University of Split
School of Medicine
Doctoral program
TRANSLATION RESEARCH IN
BIOMEDICINE
Syllabus
Split, January 2015.
Contents
General description of the program.............................................................................................................................................3
Mandatory courses ......................................................................................................................................................................4
Principles of research in medicine ..........................................................................................................................................5
General biostatistics ...............................................................................................................................................................7
Writing research manuscript ..................................................................................................................................................9
Writing the research plan .....................................................................................................................................................11
Writing the research grant ....................................................................................................................................................13
Assessment of a research article ..........................................................................................................................................15
Ethics in research ..................................................................................................................................................................17
Searching the medical literature ...........................................................................................................................................19
Lab management ..................................................................................................................................................................21
Laboratory animals science...................................................................................................................................................23
Researchers' skills .................................................................................................................................................................25
Entrepreneurship and transfer of technology ......................................................................................................................27
Communication and presentation skills ................................................................................................................................29
Elective courses ..........................................................................................................................................................................31
The puzzle of pain .................................................................................................................................................................32
Glycobiology of hematopoiesis .............................................................................................................................................34
Glycobiology of immune system ...........................................................................................................................................36
Adventures of pain in the brain ............................................................................................................................................38
Genetic analysis of complex diseases ...................................................................................................................................40
Seeing the invisible ...............................................................................................................................................................42
Development of human spinal ganglia .................................................................................................................................44
Amphioxus - a model for chordate’s evolution ....................................................................................................................46
Basis of heart electrophysiology and bioenergetics .............................................................................................................48
Colon cancer .........................................................................................................................................................................50
Genome databases and statistics .........................................................................................................................................52
Diagnostics of genetic and chromosomal diseases ...............................................................................................................54
Oxidative stree and protection mechanisms - The role of uric acid .....................................................................................56
Multivariate statistics ...........................................................................................................................................................58
Why and how we breathe? ...................................................................................................................................................60
Animal models in the stroke research ..................................................................................................................................62
Quasi-experimental and non-experimental research designs ..............................................................................................64
Communication in living organisms ......................................................................................................................................66
The role of ubiquitin in health and diseases .........................................................................................................................68
Translational research of hearing and speach ......................................................................................................................70
The Cochrane Library and evidence in medicine ..................................................................................................................72
Methods for isolation of bioactive substances .....................................................................................................................74
Brain Mapping: From Neural Basis of Cognition to Surgical Applications .............................................................................76
How to construct your own organ? ......................................................................................................................................78
Molecular and biochemical methods in biomedical research ..............................................................................................80
The choice of journal for scientific publication .....................................................................................................................82
Alphabet of the good night sleep..........................................................................................................................................84
Systematic review and meta-analysis ...................................................................................................................................86
General description of the program
Name of the program
Translational Research in Biomedicine (TRIBE)
Research field
Biomedicine and health, basic medical sciences and related branches
Institution
University of Split School of Medicine
Participating institutions
Faculty of Chemistry and Technology, Faculty of Humanities and Social
Sciences, Faculty of Sciences; Mediterranean Institute for Life Sciences.
Duration
Three years
ECTS
180
Innovativeness of doctoral
program
Orientation towards the concept of translational research, interdisciplinary,
practical laboratory work, and towards entrepreneurship in science.
Admission criteria
Students who have completed appropriate graduate studies in scientific fields
of biomedicine and health, biotechnical, social and natural sciences and
associated scientific fields.
The aim of the study TRIBE is education of competent researchers in basic
biomedical disciplines to successfully match the modern scientific and business
challenges at national and international
Learning outcomes
Academic title
Doctor of Philosophy (Ph.D.)
Mandatory courses
Code
PT-ZOP1
PT-ZOP2
PT-ZOP3
PT-ZOP4
PT-ZOP5
PT-ZOP6
PT-ZOP7
PT-ZOP8
PT-OP1
PT-OP2
PT-ZOP9
PT-OP4
PT-IP11
Course name
Principles of research in medicine
(Professor Matko Marušić)
General biostatistics
(Associate professor Ozren Polašek)
Writing research manuscript
(Associate professor Livia Puljak)
Writing the research plan
(Professor Matko Marušić)
Writing the research grant
(Professor Ivica Grković)
Assessment of a research article
(Associate professor Livia Puljak)
Ethics in research
(Professor Ana Marušić)
Searching the medical literature
(Professor Damir Sapunar)
Lab management
(Professor Damir Sapunar)
Laboratory animal science
(Assistant professor Sandra Kostić)
Researchers' skills
(Associate professor Livia Puljak)
Entrepreneurship and transfer of technology
(Professor Mile Đelalija)
Communication and presentation skills
(Associate professor Livia Puljak)
L+S+E
ECTS
6+6+0
2
4+4+8
2
10+4+10
3
0+20+0
3
2+13+0
2
8+8+0
2
6+0+4
2
2+6+6
2
12+4+4
3
10+4+0
2
4+4+6
2
10+10+5
3
P8+6V
2
30
NAME OF THE COURSE
Principles of research in medicine
Code
PT-ZOP1
Year of study
Course teacher
Professor Matko Marušić
Credits (ECTS)
Associate teachers
Professor Ana Marušić
Type of instruction
Professor Ana Jerončić
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
2
L
S
E
F
6
6
0
0
10%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Empower students to use all elements of research in clinical medicine, from key research
principles to publication of research results.
Completed university graduate program which contained the basics of scientific work and
statistic.
The students will develop the following specific competences:
Understanding of the sources and paths of production of genuine knowledge.
Recognition of types of clinical research studies.
Formulation of hypothesis and consecutive definition of main and secondary outcome
Learning outcomes
measures.
expected at the level Application of the skills of search for specific literature in relevant databases.
of the course (4 to 10 Ability of critical appraisal of all parts of research reports.
learning outcomes)
Understanding and application of basic statistical concepts in clinical research.
Application of data presentation with respect to their nature and meaning.
Understanding of the principles of evidence-based medicine and its use.
Understanding the complexity of performing own research and application of the principles
of responsible conduct of research.
The content is divided into 6 parts, where each is given 1 hour-lecture and 1-hour seminar.
General principles of planning and doing research in clinical setting. Hypothesis as the key
starting point.
Course content
Sample and population. Types of clinical studies.
broken down in detail Statistical analysis of data. Main (primary) and secondary outcome measures. Confounding
by weekly class
factors and biases.
schedule (syllabus)
The structure, critical appraisal and publication of research article.
Search for specific literature information. Evidence-based medicine.
Rush slowly: planning the research, data collection and processing. Responsible conduct of
research.
Format of instruction
☒ lectures
☒ seminars and workshops
Student
responsibilities
Screening student
Oral
examination (2
work (name the
proportion of ECTS
ECTS)
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Oral examination (pass/fail) with 50 published questions, where 3 are drawn, and all 3
should have satisfactory answers.
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Number of
Availability via
copies in the other media
library
Marušić M, editor. Principles of research in medicine. 1st
edition. Zagreb: Medicinska naklada; 2008. (ISBN 978953-176-358-5)
Ferenczi E, Muirhead N. One Stop Doc Statistics and
Epidemiology. Oxford: Oxford University Press, 2007.
- Day RA, Gastel N. How to write and publish a scientific paper, 6th edition. Westport,
Connecticut: Greenwood Press, 2006.
- Lang T, Secic M. How To Report Statistics in Medicine: Annotated Guidelines for Authors,
Editors, and Reviewers, 2nd edition. Philadelphia: American College of Physicians, 2006.
- Committee on Assessing Integrity in Research Environments. Integrity in Scientific
Research. Washington DC: Institute of Medicine and National Research Council, 2002.
Quality assurance
 Teaching quality analysis by students and teachers
methods that ensure  Exam passing rate analysis
the acquisition of exit  Committee for control of teaching reports
competences
 External evaluation
Other (as the
If a student has a problem with attendance or examination, the teacher reports the issue
proposer wishes to
to the head of the program.
add)
NAME OF THE COURSE
General biostatistics
Code
PT-ZOP2
Year of study
Associate professor Ozren
Course teacher
Credits (ECTS)
Polašek
Associate teachers
Status of the course
Mandatory
1
2
Type of instruction
(number of hours)
L
S
E
4
4
8
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The aim of the course is to demonstrate the basics of biostatistics and train students for an
independent evaluation of the results of statistical analysis in published articles and
development of their own data analysis plan
None
General: memorize the basics of statistical inference principles and fundamentals
interpretation of the results of statistical analysis. Understanding the use, advantages and
disadvantages of certain statistical methods, applying the algorithm for the choice of the
Learning outcomes
statistical tests. Application of the methods for determining the sample size and statistical
expected at the level power of the study. Synthesize knowledge of the study design, the characteristics of data
of the course (4 to 10 and statistical knowledge in a systematic basis which will enable students to read published
learning outcomes)
articles and be able to develop an analysis plan of their own.
Specific: Independent application of statistical packages, knowledge of proper presentation
of statistical aspects of the research results, the possibility of critical judgment of the
research organization and methods of analysis of the research results in the literature
1. Basics of statistical methods
Course content
2. Design and analysis of diagnostic research
broken down in detail 3. Research the organization and statistical aspects
by weekly class
4. Overview of selected methods of advanced data analysis
schedule (syllabus)
5. Statistics - friend or foe in research?
6. Data presentation
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
20
Research
60
Practical training
20
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Critical assessment of published article
NAME OF THE COURSE
Writing research manuscript
Code
PT-ZOP3
Year of study
Course teacher
Prof. Livia Puljak, MD, PhD
Credits (ECTS)
Prof. Damir Sapunar, MD,
Type of instruction
Associate teachers
PhD
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
3
L
S
E
10
4
6
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Learning structure of research article, writing one research manuscript, learning how to
work with EndNote reference management software, learning how to use online
submission systems for manuscripts; learning how to prepare figures for manuscript
submission
Appropriate undergraduate or graduate degree
Knowledge of structure of research article
Independent writing of a research manuscript
Independent usage of EndNote reference management software
Independent usage of online manuscript submission systems
Independent preparation of a figure for manuscript submission
Structure of a research article (1 h L)
EQUATOR guidelines (1 h L)
Choosing journal for manuscript submission (1 h L)
Preparing manuscript according to the instructions for authors (1 h L)
Working with online manuscript submission systems (2 h L)
Course content
Communicating with editors (1 h L)
broken down in detail What happens after manuscript acceptance (1 h L)
by weekly class
EndNote reference management software (2 h L)
schedule (syllabus)
Preparation of a figure for manuscript submission (4 h S)
Writing research manuscript: Introduction and Methods (1 h E)
Writing research manuscript: Results and Discussion (1 h E)
Writing research manuscript: References and Supplements (1 h E)
EndNote reference management software (2 h E)
Computer software for preparation of a figure (1 h E)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
work
Grading and
evaluating student
work in class and at
the final exam
The exam consists of:
Writing a research manuscript on a given subject
Inserting references in a manuscript using EndNote software
Preparing a figure for manuscript submission
Number of
Availability via
Title
copies in the
other media
library
Scientific articles and hand-outs prepared by teachers
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Essay
Seminar essay
(Other)
Tests
Oral exam
(Other)
Written exam
1
Project
1
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
(Other)
NAME OF THE COURSE
Writing the research plan
Code
PT-ZOP4
Year of study
Course teacher
professor Matko Marušić
Credits (ECTS)
Associate teachers
Status of the course
Mandatory
1.
3
Type of instruction
(number of hours)
L
S
E
F
0
20
0
20
Percentage of application
of e-learning
100%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Empower the students to write independently the detailed plan of research related to the
theme of their doctoral dissertation.
none
Students' independent plan of investigation, with 20 precisely defined elements:
1. Title of the research project; 2. Background; 3. Hypothesis; 4. Description and design of
Learning outcomes
the study; 5. Sample; 6. Methods and procedures; 7. Main independent variables; 8.
expected at the level Treatment/intervention; 9. Main outcome measure(s); 10. Secondary outcome measure(s);
of the course (4 to 10 11. Calculation of the minimal sample size; 12. Statistical tests; 13. Possible biases and
learning outcomes)
confounding variables; 14. Validity of the study; 15. Ethical approval; 16. Financing of the
research; 17. Conflict of interest; 18. Literature (references); 19. Publication plan; 20.
Authorship.
Course content
Each student individually and independently develops the plan of research, communicating
broken down in detail by e-mail with the teacher all until the plan is complete and without a single fault.
by weekly class
schedule (syllabus)
Format of instruction
☐ on line in entirety
Student
To produce a complete and completely professionally written plan.
responsibilities
Screening student
work (name the
proportion of ECTS
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
Project
course)
Grading and
The pass/fail review of the research plan.
evaluating student
work in class and at
the final exam
Number of
Availability via
Required literature
Title
copies in the
other media
(available in the
library
library and via other
1. Marušić M, editor. Principles of research in medicine. 20
no
media)
1st edition. Zagreb: Medicinska naklada; 2008. (ISBN 978-
953-176-358-5)
2. Ferenczi E, Muirhead N. One Stop Doc Statistics and
Epidemiology. Oxford: Oxford University Press, 2007.
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
20
no
A number of texts, presentations and guidelines given on the Program’s web pages.

