1. The following drugs are used for the treatment of asthma exept:
A. Salbutamolum
B. Isadrine
C. Ephedrinum
D. Anapriline*
E. Phenoterolum
2. Acetaminophen (paracetamolum):
A. can induce fatal hepatic damages in the case of poisoning*
B. can induce headache
C. can induce high temperature
D. has anticough action
E. is used to treat hypotension
3. Adverse effects of neuroleptic agents, such as galactorrhea,
gynecomastia, ejaculation disorders, are attributed to:
A. an antimuscarinic effect
B. an inhibition of angiotensin receptors
C. an inhibition of dopamine receptors*
D. an increase of prolactin secretion
E. a stimulation of the alpha1 adrenergic receptors
4. The following drug decreases delusions and hallucinations:
A. Diazepam
B. Ephedrinum
C. Droperidolum*
D. Anaprilinum
E. Paracetamolum
5. The following drugs act mainly by inhibiting the reuptake
of neurotransmitters - serotonin and noradrenaline:
A. Codeinum
B. Aminasine
C. Coffeine
D. Amitriptiline*
E. Sodium bromide
6. The following drugs are regarded as atypical neuroleptic agents:
A. Clozapine*
B. Haloperidol
C. Sodium bromide
D. Coffeine
E. Droperidolum
7. The following drug can depress respiration:
A. Adrenaline
B. Analgine
C. Morphine*
D. Anapriline
E. Aspirin
8. The following drug is used commonly as anxiolytic:
A. Flumazenil
B. Buprenorphine
C. Haloperidol
D. Diazepam*
E. Paracetamolum
9. The following drugs act mainly by inhibiting the reuptake of serotonin:
A. Fluoxetine*
B. Aminasine
C. Coffeine
D. Cordiamine
E. Sodium bromide
10.The following drugs are used as specific treatment for bipolar disorders:
A. Carbamazepine
B. Lithium*
C. Coffeine
D. Cordiamine
E. Codeinum
11.What effect of morphine administration to a patient with pain?
A. relieves pain*
B. stimulates respiration
C. induces diarrhea
D. causes a dilation of the pupil (mydriasis)
E. causes headache
12.Choose drug for general anesthesia with the widest range of narcotic
action:
A. Nitrous oxide
B. Ether for anesthesia*
C. Sombrevinum
D. Ethyl alcohol
E. Thiopental
13.What preparation does belong to the beta -adrenomimetics?
A. Isadrin.*
B. Anaprilin.
C. Adrenalin.
D. Phentholamin.
E. Reserpin.
14.-zepam or - zolam: the drugs whose common name ends by the suffix zepam or - zolam are:
A. Benzodiazepines*
B. antidepressants
C. nonsteroidal anti-inflammatory drugs
D. neuroleptics
E. adrenergic stimulants
15.What is the way of noradrenalin introduction to the organism?
A. Intravenous.*
B. Intramuscular.
C. Peroral.
D. Subcutaneous.
E. Intracutaneous.
16.At the case of anti- depolarizing myorelaxants overdose is used:
A. Proserine.*
B. Atropine.
C. Cytitone.
D. Аrmine.
E. Anapriline.
17.What concentration of Novocain solution is used for infiltrative
anesthesia?
A. 0,25-0,5%*
B. 1-2%
C. 3%
D. 10-20%
E. 0,05%
18.For the patient with depression was prescribed Nialamide. The
physician informed the patient about the necessity to remove from a diet
such product as:
A. Cheese*
B. Apples
C. Potatoes
D. Cabbages
E. Pears.
19.Selective serotonin reuptake inhibitors (SSRIs) and tricyclic
antidepressants (TCAs) both function by:
A. Blocking the reuptake of neurotransmitters at nerve endings*
B. Increasing level of neurotransmitters in peripheral neurons
C. Decreasing levels of epinephrine and serotonin at nerve endings
D. Increasing the placebo effect
E. Increasing level of endorphins
20.What food product is necessary to remove from the patient’s diet in case
of medical treatment by antidepressants- MAO inhibitors?
A. Cheese*
B. Beef
C. Cabbage
D. Potatoes
E. Apples
21.What substance is sensitive to M-cholinoreceptors?
A. Muscarine*
B. Novocaine
C. Nalorphine
D. Nicotine
E. Atropine
22.Which group of drugs may be used for treatment of hypertensive
emergencies?
A. Ganglionblockers*
B. Sympathomimetics
C. alpha-adrenomimetics
D. beta-adrenomimetics
E. Myorelaxants
23.What agent belongs to ganglionblockers?
A. Benzohexonium*
B. Mesatone
C. Proserine
D. Atropine
E. Tubocurarine
24.What group of agents does Hygronium belong to?
A. Ganglionblockers*
B. Myorelaxants
C. Anticholinesterase agents
D. М-cholinoblockers
E. N-cholinomimetics
25.Indication of Tubocurarine usage:
A. Asphyxia
B. High blood pressure crisis
C. Glaucoma
D. Ulcer disease
E. Myorelaxation*
26.What agent does belong to myorelaxants?
A. Tubocurarine chloride*
B. Hygronium
C. Proserine
D. Aceclidine
E. Atropine sulfate
27.Chooseindication of myorelaxants usage:
A. Myorelaxation in surgery*
B. High blood pressure crisis
C. Parkinson’s disease
D. Myastenia
E. Pneumonia
28.Which of the following therapeutic effects is typical for
ganglionblockers?
A. Decrease of blood pressure*
B. Increase of blood pressure
C. Increase of intestine motility
D. Relaxation of muscles
E. Contraction of pupils
29.What effects do exist in a case of myorelaxants introduction?
A. Relaxation of skeletal muscles*
B. Contraction of pupils
C. Decrease of intestine motility
D. Relaxation of smooth muscles
E. Decrease of eye pressure
30.What muscles are relaxed after myorelaxants introduction at last?
A. Diaphragm muscles*
B. Muscles of fingers of hands and feet
C. Muscles of face
D. Trunk muscles
E. Muscles of eyes
31.What tubocurarine is used for?
A. For the removal of bronchial spasm
B. For the treatment of intestine atony
C. For myorelaxation*
D. For the removal of attacks of angina pectoris
E. For the treatment of glaucoma
32.After operation of reposition of femur fracture when Tubacurarine was
used, breathing of patient did not resume. What is necessary to inject?
A. Proserine*
B. Platyphylline
C. Cyclodole
D. Atropine
E. Acetylcholine
33.Deficiency of what enzyme causes the prolongation of Ditiline
(lystenone) action from several minutes to several hours?
A. Butyrilcholinesterase of blood*
B. Succinatedehydrogenase
C. Carboanhydrase
D. N-acetyltransferase
E. К+, Na+-АТP-ase
34.What drug can improve skeletal muscles contraction after poliomyelitis?
A. Platyphylline
B. Galantamine hydrobromide*
C. Methacine
D. Atropine sulfate
E. Tubocurarine
35.What drug (short acting myorelaxant) may be used for attenuating of
skeletal muscles contraction during reposition of bones in femur
fracture?
A. Dithyline*
B. Anapriline
C. Tubacurarine
D. Atropine
E. Adrenaline
36.In 30 minutes after short-term surgical operation with Dithyline
administration the spontaneous breathing of the patient does not appear.
What is necessary to prescribe to this patient?
A. Fresh blood transfusion*
B. Hemodialysis
C. Hemosorbtion
D. Forced diuresis
E. Peritoneum dialysis
37.In 30 minutes after short-term surgical operation with Dithyline
administration the spontaneous breathing of the patient does not appear.
What genetic pathology is the main reason to this complication?
A. Deficiency of butyrilcholinesterase*
B. Deficiency of katalase
C. Deficiency of acetylcholinesterase
D. Deficiency of glucoso-6-phosphatase
E. Deficiency of glutationperoxydase
38.At 39 years old woman for the removal of high blood pressure crisis the
solution of Hygronium was injected. What is the mechanism of the drug
action?
A. Blockade of N-cholinoreceptors*
B. Blockade of М-cholinoreceptors
C. Stimulation of М-, Н-cholinoreceptors
D. Stimulation of N-cholinoreceptors
E. Stimulation of М-cholinoreceptors
39.Main pharmacological effect of myorelaxants:
A. Decline skeletal muscles tone.*
B. Decline blood pressure.
C. Increase blood pressure.
D. Bradycardia.
E. Bronchial spasm.
40.The main mechanism of NSAID action is a block of:
A. Cyclooxygenase (COG).*
B. Opiate receptors.
C. Chemoreceptors.
D. Аdrenoreceptors.
E. Histamine receptors.
41.Cholinesterase reactivator in a case of phosphor organic pesticides
poisoning is:
A. Pirenzepine.
B. Alloxime.*
C. Isadrine.
D. Ipratropium.
E. Adrenaline.
42.Diazepam is used intravenously for treatment of:
A. Endogenous depression.
B. Comatose status.
C. Schizophrenia.
D. Seizures.*
E. Intestine atony
43.Which of the following is anticough drug with central action?
A. Libexine.
B. Acetylcystein (ACC)
C. Codeine.*
D. Salbutamole.
E. Coffeine.
44.Partial agonist of opiod receptors is:
A. Paracetamol.
B. Buprenorphine.*
C. Aspirin.
D. Aminazine.
E. Coffeine.
45.Which of the following is antidepressant?
A. Nialamide.*
B. Aminazine.
C. Atropine.
D. Coffeine.
E. Lithium
46.Which effect do analeptics have on the respiratory system?
A. Relaxation of bronchial smooth muscle
B. Antitussive
C. Constriction of pulmonary arteries
D. Decreased fatigue
E. Stimulation of respiration*
47.The man appeared at the trauma department with diagnosis: fracture of
femur with displacement. 10 ml of 2 % solution of Dithyline were used
for reposition of bones. As a result protracted apnea and myorelaxation
developed. Deficit of what enzyme caused such complication?
