Sexually Transmitted Disease (STD) Surveillance Report, 2004 Minnesota Department of Health STD Surveillance System Introduction This slide set describes new cases of chlamydia, gonorrhea, and syphilis in Minnesota by person, place, and time. The slides display data from cases diagnosed through 2004 and reported to the Minnesota Department of Health (MDH) STD Surveillance System. Data analyses exclude federal and private prisoners. Introduction STD Surveillance is the systematic collection of data from cases for the purpose of monitoring the frequency and distribution of STDs in a given population. STD surveillance data are used to detect problems, prioritize resources, develop and target interventions, and evaluate the effectiveness of interventions. Interpreting STD Surveillance Data Factors that impact the completeness and accuracy of the data include: Level of STD screening and individual test-seeking behavior Sensitivity of diagnostic tests Compliance with case reporting Timeliness of case reporting Increases and decreases in STD rates can be due to actual changes in disease occurrence and/or changes in one or more of the factors described above. For example, in 2002 MDH added an active component to the previously passive STD Surveillance System. As a result, compliance with reporting improved and the number of chlamydia and gonorrhea cases reported to MDH increased by at least 7% and 5%, respectively, between 2001 and 2002 as an artifact of reporting. National Context HIV/AIDS in Minnesota: Annual Review United States: State-Specific Chlamydia Rates, 2003 276.8 280.1 156.8 261.0 218.3 213.4 176.4 329.7 342.7 192.5 298.7 324.1 221.0 302.3 274.1 268.2 383.3 277.2 168.1 334.4 289.3 234.9 403.2 266.9 315.2 372.3 143.5 266.5 327.4 195.0 289.9 356.0 Guam 344.0 316.7 Rate per 100,000 population 416.9 317.7 467.8 605.8 171.9 126.7 175.8 280.4 271.4 188.2 375.9 308.4 314.7 351.5 424.6 VT NH MA RI CT NJ DE MD 253.6 (n= 3) <=150.0 150.1-300.0 (n= 26) >300.0 (n= 24) 440.2 Puerto Rico 71.1 Virgin Is. 378.1 SOURCE: Centers for Disease Control & Prevention, Division of STD Prevention. 2003 Surveillance Slides. STDs in Minnesota: Annual Review United States: State-Specific Gonorrhea Rates, 2003 45.4 13.4 18.0 16.2 28.4 63.8 5.1 104.1 29.7 9.2 115.7 138.9 52.9 96.2 93.9 102.2 173.1 108.5 17.8 73.9 63.3 65.6 197.3 63.0 97.5 130.3 47.0 155.0 124.3 87.4 156.9 207.4 Guam 40.4 207.4 Rate per 100,000 population 206.6 112.9 264.4 89.0 15.7 9.8 45.1 91.0 90.0 92.5 139.7 147.2 181.7 146.9 220.4 VT NH MA RI CT NJ DE MD 113.5 <=19.0 19.1-100.0 >100.0 (n= 9) (n= 21) (n= 23) 101.5 Puerto Rico 7.2 Virgin Is. 82.7 SOURCE: Centers for Disease Control & Prevention, Division of STD Prevention. 2003 Surveillance Slides. STDs in Minnesota: Annual Review United States: State-Specific P&S Syphilis Rates, 2003 1.4 0.0 0.6 0.3 1.4 0.9 1.1 0.3 0.3 0.0 3.0 0.4 1.3 0.6 0.6 0.6 3.7 3.0 0.9 3.4 VT NH MA RI CT NJ DE MD 2.5 0.9 1.8 3.8 0.8 1.7 0.1 1.1 1.1 0.8 1.8 2.3 1.9 2.3 Guam 0.6 1.4 2.5 Rate per 100,000 population 6.8 3.0 4.1 0.2 0.2 1.5 2.1 3.1 0.9 2.0 0.9 5.7 3.9 <=0.2 0.21-4.0 >4.0 (n= 5) (n= 44) (n= 4) 1.1 Puerto Rico 5.2 Virgin Is. 2.7 SOURCE: Centers for Disease Control & Prevention, Division of STD Prevention. 2003 Surveillance Slides. STDs in Minnesota: Annual Review Overview of STDs in Minnesota STDs in Minnesota: Annual Review STDs in Minnesota Rate per 100,000 by Year of Diagnosis, 1994-2004† Gonorrhea P&S* Syphilis 240 10 220 9 200 8 180 7 160 140 6 120 100 5 4 80 3 60 2 40 20 1 0 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 * P&S = Primary and Secondary. Year † While P&S syphilis numbers decreased in 2004, first quarter numbers for 2005 indicate an increase back to 2003 levels. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Rate of P&S Syphilis Rate of Chlamydia and Gonorrhea Chlamydia STDs in Minnesota: Number of Cases Reported in 2004 Total of 14,703 STD cases reported to MDH in 2004: 11,601 Chlamydia cases 2,957 Gonorrhea cases 145 Syphilis cases (all stages) Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review CHLAMYDIA STDs in Minnesota: Annual Review Kittson 2004 Minnesota Chlamydia Rates by County Roseau Lake of the Woods Marshall Koochiching Pennington Beltrami Red Lake Clearwater Polk Cook St. Louis Lake Itasca Norman Mahnomen Hubbard Becker Clay Cass Crow Wing Wadena Aitkin Rate per 100,000 persons Carlton Wilkin Otter Tail Grant 0 - 75 76 - 150 Pine Mille Lacs Todd Morrison Douglas Kanabec Traverse Big Stone Stevens Pope Stearns Isanti Chisago Sherburne Swift Wright Kandiyohi Meeker McLeod Ramsey Carver Renville Nicollet Le Sueur Rice Wabasha Brown Pipestone Rock Murray Nobles Cottonwood Jackson (407 cases missing residence information) Goodhue Redwood Blue Earth Watonwan Martin Faribault Data Source: Minnesota STD Surveillance System 886 639 168 149 Dakota Scott Sibley Lyon Washington Hennepin Lac qui Parle Yellow Medicine City of Minneapolis City of St. Paul Suburban# Greater Minnesota Anoka Chippewa Lincoln 151 - 300 > 300 Benton 7-county metro area, excluding the cities of Minneapolis and St. Paul # Waseca Steele Freeborn Dodge Mower Olmsted Winona Fillmore Houston STDs in Minnesota: Annual Review Chlamydia Infections in Minnesota by Residence at Diagnosis, 2004 Total Number = 11,601 (407 missing residence information) Minneapolis 24% Greater MN 30% St. Paul 16% Suburban 30% Suburban = Seven-county metro area including Anoka, Carver, Dakota, Hennepin (excluding Minneapolis), Ramsey (excluding St. Paul), Scott, and Washington counties. Greater MN = All other Minnesota counties outside the seven-county metro area. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates by Gender Minnesota, 1994-2004 Males 400 Females 350 Rate per 100,000 300 250 200 150 100 50 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates by Age Minnesota, 1994-2004 1600 15-19 25-29 1400 20-24 30-39 Rate per 100,000 1200 1000 800 600 400 200 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates by Race/Ethnicity Minnesota, 1994-2004 2500 White American Indian Hispanic* Rate per 100,000 2000 Black Asian/PI 1500 1000 500 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates by Race/Ethnicity Excluding Blacks Minnesota, 1994-2004 1000 Rate per 100,000 800 White American Indian Asian/PI Hispanic* 600 400 200 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review GONORRHEA STDs in Minnesota: Annual Review Kittson 2004 Minnesota Gonorrhea Rates by County Roseau Lake of the Woods Marshall Koochiching Pennington Beltrami Red Lake Clearwater Polk Cook St. Louis Lake Itasca Norman Mahnomen Hubbard Becker Clay Cass Crow Wing Wadena Aitkin Carlton Wilkin Rate per 100,000 persons Otter Tail Grant Traverse 0 -19 Pine Mille Lacs Todd 20 - 100 > 100 Morrison Douglas Kanabec Benton Stevens Pope Stearns Big Stone Isanti Chisago Sherburne Swift Lac qui Parle Hennepin McLeod Lyon Ramsey Carver Renville Scott Sibley Lincoln Washington Chippewa Yellow Medicine Le Sueur (96 missing residence information) Rice Wabasha Brown Pipestone Cottonwood Blue Earth Waseca Steele Dodge Nobles Jackson Martin Faribault Data Source: Minnesota STD Surveillance System Freeborn Mower 7-county metro area, excluding the cities of Minneapolis and St. Paul # Olmsted Winona Watonwan Rock 276 190 40 21 Dakota Goodhue Redwood Nicollet Murray City of Minneapolis City of St. Paul Suburban# Greater Minnesota Anoka Wright Kandiyohi Meeker Fillmore Houston STDs in Minnesota: Annual Review Gonorrhea Infections in Minnesota by Residence at Diagnosis, 2004 Total Number = 2,957 (96 missing residence information) Greater MN 16% Minneapolis 37% Suburban 28% St. Paul 19% Suburban = Seven-county metro area including Anoka, Carver, Dakota, Hennepin (excluding Minneapolis), Ramsey (excluding St. Paul), Scott, and Washington counties. Greater MN = All other Minnesota counties outside the seven-county metro area. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Gonorrhea Rates by Gender Minnesota, 1994-2004 100 Males Females Rate per 100,000 80 60 40 20 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Gonorrhea Rates by Age Minnesota, 1994-2004 15-19 25-29 400 20-24 30-39 350 Rate per 100,000 300 250 200 150 100 50 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Gonorrhea Rates by Race/Ethnicity Minnesota, 1994-2004 2000 White American Indian Hispanic* 1800 1600 Rate per 100,000 1400 Black Asian/PI 1200 1000 800 600 400 200 0 1994 1995 1996 * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System 1997 1998 1999 2000 2001 2002 2003 2004 Year STDs in Minnesota: Annual Review Gonorrhea Rates by Race/Ethnicity Excluding Blacks Minnesota, 1994-2004 250 225 200 White American Indian Asian/PI Hispanic* Rate per 100,000 175 150 125 100 75 50 25 0 1994 1995 1996 * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System 1997 1998 1999 2000 2001 2002 2003 2004 Year STDs in Minnesota: Annual Review PRIMARY & SECONDARY SYPHILIS STDs in Minnesota: Annual Review Kittson 2004 Minnesota P&S Syphilis Rates by County Roseau Lake of the Woods Marshall Koochiching Pennington Beltrami Red Lake Clearwater Polk Cook St. Louis Lake Itasca Norman Mahnomen Hubbard Becker Clay Cass Crow Wing Wadena Aitkin Wilkin Carlton Otter Tail Rate per 100,000 persons Mille Lacs Pine Todd Grant 0 – 0.2 0.21 – 1.0 > 1.0 Morrison Douglas Kanabec Traverse Big Stone Benton Stevens Pope Stearns Isanti Chisago Sherburne Swift Anoka Wright Kandiyohi Meeker Lac qui Parle Ramsey Chippewa Hennepin McLeod Yellow Medicine Carver Renville Lyon Dakota Scott Sibley Lincoln Goodhue Redwood Nicollet Le Sueur Rock Murray Nobles Cottonwood Jackson Blue Earth Martin 7-county metro area, excluding the cities of Minneapolis and St. Paul Wabasha Watonwan Steele Waseca Faribault Data Source: Minnesota STD Surveillance System Freeborn Dodge Olmsted Mower 4.2 1.0 0.4 0.0 # Rice Brown Pipestone City of Minneapolis City of St. Paul Suburban# Greater Minnesota Washington Winona Fillmore Houston STDs in Minnesota: Annual Review Primary &Secondary Syphilis Infections in Minnesota by Residence at Diagnosis, 2004 Total Number = 27 Greater MN 4% Suburban 26% Minneapolis 59% St. Paul 11% Suburban = Seven-county metro area including Anoka, Carver, Dakota, Hennepin (excluding Minneapolis), Ramsey (excluding St. Paul), Scott, and Washington counties. Greater MN = All other Minnesota counties outside the seven-county metro area. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Primary & Secondary Syphilis Rates† by Age Minnesota, 1994-2004 9.0 8.0 15-19 20-24 25-29 30-39 Rate per 100,000 7.0 6.0 5.0 4.0 3.0 2.0 1.0 0.0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year † While P&S syphilis numbers decreased in 2004, first quarter numbers for 2005 indicate an increase back to 2003 levels. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Primary &Secondary Syphilis Rates by Gender Minnesota, 1994-2004 4.0 Males Females 3.5 Rate per 100,000 3.0 2.5 2.0 1.5 1.0 0.5 0.0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Primary & Secondary Syphilis Rates by Race/Ethnicity Minnesota, 1994-2004 40 White American Indian Hispanic* 35 Rate per 100,000 30 Black Asian/PI 25 20 15 10 5 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Primary & Secondary Syphilis Rates by Race/Ethnicity Minnesota, 1997-2004 20 White American Indian Hispanic* Rate per 100,000 15 Black Asian/PI 10 5 0 1997 1998 1999 2000 2001 2002 2003 2004 Year * Persons of Hispanic ethnicity can be of any race. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review ADOLESCENTS & YOUNG ADULTS 15-19 year olds 20-24 year olds STDs in Minnesota: Annual Review Chlamydia disproportionately impacts adolescents & young adults MN Population in 2000 Chlamydia Cases in 2004 (n = 4,919,479) (n = 11,601) 25-34 yrs 24% 25-34 yrs 14% 35+ yrs 50% 15-24 yrs 14% 35+ yrs 6% 15-24 yrs 69% <15 yrs 1% <15 yrs 22% Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Gonorrhea disproportionately impacts adolescents & young adults MN Population in 2000 Gonorrhea Cases in 2004 (n = 4,919,479) (n = 2,957) 25-34 yrs 27% 25-34 yrs 14% 35+ yrs 50% 35+ yrs 15% 15-24 yrs 14% 15-24 yrs 57% <15 yrs 1% <15 yrs 22% Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Characteristics of adolescents & young adults diagnosed with chlamydia or gonorrhea in 2004 (n=9,089) Cases % of Total Male 2,068 23% Female 7,020 77% 1 < 1% White 3,886 43% Black 2,557 28% Am Indian 329 4% Asian/PI 253 3% 2,064 23% Transgender Other/Unknown Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Characteristics of adolescents & young adults diagnosed with chlamydia or gonorrhea in 2004 (Continued) Hispanic Cases 566 % of Total 6% Non-Hispanic 5,069 56% Unknown 3,454 38% Minneapolis St. Paul Suburban MN Greater MN Unknown 2,071 1,465 2,456 2,781 316 23% 16% 27% 31% 3% Suburban = Seven-county metro area including Anoka, Carver, Dakota, Hennepin (excluding Minneapolis), Ramsey (excluding St. Paul), Scott, and Washington counties. Greater MN = All other Minnesota counties outside the seven-county metro area. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates for Adolescents & Young Adults by Gender in Minnesota, 1994-2004 2000 1800 Males Females 1600 Rate per 100,000 1400 1200 1000 800 600 400 200 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Gonorrhea Rates for Adolescents & Young Adults by Gender in Minnesota, 1994-2004 500 Males 450 Females 400 Rate per 100,000 350 300 250 200 150 100 50 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review EMERGING TRENDS: -Drug Resistant Gonorrhea -Syphilis among MSM -Chlamydia Rate Double since 1996 STDs in Minnesota: Annual Review Increasing Prevalence of Drug-Resistant Gonorrhea in Minnesota STDs in Minnesota: Annual Review Background Information CDC-recommended antibiotic treatments for gonorrhea: Ceftriaxone Cefixime Single dose therapy, administered by injection Relatively expensive Single dose therapy, administered orally Production discontinued in 2002; No longer available Ciprofloxacin, Ofloxacin, Levofloxacin (Quinolones) Single dose therapy, administered orally Spread of quinolone-resistant N. gonorrhoeae (QRNG) threatens the efficacy of fluoroquinolones as the frontline treatment for gonorrhea Prevalence of Quinolone-Resistant N. Gonorrhoeae (QRNG) 1990s 2000 2001 QRNG prevalent in Asia, >40% in some countries Hawaii discontinues use of fluoroquinolones following increase in QRNG prevalence from 1.4% in 1997 to 9.5% in 1999 California discontinues use of fluoroquinolones after reaching QRNG prevalence of 5% in 2001 2002 CDC recommends non-quinolone therapy for infections acquired in HI, CA, and other areas with high QRNG prevalence 2003 Increases in QRNG reported in other U.S. states (e.g., MI, MA) 2004 Prevalence of QRNG in MN five times higher than in 2002 Prevalence of QRNG in Minnesota, 1999 - 2004 Year # Resistant Isolates # Isolates Tested QRNG Prevalence 1999-2001 0 1,365 0% 2002 4 268 1.5% 2003 5 363 1.4% 2004 28 333 8.4% Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Prevalence of QRNG Among Male GISP† Participants by Mode of Transmission in Minnesota, 2002 - 2004 Gay/Bisexual Year Heterosexual # Resistant # Tested Prevalence # Resistant # Tested Prevalence 2002 0 38 0.0% 1 152 0.7% 2003 4 45 8.9% 1 168 0.6% 2004 18 67 26.9% 4 177 2.2% The Gonococcal Isolate Surveillance Project (GISP) is a sentinel surveillance system established by the CDC to monitor antimicrobial resistance in Gonorrhea among males. The Red Door Clinic in Minneapolis is one of the participating clinics. The data shown has been collected through this project. † Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Characteristics of the 2004 QNRG cases (n = 28) 71% 0f the cases were White 32% of cases (9) were among men under 30 years of age, the average age for cases was 32.5 years 22 of the 28 cases (79%) were among gay/bisexual males Eighteen percent of cases among gay/bisexual males were also HIV+ A majority of cases reported having multiple sex partners in the previous 60 days Two of the cases reported travel and sexual activity in areas with high QNRG prevalence (Philippines and Hawaii) What’s Being Done in Minnesota? MDH has expanded the current QRNG surveillance system to include women and Room 111 in St. Paul MDH will use the data to guide future treatment recommendations Healthcare providers are encouraged to obtain travel histories of patients and to be alert for treatment failures. Gonorrhea infections acquired in areas with high QRNG prevalence and among MSM should receive non-quinolone therapy Clinicians and laboratories are asked to report suspected treatment failures and resistant gonococcal isolates to MDH MDH Partner Services Program follows up on cases and sex partners Syphilis among Gay/Bisexual Men in Minnesota STDs in Minnesota: Annual Review Early Syphilis Cases by Stage at Diagnosis