Teaching quality analysis by students and teachers

Exam passing rate analysis

Committee for control of teaching reports

External evaluation
If the student’s work is not satisfactory, the teacher informs the head of the Program.
NAME OF THE COURSE
Writing the research grant
Code
PT-ZOP5
Year of study
1
Course teacher
prof. Ivica Grković
Credits (ECTS)
2
prof. Damir Sapunar; prof.
L
S
E
F
Colin Anderson (Dept. of
Type of instruction
Associate teachers
Anatomy & Cell Biol.,
(number of hours)
2
13
University of Melbourne,
Australia)
Mandatory
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
The objective of this course is to demonstrate necessary steps in preparation of research
project. By creating their own research project proposal students get familiar with
Course objectives
knowledge and skills of creating introduction and hypothesis, they make working plan and
design methodology to solve a particular problem, project their own findings and results
and discuss relevancy and applicability.
Course enrolment
requirements and
entry competences
required for the
course
1. To understand basic concepts of research proposal, importance of the supervisor
(project leader) and optimal research surroundings.
Learning outcomes
2. To distinguish various formats of project proposals. To get familiar with process of
expected at the level evaluation of various project components.
of the course (4 to 10 3. To analyze and compare various parts of project proposal and to discuss importance of
learning outcomes)
the summary, to understand the body of the proposal.
4. To understand and appreciate time constraints and format prerequisite in writing of the
proposal.
Lecture (2 hours): Successful project applications in biomedicine (importance of grant
proposals, general principals and rules of good proposals, organization of time and
infrastructure, involvement of collaborators, task distributions, common problems and
constrains).
Seminar 1 (2 hours) - From the idea to the title and summary (discussion of individual
Course content
ideas and suggestions how to improve them)
broken down in detail Seminar 2 (3 hours) – Creation of hypotheses based on the literature (critical appraisal of
by weekly class
the literature and creation of 2-3 working hypotheses.
schedule (syllabus)
Seminar 3 (4 hours) – Procedures, protocols and plans (critical reflection to and writing of
detailed research plan related to precise time boundaries).
Seminar 4 (2 hours) – Aims, applications and expected results (discussion of expected
results and potentials of their practical application and commercialization)
Seminar 5 (2 hours) – Associated administration (expense sheets, plan for presentation and
dissemination of results).
☒ lectures
☒ independent assignments
☒ seminars and workshops
☐ multimedia
☐ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☒ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Screening student
work (name the
proportion of ECTS
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Class
attendance
Experimental
work
Research
Practical training
Report
(Other)
Essay
Seminar essay
(Other)
Tests
Oral exam
(Other)
Written exam
Project
100%
Title
Required literature
(available in the
library and via other
media)
(Other)
Number of
Availability via
copies in the
other media
library
The First-Time Grantwriter's Guide to Success, by
Cynthia R. Knowles, Corwin Press, 2002, ISBN
0761945369.
Grant Application Writers Handbook by Liane ReifLehrer, Jones and Bartlett Publishers, 2004, ISBN
0763716421.
Original and review papers in this field:
Optional literature (at
- Writing successful grant applications for preclinical studies, Kessel D, Chest ;130: 296-8.;
the time of
- An introduction to obtaining extramural funding, Berger DH., J Surg Res ;128: 226-31.
submission of study
- How to increase your funding chances: common pitfalls in medical grant applications,
programme proposal)
Koren G., Can J Clin Pharmacol ;12:e182-5.
Quality assurance
 Teaching quality analysis by students and teachers
methods that ensure  Exam passing rate analysis
the acquisition of exit  Committee for control of teaching reports
competences
 External evaluation
Other (as the
proposer wishes to
add)
NAME OF THE COURSE
Assessment of a research article
Code
PT-ZOP6
Year of study
Course teacher
Prof. Livia Puljak, MD, PHD
Credits (ECTS)
Liz Wager, PhD
Type of instruction
Associate teachers
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
2
L
S
8
8
E
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Skills for reading a research manuscript. Basic questions (why, how, how much?). Area,
originality, study design, methods (participants, outcomes, statistics). Judgment errors. Risk
of bias. Analysis of elements of a research manuscript.
Appropriate undergraduate or graduate degree
Learn procedures of evidence-based medicine in analysis of publications. Learn and
independently differentiate credible from poor sources of research information.
Independently make assessment of validity and reliability of research result assessments.
Independently analyze risk of bias in research.
Assessment of a research manuscript (2 h L)
Scientific literature (1 h L)
Medical journals (1 h L)
Manuscript review procedure (1 h L)
Course content
Critical assessment of a manuscript (4 h S)
broken down in detail
Quality of research (1 h L)
by weekly class
Validity and reliability (1 h L)
schedule (syllabus)
Measures of effect (1 h S)
Evidence-based medicine (1 h L)
Meta-analysis (1 h S)
Systematic review (2 h S)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☐ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 1
Project
1
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
The exam consists of:
Writing a review of a given research article
Presenting the review
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Scientific articles and hand-outs prepared by teachers
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
Number of
Availability via
copies in the
other media
library
NAME OF THE COURSE
Ethics in research
Code
PT-ZOP7
Course teacher
Professor Ana Marušić
Associate teachers
Status of the course
Mandatory
Year of study
Credits (ECTS)
1
2
Type of instruction
(number of hours)
L
Percentage of application
of e-learning
0%
6
S
E
F
4
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The main objective of the course is to introduce basic ethical requirements of research in
biomedicine and related disciplines.
General knowledge of the research process.
1. Understand ethical principles and procedures during research.
2. Explain ethical concepts of research on humans and experimental animals.
3. Apply basic knowledge in ethics to concrete research activity.
4. Relate the knowledge of ethical principles with the methodology of research.
Learning outcomes
5. Compare different ethical principles in different ethical requirements and rules in EU
expected at the level countries.
of the course (4 to 10 6. Interpret the recommendations of the Ethics Committee about ethical approval for
learning outcomes)
research.
7. Assess ethical aspects of research proposals and acquire skills to participate in the work
of ethical committees.
8. Accept ethical and social responsibility for the success of research process, social benefit
of the research results and possible social consequences.
Lecture (2h): Introduction to ethics. Characteristics of clinical research. Legal regulation.
Differences in ethical requirements. Ethics of animal research.
Course content
Lecture (2h): Principles of informed consent. Work of ethical committees and other
broken down in detail relevant bodies.
by weekly class
Lecture (2h): Ethics of results presentation and publication.
schedule (syllabus)
Practical (2h): Analysis of application for ethical approval and of recommendations of the
ethical committee.
Practical (2h): Analysis of ethical presentation and publication of research results.
☒ lectures
☒ independent assignments
☐ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Class attendance and active participation, active work on seminar essays.
responsibilities
Class
Screening student
0.2
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay 0.6
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
0.2
Project
Written examination (multiple choice test), two mandatory seminar essays. The grad is the
sum of all points from three test parts – 60% from seminar essays and 40% written test.
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
EC. Syllabus on ethics in research:
http://bookshop.europa.eu/isbin/INTERSHOP.enfinity/WFS/EU-Bookshop-Site/en_GB//EUR/ViewPublication-Start?PublicationKey=KIN124551
EC. European textbook on ethics in research:
http://bookshop.europa.eu/isbin/INTERSHOP.enfinity/WFS/EU-Bookshop-Site/en_GB//EUR/ViewPublication-Start?PublicationKey=KINA24452
Helsinki Declaration:
http://www.wma.net/en/30publications/10policies/b3/
EU legislation on animal research:
http://ec.europa.eu/environment/chemicals/lab_animal
s/home_en.htm
ARRIVE guideline for reporting animal research:
http://www.plosbiology.org/article/info%3Adoi%2F10.13
71%2Fjournal.pbio.1000412
Ethical codex of the Medical School in Split:
http://neuron.mefst.hr/docs/dokumenti/pravilnici/Eticki
%20kodeks.doc i
http://neuron.mefst.hr/docs/dokumenti/pravilnici/Pravil
nik%20o%20radu%20Etikog%20povjerenstva.doc
Number of
Availability via
copies in the
other media
library
Internet
www.publicationethics.org.uk; www.cochrane.org




