6ème Réunion du Groupe Consultatif Spécial
de l’OMS sur l’Ulcère de Buruli
Unraveling Clay’s Secrets
Thierry Brunet de Courssou
Geneva, xx March 2003
Les secrets de l’argile
www.BuruliBusters.com
www.ActionBuruli.com




Dennis Eberl (US Geological Survey)
James Ferries (NASA Origin of Life)
Lynda Williams (ASU)
John Holloway (ASU)
The Challenge (1) - Buruli








Mycobacterium/toxin neutralization
Débridement
Healing (Hyper-Granulation)
Controls general infection
Skin growth
No keloids
No retractions
Stem cells stimulation (?)
The Challenge (2) – NOT Buruli






Débridement (leg ulcers, bed sores, other)
Healing (granulation)
Skin growth
No keloids
No retractions
Raymond Dextreit (world reference)
The Challenge (3) - Investment
 ROI = 0 (pharmaceutical labs perspective)
Promising Huge Payoff
 Tuberculosis (mycobacterium tuberculosis)
 Leprosy (mycobacterium leprae)
 AIDS
Clay Actions – The Clues
The Origin of Life from Clay
 Graham Cairns-Smith
 James Ferries
 John Holloway
Mycolactone / Toxin
 Reaction with clay
Aluminum Silicate + Cocktail of 74 elements
Montmorillonite clay found in Nevada



















Aluminum
Antimony
Arsenic
Barium
Beryllium
Bismuth
Boron
Bromine
Cadmium
Calcium
Cerium
Cesium
Chlorine
Chromium
Cobalt
Copper
Dysprosium
Erbium
Europium



















Fluorine
Gadolinium
Gallium
Germanium
Gold
Hafnium
Holmium
Indium
Iodine
Iridium
Iron
Lanthanum
Lead
Lithium
Lutetium
Magnesium
Manganese
Mercury
Molybdenum



















Neodymium
Nickel
Niobium
Osmium
Potassium
Palladium
Phosphorus
Platinum
Praseodymium
Rhenium
Rhodium
Rubidium
Ruthenium
Samarium
Scandium
Selenium
Silicon
Silver
Sodium

















Strontium
Sulfur
Tantalum
Tellurium
Terbium
Thallium
Thorium
Thulium
Tin
Titanium
Tungsten
Uranium
Vanadium
Ytterbium
Yttrium
Zinc
Zirconium
Smectite – 2:1
layer
interlayer
layer
cations
Absorption
Adsorption
+
- - - - - - - - - - - - The toxins have gone inside the clay and sit in
between the layers.
The contaminants are incorporated into the clay
structure
+
+
+
- - +
-
+
+
- - - +
- +
+
Through ionic exchange, the harmful poisons
are drawn to the outside surface of the clay.
Contaminant particules are attracted to the
outer surface of the clay crystal
Electrical Charge of Clays
pesticides
metals
-
-
- CLAY
PARTICLE
-
H2O
-
H2O
-
- H2O
nutrients
Smectite Crystal
+
Smectite Crystal
+
– –
–
1000 nm
–
–
+
–
–
–
–
 0.9 nm
–
+
–
–
–
+
Top View
–
– –
–
+
–
–
– –
–
–
+
Top View
–
– –
–
Edge View
– –
–
–
–
–
Edge View
HYDRATION OF A SINGLE SMECTITE CRYSTAL
SMECTITE AGGREGATE
 


 
 
 
 
 
 

Water



















































+
–







+
Enlarged edge of crystal
Ca2+ H+ K+
External
surface
Mg2+
Ca2+
H+
NH4+ Ca2+
+
Ca2+
Ca2+ H+ K
+
2+ H
Ca
Mg2+
2+
Mg
NH4+
Na+
Ca2+ H+ Ca2+
+
K
2+
Ca
+
H+
H+
H+ Na+ H
K+
+
2+
H
Ca2+ NH4+ Mg
Mg2+
H+
K+
K+
Ca2+
External
surfaces
H+
Al3+
Ca2+ H+
Na+
Ca2+
Internal
surfaces
K+
Ca2+
H+ NH4+
K+
Ca2+
K+
H+
Mg2+
Ca2+
Just cheap dirt … Medical Science – NO interest!
Not so fast….
Spray dried smectite














