BLOOD TYPING WEBQUEST Navigate to the website below. Answer on a separate sheet of paper. http://nobelprize.org/educational/medicine/landsteiner/readmore.html 1. When did blood transfusions become safer, and why? 2. What can happen if you give someone a transfusion of the wrong blood? 3. List the four parts of blood and give their function in your OWN words. A. B. C. D. 4. How is an antigen different from an antibody? 5. Blood Type A B AB O Antigens present Antibodies present 6. Draw/Find a picture showing the red blood cell (including all antigens) and any antibodies of a person with A+ blood. Draw/Find another showing what an O- person’s RBC’s and antibodies would look like. 7. If you see agglutination occurring when you are testing someone’s blood type, what does that tell you? 8. List a few problems that can occur because of agglutination if you gave someone the wrong blood type in a transfusion. 9. What kinds of blood can an A- person RECEIVE? At the bottom of the page, click on play the blood typing game (quick version-fixed). Click “play” on the next page. Click on a patient to select. Draw some blood from the patient using the syringe, then test it using the reagents at right. Scroll over to see any agglutination. Fill in the chart below to indicate the patient that came into the emergency room, what blood type they had and which blood you selected for the transfusion. Description of Patient Patient’s Blood Type Blood Type Given In Transfusion 10. Were there any patients who could have received more than one type of blood? If so, which and what other types could have been used besides the type you chose? _________ ________________________________________________________________________ 11. Besides blood type, what other information might a doctor need to know before giving a patient a blood transfusion? _______________________________________________ _______________________________________________________________________ PART 2 Begin by navigating to http://www.biology.arizona.edu/ . Select the “Human Biology” link in the upper left hand corner under “Activities”. Click on “Blood Types” to begin. Read the introduction carefully. The monohybrid cross tutorials (click on problems 11 & 13 before you move on) are essential reading at this point. Once you have studied this material completely, click on the “ABO markers” button to see the next page. Read the "The Human ABO markers: The A, B, and O alleles tutorial page." If you know your own blood type, write that here __________. (Put AB if you do not know your own.) Click on the “Blood Types/Genotypes” button to continue. Read the “How are blood types related to the six genotypes?” page. What are all of your possible genotypes, based on the blood type you listed above? ______________________________________________________________________________ What are your parent’s possible genotypes?___________________________________________ Click on the “Alleles Inherited” button to continue. Read the “How are ABO alleles inherited by our children?” page carefully. Using the blood type calculator, check to see if you were correct about the blood types of your parents. Now hook up with another person and use the second calculator to see what the possible blood types of your children would be. Write your blood types and your children’s possible types here:__________________________________________________________________________ Now click on the “Rh Factor” button to continue. Carefully study the page “What about the Rh factor?” then click on the “Blood Types Problem Set” to test what you’ve learned. Once there, click on the “Begin Problem Set” to test your group. There are only six problems, so be careful! Be sure to read the explanations both when you are right and when you are wrong… Record your score here: _____correct out of six. PART 3 Go to the following web site on blood types by typing in this address: http://anthro.palomar.edu/blood/ABO_system.htm Read through the web page very carefully. If you need to, you may print out the text and read it that way or just re-read as often as necessary. 12) Who is the scientist that is reputed as being the first to discover blood types? ____________________________________ 13) What year did he die?__________ 14-15) What are the four types of blood found in primates? ________, _________, _________, and _________ Complete the chart: ABO blood group antigen A antigen B A yes no antibody anti-A antibody anti-B B no no AB yes yes 16-17) If a person has Type B blood, what antigens and antibodies are present in their blood? antigen(s) _________________ antibody(ies) _________________________ 18-19) If a person has Type AB blood, what antigens and antibodies are present in their blood? antigen(s) _________________ antibody(ies) _________________________ 20) A person with which blood type is a universal donor? Why? ___________________ _____________________________________________________________________ 21) A person with which blood type is a universal receiver? Why? ___________________ ____________________________________________________________________ Analyzing Genetic Inheritance Patterns: 22) According to the genetic inheritance chart, can a person who is Type O blood, have a parent with type A blood? _____________ Explain why or why not? _______________________________ 23) According to the chart, what are the possible blood types of a child with 2 parents that have type AB blood. ________________________________________________________ 24) Blood typing cannot be used to determine paternity. What other tests must be used? Name and describe them. PART 4 Use a ‘google search’ to complete the following items. Give the web address where the information was located. 1. Complete the pie graph of each type of cell and the percentages contained in the average human's blood. Web Address: ___________________________________________________________ Components of Human Blood 2. Blood Types in Human Populations Use different colors to make the chart & graph correspond. Web Address: _____________________________________________________ Pie chart Bar graph