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
Internet
Internet
Internet
Internet
NAME OF THE COURSE
Searching the medical literature
Code
PT-ZOP8
Year of study
Course teacher
Professor Damir Sapunar
Credits (ECTS)
Associate teachers
Ana Utrobičić
Type of instruction
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
2
L
S
E
2
6
6
F
0%
COURSE DESCRIPTION
Course objectives
Empower students for independent search of scientific information in the online database
and of key sources of funding.
Course enrolment
Completed university graduate program.
requirements and
entry competences
required for the
course
Learning outcomes
After successfully completed course student will be able to:
expected at the level - list and describe the main sources of medical information
of the course (4 to 10 - define the search strategy
learning outcomes)
- analyze the publication of individual scientists
- implement the search within the main databases
- define the principles of evidence-based medicine.
Course content
Principles search of scientific information in web databases; Analysis publications individual
broken down in detail scientist; Finding information about the sources of financing; Principles of evidence-based
by weekly class
medicine and its application in the management of medical information; Search strategies;
schedule (syllabus)
Search for clinical evidence; The basic sources of science-based evidence (The Cochrane
Library, DARE, PubMed / Clinical Quesries, National Clearinghouse Giudelines etc.);
Converting a clinical problem in the search strategy (PICO model); Way to search a
database of evidence based medicine; Know the main resources for finding projects
(Cordis, CRISP, COS, NSF and other)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Title
Required literature
(available in the
library and via other
media)
Optional literature
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Marušić M, editor. Principles of research in medicine. 1st
edition. Zagreb: Medicinska naklada; 2008. (ISBN 978953-176-358-5)
- Centre for health evidence. Users' guides to evidencebased practice.
http://www.cche.net/usersguides/main.asp
- Ball C. The evidence based clinician: part 1, asking
answerable questions. Student BMJ 2002;10:313-4.
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
Number of
Availability via
copies in the
other media
library
NAME OF THE COURSE
Lab management
Code
PT-OP1
Course teacher
Professor Damir Sapunar
Associate teachers
Damir Juras, PhD
Status of the course
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Mandatory
Year of study
Credits (ECTS)
Type of instruction
(number of hours)
1
3
Percentage of application
of e-learning
0%
L
S
E
12
4
2
F
Empower students for independent and responsible work in research laboratory.
Completed university graduate program.
After successfully completed course student will be able to:
- describe and apply the methods of storing data
- analyze the legislation relating to the laboratory work
- list and describe the procedures associated with safe operation in the laboratory
- describe the process of designing the experiments
- list and describe standard laboratory equipment
- master the writing laboratory diaries.
Course content
Quality control; Good laboratory practice; Data storage; Organization of the laboratory
broken down in detail work; Institutional and legal regulations on laboratory safety; Acquisition, storage and
by weekly class
disposal of hazardous substances; Handling and disposal of biological material; Protective
schedule (syllabus)
clothing and footwear; General procedures in the laboratory; Standard laboratory
equipment; Laboratory notebook; How to prepare an experiment ?; The organization of
the workplace; Writing protocols; Presentation of results; Discussion about scientific
articles ( journal club).
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Required literature
Title
Number of
Availability via
(available in the
library and via other
media)
copies in the other media
library
- Making the Right Moves: A Practical Guide to Scientifıc
Management for Postdocs and New Faculty. Burroughs
Wellcome Fund and Howard Hughes Medical Institute,
2006. (http://www.hhmi.org/labmanagement)
- Barker K. At the Bench: A Laboratory Navigator At the Bench: A Laboratory Navigator.
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2005.
Quality assurance
 Teaching quality analysis by students and teachers
methods that ensure  Exam passing rate analysis
the acquisition of exit  Committee for control of teaching reports
competences
 External evaluation
Other (as the
proposer wishes to
add)
Optional literature
NAME OF THE COURSE
Laboratory animals science
Code
PT-OP2
Year of study
Assistant professor, Sandra
Course teacher
Credits (ECTS)
Kostić, PhD
Jagoda Dujić, D.V.M.
Professor Damir Sapunar,
Type of instruction
Associate teachers
MD, PhD
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
2
L
S
E
10
4
0
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The course objective is to introduce the students to the legislation and basic principles of
using the laboratory animals for scientific purposes, and to prepare the students for the
work with laboratory animals –including the information needed to acquire the necessary
permits
University diploma
Student will be able to:
- name and explain the legislations involved in acquiring, care and use of animals in
scientific research
- describe and explain the methods for handling laboratory animals
- describe the procedures for planning the experiments in which laboratory animals will be
Learning outcomes
used
expected at the level
- define, describe and explain the 3R principles (reduce, replace, refine)
of the course (4 to 10
- critically analyze the basic ethical principles and ethical issues arising from the use of
learning outcomes)
laboratory animals in research
- name and describe the animals most frequently used in scientific research (their anatomy,
genetics…)
- describe, discriminate and explain the methods for anesthetizing and euthanizing the
laboratory animals
Lectures:
The legislation involved in acquiring, the care and use of animals in scientific research 1h
Accreditation of the Facility for experimental animals;
Institutional regulations and veterinary control;
Ethical issues 1h
Good laboratory practice and laboratory animals 2h
The experimental design and procedures important for the use of laboratory animals
Course content
(surgery, anesthesia and analgesia, euthanasia) 2h
broken down in detail Experimental models;
by weekly class
Methods for testing the behavior of laboratory animals 2h
schedule (syllabus)
Nomenclature of mice and rat;
The strains and the breeding system (outbred and inbred strains) used to produce and
maintain the specific strain type;
Other experimental animals 2h
Seminars:
- visit to the Facility for experimental animals of University of Split 2h
- video projections of the important procedures and methods for the use of experimental
animals (handling, injecting, euthanizing) 2h
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☐ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Attending the lectures and passing the exam
responsibilities
Class
Screening student
1
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
1
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
Written exam
evaluating student
work in class and at
the final exam
Number of
Availability via
Title
copies in the
other media
library
National Research Council. Guide for the Care and Use of
Available on
Laboratory Animals. National Academy Press; 1996;
internet
Washington. Institute for Laboratory Animal Research
(ILAR) web resources
Required literature
http://dels.nas.edu/ilar_n/ilarhome/index.shtml
(available in the
Available on the
library and via other Materials from lectures
student’s server
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
NAME OF THE COURSE
Researchers' skills
Code
PT-ZOP9
Course teacher
Prof. Livia Puljak, MD, PhD
Prof. Damir Sapunar, MD,
Associate teachers
PhD
Status of the course
Mandatory
Year of study
Credits (ECTS)
1
2
Type of instruction
(number of hours)
L
S
E
4
4
6
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning about principles of business correspondence, communicating research
information at a conference via poster, principles of organizing a research conference,
principles of working with mentor and managing a research group, methods for
establishing research collaborations; critical thinking.
Appropriate undergraduate or graduate degree
Independently doing business correspondence
Independently making poster for a research conference
Learning outcomes
Independently organize a research conference
expected at the level
Knowledge of basic principles of working with a mentor
of the course (4 to 10
Knowledge of basic principles of managing a research group
learning outcomes)
Knowledge of methods for establishing research collaboration
Knowledge of basic principles of critical thinking
1.
Business correspondence (1 h L)
2.
Making a poster (6 h E)
Course content
3.
Organizing a research conference (1 h L)
broken down in detail
4.
Working with a mentor (1 h L)
by weekly class
5.
Managing a research group (1 h L)
schedule (syllabus)
6.
Research collaboration (2 h S)
7.
Critical thinking (2 h S)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Written exam
Grading and
evaluating student
work in class and at
the final exam
The exam consists of:
- Making a poster for a research conference
- Presenting a poster
- Organizing a research conference
- Presenting a research conference
1
Project
1
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Scientific articles and hand-outs prepared by teachers
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
(Other)
Number of
Availability via
copies in the
other media
library
NAME OF THE COURSE
Entrepreneurship and transfer of technology
Code
PT-OP4
Year of study
1
Course teacher
Professor Mile Dželalija
Credits (ECTS)
3
Professor Marina Dabić,
L
S
E
F
Type of instruction
Associate teachers
Professor Leandra Vranješ
(number of hours)
10
10
5
Markić
Mandatory
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
Course objectives
Course enrolment
Understand how to become an entrepreneur, to develop a successful business idea,
requirements and
independently and / or in cooperation with others, to create an entrepreneurial company,
entry competences
independently and / or in cooperation with others.
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Decision on the creation of entrepreneurship: introduction to entrepreneurship;
Developing a successful business idea: identify opportunities and generate ideas; feasibility
Course content
analysis; writing a business plan; analysis of competitiveness; develop an effective business
broken down in detail model; From Idea to Enterprise Business: preparing the appropriate ethical and legal
by weekly class
foundations; assessing the financial strength and viability of new ventures; construction of
schedule (syllabus)
a new business team; financing; Managing and growing entrepreneurial companies:
unique marketing issues; the importance of intellectual property; preparing for the
challenges of growth and its evaluation; strategy for growth companies; franchise.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 1
Project
1
(Other)
course)
Grading and
The exam consists of written report and oral presentation
evaluating student
work in class and at
the final exam
Required literature
Title
Number of
Availability via
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
copies in the other media
library
Bruce R. Barringer and R. Duane Ireland,
Entrepreneurship: Successfully Launching New Ventures,
2nd ed., Upper Saddle River, New Jersey, 2008
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
NAME OF THE COURSE
Communication and presentation skills
Code
PT-IP11
Year of study
Course teacher
Prof. Livia Puljak, MD, PhD
Credits (ECTS)
Prof. Ivana Bilić, PhD
Type of instruction
Associate teachers
Krešimir Macan
(number of hours)
Status of the course
Mandatory
Percentage of application
of e-learning
1
2
L
S
E
8
0
6
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning about communication with media and popularization of science; making good
presentation, presenting information in a best way; controlling public speaking anxiety,
communicating with the media, law related to media relations
Appropriate undergraduate or graduate degree
Learning basics of scientific communication
Being able to make a PPT presentation
Being able to make a press release
Being confident about public speaking
Learning basics about communication with media
Learning laws related to media relations
Scientific communication (1 h L)
Making PPT presentation and writing press release (1 h L)
Verbal and nonverbal communication (1 h L)
Course content
Public speaking (1 h L)
broken down in detail Communicating with media (5 h E)
by weekly class
Laws related to media relations (1 h E)
schedule (syllabus)
Communicating with employees and within a team (1 h L)
Communicating positive, negative, neutral and persuasive messages (1 h L)
International communication (1 h L)
Negotiating (1 h L)
☒ lectures
☐ independent assignments
☐ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
1
Project
1
The exam consist of making a:
PPT presentation
Three types of press-releases
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Scientific articles and hand-outs prepared by teachers
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
Number of
Availability via
copies in the
other media
library
Elective courses
Code
Course title
PT-IP01
PT-IP14
PT-IP15
PT-IP02
PT-IP17
PT-IP03
PT-IP05
PT-IP18
PT-IP19
PT-IP20
PT-IP06
PT-IP08
PT-IP21
PT-IP12
PT-IP14
PT-IP23
PT-IP24
PT-IP25
PT-IP26
PT-IP09
PT-IP10
PT-OP5
PT-IP31
PT-IP13
PT-OP3
PT-IP15
PT-IP32
PT-IP33
The puzzle of pain (D. Sapunar)
Glycobiology of hematopoiesis (V. Čikeš-Čulić)
Glycobiology of immune system (A. Markotić)
Adventures of pain in the brain (L. Puljak)
Genetic analysis of complex diseases (T. Zemunik)
Seeing the invisible (D. Sapunar)
Development of human spinal ganglia (K. Vukojević)
Amphioxus - a model for chordate’s evolution (I. Bočina)
Basis of heart electrophysiology and bioenergetics (M. Ljubković)
Colon cancer (J. Terzić)
Genome databases and statistics (V. Boraska)
Diagnostics of genetic and chromosomal diseases (I. Drmić, F. Stipoljev)
Oxidative stress and protection mechanisms - The role of uric acid (M. Boban)
Multivariate statistics (G. Kardum)
Why and how we breathe? (R. Pecotić)
Animal models in the stroke research (L. Cambj Sapunar)
Quasi-experimental and non-experimental research designs (D. Hren)
Communication in living organisms (M. Miloš)
The role of ubiquitin in health and diseases (I. Novak)
Translational research of hearing and speech (D. Kovačić)
The Cochrane Library and evidence in medicine (L. Puljak)
Methods for isolation of bioactive substances (I. Jerković)
Brain Mapping: From Neural Basis of Cognition to Surgical Applications (M. Rogić)
How to construct your own organ? (S. Kostić)
Molecular and biochemical methods in biomedical research (M. Pavela Vrančić)
The choice of journal for scientific publication (A. Marušić)
Alphabet of the good night sleep (R. Pecotić)
Systematic review and meta-analysis (L. Puljak)
ECTS
P10+S4
P2+S4+V10
P4+S6+V5
P10+S6
P4+S5+V6
P10+V6
P6+S4+V4
P5+S5+V5
P3+S5+V7
P4+S6+V5
P4+S4+V4
P7+S4+V4
P6+S4+V5
P4+S6+V4
P6+S5+V14
P6+S4+V4
P10+S10
P6+S4+V4
P4+S6+V5
P10+S6+V4
P5+5S+5V
P10+S6+V0
P6+S4+V4
P6+S10+V0
P4+S4+V6
P4+S2+V4
P4+7S+4V
5P+5S+5V
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
NAME OF THE COURSE
The puzzle of pain
Code
PT-IP01
Course teacher
Professor Damir Sapunar
Assoc. prof. Livia Puljak
Associate teachers
Assist. prof. Sandra Kostić
Status of the course
Elective
Year of study
Credits (ECTS)
2
2
Type of instruction
(number of hours)
L
S
10
4
Percentage of application
of e-learning
0%
E
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Understanding and adoption of the basic scientific and clinical knowledge necessary for a
multidisciplinary approach to the treatment of pain
Passed exams from first year of the Program.
Understand the main concepts in pain neurobiology.
Define main concepts in pain medicine.
Understand the evolutionary importance of pain.
Understand psychosocial and cultural aspects of pain.
Analyse current treatments in pain medicine.
Describe principles of EBM in pain medicine.
Why do we feel pain? (Neurobiology of pain)
Taxonomy of pain
European and International association for the study of pain (EFIC and IASP): mission and
Course content
goals;
broken down in detail What can rats tell us about pain? (Animal models in the study of pain)
by weekly class
Who can you trust? (Evidence Based Medicine)
schedule (syllabus)
Placebo and nocebo
Psychosocial and cultural aspects of pain
Why do we like spicy food?
Pain management and clinics for the treatment of pain.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☐ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
0,5
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
1
(Other)
work
credits for each
activity so that the
Essay
Seminar essay 0,5
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
Project
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Scientific articles and hand-outs prepared by teachers
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
(Other)
Number of
Availability via
copies in the
other media
library
NAME OF THE COURSE
Glycobiology of hematopoiesis
Code
PT-IP14
Year of study
II
Assist.prof. Vedrana Čikeš
2
Course teacher
Credits (ECTS)
Čulić
Assoc.prof.dr.sc. Anita
L
S
E
F
Markotić; Nikolina Režić
Mužinić, prof.chem.biol;
Type of instruction
Associate teachers
Angela Mastelić,
(number of hours)
2
4
10
mag.ing.mol.biotech;
mag.for.chem.mol.biol.
Sandra Dujić-Bilušić
Elective
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
1. Transfer knowledge of the expression of glycoconjugates in certain hematopoietic cells.
2. Encourage students to think critically about the role of glycoconjugates in the reactions
Course objectives
of hematopoietic cells
3. Develop students' skills in using methods to determine markers on hematopoietic cells
and functional tests on cell cultures.
Course enrolment
Passed exams from first year of the Program.
requirements and
entry competences
required for the
course
1. Describe the expression of glycoconjugate antigens in certain hematopoietic cells.
Learning outcomes
2. Explain the role of glycoconjugates in the reactions of hematopoietic cells.
expected at the level 3. Describe rare blood cells and methods of their determination.
of the course (4 to 10 4. Independently use methods for determining glycoconjugate markers of hematopoietic
learning outcomes)
cells.
5. Practically perform functional tests of cells grown in cell cultures.
In parentheses is the number of hours referred to each topic.
LECTURES (2 hours)
P1 (2) Expression of glycoconjugate markers on hematopoietic cells. Rare blood cells and
their determination.
Course content
SEMINARS (4 hours)
broken down in detail S1 (2) Flow cytometry
by weekly class
S2 (2) Basis of cell culture
schedule (syllabus)
PRACTICALS (10 hours)
P1 (3) Determination of glycoconjugate marker expression on hematopoietic cells by flow
cytometry
P2 (3) Determination of rare blood cells
P3 (4) Functional tests of individual cell lines
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Regularly attend classes and come prepared for seminars and practical.
responsibilities
Screening student
Class
0,5
Research
Practical training
work (name the
proportion of ECTS
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
attendance
Grading and
evaluating student
work in class and at
the final exam
The assessment will be conducted on the basis of three units in ECTS credits listed above.
After the presentation of seminar work, the student will receive specific questions for the
oral examination given that the issues involve additional research of literature related to
the seminar topic.
Number of
Availability via
Title
copies in the
other media
library
Lectures in electronic form and selected scientific
publications
Varki A, Cummings RD, Esko JD, Freeze H, Stanley P,
Bertozzi CR, Hart GW, Etzler ME (editors) Essentials of
Glycobiology. 2nd edition. Plainview (NY), Cold Spring
Harbor Laboratory Press, 2009. (available on PubMed).
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Experimental
work
Report
(Other)
Essay
Seminar essay 0,5
(Other)
Tests
Oral exam
(Other)
Written exam
Project
1
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
(Other)
NAME OF THE COURSE
Glycobiology of immune system
Code
PT-IP15
Year of study
II
Assoc.Prof. Anita Markotić
2
Course teacher
Credits (ECTS)
PhD
Assist.Prof. Vedrana Čikeš
L
S
E
F
Čulić PhD;
Nikolina Režić Mužinić,
Type of instruction
Associate teachers
Master in chem&biol.;
(number of hours)
4
6
5
Angela Mastelić, Master in
mol.biotech.;
Joško Božić MD
elective
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
1. Transfer knowledge to students about the role of glycoconjugate expression in the
normal immune system functioning.
Course objectives
2. Encourage students to think critically about the pathogenesis and therapy of diseases
involving changes in the glycoconjugate expression.
Course enrolment
requirements and
entry competences
required for the
course
Passed exams of the first year of study.
1. Describe the structure of membrane lipid raft microdomain and explain the
consequences of the change in its glycosphingolipid composition to the immune signal
transduction.
Learning outcomes
2. Compare the adhesion glycoconjugates that are important for the leukocyte
expected at the level extravazation with pathological cell glycophenothypes in different diseases (rheumatoid
of the course (4 to 10 arthritis, atherogenesis, metastasis).
learning outcomes)
3. State examples of the proteoglycan participation in signal transduction.
4. Present and explain examples of treatment of diseases involving the targeting expression
and metabolism glycoconjugate molecules.
5. List and briefly describe the research methods in the field of glycobiology.
The number of hours of each topic is specified in parentheses.
Lectures (4 hours)
P1 (1) Structure and metabolism of glycosphingolipids
P2 (1) Structure and metabolism of glycoproteins and proteoglycans
P3 (1) The role of glycosphingolipids in lipid rafts
P4 (1) Glycoantigens in leukocyte extravasation
Course content
broken down in detail Seminars (6 hours)
by weekly class
S1 (2) Abnormal leukocyte glycophenothypes in different diseases (rheumatoid arthritis,
schedule (syllabus)
atherogenesis, metastasis) and treatment options based on the gycobiologic mechanisms
S2 (2) Glycophenothypes of mice with deleted immune protein coding genes (TNF receptor
and beta 2-microglobulin)
S3 (2) Student presentation of independently selected original scientific papers (not
reviews) in the area of their planned PhD with a glycobiologic issue examined.
EXERCISES (5 hours)
V1 (5) Leukocyte glycoantigen determination using flow cytometry
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
0,5
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay 0,5
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
1,0
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The assessment will be conducted according to ECTS ratios listed above. After the
evaluating student
presentation of seminar work, the student will receive in advance specific questions for the
work in class and at
oral examination because additional research of literature related to the seminar topic will
the final exam
be needed.
Number of
Availability via
Title
copies in the
other media
library
Lectures in electronic form and selected scientific
publications
Required literature
Varki A, Cummings RD, Esko JD, Freeze H, Stanley P,
Available at
(available in the
Bertozzi CR, Hart GW, Etzler ME (editors) Essentials of
pubmed
library and via other Glycobiology. 2nd edition. Plainview (NY), Cold Spring
media)
Harbor Laboratory Press, 2009.
Markotić A, Božić J, Martinić R. Glycosphingolipids:
4
modulators of immune and other cell function.
Biochemistry and Immunology Intersections. Markotić A,
Glavaš-Obrovac Lj, Varljen J, Žanić-Grubišić T (urednici).
Kerala: Research Signpost, 2008. Str. 69-82.
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
 Teaching quality analysis by students and teachers
methods that ensure  Exam passing rate analysis
the acquisition of exit  Committee for control of teaching reports
competences
 External evaluation
Other (as the
proposer wishes to
add)
NAME OF THE COURSE
Adventures of pain in the brain
Code
PT-IP2
Year of study
Course teacher
Prof. Livia Puljak, MD, PhD
Credits (ECTS)
Prof Sandra Kostić, PhD
Type of instruction
Associate teachers
Mario Malički, MD, MSc
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2
2
L
S
10
6
E
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Acquiring knowledge on definition and taxonomy of pain, central mechanisms of pain,
modulation of pain in the brain, psychological determinants of pain, therapeutic
implications, imaging of pain in the brain, empathy.
Passed all exams from the first year of the program
Understanding and acquiring knowledge of basic scientific and clinical information
Learning outcomes
necessary for understanding modulation of pain in the brain
expected at the level
Acquiring knowledge on concept of psychological determinants of pain
of the course (4 to 10
Acquiring knowledge on methods of pain imaging in the brain
learning outcomes)
Acquiring knowledge on basic principles of empathy
Neurobiology and evolutionary role of pain (1 h L)
Perception of harmful stimuli (1 h L)
Three systems influencing perception of pain (1 h L)
Modulation of pain in the brain (1 h L)
Course content
Placebo and nocebo (1 h L)
broken down in detail Importance of the context for pain perception (1 h L)
by weekly class
Attention and pain experience (1 h L)
schedule (syllabus)
Mood and pain experience (1 h L)
Fear, anxiety and depression, and pain experience (4 h S)
Methods for imaging of pain in the brain (1 h L)
Pain without any injury (1 h L)
Empathy and pain (2 h S)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☐ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
F
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
1
Project
1
The exam consists of:
Making analysis of a research article about psychological determinants of pain perception
Presenting analysis
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Scientific articles and hand-outs prepared by teachers
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
Number of
Availability via
copies in the
other media
library
NAME OF THE COURSE
Genetic analysis of complex diseases
Code
PT-IP17
Year of study
Course teacher
Prof. Tatijana Zemunik
Credits (ECTS)
Assist. Prof. Vesna Boraska
Type of instruction
Associate teachers
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
II
2
L
S
E
4
5
6
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
To inform students about the genetic background of complex diseases, types of studies
that are carried out and principles of their selection, to introduce students to the
genotyping methods.
According to the regulation of the Study
Describe and explain the principles of association between gene polymorphisms and
environmental factors with the development of complex diseases
Plan research, select the type of study
Explain the genetic background of complex phenotypes in practice
Explain and apply the methods of genotyping in the laboratory, prepare samples and
analyze the results of genotyping.
New approach in analysis of genetic background and pathogenesis of complex diseases
(polymorphisms, risk and protective genetic variants and their interaction with
Course content
environmental factors, methods in genetic studies); types of genetic studies (population
broken down in detail
and family studies), selection of polymorphisms (candidate genes or genome wide studies);
by weekly class
introduction to the study - 10,001 Dalmatians; preparation of DNA samples for analysis
schedule (syllabus)
(measurement of the DNA concentration and dilution of samples), genotyping methods
(Real-Time PCR), analysing of results.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Grading and
evaluating student
work in class and at
the final exam
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Notes from lectures
Selected scientific publications