A. Butyrilcholinesterase*
B. Uridindiphosphoglucoronic transferase
C. Glucoso-6-phosphatdehydrogenase
D. Methemoglobinreductase
E. N-acetyltransferase
48.Typical effect, which develops during introduction to ether anesthesia:
A. Protracted stage of excitation*
B. Does not irritate mucous membranes
C. does not cause myorelaxation
D. Rapid development of anesthesia
E. Absence of sleep after narcosis
49.Choose the medicine for i.v. and i.m. anesthesia:
A. Ketaminum*
B. Ether for anesthesia
C. Nitrous oxide
D. Phthorothanum
E. Propanidid
50.Choose the preparation for inhalation anesthesia:
A. Nitrous oxide*
B. Natrii oxybutyras
C. Sombrevin
D. Ketamin
E. Propanidid
51.Nitrous oxide is characterized by
A. Proper myorelaxation
B. Prolonged stage of excitation
C. Mucous membrane irritation
D. Expressed analgesia*
E. Deep anesthesia
52.Choose drug for general anesthesia, the derivative of barbiturates, which
contains sulfur:
A. Thiopentalum*
B. Nitrous oxide
C. Aether pro narcosi
D. Ketamin
E. Sombrevin
53.The duration of Propanidide action is:
A. 3-5 min.*
B. 3-5 hours
C. 20-30 min.
D. 0,5-1 hours
E. 20-30 sec.
54.Which of the following preparations used for insomnia treatment?
A. Difenine
B. Ethosuximidum
C. Nitrazepam*
D. Carbamazepine
E. Ketaminum
55.Diazepame main property which used for neurosis treatment is:
A. Analeptical
B. Narcotic
C. Anxiolytic*
D. Antipsychotic
E. Anaesthetic
56.What is the phenobarbital main property?
A. Does not change the structure of sleep
B. Stimulates psychical activity
C. Shortens the phase of rapid sleep*
D. Does not cause accumulation
E. Does not activate microsomal enzyme system
57.The long-term phenobarbitale admininstration may cause:
A. Anaesthesia
B. Tachyphylaxis
C. Material accumulation*
D. Blockade of microsomal enzymes
E. Analgesia
58.Which preparation can markedly change the structure of sleep?
A. Phenitoin
B. Phenobarbital*
C. Zopiclone
D. Gidasepam
E. Bromide
59.Choose the preparation with somnolent and antihistaminic activity:
A. Phenobarbital
B. Zopiclone
C. Dimedrolum*
D. Sibazone
E. Nitrazepamum
60.Which preparation is effective for trigeminal neuralgia?
A. Nitrazepamum
B. Carbamazepine*
C. Sibazone
D. Bromide
E. Phenobarbital
61.Typical side effect of diphenine (phenitoin), showing up in the cavity of
mouth is:
A. Dryness
B. Hypersalivation
C. Stomatitis
D. Gingival hyperplasia*
E. Glossitis
62.What is the drug for epilepsia treatment?
A. Amitryptilin
B. Carbamazepinum*
C. Magnesium sulfate
D. Ketaminum
E. Valeriana
63.Carbamazepine is applied for:
A. Improvement of mood
B. For local anaesthesia
C. Breathing stimulations
D. Epilepsy treatment*
E. General anesthesia
64.Which concentration of Ethyl alcohol solution for surgeon hands rinsing
correlates with proper antiseptic effect?
A. 96%
B. 70%*
C. 40%
D. 30%
E. 10%
65.What Ethyl alcohol concentration is for disinfection of surgical
instruments?
A. 70%
B. 96%*
C. 40%
D. 76%
E. 30%
66.Ethyl alcohol is used for inhalation at:
A. Pulmonary edema*
B. Insomnia
C. Allergy
D. Oppressing of breathing
E. Cardiac arrhythmia
67.Which effect is characteric to Natrii oxybutyras?
A. Antihypoxic*
B. Antipsychotic
C. Analeptical
D. Local anesthesia
E. Psycho-motor stimulant
68.The drug used for Parkinson disease which affects dophaminergic
processes in CNS:
A. Cyclodolum
B. Levodopum*
C. Difenin
D. Karbamazepinum
E. Phenobarbital
69.What drug is used for Parkinson disease with the central
cholinoblocking action?
A. Levodopum
B. Carbidopa
C. Cyclodolum*
D. Phenobarbital
E. Nitrazepam
70.Levodopa effect at Parkinsonism is due to:
A. Stimulation of dophaminergic processes in CNS*
B. Oppression of dophaminergic processes in CNS
C. Stimulation of cholinergic processes in CNS
D. Oppression of cholinergic processes in CNS
E. Oppression of glutamatergic processes in CNS
71.Cyclodolum is used for:
A. Parkinson disease*
B. Pain
C. Anesthesia
D. Epilepsia
E. Insomnia
72.Property of Nitrous oxide which may be used in ambulatory dental
practice for tooth extraction:
A. Drying
B. Anesthetic
C. Irritating
D. Disinfecting
E. Analgesic*
73.Coffeine is
A. Antidepressant
B. Psycho-motor stimulant*
C. Nootropic drug
D. Analgesic
E. Anxiolytic
74.Preparation which belongs to the analeptics:
A. Proserinum
B. Lidocainum
C. Adrenalini hydrochloridum
D. Cordiaminum*
E. Ketamini hydrochloridum
75.Preparation which belongs to analeptics
A. Piracetam
B. Sydnocarb
C. Natrii oxybutyras
D. Lobeline hydrochloride*
E. Amitriptyline
76.Basic pharmacological effect of analeptics:
A. Antidepressive
B. Anti cough
C. Breathing stimulation*
D. Dilation of vessels
E. Memory increase
77.Psychomotor stimulant:
A. Aethimizolum
B. Bemegridum
C. Caffeine*
D. Cordiaminum
E. Camphora
78.What is the indication for analeptics usage?
A. Psychical depression
B. Oppressing of breathing*
C. Postoperative atony of the intestine
D. Hypertension crisis
E. Insomnia
79.The preparation used for respiratory and vasomotor centers stimulation
is called:
A. Paracetamolum
B. Proserinum
C. Amitriptyline
D. Caffeine*
E. Morphinum
80.Nootropic drug (neurometabolic cerebroprotector):
A. Caffeine
B. Noradrenalinum
C. Piracetam*
D. Proserinum
E. Cordiaminum
81.Caffeine action caused by excitation of brain stem center:
A. Tranquilizer
B. Improvement of memory
C. Breathing stimulation*
D. Mental and physical capacity increase
E. Tachycardia
82.Antidepressant used for treatment of endogenous depressions
(schizophrenia, manic-depressive psychosis) is:
A. Proserinum
B. Caffeine
C. Amitriptyline*
D. Bemegridum
E. Sibazonum
83.Sulfocamphocainum is used:
A. For medulla centers activation*
B. For endogenous depression
C. For rheumatism
D. For arterial hypertension
E. For tachyarrhythmias
84.Caffeine is
A. Analeptic and psychomotor stimulant*
B. Analeptic and antidepressant
C. Antidepressant and psychomotor stimulant
D. Antidepressant and nootropic
E. Analeptic and nootropic
85.Piracetamum nootropic activity reveals in:
A. Delirium and hallucinations
B. Fear
C. Improvement of studying and memory*
D. Fatigue
E. Depression
86.Coffeine is not used for cardiac insufficiency treatment due to its ability:
A. To increase oxygen consumption of myocardium*
B. To diminish oxygen consumption of myocardium
C. To increase intensity of systole
D. To diminish intensity of systole
E. To cause bradycardia
87.Bemegridum is not applied at somnolent poisoning due to its ability:
A. To provoke cramps and hypoxia of CNS*
B. To promote excitability of neurons of CNS
C. To stimulate the centers of brain stem
D. To promote arterial hypertension
E. To stimulate breathing
88.What is the mechanism of Cordiaminum stimulative influence on the
breathing?
A. Direct action on respiratory center
B. Reflex action on respiratory center
C. Mixed action on respiratory center*
D. Intensive contraction of respiratory muscles
E. Intensive contraction of the diaphragm
89.Bronchial asthma attacks are relieved with:
A. Noradrenalinum
B. Salbutamolum*
C. Mesatonum
D. Anaprilinum
E. Reserpine
90.What is the mechanism of Salbutamole bronchodilation action?
A. Stimulation alpha 1 - adrenoreceptors of the bronchi
B. Stimulation beta 2 - adrenoreceptors of the bronchi*
C. Stimulation of M - cholinoreceptors of the bronchi
D. Blockage of M-cholinoreceptors of the bronchi
E. Blockage of beta 2 - adrenoreceptors of the bronchi
91.What is the mechanism of Cytitonum stimulant influence on breathing?
A. Direct action on a respiratory center
B. Reflex action on the respiratory center*
C. Mixed action on a respiratory center
D. Intensive contraction of the intercostal muscles
E. Intensive contraction of the diaphragm
92.Choose the expectorant of reflex action:
A. Thermopsis drugs*
B. Acetylcysteinum
C. Trypsinum
D. Natrii hydrocarbonate
E. Bromhexinum
93.Complications, arising up at codeine application as anti cough agent:
A. Constipation, medical dependence*
B. Dry mouth, insomnia
C. Tachycardia, arrhythmia
D. Tachypnoe, bronchospasme
E. Increase of arterial pressure
94.Bemegridum belongs to the group of:
A. Narcotic analgesics
B. Non-narcotic analgesics
C. Analeptics*
D. Antidepressants
E. Psychostimulants
95.Complication, arising up at the overdose of the Thermopsis herb extract:
A. Vomiting*
B. Bronchial asthma
C. Arrhythmia
D. Bradycardia
E. Dry mouth
96.Libexinum belongs to the group of:
A. Narcotic analgesics
B. Anti cough drugs*
C. Non-narcotic analgesics
D. Mucolytics agents
E. Stimulators of breathing
97.Acetylcysteinum is used for treatment of:
A. Chronic bronchitis*
B. Hypertensive disease
C. Ulcer disease
D. Angina pectoris
E. Arrhythmias
98.Cordiaminum is used for:
A. Collapse*
B. Bronchial asthma
C. Hypertensive disease
D. Bronchitis
E. Gastritis
99.Bromhexinum belongs to the group of:
A. Non-narcotic analgesics
B. Mucolytics*
C. Non-steroidal anti-inflammatory drugs
D. Laxatives
E. Analeptics
100.
