Megan McClintock Winter 2012 FLUID & ELECTROLYTES ACID BASE IMBALANCES CHAPTER 17 HOMEOSTASIS Maintained by the intake and output of water and electrolytes and regulation by the renal and pulmonary systems Acid-base balance is necessary for many physiologic processes (respiration, metabolism, function of the CNS) Many disease and treatments affect this balance WATER More important to life than any other nutrient 60% of an adult’s body weight, more in a child, less in the elderly Found in foods (but not in alcohol) Daily need is about 2000 mL 1 liter of water weighs 1 kg URINE SPECIFIC GRAVITY Measures the kidney’s ability to concentrate or dilute urine 1.002 – 1.028 High is dehydrated Low is overhydrated (or unable to concentrate) Kidney failure often causes a fixed specific gravity ELECTROLYTES Cations (positively charged) K+, Na+, Ca+, Mg+ Transmit nerve impulses to muscles and contract skeletal and smooth muscles Anions (negatively charged) Attached to cations Cl-, HCO3-, PO4-, SO4 Are always kept in balance DISTRIBUTION OF BODY FLUIDS & ELECTROLYTES Intracellular (2/3) – K+, PO4 Extracellular (1/3) – Na+, Cl Interstitial (lymph) Intravascular (blood plasma) Transcellular (cerebrospinal, pleural, peritoneal, synovial fluids) REGULATION OF FLUID & ELECTROLYTE MOVEMENT OSMOLALITY Indicates the water balance of the body Serum osmolality (275 - 295) High is water deficit Low is water excess Urine osmolality (100-1300) High is concentrated Low is dilute FLUID SPACING First spacing Normal Second spacing Edema Third spacing Ascites Burn edema REGULATION OF WATER BALANCE Hypothalmic Regulation Thirst is stimulated ADH (vasopressin) release is stimulated Pituitary Regulation Adrenal Cortical Regulation ADH (vasopressin) is released Glucocorticoids & mineralocorticoids are released Renal Regulation Adjust urine volume and electrolyte excretion Normal is 1.5 Liters of urine/day REGULATION OF WATER BALANCE (CONT.) Cardiac Regulation ANP & BNP will stop the action of the adrenal cortex and the kidney GI Regulation Intake and output are reabsorbed here Diarrhea and vomiting can lead to significant losses Insensible Water Loss 600-900 mL/day from the lungs and skin Increases with fever, exercise GERONTOLOGIC CONSIDERATIONS Structural changes in the kidney and decreased renal blood flow Decreased GFR Decreased creatinine clearance Loss of ability to concentrate urine and thus conserve water Decrease in renin and aldosterone Increase in ADH and ANP Loss of subcutaneous tissue Decrease in thirst mechanism Musculoskeletal changes Mental status changes Incontinence FLUID VOLUME DEFICIT What causes it? What can you do? FLUID VOLUME EXCESS What causes it? What can you do? NURSING INTERVENTIONS Strict I/O Intake – oral, IV, tube feedings, retained irrigants Output – urine, excess sweating, wound/tube drainage, vomitus, diarrhea Urine specific gravity Assessment of CV, Resp, Neuro, Skin status Daily weight under standardized conditions Don’t “catch up” IV fluids No water with NG suction, use isotonic saline Keep fluids accessible and within reach Give warm or cold fluids (not room temperature) SERUM ELECTROLYTES Sodium (Na) 135 - 145 Primarily responsible for maintaining osmotic pressure (intracellular and extracellular fluids) Increased with fluid deficit Decreased with fluid excess Potassium (K) 3.5 – 5.0 Chloride (Cl) 96 – 106 Works with Na to maintain osmotic pressure Increased with poor kidney function Decreased with excessive vomiting or diarrhea Calcium (Ca) 8.6 – 10.2 Major component of cardiac function Increased with poor kidney function Decreased with excessive urination, diarrhea or vomiting Transmission of nerve impulses, heart and muscle contractions, blood clotting, formation of teeth and bone Phosphate (PO4) 2.4 – 4.4 Function of muscle, RBCs, and the nervous system THE MAGIC FOURS Electrolyte Potassium Chloride Sodium pH CO2 HCO3 Range 3.5 - 5.0 96 - 106 135 - 145 7.35 - 7.45 35 - 45 22 - 26 Magic 4 4 104 140 7.4 40 24 Hematocrit normal is 3 times the hemoglobin SODIUM (135 - 145) Major cation of ECF Primary determinant of osmolality GI tract absorbs sodium from food Regulated by kidneys, ADH, aldosterone Sodium level reflects the ratio of sodium to water Imbalances are typically associated with fluid volume problems HYPERNATREMIA (HIGH SODIUM) What causes it? What can you do? HYPONATREMIA (LOW SODIUM) What causes it? What can you do? POTASSIUM (3.5 - 5.0) Major cation of ICF Sodium-potassium pump requires magnesium Moves into cells during formation of new tissues and leaves the cell during tissue breakdown Diet is the source of potassium Kidneys are primary route of loss HYPERKALEMIA (HIGH POTASSIUM) What causes it? What can you do? HYPOKALEMIA (LOW POTASSIUM) What causes it? What can you do? CALCIUM (8.6 – 10.2) Primary source is bones Regulated by