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Seeing the invisible
Code
PT-IP03
Year of study
Course teacher
Professor Damir Sapunar
Credits (ECTS)
Associate teachers
Status of the course
Elective
2
2
Type of instruction
(number of hours)
L
S
E
10
0
6
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
To inform students about current advancements in microscopy.
Course enrolment
According to the regulation of the Study
requirements and
entry competences
required for the
course
After passing the course students will be able to:
Learning outcomes
- explain the principles of confocal microscopy
expected at the level - list modern super-resolution microscope techniques
of the course (4 to 10 - list the fields of application of modern microscopic techniques
learning outcomes)
- list and describe ways of documenting the image material
- explain the principles of processing digital photos.
Course content
1) Classic microscopy techniques; 2) Confocal microscopy techniques F; 3) New microscopic
broken down in detail techniques, 4) Deconvolution; Super Resolution; LED microscopes; Quantum dots;
by weekly class
Stimulated emission depletion (STED) microscopy; Total internal reflection fluorescence
schedule (syllabus)
microscopy (TIRF); 5) Digital photography; Photoshop.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Availability via
Required literature
Title
copies in the
other media
(available in the
library
library and via other
Notes from lectures
media)
Selected scientific publications
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Development of human spinal ganglia
Code
PT-IP05
Year of study
Associate Professor Katarina
Course teacher
Credits (ECTS)
Vukojević MD PhD
Assistant Professor Sandra
Type of instruction
Associate teachers
Kostić, PhD
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2
2
L
S
E
6
4
4
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The course objective is understanding the concept of normal human spinal ganglia
development
Passed exams from first year of the doctoral program
- Describe the role of human nervous system development; describe and explain
the basic principles in the human spinal ganglia formation
Learning outcomes
- Name and explain the most relevant achievements in the field of spinal ganglia
expected at the level developmental potential and their therapeutic targets
of the course (4 to 10 - Describe, discriminate and explain spinal ganglia cell lines differentiation
learning outcomes)
- Describe and explain spinal ganglia developmental disorders
- Explain and critically judge the application of neural crest stem cells and name the
advantages and disadvantages of this approach in disease treatment
Lectures (6 hours):
Nervous system development 2h P
„High impact“ information about spinal ganglia 2h P
Course content
Spinal ganglia developmental disorders 2h P
broken down in detail Seminars (4 hours):
by weekly class
Genetic background od spinal ganglia development 2h S
schedule (syllabus)
Spinal ganglia anatomy 2h S
Exercises (4 hours)
Spinal ganglia microscopy 2h V
Spinal ganglia - critical litetature review 2h V
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
x
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
F
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
x
Project
Written exam
Number of
Availability via
copies in the
other media
library
Vukojevic K, Carev D, Sapunar D, Petrovic D, Saraga-Babic
Yes
M. Developmental patterns of caspase-3, bax and bcl-2
proteins expression in the human spinal ganglia. Journal
of molecular histology. 2008;39:339-49.
Vukojevic K, Janjic T, Saraga-Babic M. Developmental
Yes
patterns of Ki-67, Oct-4 and alpha-tubulin proteins
expression in the human spinal cord. Acta histochemica.
2014;116:619-26.
Vukojevic K, Petrovic D, Saraga-Babic M. Nestin
Yes
expression in glial and neuronal progenitors of the
developing human spinal ganglia. Gene expression
patterns : GEP. 2010;10:144-51.
Vukojevic K, Skobic H, Saraga-Babic M. Proliferation and
Yes
differentiation of glial and neuronal progenitors in the
development of human spinal ganglia. Differentiation;
research in biological diversity. 2009;78:91-8.
Yes
Yes
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Sadler TW. Lagman's Medical embryology. Eleventh edition