Beta 2-adrenomimetics include:
A. Nafthyzinum
B. Adrenalini hydrochloridum
C. Salbutamolum*
D. Atropini sulfas
E. Methacinum
101.
Glucocorticoid used as inhalation for bronchial asthma treatment:
A. Beclometazoni dipropionate*
B. Isadrinum
C. Salbutamolum
D. Euphyllinum
E. Cromolinum-natrium
102.
Ketotifenum is used for:
A. Constipation
B. Prophylaxis of bronchial asthma attack*
C. Pneumonia treatment
D. Gastritis
E. Angina pectoris
103.
Mechanism of action of Cromolinum-sodium:
A. Blockage of adenosine A alpha1- receptors in the bronchi
B. Stabilisation of mast cells membranes and prevention release of
allergy mediators*
C. Stimulation of beta2 - adrenoreceptors of the bronchi
D. Blockage of beta2 - adrenoreceptors of the bronchi
E. Blockage of M - cholinoreceptors of the bronchi
104.
Local anesthetics affect on the:
A. Cortex of cerebrum
B. Thalamus
C. Limbic system
D. Endings of sensitive nerves and nerve fibers*
E. Proteins of superficial layer of mucous membranes and skin
105.
The action of local anesthetics is:
A. Increase of permeability of cellular membranes for calcium ions
B. Decrease of permeability of cellular membranes for sodium ions*
C. Oppressing of pain impulses in the spinal cord
D. Oppressing of pain impulses at thalamus
E. Activating of the endogenous antinociceptive system
106.
Choose local anesthetic of the ether group (according to chemical
structure):
A. Lidocaine
B. Novocaine*
C. Ultracaine
D. Trimecaine
E. Bupivacaine
107.
How does action of local anesthetics change in the locus of
inflammatory process?
A. Does not change
B. Increases
C. Accelerates
D. Lengthens
E. Reduces*
108.
Choose local anesthetic of the amide group (according to
chemical structure):
A. Cocaine
B. Lidocaine*
C. Anaesthesine
D. Novocaine
E. Dicaine
109.
Vasoconstrictive agents supplements to the solutions of local
anesthetics results in:
A. Systemic action increases
B. Acceleration of local anesthetic absorption
C. Prophylaxis of their resorbtive (systemic) action*
D. Effect decreases
E. Toxic effect increases
110.
The group of drugs, which intensify and increase the duration of
action of local anesthetics:
A. Analeptics
B. alfa-adrenomimetics*
C. alfa-adrenoblockers
D. M-cholinomimetics
E. N-cholinomimetics
111.
What preparation can be used for all types of local anesthesia?
A. Cocaine
B. Lidocaine*
C. Dicaine
112.
113.
114.
115.
116.
117.
118.
119.
D. Anaesthesine
E. Novocaine
Lidocaine:
A. Is used for all kinds of local anesthesia*
B. Is used only for infiltrative and conductive anesthesia
C. Is not used for anesthesia
D. Is used only for superficial anesthesia
E. Is used only for spinal anesthesia
Novocaine:
A. Is used only for infiltrative anesthesia
B. Often causes allergic reactions*
C. Is not a derivative of PABA
D. Is not destroyed by cholinesterase
E. May be combined with sulphonamides
Neuroleptics are administered for:
A. Psychoses*
B. Neuroses
C. Hyperkinesis
D. Collapse
E. Parkinson’s disease
The typical effect for all neuroleptics:
A. Antipsychotic*
B. Anti cough
C. Expectorant
D. Nootropic
E. Psychostimulative
What neuroleptic isused for neuroleptanalgesia?
A. Aminazin
B. Triftazin
C. Levomepromazine
D. Haloperidole
E. Droperidole*
What is the mechanism of myorelaxation of tranquilizers?
A. Oppress the central mechanisms of muscular tonus*
B. Oppress an acetylcholinesterase
C. Block M-cholinoreceptors of smooth muscles
D. Block N-cholinoreceptors of skeletal muscles
E. Direct influence on myofibrils of skeletal muscles
Mechanism of antipsychotic action of neuroleptics:
A. Blockade of cholinoreceptors in CNS
B. Blockade of dopamine D2-receptors in CNS*
C. Blockade of adenosine receptors in CNS
D. Blockade of histamine receptors in CNS
E. Activating of GABA-receptors in CNS
The typical effect of tranquilizers of benzodiazepine is:
A. Antipsychotic
B. Anxyolitic*
C. Hypothermal
D. Antivomiting
E. M-cholinoblocking
120.
The tranquilizer, applied for premedication before an operation:
A. Nitrazepamum
B. Haloperidolum
C. Diazepamum*
D. Droperidolum
E. Aminazin
121.
Choose tranquilizer with the expressed somnolent action:
A. Codeine
B. Aminazin
C. Nitrazepamum*
D. Dimedrolum
E. Ephedrine
122.
The effect of Diazepamum:
A. Anxyolitic*
B. Antipsychotic
C. Antivomiting
D. Hypothermal
E. M-cholinoblocking
123.
The effect of Aethaperazinum:
A. Psychostimulative
B. Provokes vomiting
C. Antivomiting*
D. Hypertensive
E. Spasmolytic
124.
The preparation, applied at neuroses:
A. Adrenalinum
B. Isadrinum
C. Sibazone*
D. Cordiaminum
E. Atropinum
125.
The typical complication, developing after long-term
administration of Aminasinum and other neuroleptics:
A. Euphoria
B. Increase of arterial pressure
C. Vomiting
D. Parkinsonism*
E. Bradycardia
126.
The typical complication, developing after the prolonged usage of
Diazepamum and other tranquilizers:
A. Drug dependence*
B. Extrapyramidal disorders
C. Gastritis
D. Bronchial asthma
E. Arterial pressure increase
127.
What is the basic difference of neuroleptics from tranquilizers?
A. Anticonvulsant properties
B. Antipsychotic effect*
C. Do not affect the vegetative nervous system
D. Do not intensify the action of anesthesia drugs
E. Cause tachyphylaxis
128.
The tranquilizer is:
A. Aminazin
B. Morphine
C. Sibazone*
D. Droperidol
E. Fentanil
129.
Aminazinum, Droperidolum, Triphthasinum belong to:
A. Tranquilizers
B. Neuroleptics*
C. Antidepressants
D. Analeptics
E. Nootropic drugs
130.
The mechanism of action of sodium bromide:
A. Excitation of M-cholinoreceptors in the brain
B. Intensifying processes of depression in the brain*
C. Intensifying processes of excitation in CNS
D. Blockade of the histamine receptors in CNS
E. Blockade of dopamine receptors in CNS
131.
Valerian and Motherwort preparations belong to the group of:
A. Tranquilizers
B. Neuroleptics
C. Sedative preparations*
D. Sleeping-pills
E. Anticonvulsant preparations
132.
The symptoms of bromism (side effect of long-term bromides
administration):
A. Acne rashes, somnolence, rhinorhea*
B. Excitation of CNS, dryness of mucous membranes
C. Constipation, stomach-ache
D. Tachycardia, insomnia
E. Nausea, vomiting
133.
The plant with sedative action:
A. Valeriana*
B. Lemon
C. Thermopsis
D. Foxglove
E. Strophanthus
134.
The drug which after long-term administration causes
phenomenon of bromism:
A. Sodium bromide*
B. Sodium hydrocarbonate
C. Sodium sulfate
D. Sodium citrate
E. EDTA (Trilonum B)
135.
How do we mark the neuroleptics effect of removing delirium and
hallucinations?
A. Antipsychotic*
B. Antivomiting
C. Sedation
D. Hypothermal
E. Myorelaxation
136.
The main complication after neuroleptics administration is:
A. Extrapyramidal disorders*
B. Arterial pressure increase
C. Bradycardia
D. Drug dependence
E. Euphoria
137.
Which preparation belongs to neuroleptics?
A. Chlozepid
B. Aminazinum*
C. Sibazone
D. Phenazepamum
E. Nitrazepamum
138.
Neuroleptic which causes Parkinson syndrome due to its Mcholinoblocking activity:
A. Aminazine*
B. Rezerpine
C. Aspirin
D. paracetamol
E. Aethaperazinum
139.
The excitation of benzodiazepine receptors is accompanied with:
A. Anxiolytic effect*
B. Antipsychotic effect
C. Antivomiting effect
D. Arterial pressure increase
E. Arterial pressure decrease
140.
Benzodiazepine tranquilizers intensify the action of:
A. Psychomotor stimulants
B. General anesthetics, analgesics, somnolents*
C. Analeptics
D. Antidepressants
E. Nootropic preparations
141.
Prolonged administration of tranquilizers is limited due to their
ability to cause:
A. Drug dependence*
B. Myorelaxation of central genesis
C. Intensifying of analgesics action
D. Somnolent effect
E. Anticonvulsant effect
142.
«Atypical» antipsychotic agent is:
A. Аminazine.
B. Тriftazine.
C. Clozapine.*
D. Haloperidole.
E. Aethaperazine.
143.
What is the general mechanism of antipsychotics’ action:
A. Block of dopamine receptors.*
B. Block of M-cholinergic receptors.
C. Block of re-uptake of serotonin.
D. Disturbance of neurotransmitter synthesis in CNS.
E. Block of histamine receptors.
144.
Volatile liquid used for inhalation during general anesthesia:
A. Phenazepam.
B. Morphine.
C. Phthorothanun*
D. Natrii oxybutyras.
E. Naloxone.
145.
What anticholinesterase agent is used only for glaucoma?
A. Proserine.
B. Physostigmine
C. Armine (Phosphacolum)*
D. Galanthamine.
E. Halazoline.
146.
Nootropic agent is:
A. Caffeine.
B. Camphora.
C. Piracetame.*
D. Bemegride.
E. Valeriana root.
147.
Which of the following, would not be diminished by atropine?
A. Bradycardia
B. Salivary secretion
C. Bronchoconstriction
D. Skeletal muscle contraction*
E. Myosis
148.
An example of a cardioselective beta-blocker includes:
A. Propranolol
B. Nitroglycerine
C. Atenolol*
D. Epinephrine
E. Enalaprile
149.
