UNIVERSITY OF FLORIDA
COLLEGE OF NURSING
COURSE SYLLABUS
Summer 2011
COURSE NUMBER
NGR 7176 section 8019
COURSE TITLE
Advanced Topics in Pharmacotherapeutics in Nursing
Specialties
CREDITS
3
PLACEMENT
DNP Program
PREREQUISITES
NGR 6140 Physiology and Pathophysiology for Nursing
NGR 6192 Pharmacotherapeutics for Advanced Nursing
Practice
COREQUSITE
None
FACULTY
Office Hours
Rose M. Nealis, PhD, ARNP
PNP-BC
Clinical Associate Professor
PNP Clinical Track Coordinator
nealirm@ufl.edu
HPNP 2220
(352)273-6412
Wednesday
1-3 pm
HPNP 2229
352-273-6366
By Appointment
DEPARTMENT CHAIR
Susan Schaffer, PhD,
FNP-BC, ARNP
Clinical Associate Professor
FNP Clinical Track Coordinator
sdschaf@ufl.edu
JACKSONVILLE CAMPUS DIRECTOR
Andrea C. Gregg, DSN, RN
Associate Professor
greggac@ufl.edu
Jacksonville Campus
904-244-5172
By Appointment
COURSE DESCRIPTION
This course presents complex care issues related to
pharmacotherapeutics as an integral part of overall treatment. Emphasis is on evaluation
research reports and discussion of current research literature in extant drug treatment
and present and future developments. Focus is on the management of complex
problems and issues exemplified in case studies emerging from specialty areas of
practice.
COURSE OBJECTIVES
Upon completion of this course, the student will be able to:
1.
Analyze original research reports related to pharmacological regimens in
specialty areas of practice.
2.
Analyze practice specific issues related to administrative, legal and economic
aspects of pharmacological management.
3.
Integrate presenting symptomatology, underlying pathophysiology and
responses to pharmacological agents in specialty practice.
4.
Design pharmacotherapeutic regimens taking into consideration desired
outcomes, cost, risk, manageability of side effects, and potential for
adherence.
5.
Evaluate the effects of information resources on prescribing trends.
COURSE SCHEDULE
Section
8019
Course Delivery
on-line Delivery
ATTENDANCE
Students may be expected to attend on-campus or synchronous classes
periodically throughout the semester. Students are expected to participate in the
activities and discussions as listed in the course syllabus and on the course web-site.
Timeframes for the posting and receiving of materials are listed in the course materials
on the course web-site.
E-Learning is the course management system that you will use for this course. ELearning is accessed by using your Gatorlink account name and password at
http://lss.at.ufl.edu. There are several tutorials and student help links on the E-Learning
login site. If you have technical questions call the UF Computer Help Desk at 352-392HELP or send email to helpdesk@ufl.edu.
It is important that you regularly check your Gatorlink account email for College
and University wide information and the course E-Learning site for announcements and
notifications.
Course websites are generally made available on the Friday before the first day of
classes.
ACCOMMODATIONS DUE TO DISABILITY
Each semester, students are responsible for requesting a memorandum from the
Disability Resource Center to notify faculty of their requested individual
accommodations. This should be done at the start of the semester.
STUDENT HANDBOOK
Students are to refer to the College of Nursing Student Handbook for information
about College of Nursing policies, honor code, and professional behavior.
TOPICAL OUTLINE
1.
Pharmacogenetics/Pharmacogenomics
2.
New and projected drug developments and uses – design, methodology, and
clinical testing
3.
Drug interactions and polypharmacy
4.
Randomized clinical trials
5.
Economic issues
6.
Legal and ethical issues
7.
Administrative and regulatory issues
8.
Drug research, development and marketing issues
9.
Reading and interpreting drug research for applicability
10.
Sources of public information and influences on demand for drugs
11.
Special problems regarding the decision-making process for complex
pharmacological management
TEACHING METHODS
Lecture, discussion, case studies,
LEARNING ACTIVITIES
Debate, Papers, Evaluation of Levels of Evidence,
EVALUATION METHODS/COURSE GRADE CALCULATION
Paper on Cytochrome p450 Cycle 35%
Advanced Paper
35%
Seminar/e-learning participation
30%
Students can expect to receive feedback on assignments within 2 weeks of the
due date.
GRADING SCALE
A
AB+
B
BC+
94-100
93
92
84-91
83
82
C
CD+
D
DE
74-81*
73
72
64-71
63
62 or below
*74 is the minimal passing grade
REQUIRED TEXT
Selected journal readings and online resources
Recommended References: * This book is available through e-books on the HSC web
site
Brunton, L., Lazo, J. and Parker, K. (2009). Goodman & Gilman's The Pharmacological
Basis of Therapeutics (Goodman and Gilman's the Pharmacological Basis of
Therapeutics. 12th ed. New York, N. Y.: McGraw- Hill.
WEEKLY CLASS SCHEDULE
DATE
TOPIC/
Week
of
May 9
ASSIGNMENTS/READINGS
(See website for Full assignment Description)
Course Overview and Orientation
Core Competencies for All Health Care Professionals (2007)
http://www.nchpeg.org/index.php?option=com_content&view=article&id=94&Itemid=
Has the Revolution Arrived? Francis Collins
http://www.nature.com/nature/journal/v464/n7289/full/464674a.html
Watson, J. (2009). Living with my personalized Genome.
Personalized Medicine (Nov 2009):
P 607.
The Dawning Era of personalized medicine Exposes a Gap in
Medical Education (A Blog)
http://speakingofmedicine.plos.org/2009/08/24/the-dawning-era-of-personalized-me
exposes-a-gap-in-medical-education/
Week
of May
16
Genetics
Cavallari Larisa H, Lam Y. W, "Chapter 6. Pharmacogenetics" (Chapter).
Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. We
Michael Posey: Pharmacotherapy: A Pathophysiologic Approach, 7e:
http://www.accesspharmacy.com/content.aspx?aID=3198295
. Available as an e Book
Goodman & Gilman Chapter 7. Pharmacogenetics
Genetic Concepts and genetic Tests
Evidence Based practice: http://acestar.uthscsa.edu/Learn_model.htm
Evidence Based Practice the Tutorial http://www.biomed.lib.umn.edu/learn/ebp/
Center for Evidence Based Practice http://www.cebm.utoronto.ca/practise/
Penetrance http://www.phgfoundation.org/tutorials/penetrance/
The Education Potential of the Pharmacogenetics and Pharmacogenomics
Knowledge Base (PharmGKB)
Go to this site and register http://www.pharmgkb.org/ Complete the tutorial
How to Search for Data in PharmGKB and the 2 exercises.
Week
of May
23
PharmacoGenetics/Pharma
cogenomics
Pharmacogenomics: http://www.phgfoundation.org/tutorials/pharmacogenomics/
Learn Genetics Tutorial - http://learn.genetics.utah.edu/
Go to : . http://pharmacogenomics.ucsd.edu/home.aspx
You will need to register for this website. Instructions for specific learning activities
will be in the specific modules in Sakai.
Discussion 1 posting due by May30, 2011 EDT by 06:00 EDT..
Week
of May
30
Cytochrome p450
Drug Interactions
Specific learning activities in the module.,
Drug Interaction Table http://medicine.iupui.edu/clinpharm/ddis/
Response to Discussion 1 posting due by June 6, 2011 by 06:00 EDT..
Week
of
June 6
Cytochrome p450
Drug Interactions
Warfarin Pharmacogenetics
http://www.accessmedicine.com/updatesContent.aspx?aid=1001507
Roden DM, Wilke RA, Kroemer HK, Stein CM. (2011)Pharmacogenomics:
the genetics of variable drug responses. Circulation: 123: 1661-1670
Week
of
June
13
New and
Projected Drug
development,
Clinical Trials
Price Waterhouse Personalized medicine: The emerging pharmacogenomics
revolution
http://www.pwc.com/us/en/healthcare/publications/personalized-medicine-the-emerg
pharmacogenomics-revolution.jhtml
Cytochrome P-450 Case Study Due at June 20, 2011 by by 06:00 EDT.
Week
of
June
20
Week
of
June
27
Summer Break
Drug research
Development and
marketing Issues
United States Pharmacy Law and Drug Regulation Review: Introduction e-book
Access Pharmacy : Sections on:
New Drug Approval and Development
Preclinical Investigation
Investigational New Drug Application
Phase I
Phase II
Phase III
New Drug Application
Discussion Board 2 posting due by July 1, 2011 by by 06:00 EDT.
Week
of July
5
Legal/Ethical
Issues
Hanson, M.G.,Taking the patient's side: the ethics of pharmacogenetics.
Personalized Medicine 7.1 (Jan 2010): p75(11
Pharmacogenetics: Ethical Issues
http://www.nuffieldbioethics.org/go/ourwork/pharmacogenetics/publication_314.html
Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African
Americans http://www.nature.com/tpj/journal/v9/n1/index.html
Kosegarten,D.C.. & Pisano, D.J.(2006) Pharmacy and Federal Drug Law Review:
A Patient Profile Approach. E-book available @Access Pharmacy, HSC library.
Ethics( a review): http://www.phgfoundation.org/tutorials/moral.theories/2.html
Pharmacogenomics:A Primer for Policymakers
http://www.nhpf.org/library/background-papers/BP_Pharmacogenomics_01-28-08.pd
Response to Discussion Board 2 posting due by July 8, 2011 by 06:00 EDT.
Week
of July
11
Week
of
July
18
Poly Pharmacy
.
Complimentary
and Alternative
Medicine
NCCAM http://nccam.nih.gov/
Complementary and Alternative Medical Therapies for Diabetes
http://diabetes.niddk.nih.gov/dm/pubs/alternativetherapies/
Drug Interactions with Vitamins and Minerals
http://www.uspharmacist.com/content/tabid/92/c/10439/default.aspx?t=n
utrition%2Fdiet
Pharmacology of Herbal Remedies and the Placebo Effect
by Arthur P. Grollman, MD
http://www.accessmedicine.com/grandRounds/Grollman01/Grollman01_lecturehome
St. John’s Wort: A Mini-Review of its Pharmacokinetics and Anti-Depressant
Effects
http://www.accessmedicine.com/updatesContent.aspx?aid=1001530
Discussion Board 3 posting due by July 18, 2011 by 06:00 EDT
Week
of July
25
Controlled
Substances:
Prescribing,
Monitoring and
Abuse
Tools to Assess Opioid Risk Management http://www.painedu.org/soapp.asp
Goodman & Gilman Chapter 18 Opioids, Analgesia and Pain Management
Response to Discussion Board 3 posting due by July 25, 2010 by 06:00 EDT.
Week
of
Aug 1
Clinical Decision
Making in
Complex Illness
Model: Pain
http://www.guideline.gov/summary/summary.aspx?view_id=1&doc_id=
12243 –
Interagency guideline on opioid dosing for chronic non-cancer pain: an
educational pilot to improve care and safety with opioid treatment
Final Paper due August 1, 2011 by 06:00 EDT
Approved:
Academic Affairs Committee: 02/05; 03/05
Faculty:
03/05
UF Curriculum:
02/06