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Amphioxus - a model for chordate’s evolution
Code
PT-IP18
Year of study
Course teacher
Associate Professor
Ivana Bočina, PhD
Credits (ECTS)
Associate teachers
Status of the course
Elective
2
2
Type of instruction
(number of hours)
L
S
E
5
5
5
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
The course objective is empower students to understand the scientific concept and role of
Amphioxus during Chordates’ evolution.
Passed exams from first year of the doctoral program.
- Explain the role of Amphioxus as a model for Chordates’ evolution
- Describe the taxonomic position of Amphioxus among Chordates
- Describe and explain the role and importance of the notochord in Vertebrates’ evolution
- Name and describe the most important scientific achievments in the field of Vertebrates'
evolution
LECTURES:
The features of the phyllum Chordates and subphyllum Cephalochordates (2 h).
Notochord – the most important feature of Chordates. Morphological and
Course content
immunohistochemical characteristics of the notochord in Amphioxus. (2 h)
broken down in detail Amphioxus – invertebrate or vertebrate?
1 hour
by weekly class
SEMINARS:
schedule (syllabus)
Critical retrospection on scientific papers regarding the role of notochord and amphioxus in
Chordate's evolution.
5 hours
EXERCISES:
Amphioxus and other Chordate's microscopy
5 hours
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Involvement in course objectives
responsibilities
Class
Screening student
1
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 1
Project
(Other)
course)
Grading and
Written exam
evaluating student
work in class and at
the final exam
Title
Required literature
(available in the
library and via other
media)
J.Z. Young; The Life of Vertebrates. Oxford, 1962.
Bočina, Ivana; Ljubešić, Nikola; Saraga-Babić, Mirna.
Cilia-like structures anchor the amphioxus notochord to
its sheath. // Acta Histochemica. 113 (2011) , 1; 49-52.
Bočina, Ivana; Saraga-Babić, Mirna.
The notochordal sheath in amphioxus - an ultrastructural
and histochemical study. // Collegium Antropologicum.
30 (2006) , 2; 361-367
Bočina, Ivana; Saraga-Babić, Mirna.
Immunohistochemical study of cytoskeletal and
extracellular matrix components in the notochord and
notochordal sheath of amphioxus. // International
Journal of Biological Sciences. 2 (2006) , 2; 73-78
Deng, Wei; Nies, Florian; Feuer, Anja; Bočina, Ivana;
Oliver, Dominik; Jiang, Di.
Anion translocation through an Slc26 transporter
mediates lumen expansion during tubulogenesis. //
Proceedings of the National Academy of Sciences of the
United States of America. 110 (2013) , 37; 14972-14977
Denker, Elsa; Bočina, Ivana; Jiang, Di.
Tubulogenesis in a simple cell cord requires the
formation of bi-apical cells through two discrete Par
domains. // Development (Cambridge). (2013) , 140;
2985-2996
Number of
Availability via
copies in the
other media
library
No
Yes
Yes
Yes
Yes
Yes
Optional literature (at
Microscopic Anatomy of Invertebrates, Editor (s) F.W. Harrison, E.E. Ruppert, Vol. 15,
the time of
Wiley – Liss, 1997.
submission of study
programme proposal)
Quality assurance
 Teaching quality analysis by students and teachers
methods that ensure
 Exam passing rate analysis
the acquisition of exit
 Committee for control of teaching reports
competences
 External evaluation
Other (as the
proposer wishes to
add)
NAME OF THE COURSE
Basis of heart electrophysiology and bioenergetics
Code
PT-IP19
Year of study
2
Course teacher
Professor Marko Ljubković
Credits (ECTS)
2
Professor Jasna Ljubković
L
Type of instruction
Associate teachers
(number of hours)
3
Status of the course
Elective
Percentage of application
of e-learning
S
E
5
7
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Understanding and acquisition of the basic scientific and clinical knowledge necessary for
multidisciplinary understanding hart function
According to the regulation of the Study
Elective course is intended for students who want to learn more about the principles of
electrophysiological function of heart cells, as well as mechanisms to create and use
Learning outcomes
energy-rich molecules in the myocardium. Students will learn about the importance of ion
expected at the level
channels in physiological function of the myocardium, as well as their contribution and role
of the course (4 to 10
in the development of various pathological processes relevant to clinical practice. Students
learning outcomes)
will also learn more about the role of mitochondria in health and disease as well as
theoretical and practical therapeutic possibilities related to their function.
Special attention will be devoted to the nature of ion channels located on the surface
membrane of cardiomyocytes; their structure, dynamics and significance for the normal
Course content
functioning of the heart muscle. The role and importance of ion channels in various
broken down in detail
pathological states will also be discussed. In addition, students will become familiar with
by weekly class
the detailed biochemical principles of functioning mitochondria, peculiarities of their role
schedule (syllabus)
in cardiac cells associated with the production of ATP, as well as contributions to other
biological processes involved in physiological and pathophysiological conditions.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Berne RM, Levy MN, Koeppen BM, Stanton BA.
Physiology, Elsevier Inc, 2004.; Stryer L, Berg JM,
Tymoczko JL. Biochemistry, 5th Revised edition,
W.H.Freeman & Co Ltd., 2002.
Selected scientific publications




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Colon cancer
Code
PT-IP20
Course teacher
Professor Janoš Terzić
Associate Professor Ivana
Associate teachers
Marinović Terzić, Sergei
Grivennikov MD, PhD
Elective
Status of the course
Year of study
Credits (ECTS)
2
2
Type of instruction
(number of hours)
L
S
E
4
6
5
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Understanding and acquisition of the basic scientific and clinical knowledge necessary for
multidisciplinary understanding of colon cancer.
According to the regulation of the Study
After passing the course students will be able to:
Learning outcomes
- explain the basic concepts associated with diagnostic and treatment of colon cancer
expected at the level
- describe the signaling pathways involved in the development of colon cancer
of the course (4 to 10
- explain the role of chronic inflammation in the development of colon cancer.
learning outcomes)
- describe the most important animal models used to study colon cancer.
All aspects of colorectal cancer will be explained as well as colon cancer that is a result of
Course content
chronic inflammation. The basic signaling pathways involved in the disease will be
broken down in detail
explained, including the role of inflammation in the onset of colon cancer. The role of
by weekly class
intestinal microflora, nutritional elements, anti-inflammatory and modern biological drugs
schedule (syllabus)
will be discussed. Also, the models used to study colon cancer will be described.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Required literature
Availability via
Title
copies in the
(available in the
other media
library
library and via other
media)
Notes from lectures
Selected scientific publications
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Genome databases and statistics
Code
PT-IP06
Year of study
Assoc. Professor Vesna
Boraska
Course teacher
Credits (ECTS)
Assoc. Professor Tatijana
Zemunik
Associate teachers
Status of the course
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Elective
2
2
Type of instruction
(number of hours)
L
S
E
4
4
4
Percentage of application
of e-learning
0%
F
Analysis of genetic variation connection with the development of the disease.
Acquiring the necessary background knowledge and skills for the use of basic genomic
databases relevant to planning, interpretation and understanding of the results obtained
by genetic studies of disease.
The variations in the genome and the basic methods of genetic research; principles of
Course content
statistical genetics (Haploview program); the use of genomic databases (NCBI, UCSC,
broken down in detail
Ensembl, HapMap, 1000 Genomes Project);
by weekly class
Biomedical importance of genetic research and application of new knowledge into clinical
schedule (syllabus)
practice.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Required literature
Number of
Availability via
(available in the
Title
copies in the
other media
library and via other
library
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
1. Suárez E, Sariol CA, Burguete A, Mclachlan G. A tutorial
in genetic epidemiology and some considerations in
statistical modeling. P R Health Sci J. 2007;26(4):401-21.
Review.
2. Lunetta KL. Genetic association studies. Circulation.
2008;118(1):96-101. Review.
3. Joshua AM, Boutros PC. Web-based resources for
clinical bioinformatics. Review. Methods Mol Med.
2008;141:309-29.