What is the mechanism of indirect-action cholinergic stimulants
action?
A. Block of cholinesterase*
B. Stimulate beta-adrenoreceptors
C. Block of М-cholinoreceptors
D. Block of monoaminooxidase
E. Affect serotonine receptors
150.
Patient entered the hospital neurological department with poststroke syndrome. What cholinergic medicine is the most expediently to
the patient?
A. Galantamine*
B. Atropine
C. Dipiroxim
D. Salbutamol
E. Aspirine
151.
Patient with the acute stomach ache, vomiting, heavy breathing,
bronchospasm, was delivered to the intensive therapy department.
During examination of patient - skin moisture, hypersalivation, myosis,
bradycardia, muscular fascilation was noted. From the anamnesis it is
known, that patient – toxin abused person, used aerosols against insects
as abuse substance. What pharmacological group of agents the
poisoning substance belongs to?
A. N- cholinomimetic
B. М-choliniblockers
C. Myorelaxants
D. Ganglion-blockers
E. Anticholinesterase agents*
152.
To the patient with signs of poisoning by phosphor organic
substance cholinesterase reactivator was injected. Indicate a mechanism
of action of this drug.
A. Dephosphorilation of cholinesterase with renewal of its activity*
B. Inactivation of cholinesterase
C. Block of cholinoreceptors
D. Activate of cholinoreceptors
E. Oppression of acetylcholine synthesis
153.
What is the mechanism of action of proserine?
A. Blocks of cholinesterase*
B. Stimulates beta – adrenoreceptors
C. Blocks М-cholinoreceptors
D. Blocks monoaminooxidase
E. Acts on serotonin receptors
154.
Patient complaints to dizziness, nausea, salivation and spastic
stomachache. He was delivered to a hospital. The diagnosis: poisoning
by the phosphor organic substance. What medicines must be included to
the complex therapy?
A. Atropine sulfate and Dipiroxim*
B. Tiosulfate sodium and Bemegridum
C. Tetacin-calcium and Unitiolum
D. Nalorphine hydrochloride and Bemegridum
E. Glucose and Bemegridum
155.
To the patient with post-operation atony of intestine Proserine
was injected. What is the mechanism of drug’s action?
A. Enzyme (cholinesterase) blockade*
B. Receptor
C. Physical and chemical inter-reaction
D. Affects ionic channels of cellular membrane
E. Affects the transport systems of cellular membranes
156.
The woman of 63 years for renewal of functions of CNS after the
stroke of brain injections of Galantamine was recommended. What is
the mechanism of action of this drug?
A. Block of cholinesterase*
B. Block of MAO
C. Block of KOMT
D. Block of GABA-receptors
E. Block of Catalase
157.
What is therapeutic indication of Proserine?
A. The treatment of glaucoma*
B. Dislocation of lens
C. bever
D. Ulcer disease
E. Hypertension
158.
Which of the following therapeutic effect do indirect cholinergic
stimulants have?
A. Decreased GI motility
B. Increased GI motility*
C. Mydriasis
D. Vasoconstriction
E. Increase of arterial pressure
159.
What agent does belong to М-cholinomimetics?
A. Aceclidine*
B. Proserine
C. Atropine
D. Platyphylline
E. Ephedrine
160.
What agent does belong to М-cholinoblockers?
A. Atropine*
B. Proserine
C. Phosphacole
D. Acetylcholine
E. Cytitone
161.
What group of agents does Atropine sulfate belong to?
A. М-cholinoblockers*
B. М-cholinomimetics
C. N-cholinomimetics
D. Adrenoblockers
E. Anticholinesterase agents
162.
What group of agents is used for the treatment of ulcer disease of
stomach and duodenum?
М-cholinoblockers*
N-cholinomimetics
Myorelaxants
Adrenomimetics
Anticholinesterase agents
163.
How do М-cholinomimetics act?
A. Block of M-cholinoreceptors
B. Activate of M-cholinoreceptors*
C. Inactivate of cholinesterase
D. Activate cholinesterase
E. Block cholinacetylase
164.
What drug is used for dilatation of pupil when eye examination
has been made?
A. Proserine
B. Atropine*
C. Tubacurarine
D. Methacine
E. Pilocarpine
165.
Which of the following therapeutic effect does Skopolamine
hydrobromide have?
A. Relaxation of smooth musculature*
B. Reduce intraocular pressure
C. Atony of skeletas musculature
D. Arterial hypertension
E. Myorelaxation
166.
Choose group of drugs that produce paralysis of visual
accommodation:
A. М-cholinoblockers*
B. М-cholinomimetics
C. N-cholinomimetics
D. Adrenomimetics
E. Cholinesterase blockers
167.
Group of medicines that causes a spasm of visual
accommodation?
A. Anticholinesterase agents*
B. М-cholinoblockers
C. N-cholinomimetics
D. Adrenomimetics
E. Sympatholitics
168.
Choose the indication to atropine:
A. Ulcer disease*
B. Glaucoma
C. Myasthenia
D. Atony of intestine
E. Epilepsy
169.
Patient complaints to dry mouth, photophobia and violation of
vision was delivered to the hospital. The other symptoms: hyperemic,
A.
B.
C.
D.
E.
dry skin, dilated pupils, tachycardia. Acute poisoning by alkaloids of
Belladonna was diagnosed. What medicine is the most expediently to
patient?
A. Proserine*
B. Aceclidine
C. Pilocarpine
D. Armine
E. Dipiroxime
170.
The child, by chance, drank solution from the small bottle, which
his grandmother used for the treatment of glaucoma. The physician
prescribed atropine to the child. What is the mechanism of atropine
antidote action?
A. Antagonism to specific receptors*
B. Enzymic
C. Co-operation with cellular metabolites
D. Physic-chemical
E. Antienzymic
171.
At 5 years old child was noted: moving excitation, delirium,
hoarse voice, dilated pupils which are not irresponsive on light, dry, hot,
hyperemic skin, tachycardia, tachypnoe. The indicated symptoms
appeared after the child ate Belladonna berries. Medicine of which
pharmacological group it is necessary to prescribe?
A. Anticholinesterase agents*
B. N-cholinolitics
C. N-cholinomimetics
D. M-cholinomimetics
E. Cholinesterase reactivates
172.
At adult man in 15-20 min after ingestion the Ammanita muscaria
mushrooms the excitation, increased sweating, the phenomena of acute
gastroenteritis, the narrowed pupils were noted. Then cramps,
bradycardia, considerable general weakness, somnolence, the collapse
developed. The doctor immediately injected to the sick patient antidote
from the group of:
A. М-cholinoblockers*
B. N-cholinomimetics
C. N-cholinolitics
D. Anticholinesterase agents
E. Reactivators of cholinesterase
173.
The 6 years old child was delivered to the hospital with symptoms
of psycho-motor excitation, dry mouth, bad swallowing and horse voice.
A skin was dry, hot. Pupils were extended; photophobia, tachycardia.
From anamnesis it is known, that child ate some berries of dark-violet
color. What toxic substance has caused acute poisoning?
A. Atropine*
B. Pirenzepine
C. Pilocarpine
D. Proserin
E. Methacine
174.
To the patient with ulcer disease of stomach in the period of
increased acidity of gastric juice (in anamnesis is glaucoma) it is
necessary to prescribe some М-cholinoblocker. What agent must be
chosen, taking into account attendant diseases?
A. Methacine*
B. Adrenaline
C. Atropine
D. Scopolamine
E. Mesatone
175.
Patient with the complaints to dry mouth, photophobia and
violation of sight was delivered to the hospital. The skin was hyperemic,
dry, pupils were extended, tachycardia. After examination it was
diagnosed: poisoning by alkaloids of Belladonna. What medicine is the
most expediently to patient?
A. Pilocarpine
B. Dipiroxime
C. Diazepam
D. Armine
E. Proserine*
176.
What preparation belongs to the alpha-adrenoblockers?
A. Phentholamine.*
B. Adrenaline.
C. Octadine.
D. Mezatone.
E. Anapriline.
177.
What group of remedies does Anaprilin belong to?
A. beta-adrenoblockers.*
B. alpha-adrenoblockers.
C. alpha, beta-adrenomimetics.
D. sympatholytics.
E. beta-adrenomimetics.
178.
What substance is a mediator of adrenergic synapses?
A. Noradrenaline*
B. Anapriline
C. Acethylcholine.
D. Mezatone.
E. Dophamine.
179.
What disease is the main indication to reserpin administration?
A. Hypertensive disease.*
B. Diabetes mellitus.
C. Hypotonic disease.
D. Endarteriitis.
E. Arrhythmia.
180.
What is the main effect after noradrenalin usage?
A. Vasodilatation
B. Vasoconstriction*
C. Bronchodilatation
D. Bronchoconstriction
E. Analeptic
181.
When is naphthysin used?
A. Rhinitis*
B. Collapse
C. Bronchial asthma
D. Cardiac arrhythmia
E. Cardiac arrest.
182.
After eye drops usage the patient began to suffer from paralysis of
accommodation and midriasis. What group of preparations can cause
such effect?
A. M-cholinoblockers*
B. M-cholinomimetics
C. Cholinesterase inhibitors
D. Beta-adrenoblockers
E. Beta-adrenomimetics
183.
The patient with disturbed circulation of lower limbs was treated
with alpha adrenoblocker. Which of them?
A. Phentolamine*
B. Adrenaline.
C. Acethylcholine.
D. Mezatone.
E. Dophamine.
184.
The patient, who suffered from endarteriitis, was prescribed a
phentholamin. After its usage tachycardia occured. What is the reason to
this undesirable effect?
A. Blockade of the presynaptic alpha-adrenergic receptors.*
B. Blockade of the postsynaptic beta-adrenergic receptors
C. Blockade of the postsynaptic N-cholinenergic receptors
D. Blockade of the postsynaptic M-cholinenergic receptors
E. Blockade of serotonine receptors
185.
With what pharmacological group is narcotic analgesic combined
in a case of neuroleptanalgesia?
