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Acid-Base Properties of Drugs
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Bronsted-Lowry theory of acids and bases
Acid dissociation constant (Ka) and base association contant (K b)
Hydrolysis reaction, hydrolysis constant
Solubility and ionizability
Ionization Equilibrium
Relative strength of acids and bases
Conjugate acids and conjugate bases
Effect of functional groups on ionizability
The Henderson-Hasselbach equation
Effect of pH of body fluid on proportion of ionized and unionized species
Author:
Title:
Publisher:
Edition:
Notes:
Solomons, T.W. Graham
Organic Chemistry
New York: Wiley, c2000.
7th ed./T.W. Graham Solomons, Graig B. Fryhle
Especially chapter on acids and bases
Title:
Publisher:
Edition:
Notes:
Wilson and Gisvold's texbook of organic medicinal and pharmaceutical chemistry
Philadelphia: Lippincott-Ravan, c 1998
10th ed./edited by Jaime N. Delgado and William A. Remers; 24 contributors
Especially Table of pKa's on page 915 -921
Title:
Publisher:
Edition:
Remington, the science and practice of pharmacy / Algonso R. Gennaro, chairman of the editorial
board and editor
Baltimore, MD : Lippincott Williams & Wilkins, c2000.
20th ed.
Author:
Title:
Publisher:
Barone, Stephen B.
Introduction to general chemistry/ Stephen B. Barone.
Malden, Mass. : Blackwell Science, c2000.
HPD library to StatRef! Database for pharmacology texbooks online, especially Katzung's
American Chemical Society website: http://www.acs.org and educational links
Chemical structures of drug molecules: http://chemfinder.cambridgesoft.com
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