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Diagnostics of genetic and chromosomal diseases
Code
PT-IP08
Year of study
2
Professor Irena Drmić
2
Hofman
Course teacher
Credits (ECTS)
Assoc. Professor Feodora
Stipoljev
Associate teachers
Status of the course
Elective
Type of instruction
(number of hours)
L
S
E
6
4
5
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
- Defining the basic genetic concepts. The structure and function of genes and
chromosomes; disorders of structure (examples: risk assessment carriers of chromosomal
abnormalities, genomic imprinting and uniparental disomy)
- Methods of cytogenetics in prenatal and postnatal diagnosis (exercise: making karyotype
Course content
from peripheral blood)
broken down in detail - Methods of molecular diagnosis of hereditary genetic disorders (exercise: mutations in
by weekly class
individual genes)
schedule (syllabus)
- The principles of genetic testing multifaktorijskih hereditary diseases (cancers,
cardiovascular disease)
- Application of molecular diagnostics in clinical practice and therapeutic implications
("smart drugs")
- Ethical aspects of genetic testing
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Trent RJ. Molecular Medicine, Churchill Livingstone,
2005.
Mc Kinlay Gardner RJ, Suderland GR. Chromosome
abnormalities and genetic counceling, 3rd edition,
Oxford University Press, 2004.




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Oxidative stree and protection mechanisms - The role of uric acid
Code
PT-IP21
Year of study
2
Course teacher
Professor Mladen Boban
Credits (ECTS)
2
Assoc. professor Darko
L
S
E
F
Type of instruction
Associate teachers
Modun Terzić, dr. sc. Sergei
(number of hours)
6
4
5
Grivennikov
Elective
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
Empower students to acquire knowledge about the physiology and pathophysiology of uric
Course objectives
acid, the role of uric acid as an antioxidant, and the application of spectroscopic methods in
determining the oxidative / antioxidative status of biological samples.
Course enrolment
According to the regulation of the Study
requirements and
entry competences
required for the
course
After passing the course students will be able to:
Learning outcomes
- Explain the physiology and pathophysiology of uric acid
expected at the level
- Describe the role of uric acid as an antioxidant
of the course (4 to 10
- Describe the application of spectroscopic methods in determining the oxidative /
learning outcomes)
antioxidative status of biological samples.
Course content
The mechanisms of defense against oxidative stress in the human body. Physiology and
broken down in detail pathophysiology of uric acid. The theory of evolutionary selection antioxidants. Uric acid as
by weekly class
an antioxidant. Spectrophotometric methods for determination of antioxidant capacity and
schedule (syllabus)
oxidative stress markers in human plasma.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Presentation of a scientific paper that links the course content and student interest.
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Required literature
Availability via
Title
copies in the
(available in the
other media
library
library and via other
media)
Doktorska disertacija: „Zaštitno djelovanje mokraćne
kiseline na oksidacijski stres i elastičnost arterijske
stijenke“ Jonatan Vuković, Medicinski fakultet u Splitu,
2009;
Doktorska disertacija: „Mehanizmi antioksidacijskog i
vazodilatacijskog učinka crnog vina" Darko Modun,
Medicinski fakultet u Splitu, 2006.
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Multivariate statistics
Code
PT-IP12
Year of study
Course teacher
Professor Goran Kardum
Credits (ECTS)
Professor Davor Eterović
Type of instruction
Associate teachers
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2.
2
L
S
E
4
6
4
F
0%
COURSE DESCRIPTION
Course objectives
Understanding and adoption of the basic multivariate statistical methods used in the field
of biomedicine and generally different multidisciplinary research.
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Course content
Analysis of variance and covariance (ANCOVA). GLM models. Models of regression analysis.
broken down in detail Discriminant analysis. Cluster analysis. Survival analyzes. Basics of factor analysis.
by weekly class
Introduction to structural modeling.
schedule (syllabus)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Number of
Availability via
Title
copies in the
Required literature
other media
library
(available in the
library and via other Everitt, BS, Dunn G, Dunn G. Applied Multivariate Data
3
media)
Analysis, 2nd edition. Arnold Publishers, 2001.
Loehlin, JC.. Latent Variable Models: An Introduction to
1
Factor, Path, and Structural Equation Analysis, Lawrence
Erlbaum Associates. 2004.
20
3
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Why and how we breathe?
Code
PT-IP14
Year of study
2.
Doc. dr. sc. Renata Pecotić/
2
Course teacher
Credits (ECTS)
Prof. dr. sc. Zoran Đogaš
Prof. dr. sc. Maja Valić;
L
S
E
F
Type of instruction
Associate teachers
Doc.dr.sc. Nenad Karanović;
(number of hours)
6
4
10
Doc. dr.sc. Mladen Carev
Elective
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
Course objectives
Course enrolment
The aim of the course is to understand the role of the brain in breathing process and
requirements and
mechanisms of neural control of breathing.
entry competences
required for the
course
Identify, describe and explain the most important features of the physiological functions of
Learning outcomes
breathing
expected at the level Describe and discuss the control mechanisms required to maintain the homeostasis of
of the course (4 to 10 breathing in various situations such as wakefulness, sleep and anesthesia.
learning outcomes)
Critically assess teaching materials, participate in reasoned debate and express opinions.
Apply acquired theoretical knowledge for solving practical problems.
Lectures (6 hours):
Number of hours:
1. Why and how we breathe?
2
2. Sleep and breathing disorders
2
3. Intermittent hypoxia-from animal model toward clinical practice
2
Seminars (4 hours):
Number of hours:
Course content
1. Effects of anesthesia on breathing
2
broken down in detail
2. Sleep-related breathing disorders-comorbidities
2
by weekly class
Exercises (10 hours):
Number of hours:
schedule (syllabus)
1. Sleep lab- questionnaires, anamnesis
2
2. Sleep lab- polygraphy
2
3. Sleep lab- polysomnography
2
4. Animal model – breathing control
2
5. Animal model – neurotransmitters
2
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
The student success is assessed according to their activities during class.
Number of
Availability via
copies in the
other media
library
3
Title
Required literature
(available in the
library and via other
media)
Project
Purves D et al.: Neuroscience, 5th edition, Sinauer
Associates INC, USA.
Zigmond, M.J., Bloom, F.E., Landis, S.C., Roberts, J.L.,
1
Squire, L.R.: Fundamental Neuroscience, Academic Press,
1st ed.,1999
A. C. Guyton i J. E. Hall, Medicinska fiziologija, 12. izd.,
20
Medicinska naklada, Zagreb, 2012.
Bassetti CL, Dogas Z, Peigneux: European Sleep Medicine 3
Textbook, European Sleep Research Society 2014
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Animal models in the stroke research
Code
PT-IP23
Year of study
Associate Professor Liana
Course teacher
Credits (ECTS)
Cambj Sapunar
Associate teachers
Status of the course
Elective
2.
2
Type of instruction
(number of hours)
L
S
E
6
4
4
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Critical evaluation of the stroke experimental models of stroke, pathophysiology and
treatment of ischemic stroke and subarachnoid hemorrhage.
Course enrolment
requirements and
entry competences
required for the
course
After completing this course students will be able to:
Learning outcomes
- explain the advantages and disadvantages of experimental models of stroke
expected at the level
- explain the pathophysiology and treatment of ischemic stroke and subarachnoid
of the course (4 to 10
hemorrhage
learning outcomes)
- list and describe the models used in the study of ischemia stroke.
Course content
Definition and types of stroke; The pathophysiology of stroke; Diagnosis and treatment of
broken down in detail stroke; Animals used in the study of stroke; The models used in the study of ischemic
by weekly class
stroke; The models used in the study subarachnoid hemorrhage.
schedule (syllabus)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Number of
Required literature
Availability via
Title
copies in the
(available in the
other media
library
library and via other
media)
Acute Ischemic Stroke Editor(s): Gonzalez R.G., Hirch J.A., 3
Koroshetz W.J., Lev M.H., Schaefer P. Springer, BerlinHeidelberg- New York, 2006.
1
20
3
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Quasi-experimental and non-experimental research designs
Code
PT-IP24
Year of study
2.
Course teacher
Assoc. prof. Darko Hren
Credits (ECTS)
2
Associate teachers
Status of the course
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Course content
broken down in detail
by weekly class
schedule (syllabus)
Elective
Type of instruction
(number of hours)
L
S
E
10
10
0
Percentage of application
of e-learning
0%
F
Understanding quasi-experimental and non-experimental research designs and the
problems and potential solutions of their validity.
Quasi-experimental research; Single subject design; Correlative research; Survey research;
Basics of qualitative research
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Number of
Availability via
Title
copies in the
other media
Required literature
library
(available in the
Milas G. Istraživačke metode u psihologiji i drugim
3
library and via other
društvenim znanostima. Jastrebarsko, Slap. 2005.
media)
Campbell DT, Stanley JC. Experimental and quasi1
experimental designs for research. Boston, Houghton
Mifflin Company, 1963.
20
3
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Communication in living organisms
Code
PT-IP25
Year of study
Course teacher
professor Mladen Miloš
Credits (ECTS)
Associate teachers
Status of the course
Elective
2.
2
Type of instruction
(number of hours)
L
S
E
6
4
4
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Biochemical understanding of the principles of communication between living cells and
tissues at the molecular level.
Course enrolment
requirements and
entry competences
required for the
course
After passing the course students will be able to:
Learning outcomes
- explain the principles of communication in living organisms
expected at the level
- list the most important elements in the process of intercellular communication
of the course (4 to 10
- exeplain the role of biological membranes in signal transduction.
learning outcomes)
- explain the role of calcium in communication.
Lectures: Communications in living organisms. Biological membranes. Structural
architecture of proteins. Molecules intercellular communication. The primary messanges.
Course content
The specific activity of the neurotransmitter and hormone. Secondary messageres. Cyclic
broken down in detail adenosine monophosphate. Inositol and diacylglycerols. Ca2+ ions. Proteins that react with
by weekly class
Ca2+ ions. Membrane proteins carriers of Ca2+ ions. Cytoplasmic proteins, troponin C,
schedule (syllabus)
parvalbumin, calmodulin, kalcikestrin. Seminars: Mechanisms of protons and ions Ca2 +
through a biological membrane. The interaction of protein-metal ion. Exercise: Research
Methods interacting protein-metal ion. Determination competitiveness ions for a protein
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Required literature
Title
Number of
Availability via
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
copies in the other media
library
3
Jeremy M Berg, John L Tymoczko and Lubert Stryer,
Biochemistry (6th ed.), W. H. Freeman and Comp., San
Francisko, 2006., Voet & Voet, Biochemistry (3rd ed.),
John Wiley & Sons, 2004.
J.A.Cox, M. Comte, A. Mamar, M. Milos. and J.J. Schaer in 1
Calcium and calcium binding proteins, Springer - Verlag,
Gerday C., Gilles R., Bolis L. (Eds), Berlin, 1988:141-162.
20
3
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
The role of ubiquitin in health and diseases
Code
PT-IP26
Year of study
Course teacher
Ivana Novak, MD, PhD
Credits (ECTS)
Associate teachers
Status of the course
Elective
2.
2
Type of instruction
(number of hours)
L
S
E
6
4
4
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
The goal is to understand and learn basic scientific knowledge in the field of autophagy and
the role of ubiquitin in the regulation of this process.
Course enrolment
requirements and
entry competences
required for the
course
After passing the course students will be able to:
Learning outcomes
- explain the process of harmful substances accumulation in the cells
expected at the level
- describe the role of ubiquitin
of the course (4 to 10
- explain the process of autophagy
learning outcomes)
- explain the role of autophagy in sickness and in health.
Most diseases associated with aging are characterized by accumulation of invalid
Course content
ubikvitiniranih proteins and their aggregates in the cells. Autophagy, evolutionarily
broken down in detail conserved process, is the basic mechanism that protects cells from the harmful
by weekly class
accumulation of proteins and whole cell organelles by removal of such clusters. The course
schedule (syllabus)
will explain the importance of ubiquitin in autophagy and the process of autophagy in
healthy and diseased cell states.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Required literature
Number of
Availability via
(available in the
Title
copies in the
other media
library and via other
library
media)
Novak I, et al. Nix is a selective autophagy receptor for
3
mitochondrial clearance. EMBO Reports. 2010
Jan;11(1):45-51.
Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin 1
in selective autophagy. Mol Cell. 2009 May 15;34(3):25969. Review.
20
3
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Original scientific papers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Translational research of hearing and speach
Code
PT-IP09
Year of study
Course teacher
Damir Kovačić, PhD
Credits (ECTS)
Maja Rogić, PhD
Type of instruction
Associate teachers
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2
2
L
S
E
10
6
4
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Understanding and learning of the basic concepts and methods in the study of hearing and
speech, with special emphasis on translational aspects of research.
Passed all exams from the first year of the program
Acoustics and physiology of hearing and speech; Neurocognitive mechanisms of auditory
Course content
perception and speech production; Research methods of hearing and speech; Disorders of
broken down in detail
hearing and speech; Verbotonal method for the development of hearing and speech;
by weekly class
Neuroengineering and new technology in hearing and speech (cochlear implants - cochlear
schedule (syllabus)
implants)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 1
Project
1
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Required literature
Number of
Availability via
(available in the
Title
copies in the
other media
library and via other
library
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Scientific articles and hand-outs prepared by teachers
Brian C. J. Moore: An introduction to the psychology of
hearing
William Yost:Fundamentals of Hearing Science
Daniel J. DiLorenzo and Joseph D. Bronzino:
Neuroengineering
James O. Pickles: An introduction to the physiology of
hearing