A. Tranquilizers
B. Nonnarcotic analgesics
C. M-cholinomimetics
D. M-cholinoblockers
E. Neuroleptics.*
186.
What medicine belongs to antipsychotics’?
A. Aminasine*
B. Anapriline
C. Sibasone.
D. Sodium bromide
E. Caffeine.
187.
What medicine belongs to tranquilizers?
A. Aminasine
B.
C.
D.
E.
Sibasone*
Haloperidole
Sodium bromide.
Tincture of Valeriana.
188.
What preparation does belong to the sedative remedies?
A. Tincture of Valeriana*
B. Aminasine
C. Haloperydole
D. Sibazone
E. Chlozepide.
189.
What medicine is used for psychosis treatment?
A. Phenthanile
B. Aminasine*
C. Paracetamole
D. Codeine phosphate.
E. Nalorphine.
190.
In the patient, who suffered from irritability, sleeplessness, rapid
fatigability and emotional disbalance, neurosis has been diagnosed.
What drug can be prescribed?
A. Anapriline
B. Sodium chloride
C. Aminasine.
D. Atropine
E. Sibasone.*
191.
The patient, who suffered from anxiety, fear, hesitancy Sibasone
has been prescribed. What is the mechanism of its tranquilizing activity?
A. Interaction with benzodiazepine receptors.*
B. Interaction with adrenergic receptors.
C. Interaction with cholinergic receptors.
D. Interaction with serotonin receptors.
E. Interaction with dophaminergic receptors.
192.
The patient, who suffered from hyper excitability, irritability,
sleeplessness was prescribed phenazepam. What is the mechanism of its
action?
A. Stimulation of benzodiazepine receptors.*
B. Stimulation of GABA (gamma amino butyric acid) receptors.
C. Stimulation of beta-adrenergic receptors.
D. Stimulation of M-cholinergic receptors.
E. Stimulation of N-cholinergic receptors.
193.
Neuroleptanalgesia was used in a case of surgical operation. What
neuroleptic is often used with phenthanile for this type of general
anesthesia?
A. Droperidole*
B. Coffeine
C. Diazepame
D. Clozapine.
E. Anapriline.
194.
Neuroleptanalgesia was used in a case of myocardial infarction.
What narcotic analgesic is often used with droperidole in this case?
A. Phenthanile*
B. Pentazocine
C. Omnopone
D. Morphine.
E. Promedole.
195.
The patient, suffered from schizophrenia, was prescribed
aminazine for delirium and hallucinations reducing. What is the
mechanism of its antipsychotic action?
A. Block dophaminergic receptors in CNS.*
B. Stimulate dophaminergic receptors in CNS.
C. Stimulate cholinergic receptors in CNS.
D. Block cholinergic receptors in CNS.
E. Inhibition of re-uptaking of MAO.
196.
After examining the patient was prescribed a remedy that is used
in a case of neurosis or neurosis-like situation, hyper excitability and
irritability. What pharmacological group does this remedy belong to?
A. Analgesics
B. Anxiolytics*
C. Analeptics
D. Antipsychotics
E. CNS stimulants.
197.
The patient instead aminasine was prescribed another neuroleptic.
What drug does belong to this group?
A. Haloperidole*
B. Phentanile
C. Paracetamol
D. Sibasone
E. Morphine.
198.
The physician monitors for side effects a patient who is treated
with neuroleptic. What side effect is the most typical for these drugs?
A. Hyper salivation
B. Hypetension
C. Diarrhea
D. Extrapyramidal syndrome*
E. Cramps
199.
At the hands of nurse, which works at the psychiatric unit the
symptoms of neurodermitis appear. What drug can cause such adverse
effect?
A. Aminazine*
B. Morphine
C. Paracetamole
D. Atropine
E. Diasepame.
200.
Antipsychotic medication which is beneficial for schizophrenia is:
A. Closapine*
B.
C.
D.
E.
Morphine
Paracetamol
Atropine
Diasepame.
201.
What is the mechanism of irritating substances action?
A. distant action on CNS
B. form albuminates
C. cutano-visceral reflexes*
D. direct action on CNS
E. Decrease of vessel’s wall penetration
202.
What kind of anaesthesia is Anaesthesinum used for?
A. Superficial anaesthesia*
B. Conductive anaesthesia
C. Trunk anaesthesia
D. Infiltrative anaesthesia
E. Spinal anaesthesia
203.
Ammonii caustici is used for?
A. Unconsciousness*
B. As antiseptic for wounds
C. Heavy metal salts poisoning
D. Instrument sterilisation
E. Superficial anaesthesia
204.
What kind of anaesthesia is Dicainum used for?
A. Superficial anaesthesia*
B. Conductive anaesthesia
C. Trunk anaesthesia
D. Infiltrative anaesthesia
E. Spinal anaesthesia
205.
Drug of choice for cleaning the stomach during heavy salts metal
and alkaloids poisoning:
A. Solution of Tannin*
B. Solution of Menthol
C. Solution of Ammonia caustic
D. Bismuth nitras
E. Infusion of Salvia leaves
206.
Indication for Bismuth nitras external usage:
A. Dermatitis, eczema*
B. Alkaloid poisoning
C. Heavy metal salts poisoning
D. Crakes of rectum
E. Alcohol poisoning
207.
What drug does depend to the irritative agents?
A. Menthol*
B. Tannin
C. Bismuth nitras
D. Argenti nitras
E. Carbo activatus
208.
Drug that is used for treatment of poisoning and meteorism (gas
in the stomach and intestine):
A. Carbo activatus*
B. Tanninum
C. Bismuthi nitras
D. Argenti nitras
E. Solution of ammomii caustici
209.
What antiarrhythmic agent has local anaesthetic activity?
A. Anaprilin
B. Xycaine*
C. Verapamile
D. Cordarone
E. Ethmosine
210.
To the patient with myocardial infarction, which is complicated
by ventricle arrhythmia? After the injection of antiarrhythmic drug with
local anaesthetic activity cardiac rhythm has been normalized. What
drug was used?
A. Lidocaine*
B. Anaesthesine
C. Verapamile
D. Adrenaline
E. Аnapriline
211.
What structures of skin and mucus during superficial anesthesia
are influenced?
A. Sensitive nerves*
B. Epidermis
C. Subcutaneous fat tissue
D. Vessels walls
E. Actually derma
212.
Choose what food products are necessary to remove from the
patients' diet in the case of inhibitor of monooxygenase prescribing:
A. Cheese, bananas*
B. Cabbages, tomatoes
C. Millet, buckwheat
D. Milk, porridges
E. Honey, fruits
213.
The old patient complains to headache, dizziness, rapid fatigue,
worsening a memory. In anamnesis is cranial-cerebral trauma. What
pharmacological group is necessary to prescribe?
A. Hypnotics
B. Neuroleptics
C. Tranquilizers
D. Nootropic agents*
E. Analgesics
214.
The psychiatrist diagnosed in the patient endogenous depression.
What drug is necessary to prescribe?
A. Morphine
B.
C.
D.
E.
Sibasone
Mesatone
Amitripthyline*
Procaine
215.
Which of the following should the patient be cautioned against
while taking an MAO inhibitor?
A. Eating apples
B. Sunbathing at the pool
C. Eating cheese*
D. Dancing
E. Swimming
216.
At the old man with cranial-cerebral trauma the breathing is
weakened, pulse is threadlike, the reflexes are depressed. What route of
Piracetame introduction is the most expedient in this case?
A. Rectal
B. Inhalation
C. Per oral
D. Subcutaneous
E. Intravenous*
217.
The physician prescribed some pills to the patient with depressive
syndrome. Thus he informed about necessity of exception from the diet
such products as cheese, creams, coffee, beer, wine. After month of
medical treatment patient broke diet, as result hypertensive crisis
appear. What drug from the group of antidepressants has been taken by
patient?
A. Aminazine
B. Caffeine
C. Acetaminophen
D. Piracetame
E. Nialamide.*
218.
The physician notes lithium admission in a patient's history. The
physician would suspect that this patient suffers from:
A. Obesity
B. Abstinent syndrome
C. Renal disorder
D. Maniac-depressive psychosis*
E. Diabetes mellitus
219.
Contra-indication for M-cholinoblockers usage is:
A. Glaucoma.*
B. Bronchial asthma.
C. Ulcer disease.
D. Kidney colic
E. Parkinson disease.
220.
Opiod abstinence syndrome is:
A. Improvement patient’s condition after abolishing of drug.
B. Euphoria after usage of drug.
C. The physical adaptation of the body to the presence of an opiod.
D. Desire of repeated usage of medicine.
E. The symptoms of opioid analgesics withdrawal syndrom.*
221.
What is the contra-indication for cholinesterase inhibitors
administration?
A. Glaucoma.
B. Bronchial asthma.*
C. Myasthenia.
D. Postoperative atony of intestine.
E. Postoperative atony of urine bladder
222.
What drug from opioid analgesics is of plant origin?
A. Promedole.
B. Morphine.*
C. Fentanyl.
D. Buprenorphine.
E. Pentazocine
223.
Antipsychotic, mainly used as anti-vomiting agent:
A. Sibazone.
B. Valeriana.
C. Sodium bromide.
D. Morphine.
E. Aethaperazine.*
224.
What drug is used at the case of overdose of anti-depolarizing
myorelaxants?
A. Proserine.*
B. Atropine.
C. Cytitone.
D. Аrmine.
E. Anapriline.
225.
Mechanism of ephedrine action:
A. Binds to postsynaptic adrenoreceptors.
B. Blocks cholinacethylase
C. Increases quantity of norepinephrine in the synaptic gap.*
D. Decreases norepinephrine synthesis.
E. Blocks cholinesterase.
226.
Which of the following is antipsychotic drug with psychostimulative activity?
A. Galazoline.
B. Sibazone.
C. Anaprilin.
D. Тriftazine.*
E. Naphthyzint
227.
The drug of a first choice for treatment of anaphylactic shock is:
A. Noradrenaline.
B. Naphthyzine.
C. Isadrine.
D. Adrenaline.*
E. Anapriline.
228.
Non-selective beta -adrenoblocker is:
A. Anaprilin (Propranolol).*
B. Metoprolol.
C. Аtenolol.
D. Talinolol.
E. Isadrine.
229.
