K or T award
40
No human subject approval required
130
Only children included
122
No human participants; only biospecimens, etc
35
Animal
22
Lung related
114
Blood, circulatory related
144
Genetics, gene therapy, genotype guided
46
Not randomized clinical trial
201
Active grant
266
Kidney related
30
Stem cells related
10
Technology/measurement development
49
Hypo/hyperthermia related
2
Cell therapy related
3
No cardiovascular or diabetes outcome
13
Pilot, feasibility studies
6
Imaging only studies
3
Registries, networks, repositories
22
Service, delivery
33
Surgery
13
Media
14
Abstract aimed to analyzed only sub-groups
2
Transplants
12
Device/procedures
18
Biologics
1
Drug trial
71
Liver
18
Urinary
13
Cystic Fibrosis
6
Digestion
5
IBS
6
Pancreas
2
Skin, wound
2
Full-text articles searched and reviewed
106
Article not published
20
Articles excluded, reasons below
48
Duplicate site, ancillary study
9
Drug trials
6
Not RCTs
10
Device/technology
1
Community trials
6
Randomized clusters (clinics, churches)
5
Intervention of physicians adhering to guidelines
5
Not behavior change intervention
3
Insufficient data reported to include
2
Liver
1
Grant with published outcome retained
38
a. NIH grant databases searched were QVR, Reporter and CRISP