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
The Cochrane Library and evidence in medicine
Code
PT-IP10
Year of study
Course teacher
Prof. Livia Puljak, MD, PhD
Credits (ECTS)
Irena Zakarija Grković, MD,
Type of instruction
Associate teachers
PhD
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2
2
L
S
E
5
5
5
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Understanding concepts of evidence-based medicine, hierarchy of evidence in medicine,
grading evidence in medicine, sources of information about evidence-based medicine, The
Cochrane Collaboration and The Cochrane Library
Passed all exams from the first year of the program
Knowledge about concepts of evidence-based medicine
Knowledge about concepts of hierarchy of evidence in medicine
Learning outcomes
Knowledge about concepts of grading evidence in medicine
expected at the level
Knowledge about sources of information about evidence-based medicine
of the course (4 to 10
Knowledge about The Cochrane Collaboration
learning outcomes)
Independent search of The Cochrane Library
Independent writing of a title registration for Cochrane systematic review
Evidence-based medicine (1 h L)
The Cochrane Collaboration (2 h S)
Structure of The Cochrane Collaboration (2 h S)
Course content
The Cochrane Library (2 h E)
broken down in detail Systematic review (2 h L)
by weekly class
Cochrane systematic review (2 h L)
schedule (syllabus)
PRISMA guidelines (1 h S)
Searching The Cochrane Library (1 h E)
Accessing full texts of Cochrane systematic reviews (1 h E)
Filling out Cochrane title registration form (1 h E)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
1
Project
1
The exam consist of:
Writing a Cochrane title registration protocol
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Scientific articles and hand-outs prepared by teachers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Methods for isolation of bioactive substances
Code
PT-OP5
Year of study
Course teacher
Professor Igor Jerković
Credits (ECTS)
Associate teachers
Status of the course
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Learning outcomes
expected at the level
of the course (4 to 10
learning outcomes)
Elective
2
2
Type of instruction
(number of hours)
L
S
E
10
6
0
Percentage of application
of e-learning
0%
F
Passed all exams from the first year of the program
The student will learn about theoretical and practical application of a wide range of
modern laboratory methods of isolation of bioactive compounds that are used in
biomedical research.
Methods for the initial isolation of bioactive compounds from natural sources, isolation
and fractionation isolate pure substances: Introduction. Extraction methods. Initial
continuous and discontinuous extraction (conventional processes). Ultrasonic extraction
Course content
(UE). Microwave extraction (ME). Accelerated solvent extraction (ASE). Superktitična
broken down in detail extraction fluids (SFE). Methods distillation (hydrodistillation, water-steam distillation,
by weekly class
steam distillation). Simultaneous distillation-extraction (SDE). Artifacts in isolation. Initial
schedule (syllabus)
purification of the isolate. Fractionation isolates. Thin layer chromatography (TLC). Liquid
chromatography (LC). High performance liquid chromatography (HPLC). Gas
chromatography (GC). Coupled techniques (GC-MS, HPLC-MS, etc.). Isolation of pure
substances. Separation of optically pure substances.
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 1
Project
1
(Other)
course)
Grading and
evaluating student
work in class and at
the final exam
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Natural Products Isolation, Humana Press, 2006
Sujata V. Bhat, Bhimsen A. Nagasampagi, Meenakshi,
Chemistry of Natural Products, Springer, Berlin, 2005
Ikan R. Natural Products A Laboratory Guide, Academic
Press, 1991.




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Brain Mapping: From Neural Basis of Cognition to Surgical Applications
Code
PT-IP31
Year of study
2
Course teacher
Maja Rogić Vidaković, PhD
Credits (ECTS)
2
Profressor Marina Zmajević
L
S
E
Type of instruction
Associate teachers
Schonwal
(number of hours)
6
6
2
Status of the course
Elective
Percentage of application
of e-learning
F
0%
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The aim of the elective subject: by applying the knowledge acquired in other subjects
(neurology, anatomy, neuroscience) adopt knowledge about the neural basis of cognition
and methods used in the preoperative and intraoperative mapping (testing) of eloquent
brain cortices (motor and somatosensoric areas, motor speech cortical areas and language
related cortical areas).
Passed exams of the first year of study.
Previous knowledge in neurology, anatomy and neuroscience.
Understanding the basics of neurophysiology is recommended but not required
- Identify, describe and explain the most important anatomical and functional features of
eloquent brain cortices (motor area of the cortex, cortical areas of the brain involved in the
formation of speech and language).
- Identify, describe and explain the most important anatomical pathways (white matter
pathways).
- Identify, analyze, describe the most important methods used in brain mapping (methods
of preoperative and intraoperative mapping of eloquent brain areas)
Learning outcomes
- Discuss the findings of neuro-cognition provided by brain mapping studies.
expected at the level
- Describe and explain the neurophysiological and behavioral changes induced by electrical
of the course (4 to 10
and magnetic stimulation of the eloquent brain cortices (primary motor cortex, Broca’s
learning outcomes)
region, language related cortical areas).
- Describe the main features of the application of navigated transcranial magnetic
stimulation (nTMS) in mapping speech and language regions of the cortex.
- Describe and explain the basic methods of motor evoked potentials used in monitoring of
motor system
- Describe and explain the fundamentals of mapping of eloquent brain functions during
awake brain surgery.
1. Anatomy and cortical brain functions
2. Methods of mapping the brain (MRI; DTI; MEG; TMS; TES)
3. Mapping of primary motor cortex
(preoperatively and intraoperatively)
4. Mapping of speech and language related cortical areas of the
Course content
(preoperatively and intraoperatively)
broken down in detail
Seminars (6 student hours):
by weekly class
MT Forster et al. Neurosurgery. 2011; 68 (5): 1317-24; discussion 1324-5
schedule (syllabus)
Picht et al. Neurosurgery. 2011 Sep; 69 (3): 581-8.
Krieg et al. BMC Neurosci. 2014 Jan 30; 15: 20th doi: 10.1186 / 1471-2202-15-20.
Kato et al. Acta Neurochir (Wien). 2014; 156 (5): 885-95.
Picht et al. Neurosurgery. 2013; 72 (5): 808th
De Witte et al. Brain Lang. 2015; 140: 35-48.
Format of instruction ☒ lectures
☐ independent assignments
☒ seminars and workshops
☒ exercises
☐ on line in entirety
☐ partial e-learning
☐ field work
Student
responsibilities
Screening student
work (name the
proportion of ECTS
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Class
attendance
Experimental
work
+
☐ multimedia
☐ laboratory
☐ work with mentor
☐
(other)
Research
Practical training
Report
(Other)
Essay
Seminar essay
(Other)
Tests
Oral exam
Written exam
Project
+
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
The requirement for access to the exam is duly attendance.
The oral exam.
Title
Required literature
(available in the
library and via other
media)
(Other)
Duffau H. (2011).Brain mapping. From Neural Basis of
Cognition to Surgical Applications.Springer, New York
 Teaching quality analysis by students and teachers
 Exam passing rate analysis
 Committee for control of teaching reports
 External evaluation
Number of
Availability via
copies in the
other media
library
1
pdf
NAME OF THE COURSE
How to construct your own organ?
Code
PT-IP13
Year of study
2
Course teacher
Assistant prof. Sandra Kostić, Credits (ECTS)
2
PhD, MSc in Molecular
Biotechnology
Associate teachers
prof. Livia Puljak, MD, PhD
Type of instruction
L
S
E
F
prof. Damir Sapunar, MD,
(number of hours)
6
10
PhD
Status of the course Elective
Percentage of application 0%
of e-learning
COURSE DESCRIPTION
The course objective is understanding the concept of production of regenerative biological
Course objectives
materials (tissues and organs) and the basic principles of tissue engineering
Course enrolment
Passed exams from first year of the doctoral program
requirements and
entry competences
required for the
course
- Describe the role of biotechnology in biomedicine; describe and explain
the basic principles in the production of regenerative biological materials (tissues and
organs)
- Name and explain the most relevant achievements in the field of bioengineering of
Learning outcomes
artificial organs and their therapeutic potential
expected at the level
- Describe, discriminate and explain bioengineering process for the specific tissues and
of the course (4 to 10
organs
learning outcomes)
- Explain and critically judge the application of 3D printers in bioengineering and name the
advantages and disadvantages of this technology
- Describe and explain ethical aspects in the field of tissue engineering and regenerative
medicine
Lectures (6 hours):
Introduction to biotechnology; Bioengineering of the tissues and organs as an alternative
to drugs, gene therapy and organ transplantation; The most relevant achievements in the
field of bioengineering of artificial organs and their therapeutic potential (2h).
The possibilities of using the cell culture for production of tissues and organs; Regenerative
Course content
medicine – application of the stem cells; Application of the stem cells in research and the
broken down in detail
use of animal models (2h).
by weekly class
3D printers in biomedicine (2h)
schedule (syllabus)
Seminars (10 hours):
Construction of the specific organs and tissues ( skin, cartilage, bone, heart, bladder, blood
vessels, vagina) (4h)
Ethical aspects in the field of tissue engineering and regenerative medicine (4h).
Analysis of the scientific articles (2h)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Screening student
Class
Research
Practical training
work (name the
proportion of ECTS
credits for each
activity so that the
total number of ECTS
credits is equal to the
ECTS value of the
course)
attendance
Grading and
evaluating student
work in class and at
the final exam
Seminar presentation – the assignment in which students need to analyze the articles
about the construction of the specific organ and create a MS PPT presentation in which
they will present thiese articles.
Experimental
work
Report
(Other)
Essay
Seminar essay
(Other)
Tests
Oral exam
(Other)
Written exam
Project
(Other)
Number of
Availability via
copies in the
other media
library
Vacanti J. Tissue engineering and regenerative medicine:
Yes
from first principles to state of the art. J. Pediatr. Surg.
2010;45(2):291–294.
Atala A. Regenerative medicine strategies. J. Paediat.
Yes
Surg. 2012; 47:17–28.
Atala A (2009) Engineering organs. Curr Opin Biotechnol
Yes
20: 575-592.
Sheyn D, Mizrahi O, Benjamin S, Gazit Z, Pelled G, Gazit
Yes
D. Genetically modified cells in regenerative medicine
and tissue engineering. Adv Drug Deliv Rev. 2010;
62:683–98.
Shilpa PS, Kaul R, Sultana N, Bhat S. (2013) Stem cells:
Yes
Boon to dentistry and medicine. Dent Res J 10 (2):14954.
Vacanti J. Tissue engineering and regenerative medicine:
Yes
from first principles to state of the art. J. Pediatr. Surg.
2010;45(2):291–294.
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Meyer U, Meyer TH, Handschel J, Wiesmann HP (2009) Fundamentals of Tissue Engineering
and Regenerative Medicine, Springer, New York