parathyroid hormone, calcitonin, and vitamin D Affects transmission of nerve impulses, heart and muscle contractions, blood clotting, and forming of teeth and bone HYPERCALCEMIA (HIGH CALCIUM) What causes it? What are the symptoms? What can you do? HYP0CALCEMIA (LOW CALCIUM) PHOSPHATE IMBALANCES Hyperphosphatemia Cause - renal failure S/S – calcium deposits in joints, skin, kidneys, eyes; hypocalcemia, tetany, neuromuscular irritability Tx – decrease intake of dairy products, good hydration, fix hypocalcemia Hypophosphatemia Cause – malnutrition, malabsorption syndrome, alcohol withdrawal S/S – CNS depression, confusion, muscle weakness, dysrhythmias Tx – oral supplements (Neutra-Phos), lots of dairy products, IV phosphate (but this can cause sudden hypocalcemia) MAGNESIUM IMBALANCES Hypermagnesemia Cause – increased intake (ie. MOM, Maalox) with chronic kidney disease S/S – lethargy, n/v, loss of DTRs, can have respiratory and cardiac arrest Tx – avoid magnesium-containing drugs, IV calcium, increased fluid intake, may need dialysis Hypomagnesemia Cause – prolonged fasting or starvation, chronic alcoholism, diuretics S/S – confusion, hyperactive DTRs, tremors, seizures, cardiac dysrhythmias Tx – oral supplements, increase green veggies, nuts, bananas, oranges, peanut butter, chocolate; IV or IM magnesium (if given too rapidly can cause cardiac or respiratory arrest) MEDICATIONS Loop diuretics Thiazide diuretics Potassium sparing diuretics Electrolytes Kayexolate ACID BASE BALANCE REGULATION OF ACID-BASE BALANCE Buffer system (immediate) Primary regulator Won’t work without good functioning respiratory and renal symptoms Respiratory system (minutes, max in hours) Excretes CO2 and water Renal system (2-3 days to max respond) Reabsorbs HCO3 ARTERIAL BLOOD GAS pH (7.35 – 7.45) CO2 (35 – 45) HCO3 (22 – 26) Base excess (+2 to -2) If high, metabolic alkalosis If low, metabolic acidosis DETERMINING ACID–BASE BALANCE 1. 2. 3. 4. 5. Is pH acid, base or normal? Is CO2 acid, base or normal? Is HCO3 acid, base or normal? Which of the components match? Is there compensation? Is non-matching reading abnormal? – partial compensation Is non-matching reading normal? – no compensation RESPIRATORY ALKALOSIS RESPIRATORY ALKALOSIS Causes Hyperventilation Pulmonary disease High altitudes Signs/symptoms Hyperventilation Feels “light-headed” Arrhythmias Anxiety Treatment Breathe into paper bag Rebreather mask Anti-anxiety medicine Relaxation techniques Reduce stimulation Treat pain/fever Assess: Resp rate/depth HR & BP Serum K levels Hydration status Check for digitalis toxicity RESPIRATORY ACIDOSIS RESPIRATORY ACIDOSIS Causes CNS depression Loss of lung surface Neuromuscular disease Immobility Mechanical ventilation Treatment Signs/symptoms Dyspnea Hypoxia Drowsiness Tachycardia Seizures Diaphoresis Turn, cough, deep breathe Semi-Fowler’s position Suction Incentive spirometer Seizure precautions Decrease use of sedatives Bronchodilators May need ventilator Assess: Resp rate/depth HR & BP Patiency of airway METABOLIC ALKALOSIS METABOLIC ALKALOSIS Causes NG suctioning Prolonged vomiting Diuretic use Multiple blood transfusions CPR (given bicarb) Signs/symptoms Dizziness Dysrhythmias Convulsions Confusion Muscle cramps (late sign) Treatment Identify and treat the cause! IV fluids Stop giving bicarbonate Give antiemetics Give Diamox Assess: Resp rate/depth HR & BP Serum K levels (usually low) Hydration status (tend to be dehydrated) Check for digitalis toxicity Parasthesias METABOLIC ACIDOSIS METABOLIC ACIDOSIS Causes Diabetic ketoacidosis Renal or liver failure Severe diarrhea Vomiting Starvation Signs/symptoms Kussmaul respirations Hypotension Arrythmias Warm to hot ,flushed skin Confusion Treatment Identify and treat the cause! Administer insulin (if due to ketoacidosis) Give antiemetics IV fluids IV bicarbonate Assess: Renal function (BUN, creatinine) Serum K levels (tends to go up but down once insulin given) Hydration status IV FLUIDS Isotonic Hypertonic 3% NS D51/2NS D10W Hypotonic NS D5W LR 1/2NS Plasma Expanders CENTRAL VENOUS ACCESS DEVICES Centrally inserted catheters (CVCs) Peripherally inserted central catheters (PICCs) Implanted infusion ports NURSING CARE OF CVADS Inspect site for redness, edema, warmth, drainage, pain Dressing change/cleaning with sterile technique using chlorhexidine (back and forth scrub to generate friction) Maintain transparent dressing c/d/I Change injection caps using sterile technique Teach pt to turn head away from insertion site during cleaning and cap change Have patient Valsalva during cap change if unable to clamp Use push-pause method to flush (creates turbulence) Removal of non-tunneled CVCs and PICCs may be done by a trained nurse (have pt Valsalva as last of catheter is withdrawn, apply pressure immediately, inspect catheter tip)