Minnesota, 1994-2004 100 80 Number of Cases Primary Secondary Early Latent 60 40 20 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Early Syphilis* among Gay/Bisexual Men Minnesota, 2001-2004 • 48 early syphilis cases diagnosed in 2004, compared with: • 92 cases in 2003 • 82 cases in 2002 • 49 cases in 2001 • 34 cases among gay/bisexual men in 2004, compared with: • 71gay/bisexual men in 2003 • 56 gay/bisexual men in 2002 • 5 gay/bisexual men in 2001 • Characteristics of the 2004 gay/bisexual male cases (n=34): 80% White 71% live in Hennepin County Average age = 37 32% HIV+ * Early Syphilis includes primary, secondary, and early latent stages of syphilis. Early Syphilis* among Gay/Bisexual Men Minnesota, 2004 While the number of cases in 2004 decreased, first quarter data for 2005 indicate an increase back to 2003 levels Despite the decrease in 2004, cases among MSM remain high compared to 2001 (34 versus 5) MSM accounted for 81% of cases among males Internet was the most common venue for meeting partners (78%) Among MSM, most reported having anonymous sex (81%), and of these 41% reported no condom use * Early Syphilis includes primary, secondary, and early latent stages of syphilis. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review What’s Being Done in Minnesota? MDH is continuing awareness campaigns (e.g., Health Notices, press releases) Encouraging physicians to screen gay/bisexual men at least annually Community-based programs intensifying outreach activities to reach gay/bisexual men MDH has implemented innovative prevention strategies (e.g., internet banners, partnering with venues) MDH Partner Services Program continues to follow up on cases and sex partners Doubling of the Chlamydia Rate Since 1996 STDs in Minnesota: Annual Review Chlamydia in Minnesota Rate per 100,000 by Year of Diagnosis, 1994-2004 Chlamydia 240 Rate of Chlamydia and Gonorrhea 220 200 180 236 per 100,000 160 140 120 100 80 115 per 100,000 60 40 20 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 Year Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review Chlamydia Rates in Minnesota, 1996-2004 Since 1996 the rate of Chlamydia infection has doubled from 115 to 236 per 100,000 The rate has doubled both among men (54 to 126) and women (175 to 343) Rates have almost tripled among 25-29 year olds (214 to 597) and among 30-39 year olds (56 to 156) Among 15-19 year olds rates have increased 1½ times (640 to 968) and among 20-24 year olds rates have doubled (567 to 1372) Chlamydia Rates in Minnesota, 1996-2004 Rates have also increased by race, doubling among Hispanics, Whites and Asian/Pacific Islanders In this time period, the chlamydia rate for Blacks and American Indians increased by 32% and 60%, respectively Rates have also increased by geography with the most marked increases happening in Greater Minnesota and the suburban 7county metro area In both areas the rate more than doubled, compared to an increase of 25% in Minneapolis and 64% in St. Paul What’s Behind the Increase? The observed increase since 1996 is most likely due to the combination of four factors: 1. Improved testing technology with increased sensitivity 2. Improved screening practices by clinicians 3. Addition of active surveillance component 4. Increase of the disease in the population However, the effect of the first three factors would have leveled off over time so the increase is most likely being driven by an actual increase of the disease in the population. Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review SURVEILLANCE SUMMARY Summary of STD Trends in Minnesota Between 2003-2004, the overall chlamydia rate increased while rates of gonorrhea and early syphilis decreased STD rates continue to be highest in Minneapolis and St. Paul STD rates are highest among persons of color Chlamydia and gonorrhea rates are highest among adolescents and young adults; syphilis rates are highest among adults While the number of early syphilis cases is down, the numbers among gay/bisexual men are continue to be high Prevalence of antibiotic-resistant gonorrhea has increased five fold between 2002 and 2004 Data Source: Minnesota STD Surveillance System STDs in Minnesota: Annual Review