М-cholino blocker with substantial sedative effect:
A. Atropine.
B. Belladonna.
C. Scopolamine.*
D. Platyphylline.
E. Anapriline.
230.
Adrenergic agent that is used for treatment of bronchial asthma
attack:
A. Мesatone.
B. Noradrenaline.
C. Xylometazoline.
D. Salbutamole.*
E. Anapliline.
231.
The most common adverse effect of Anapriline is:
A. Tachycardia.
B. Hypertension.
C. Bronchial spasm.*
D. Hypertonus of skeletal muscles.
E. Hypotonus of skeletal muscles.
232.
What diuretic is a drug of choice for hypertensive emergencies
complicated with lung edema?
A. Dichlothiazide.
B. Furosemide.*
C. Spironolactone.
D. Тriamterene.
E. Mannit.
233.
Non-narcotic analgesic is most effective at pain connected with:
A. Kidney colic.
B. Rheumatoid arthritis.*
C. Correction of dislocation.
D. Traumatic shock.
E. Cancer.
234.
Drug which is highly selective blocker of COG-2
(cyclooxygenase-2):
A. Celecoxibe.*
B. Indometacine.
C. Piroxicame.
D. Butadione.
E. Diclofenac-sodium.
235.
Antagonist of benzodiazepines tranquilizers is:
A. Naloxon.
B.
C.
D.
E.
Flumazenile (annexat).*
Unithiol
Potassium chloride
Phenobarbital.
236.
Main effect of ganglion-blockers is:
A. Decrease of vessels’ tone.*
B. Increase of vessels’ tone.
C. Increase smooth muscles tone.
D. Analeptic action.
E. Bronchial spasm.
237.
What selective M1-cholinoblocker is used for ulcer disease?
A. Мethacine.
B. Ipratropium bromide.
C. Plathyphylline.
D. Pirenzepine (Gastrocepin).*
E. Aceclidine.
238.
Аdrenergic agonist, used for prophylaxis of premature labor:
A. Phenoterole.*
B. Noradrenaline.
C. Меsatone.
D. Halazoline.
E. Ephedrine.
239.
Expectorant of reflex action is:
A. Potassium chloride
B. Grass of Thermopsidis.*
C. Sodium chloride.
D. Acetylcysteine.
E. Codeine.
240.
The most dangerous side-effect of Analgine (Methamisole) is:
A. Dizziness.
B. Bleeding.
C. Arrhythmia.
D. Agranulocytosis*
E. Cough.
241.
Which of the following is associated with abuse of narcotic
analgesics?
A. Decreasing of blood pressure.
B. Mydriasis.
C. Myosis.*
D. Hyperemia of face.
E. Increase of intraocular pressure.
242.
Duration of action of Phentanyle:
A. 5-6 hours.
B. 2 -3 hours.
C. 5-10 minutes.
D. 20-30 minutes.*
E. More than 12 hours
243.
General anesthetic that increases sensitivity of myocardium to
catecholamines:
A. Ether.
B. Phthorothanun.*
C. Natrii oxybutyras.
D. Thiopentalum-natrium.
E. Мorphine.
244.
Which of the following is typical adverse effect of antipsychotics,
related to their mechanism of action:
A. Parkinsonism.*
B. Insomnia.
C. Bronchial spasm
D. Tachycardia.
E. Tachyphylaxia.
245.
The myorelaxant of depolarizing action is:
A. Dithylinum.*
B. Isadrinum.
C. Platyphyllinum.
D. Atropinum.
E. Proserinum.
246.
Antidote in a case of poisoning by atropine or atropine’s like
substances is:
A. Аdrenaline.
B. Тubocurarine.
C. Proserine.*
D. Аnapriline.
E. Dipiroxime.
247.
Which of the following is broncholytic from the group of beta 2adrenomimetics?
A. Ephedrine.
B. Salbutamole.*
C. Platyphylline.
D. Euphylline.
E. Adrenaline.
248.
Route of Cromolyn Sodium introduction for the treatment of
bronchial asthma:
A. Рer rectum.
B. Intramuscularly.
C. Under tongue.
D. By inhalation.*
E. Subcutaneously
249.
Drug from NSAIDs, which irreversibly blocks cyclooxygenase of
platelets:
A. Acetylsalicylic acid.*
B. Paracetamol.
C. Morphine.
D. Omnopone.
E. Phentanile.
250.
Which of the following opiod analgesics is used for
neuroleptanalgesia:
A. Morphine.
B. Promedole.
C. Phentanile.*
D. Naloxone.
E. Paracetamole.
251.
Analeptical remedy of reflective type from the N-cholinomimetics
group was given to the patient for restoration of breathing after
poisoning with carbon monoxide. What medicine was prescribed to the
patient?
A. Pentamin
B. Lobeline hydrochloride *
C. Adrenalin hydrochloride
D. Mesaton
E. Atropine sulphate
252.
Patient with complaints of dryness in the mouth, photophobia and
vision violation was admitted to the reception-room. Skin is hyperemic,
dry, pupils are dilated, tachycardia. Poisoning with belladonna alkaloids
was diagnosed on further examination. What medicine should be
prescribed?
A. Diazepam
B. Armine
C. Pilocarpine
D. Prozerin*
E. Dipyroxim
253.
Patient in the unconscious state was admitted to the emergency
room. Skin is cold, pupils are delayed, breathing is heavy, with cycles of
the Cheyne-Stokes type, blood pressure is decreased, urinary bladder is
overloaded. Poisoning with what substance is the most likely?
A. М-cholinergic antagonists
B. Sedatives
C. Narcotic analgesics *
D. Non-narcotic analgesics
E. None of the above
254.
A patient suffers from nocturnal paroxysms of bronchial asthma
accompanied by bradycardia, spastic intestinal pains and diarrhea.
Medicine of what group can releave these symptoms?
A. Sympatholytics
B. H-cholinergic receptors
C. M-cholinergic receptors*
D. Saluretics
E. β-adrenoblockers
255.
A patient with bronchial asthma is administered inhalation of 0,5
% isadrine solution. Bronchospasm was releaved, but the patient began
complaining of pain in the heart region and palpitation. It is connected
with the stimulation of:
A. α1 –adrenoreceptors
B. β1 –adrenoreceptors*
C. β2 –adrenoreceptors
D. Acetylcholine synthesis
E. M-cholinergic receptors
256.
A patient with fibrillation, who has had bronchial asthma in his
anamnethis, should be administered antiarrhythmic drug. Which
preparation from the suggested group is contraindicated for this patient?
A. Ajmaline
B. Nifedipine
C. Anapriline (Propranolol)*
D. Novocainamid
E. Verapamil
257.
A patient has got a spasm of smooth muscles of bronchi.
Activators of what membrane cytoreceptors are phisiologically reasoned
to stop an attack?
A. beta-adrenoreceptors*
B. alpha- and beta –аdrenoreceptors
C. N-cholinoreceptors
D. M-, N-cholinoreceptors
E. М-cholinoreceptors
258.
Introduction of a pharmaceutical substance to an experimental
animal resulted in reduction of salivation, pupil mydriasis. Next
intravenous introduction of acetylcholine didn't lead to any significant
changes of heart rate. Name this substance:
A. Proserin
B. Atropine*
C. Propranolol
D. Adrenaline
E. Salbutamol
259.
Acetylcholine IS NOT a specific neurotransmitter at:
A. Sympathetic ganglia
B. Sympathetic postganglionic nerve endings*
C. Parasympathetic ganglia
D. Parasympathetic postganglionic nerve endings
E. None of the above
260.
Muscarinic receptors are located in:
A. Autonomic ganglia
B. Skeletal muscle neuromuscular junctions
C. Autonomic effector cells*
D. Sensory carotid sinus baroreceptor zone
E. All of the above
261.
Which of the following cholinomimetics is commonly used in the
treatment of glaucoma?
A. Pilocarpini hydrochloridum*
B. Lobelini hydrochloridum
C. Carbocholinum
D. Atropini sulfas
E. Galanthamini hydrobromidum
262.
Which of the following cholinomimetic is most widely used for
paralytic ileus and atony of the urinary bladder?
A. Pilocarpini hydrochloridum
B. Lobelini hydrochloridum
C. Proserinum*
D. Atropini sulfas
E. Phosphacolum
263.
Which of the following cholinomimetics is a drug of choice for
reversing the effects of nondepolarizing neuromuscular relaxants?
A. Pilocarpini hydrochloridum
B. Lobelini hydrochloridum
C. Proserinum*
D. Atropini sulfas
E. Phosphacolum
264.
Which of the following cholinomimetics is used in the treatment
of atropine intoxication?
A. Pilocarpini hydrochloridum
B. Aceclidinum
C. Carbocholinum
D. Proserinum*
E. Phosphacolum
265.
Which of the following drugs is used for acute toxic effects of Mcholinomimetics?
A. Atropini sulfas*
B. Proserinum
C. Galanthamini hydrobromidum
D. Carbocholinum
E. Proserinum
266.
Which of the following agents is a ganglion-blocking drug?
A. Scopolamini hydrobromidum
B. Proserinum
C. Galanthamini hydrobromidum
D. Phosphacolum
E. Pirilenum*
267.
Indicate the skeletal muscle relaxant, which is a depolarizing
agent:
A. Dithyllinum*
B. Pipecuronii bromidum
C. Mellictinum
D. Tubocurarini chloridum
E. Amizylum
268.
Which of the following drugs is a nondepolarizing muscle
relaxant?
A. Dithyllinum
B.
C.
D.
E.
Pirilenum
Aceclidinum
Tubocurarini chloridum*
Amizylum
269.
Which of the following antimuscarinic drugs is often effective in
preventing or reversing vestibular disturbances, especially motion
sickness?
A. Atropini sulfas
B. Scopolamini hydrobromidum*
C. Proserinum
D. Phosphacolum
E. Carbocholinum
270.
Which of the following agents is used as an inhalation drug in
asthma?
A. Atropini sulfas
B. Ipratropium bromide*
C. Lobelini hydrochloridum
D. Amizylum
E. Galanthamini hydrobromidum
271.