Use for thousand of years in all continents
Remove metals
Radiochemicals contamination entrapment
NanoClay
Clay Mineral Society promoting research
IBM Clay-protein research project
People living next to montmorillonite deposit life 120~140 years
Domestic water filters
Caffeine adsorbent liquid filter
Water Based Paint additives
ultra-pure smectite clays for GM (enhanced physical properties
nanocomposites)
Laponite ™ synthetic clay mineral
Barasym ™ synthetic clay mineral
Nanoplastics = polymeric nanocomposites







Origin of Life
Detection of life on Mars
Fireproofing
Crop mineral fertilizing
Extraordinary observation during Buruli treatment
Berkeley Earth Sciences Lab -- Molecular Simulations of
Hydrated Montmorillonite Interlayers
Because of their ubiquitous presence in natural materials
and their strong surface reactions with cations and organic
molecules, clay minerals figure importantly in a broad range
of phenomena, from global climate change to contaminant
management. Research is designed to provide molecularscale information about the mechanisms of these surface
reactions, based on state-of-the-art computer simulation
using tested codes and realistic models of clay mineral
interactions with liquid water and a variety of dissolved
chemicals
11,495 US Patents “montmorillonite”
1,239 US Patents “illite”
8,470 US Patents “clay minerals”
522 Canadian Patents “montmorillonite”
Water droplets on Illite (left) and Quartz (right)
Water droplets
Typical “Spiky” Crystals
Water droplets on Illite (and Illitized Kaolinite).
swelling type of Namontmorillonite,
where the plates are
expanded by high
hydration
Smectite
Wavy, lettuce appearance
Ca-montmorillonite,
with low hydration,
where the plates are
held tightly
Scale = 10 µm
Smectite and quartz crystals
Kaolinite booklets on Smectite-Illite
Guadeloupe vertsols have natural suppressiveness to bacterial wilt, mainly of physicochemical origin. Pictures shows
cells (black arrow) of R. solanacearum observed in the porosity of native montmorillonite extracted from a Guadeloupe
vertisol. General view of bacterial cells (B) embedded in the tactoidal clay matrix [A], which is deformable and able to
wrap around cells or to come in contacts at several points as seen in the detailed TEM where individuals cristallites of
montmorillonite associate to form tactoids (T) delimiting pores (P) where bacteria are entrapped and not available for the
infectious process .
To know more about vertisol suppressive to bacterial wilt in Guadeloupe see;
Prior P., Béramis M., Clairon M., Quiquampoix H., Robert M., Schmit J. 1993. Contribution to integrated control against
bacterial wilt in opposite pedoclimatic situations: Guadeloupe experience. In "Bacterial Wilt" Proceedings of an
international conference held at Kaoshiung, Taiwan, 28-31 October 1992. ACIAR Proceedings No 45, 294-304.
http://ibws.nexenservices.com/suppressive_soils.htm
http://www.che.gatech.edu/drugdelivery/
Microfabricated devices for drug delivery
oMicroneedles for transdermal drug
delivery
oMicroparticles with controlled geometry
http://www.utdallas.edu/~jblee/research/Microneedle%20Array%20for%20BioMEMS.htm
2:1’s
VERMICULITE
MICA
2:1 layer
-- - - -
interlayer
--- - K+ K+ K+ K+
2:1 layer
--- ------- - -
-- - -
SMECTITE
-
-
- - - Ca+2
K+
Mg+2
Ca+2
K+
Ca+2
Mg+2
-- --- -
- -
-
Nanotherapy
Repeatable Observable
Experiments
 Animal Testing
 Testing on humains
 Africa
 Bee stings
 Spider bites (milking)
Vaccination Hazard
Thimerosal (ethylmercury) poisoning
Clay Bath
(www.MagneticClay.com)
Kirlian effect
Tap Water
Evian + Clay
Sea water + Clay
Kirlian effect
45 minutes after drinking a glass of Illite
Clay pack on thumb
Kirlian effect
Jacques Benveniste
Masaru Emoto
Snow Crystals
Homeopathy
PROTEIN CRYSTAL GROWTH
All infos on this preliminary study
including the slide show are available at:
Toutes les infos sur ces études
préliminaires sont disponibles à:
www.BuruliBusters.com
www.ActionBuruli.com