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Molecular and biochemical methods in biomedical research
Code
PT-OP3
Year of study
2
Professor Maja Pavela1
Course teacher
Credits (ECTS)
Vrančić
Assist. professor Stjepan
L
S
E
F
Orhanović,
Type of instruction
Associate teachers
Viljemka Bučević-Popović,
(number of hours)
4
4
6
Matilda Šprung
Elective
Percentage of application 0%
Status of the course
of e-learning
COURSE DESCRIPTION
The main objective of the course is to introduce basic principles of publishing research in
Course objectives
scientific journals.
Course enrolment
General knowledge of the research process.
requirements and
entry competences
required for the
course
1. Understand the choice of scientific article in a journal.
2. Apply knowledge of technical preparation of the article to a concrete example.
Learning outcomes
3. Apply knowledge of submission standards for journals to a concrete example.
expected at the level
4. Understand, correlate and compare basic principles of scientific publishing: intellectual
of the course (4 to 10
rights, publishing rights, license to publish.
learning outcomes)
5. Differentiate specific differences in publishing in different disciplines.
6. Appraise the quality of scientific journal.
Pregled biokemijskih metoda u biomedicinskim istraživanjima. Rekombinantne DNA
tehnike; Potenciometrija; Sedimentacijske tehnike: isoljavanje, centrifugiranje;
Spektroskopske metode: UV-VIS spektrofotometrija, fluorimetrija, masena spektrometrija
Course content
(MS), MALDI-TOF; Kromatografija: afinitetna kromatografija, kromatografija na ionskom
broken down in detail
izmjenjivaču, kromatografija hidrofobnih interakcija, gel filtracija; Tekućinska
by weekly class
kromatografija visoke djelotvornosti – HPLC; Elektroforetske tehnike: SDS-PAGE, 2D
schedule (syllabus)
elektroforeza; Imunokemijske metode: Western blot, ELISA; Enzimska analiza; Analiza
strukturno-funkcionalnih svojstava proteina: sekvencioniranje, NMR, kristalografija;
Proteomika; Baze podataka, vizualizacija molekulskih struktura.
☒ lectures
☒ independent assignments
☐ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Class attendance and active participation, active work on seminar essays.
responsibilities
Class
Screening student
0.2
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay 0.6
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
0.2
Project
Provjera znanja temelji se na kontinuiranom praćenju rada polaznika i završnom
izlaganju/prezentaciji. U formiranju konačne ocjene oba načina provjere znanja sudjeluju
ravnopravno.
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Alexander J. Ninfa, David P. Ballou, Marilee Benore,
Fundamental Laboratory Approaches for Biochemistry
and Biotechnology, 2nd Ed., 2009, John Wiley & Sons, Inc.
Jeremy M. Berg, John L. Tymoczko, Lubert Stryer,
Biochemistry, 6th Ed., 2006, W. H. Freeman and Co.
Donald Voet, Judith G. Voet, Charlotte W. Pratt,
Fundamentals of Biochemistry, 3rd Ed., 2005, John Wiley
& Sons, Inc.
www.publicationethics.org.uk; www.cochrane.org




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
The choice of journal for scientific publication
Code
PT-IP15
Year of study
Course teacher
Ana Marušić
Credits (ECTS)
Associate teachers
Status of the course
Elective
2
2
Type of instruction
(number of hours)
L
Percentage of application
of e-learning
0%
6
S
E
F
4
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
The main objective of the course is to introduce basic principles of publishing research in
scientific journals.
General knowledge of the research process.
1. Understand the choice of scientific article in a journal.
2. Apply knowledge of technical preparation of the article to a concrete example.
Learning outcomes
3. Apply knowledge of submission standards for journals to a concrete example.
expected at the level
4. Understand, correlate and compare basic principles of scientific publishing: intellectual
of the course (4 to 10
rights, publishing rights, license to publish.
learning outcomes)
5. Differentiate specific differences in publishing in different disciplines.
6. Appraise the quality of scientific journal.
Lecture (2h): Characteristics of scientific journals, indexing and citation databases,
Course content
measures of journal quality.
broken down in detail Lecture (2h): Standards in scientific publishing.
by weekly class
Lecture (2h): Journals and measures of their quality in different disciplines.
schedule (syllabus)
Practical (2h): Choice of a journal for specific research.
Practical (2h): Registration of a clinical trial and registration of results of clinical a trial.
☒ lectures
☒ independent assignments
☐ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
Class attendance and active participation, active work on seminar essays.
responsibilities
Class
Screening student
0.2
Research
Practical training
attendance
work (name the
proportion of ECTS
Experimental
Report
(Other)
credits for each
work
activity so that the
Essay
Seminar essay 0.6
(Other)
total number of ECTS
credits is equal to the Tests
Oral exam
(Other)
ECTS value of the
Written exam 0.2
Project
(Other)
course)
Grading and
Written examination (multiple choice test), two mandatory seminar essays. The grad is the
evaluating student
sum of all points from three test parts – 60% from seminar essays and 40% written test.
work in class and at
the final exam
Required literature
Title
Number of
Availability via
(available in the
library and via other
media)
Marušić M., ur. Uvod u znanstveni rad u medicini.
Zagreb: Medicinska naklada, 2013.
Marušić M., ur. Principles of research in Medicine.
Zagreb: Medicinska naklada, 2008.
EQUATOR Network. Toolkit for authors. Dostupno na:
http://www.equatornetwork.org/toolkits/authors/#auplan .
copies in the other media
library
20
20
Internet
Internet
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
www.publicationethics.org.uk; www.cochrane.org




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Alphabet of the good night sleep
Code
PT-IP32
Year of study
Course teacher
Doc. dr. sc. Renata Pecotic
Credits (ECTS)
Prof. dr. sc. Zoran Đogaš
Type of instruction
Associate teachers
Prof. dr. sc. Maja Valić
(number of hours)
Status of the course
Elective
Percentage of application
of e-learning
2
2
L
S
E
4
7
4
F
0%
COURSE DESCRIPTION
Course objectives
Objective of the course is to provide knowledge about importance of the good sleep
hygiene and the effects of the sleep disorders on human health.
Course enrolment
requirements and
entry competences
required for the
course
Identify, describe and explain the most important characteristics of sleep hygiene and sleep
architecture.
Describe, discriminate and explain mechanisms of regulation of sleep and wakefulness.
Learning outcomes
Name and explain changes that occur during sleep as a consequence of deviation of sleep
expected at the level hygiene and architecture.
of the course (4 to 10 Critically judge educational materials (textbooks and lectures), participate in argumentative
learning outcomes)
discussions and construct opinions.
Use acquired theoretical knowledge in solving practical problems regarding changes in
sleep architecture based on polysomnography recordings.
Lectures (4 hours):
1. Sleep hygiene
2. Regulation of sleep and wakefulness
Seminars (8 hours):
Course content
1. Insomnia
broken down in detail
2. Gender differences in sleep
by weekly class
3. Actygraphy
schedule (syllabus)
4. Sleep and academic performance
Exercises (8 hours):
1. Sleep medicine Center- sleep diary, questionnaires, patient anamnesis
2. Sleep architecture- polysmnography recordings
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Student
responsibilities
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS Tests
Oral exam
(Other)
credits is equal to the
ECTS value of the
Written exam
Project
(Other)
course)
Grading and
The student success is assessed according to their activities during class.
evaluating student
work in class and at
the final exam
Number of
Availability via
Title
copies in the
other media
library
1.
Purves D et al.:
3
Neuroscience,
5th
edition,
Sinauer
Associates
INC,
USA.
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
Bassetti CL, Dogas Z, Peigneux: European Sleep Medicine Textbook, European Sleep
Research Society 2014




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation
NAME OF THE COURSE
Systematic review and meta-analysis
Code
PT-IP33
Year of study
Course teacher
Prof. Livia Puljak, MD, PhD
Credits (ECTS)
Associate teachers
Status of the course
Elective
2
2
Type of instruction
(number of hours)
L
S
E
5
5
5
Percentage of application
of e-learning
0%
F
COURSE DESCRIPTION
Course objectives
Course enrolment
requirements and
entry competences
required for the
course
Understanding concepts of systematic review and meta-analysis; conducting steps of the
systematic review and meta-analysis methodology
Passed all exams from the first year of the program
Knowledge about systematic review and meta-analysis methodology
Independent screening of search results
Independent analysis of full text studies and checking for inclusion criteria
Learning outcomes
Independent data extraction
expected at the level
Independent performance of risk of bias assessment
of the course (4 to 10
Independent GRADE-ing of evidence
learning outcomes)
Independent meta-analysis
Independent use of RevMan and GRADE software
Systematic review and meta-analysis methodology (1 h L)
Screening of search results (2 h L)
Course content
Analysis of full text studies and checking for inclusion criteria (2 h L)
broken down in detail Data extraction (2 h S)
by weekly class
Risk of bias assessment (2 h S)
schedule (syllabus)
GRADE-ing of evidence (1 h S)
Conducting meta-analysis (4 h E)
RevMan and GRADE software (1 h E)
☒ lectures
☐ independent assignments
☒ seminars and workshops
☐ multimedia
☒ exercises
Format of instruction
☐ laboratory
☐ on line in entirety
☐ work with mentor
☐ partial e-learning
☐
(other)
☐ field work
Attending classes
Student
Active participation in lessons
responsibilities
Completing tasks during lessons
Taking an exam
Class
Screening student
Research
Practical training
attendance
work (name the
Experimental
proportion of ECTS
Report
(Other)
work
credits for each
activity so that the
Essay
Seminar essay
(Other)
total number of ECTS
Oral exam
(Other)
credits is equal to the Tests
ECTS value of the
course)
Grading and
evaluating student
work in class and at
the final exam
Written exam
1
Project
1
The exam consist of:
Data extraction from given studies
Meta-analysis of given data
Number of
Availability via
copies in the
other media
library
Title
Required literature
(available in the
library and via other
media)
Optional literature (at
the time of
submission of study
programme proposal)
Quality assurance
methods that ensure
the acquisition of exit
competences
Other (as the
proposer wishes to
add)
(Other)
Scientific articles and hand-outs prepared by teachers




Teaching quality analysis by students and teachers
Exam passing rate analysis
Committee for control of teaching reports
External evaluation