Indicate an antimuscarinic drug, which is effective in the treatment
of mushroom poising:
A. Atropini sulfas*
B. Proserinum
C. Pilocarpini hydrochloridum
D. Carbocholinum
E. Aceclidinum
272.
Antimuscarinics are used in the treatment of the following
disorders EXCEPT:
A. Motion sickness
B. Glaucoma*
C. Hyperhidrosis
D. Asthma
E. Intestinal, renal and hepatic colic
273.
The Atropini sulfas poisoning includes all of the following
symptoms EXCEPT:
A. Mydriasis, cycloplegia
B. Hyperthermia, hot and flushed skin
C. Dry mouth
D. Agitation and delirium
E. Bradycardia, orthostatic hypotension*
274.
Contraindications to the use of antimuscarinic drugs are all of the
following EXCEPT:
A. Glaucoma
B. Myasthenia
C. Bronchial asthma*
D. Paralytic ileus and atony of the urinary bladder
E. All of the above
275.
The applications of the ganglion blockers have disappeared
because of all of the following reasons EXCEPT:
A. Orthostatic hypotension
B. Lack of selectivity
C. Homeostatic reflexes block
D. Respiratory depression*
E. None of the above
276.
Which of the following agents is a short-acting ganglion blocker?
A. Hygronium*
B. Pirilenum
C. Benzohexonium
D. Pentaminum
E. Mellictinum
277.
Ganglion blocking drugs are used for the following emergencies
EXCEPT:
A. Hypertensive crises
B. Controlled hypotension
C. Cardiovascular collapse*
D. Pulmonary edema
E. Peripheral vascular spasms
278.
Which of the following neuromuscular blocking drugs is an
intermediate-duration muscle relaxant?
A. Tubocurarini chloridum
B. Mellictinum*
C. Dithylinum
D. Pipecuronium bromidum
E. Amizylum
279.
Which neuromuscular blocking agent has the potential to cause
the greatest release of histamine?
A. Tubocurarini chloridum*
B. Cyclodolum
C. Amizylum
D. All of the above
E. None of the above
280.
Which cholinergic blocking agent is contraindicated in patients
with glaucoma?
A. Proserinum
B. Atropini sulfas*
C. Aceclidinum
D. Pilocarpini hydrochloridum
E. Carbocholinum
281.
Indicate the following neuromuscular blocker, which would be
contraindicated in patients with renal failure:
A. Pipecuronium bromidum*
B. Aceclidinum
C. Pilocarpini hydrochloridum
D. Atropini sulfas
E. Aceclidinum
282.
The patient was treated medically for psychosis for 2 weeks.
Patient's condition improved but rigidity, tremor, hypokinesia
developed. Which of the drugs can cause such complications?
A. Sydnocarb
B. Diphenine
C. Imipramine
D. Chlordiazepoxide
E. Aminazine*
283.
A patient suffers from nocturnal paroxysms of bronchial asthma
accompanied with bradycardia, spastic intestinal pains and diarrhea.
Medicine of what group can relieve these symptoms?
A. Sympatholytics
B. N-cholinergic receptors
C. M-cholinergic receptors*
D. Saluretics
E. β-adrenoblockers
284.
A patient with bronchial asthma is administered inhalation of
0,5 % isadrine (isoproterenol) solution. Bronchospasm was relieved, but
the patient began complaining of pain in the heart region and palpitation.
It is connected with the stimulation of:
A. alpha1 –adrenoreceptors
B. beta1 –adrenoreceptors*
C. beta2 –adrenoreceptors
D. Acetylcholine synthesis
E. M-cholinergic receptors
285.
A 50-year-old male farm worker has been brought to the
emergency room. He was found confused in the orchard and since then
has remained unconscious. His heart rate is 45 and his blood pressure is
80/40 mm Hg. He is sweating and salivating profusely. Which of the
following should be prescribed?
A. Atropine sulfas*
B. Proserine
C. Physostigmine
D. Norepinephrine
E. Pentamine
286.
A patient with complaints of dryness in the mouth, photophobia
and vision impairment was admitted to the reception-room. Skin is
hyperemic, dry, pupils are dilated, tachycardia. Poisoning with
belladonna alkaloids was diagnosed on further examination. What
medicine should be prescribed
A. Pilocarpine
B. Dipiroxim
C. Prozerin *
D. Diazepam
E. Armine
287.
A 25-year-old woman with red and itchy eczematous dermatitis
visits your office. She had a dental procedure one day earlier with
administration of a local anesthetic. There were no other findings,
although she indicated that she had a history of allergic reactions. Which
of the following drugs is most likely involved?
A. Proserine
B. Cocaine
C. Bupivacaine
D. Lidocaine
E. Procaine (Novocaine)*
288.
A patient has got a spasm of smooth muscles of bronchi.
Activators of what membrane cytoreceptors are physiologically reasoned
to stop an attack?
A. beta-adrenoreceptors*
B. alpha- and beta –аdrenoreceptors
C. N-cholinoreceptors
D. M-, H-cholinoreceptors
E. М-cholinoreceptors
289.
Introduction of a pharmaceutical substance to an experimental
animal resulted in reduction of salivation, pupil mydriasis. Next
intravenous introduction of acetylcholine didn't lead to any significant
changes of heart rate. Name this substance:
A. Proserin
B. Atropine*
C. Propranolol
D. Adrenaline
E. Salbutamol
290.
A patient with II stage hypertension has been taking one of
hypotensive medications for the purpose of treatment. After a time
arterial pressure decreased, but the patient started complaining of
flaccidity, sleepiness, indifference. A bit later he felt stomach pain. He
was diagnosed with ulcer. What hypotensive medication has the patient
been taking?
A. Captopril
B. Dibasole
C. Reserpine*
D. Furosemide
E. Verapamil
291.
A patient with fracture of his lower jaw was admitted to the
maxillofacial department. It was decided to fix his bones surgically
under anaesthetic. After intravenous introduction of muscle relaxant
there arose short fibrillar contractions of the patient's facial muscles.
What muscle relaxant was applied?
A. Dithylinum*
B. Pipecuronium bromide
C. Diazepam
D. Melictine
E. Tubocurarin chloride
292.
Examination of a patient revealed extremely myotic pupils,
sleepiness, infrequent Chain-Stoke's respiration, urinary retention,
slowing-down of heart rate, enhancement of spinal reflexes. What
substance caused the poisoning?
A. Atropine sulfas
B. Phosphacole
C. Caffeine
D. Morphine*
E. Barbital
293.
A patient who has been treated with diazepam on account of
neurosis complains of toothache. Doctor administered him an analgetic,
but its dose was lower than average therapeutic dose. What phenomenon
did the doctor take into account while prescribing the patient an
underdose?
A. Summation
B. Potentiation*
C. Cumulation
D. Tolerance
E. Drug dependence
294.
On the 2-3rd day after stomach resection intestinal peristalsis
wasn't restore D. What is to be administered for stimulation of
gastrointestinal tract?
A. Atropine sulfate
B. Proserine *
C. Prasosin
D. Cyclodole
E. Acetylcholine
295.
A stomatologist injected a patient with a certain drug in order to
reduce salivation during tooth filling. What drug is it?
A. Atropine sulfate*
B. Pilocarpine hydrochloride
C. Proserine
D. Mesaton
E. Adrenaline hydrochloride
296.
A patient with acute morphine poisoning was delivered to a
hospital. What specific narcotic antagonist should be chosen in this
case?
A. Unithiol
B. Naloxone *
C. Methacin
D. Digoxin
E. Paracetamol
297.
A patient who has been treated in a neural clinic and has been
taking a sedative for a long time got the following complication: cough,
rhinitis, dermatitis. What drug caused these disturbances?
A. Phenazepam
B. Valerian
C. Sodium bromide*
D. Diazepam
E. Reserpine
298.
A patient with coronary artery disease was admitted to the
cardiological department. For stenocardia prevention a drug from the
group of -adrenoceptor blockers was administered. What drug is it?
A. Morphine hydrochloride
B. Oxytocin
C. Metoprolol *
D. Furosemide
E. Atropine sulfate
299.
A patient with a limb fracture must be administered a depolarizing
drug from the myorelaxant group for the purpose of a short-time surgery.
What drug is it?
A. Atropine sulfate
B. Dithylinum *
C. Tubocurarine chloride
D. Cytitonum
E. Pentaminum
300.
A 63-year-old patient with collapse presentations was delivered to
the emergency hospital. A physician has chosen noradrenalin against
hypotension. What is its mechanism of action?
A. Activation of 1-adrenoreceptors *
B. Activation of serotonin receptors
C. Activation of dopamine receptors
D. Block of M-cholinoreceptors
E. Activation of -adrenoreceptors
301.
Indicate the location of beta1 adrenoreceptors type:
A. Heart*
B. Glands
C. Smooth muscle
D. Endothelium
E. All of the above
302.
Which of the following cholinomimetics activates both muscarinic
and nicotinic receptors?
A. Lobeline
B. Pilocarpine
C. Nicotine
D. Carbacholine*
E. Adrenalin hydrochloride
303.
Indicate a cholinomimetic agent, which is related to direct-acting
drugs:
A. Aceclidine
B. Cytitone
C. Carbacholine*
D. Proserine
E. Dipiroxim
304.
Which of the following local anesthetics is an acetanilide
derivative?
A. Tetracaine
B. Lidocaine *
C. Cocaine
D. Procaine
E. Anesthesine
305.
Indicate the function, which the last to be blocked, when local
anesthetic are used:
A. Pain
B. Temperature
C. Muscle spindles
D. Motor function *
E. Touch
306.
Which of the following local anesthetics is an useful
antiarrhythmic agent?
A. Cocaine
B. Lidocaine *
C. Bupivacaine
D. Ropivacaine
E. Procaine
307.
Indicate the route of local anesthetic administration, which is
associated with instillation within epidural or subarachnoidal spaces:
A. Topical anesthesia
B. Infiltrative anesthesia
C. Regional anesthesia
D. conductive anesthesia
E. Spinal anesthesia*
308.
The choice of a local anesthetic for specific procedures is usually
based on:
A. The duration of action
B. Water solubility
C. Capability of rapid penetration through the skin or mucosa with
limited tendency to diffuse away from the site of application
D. Absents of the allergic reaction
E. All of the above*
309.
The anesthetic effect of the agents of short and intermediate
duration of action CAN NOT be prolonged by adding:
A. Epinephrine
B. Norepinephrine
C. Dopamine*
D. Phenylephrine
E. Ephedrine
310.
Which of the following local anesthetics is only used for surface
or topical anesthesia?
A. Anaethesine *
B.
C.
D.
E.
Tetracaine
Procaine
Bupivacaine
Lidocaine
311.
Indicate the local anesthetic, which is mainly used for regional
nerve block anesthesia:
A. Dibasole
B. Bupivacaine *
C. Aspirine
D. Anesthesine
E. Proserine
312.
Which of the following local anesthetics is used for infiltrative and
regional anesthesia?
A. Procaine
B. Lidocaine
C. Ultracaine
D. Mepivacaine
E. All of the above*
313.
Which of the following local anesthetics is called a universal
anesthetic?
A. Procaine
B. Ropivacaine
C. Lidocaine *
D. Bupivacaine
E. Anesthesine
314.
Tetracaine has all of the following properties EXCEPT:
A. Slow onset
B. Low potency*
C. Long duration
D. High toxicity
E. It has ester linkage
315.
Which of the following sympathomimetics acts indirectly?
A. Epinephrine
B. Norepinephrine
C. Dopamine
D. Ephedrine*
E. Methoxamine
316.
Catecholamine includes following EXCEPT:
A. Ephedrine*
B. Epinephrine
C. Isoprenaline
D. Norepinephrine
E. Dopamine
317.
All of the following agents are beta receptor agonists EXCEPT:
A. Epinephrine
B. Isoproterenol
C. Methoxamine*
D. Dobutamine
E. Norepinephrine
318.
Αlfa-receptor stimulation includes all of the following effects
EXCEPT:
A. Relaxation of gastrointestinal smooth muscle
B. Contraction of bladder base
C. Contraction of uterus and prostate
D. Stimulation of insulin secretion*
E. Stimulation of platelet aggregation
319.
Beta 1 receptor stimulation includes all of the following effects
EXCEPT:
A. Increase in contractility
B. Bronchodilation*
C. Tachycardia
D. Increasing strength and heart rate
E. Increase in conduction velocity in the atrioventricular node
320.
Beta 2 receptor stimulation includes all of the following effects
EXCEPT:
A. Stimulation of renin secretion
B. Fall of potassium concentration in plasma
C. Relaxation of uterus
D. Relaxation of bladder
E. Tachycardia*
321.
Hyperglycemia induced by epinephrine is due to:
A. Gluconeogenesis (beta 2 )
B. Inhibition of insulin secretion (alfa)
C. Stimulation of glycogenolysis (beta 2 )
D. All of the above*
E. None of above
322.
Which of the following effects is associated with beta 3 -receptor
stimulation?
A. Lipolysis*
B. Decrease in platelet aggregation
C. Bronchodilation
D. Tachycardia
E. Bradicardia
323.
Which of the following statements is not correct?
A. Epinephrine acts on both alfa- and beta-receptors
B. Norepinephrine has a predominantly beta action
C. Epinephrine used for hypertension treatment*
D. Norepinephrine acts on both alfa- and beta-receptors
E. Isoprenaline has a predominantly beta action
324.
Indicate the drug, which is a direct-acting both alfa- and betareceptor agonist:
A. Norepinephrine*
B. Methoxamine
C. Isoproterenol
D. Ephedrine
E. Metoprolol
325.
Which of the following agents is an alfa-1, alfa-2, beta-1, beta-2
receptor agonist?
A. Methoxamine
B. Albuterol
C. Epinephrine*
D. Metoprolol
E. Norepinephrine
326.
Which of the following agents is an alfa-1 -selective agonist?
A. Norepinephrine
B. Methoxamine*
C. Ritodrine
D. Ephedrine
E. Isoproterenol
327.
Indicate the alfa 2 -selective agonist:
A. Xylometazoline*
B. Epinephrine
C. Norepinephrine
D. Dobutamine
E. Methoxamine
328.
Which of the following agents is a nonselective beta receptor
agonist?
A. Norepinephrine
B. Epinephrine
C. Ephedrine
D. Isoproterenol*
E. Dobutamine
329.
Indicate the beta 1 -selective agonist:
A. Isoproterenol
B. Dobutamine*
C. Metaproterenol
D. Epinephrine
E. Norepinephrine
330.
Which of the following sympathomimetics is a beta 2 -selective
agonist?
A. Terbutaline*
B. Xylometazoline
C. Ephedrine
D. Isoproterenol
E. Dobutamine
331.
Indicate the indirect-acting sympathomimetic agent:
A. Epinephrine
B. Norepinephrine
C. Phenylephrine
D. Ephedrine*
E. Isoproterenol
332.
Epinephrine produces all of the following effects except:
A. Positive inotropic action on the heart (beta 1 receptor)
B. Increase peripheral resistance (alfa receptor)
C. Predominance of alfa effects at low concentration*
D. Positive chronotropic action on the heart (beta 1 receptor)
E. Skeletal muscle blood vessel dilatation (beta 2 receptor)
333.
Epinephrine produces all of the following effects except:
A. Decrease in oxygen consumption*
B. Increase in oxygen consumption
C. Bronchodilation
D. Hyperglycemia
E. Mydriasis
334.
Epinephrine is used in the treatment of all of the following
disorders except:
A. Bronchospasm
B. Anaphylactic shock
C. Cardiac arrhythmias*
D. Open-angle glaucoma
E. Hypoglycemic coma
335.
Compared with epinephrine, norepinephrine produces all of the
following effects except:
A. Similar effects on beta 1 receptors in the heart and similar potency
at an alfa receptor
B. Decrease the mean pressure below normal before returning to the
control value*
C. Significant tissue necrosis if injected subcutaneously
D. Increase systolic blood pressure
E. Increase diastolic blood pressure
336.
Which of the following direct-acting drugs is a relatively pure alfa
agonist, an effective mydriatic and decongestant and can be used to raise
blood pressure?
A. Epinephrine
B. Norepinephrine
C. Phenylephrine*
D. Ephedrine
E. Reserpine
337.
Characteristics of methoxamine include all of the following
except:
A. It is a direct-acting alfa 1 -receptor agonist
B. It increases heart rate, contractility and cardiac output*
C. It causes reflex bradycardia
D. It increases total peripheral resistance
E. Induced vasoconstriction
338.
Which of the following agents is an alfa 2 -selective agonist with
ability to promote constriction of the nasal mucosa?
A. Xylometazoline*
B. Phenylephrine
C. Propranolole
D. Epinephrine
E. Norepinephrine
339.
During an operation a patient got injection of muscle relaxant
Dithylinum. Relaxation of skeletal muscles and inhibition of respiration
lasted two hours. This condition was caused by absence of the following
enzyme in blood serum
A. Glutathione peroxidase
B. Butyrylcholinesterase *
C. Acetylcholinesterase
D. Catalase
E. Glucose 6-phosphatase
340.
A patient who suffers from insomnia caused by emotional disorder
was prescribed a hypnotic drug with tranquillizing effect. What hypnotic
was prescribed?
A Bromisoval
B Nitrazepame*
C Chloral hydrate
D Phenobarbitale
E Sodium ethaminale
341.
A patient had to go through an operation. Doctors introduced him
dithylinum (listenone) and performed intubation. After the end of
operation and cessation of anesthesia the independent respiration wasn't
restored. Which enzyme deficit prolongs the action of muscle relaxant?
A Carbanhydrase
B Succinate dehydrogenase
C Pseudocholinesterase*
D N-acetyltransferase
E K-Na-adenosine triphosphatase
342.
Patient with complaints of dryness in the mouth, photophobia and
vision violation was admitted to the reception-room. Skin is hyperemic,
dry, pupils are dilated, tachycardia. Poisoning with belladonna alkaloids
was diagnosed on further examination. What medicine should be
prescribed?
A. Pilocarpine
B. Diazepame
C. Prozerine*
D. Armine
E. Dipyroxime
343.
Proserin increases skeletal muscle tone when given systematically.
Halothane induces relaxation of skeletal muscles and reduces proserin
effects. What is the nature of proserin and halothane interaction?
A. Direct functional antagonism
B. Independent antagonism
C. Noncompetitive antagonism
D. Indirect functional antagonism*
E. Competitive antagonism
344.
A 40-year-old man, who suffered from chronic bronchitis, was
prescribed medicine for the cough - codeine. What is the mechanism of
anticoughing effect?
A. Local effect
B. Peripheral effect
C. Reflex
D. Competitive
E. Central*
345.
The patient has taken the mixture prescribed by neuropathologist
for neurasthenia for 2 weeks. Patient felt better but developed coryza,
conjunctivitis, rash, inertia, decrease of memory. Bromizm was
diagnosed. What should be prescribed to decrease symptoms?
A. Polyglucine
B. Analgine
C. Glucose solution 5%
D. Asparcam
E. Natrium chloride*
346.
Analeptical remedy of reflective type from the N-cholinomimetics
group was given to the patient for restoration of breathing after
poisoning with carbon monoxide. What medicine was prescribed to the
patient?
A. Adrenalin hydrochloride
B. Atropine sulphate
C. Lobeline hydrochloride*
D. Mesatone
E. Pentamine
347.
The patient was treated medically for psychosis for 2 weeks.
Patients condition improved but rigidity, tremor, hypokinesia developed.
Which of the drugs can cause such complications?
A. Sydnocarbe
B. Diphenine
C. Aminazine*
D. Imipramine
E. Chlordiazepoxide
348.
Patient with bronchial asthma was taking tablets which caused
insomnia, headache, increased blood pressure. What medicine can cause
such complications?
A. Euphylline
B. Izadrine
C. Adrenaline
D. Chromolin sodium
E. Ephedrine*
349.
Introduction of a pharmaceutical substance to an experimental
animal resulted in reduction of salivation, pupil mydriasis. Next
intravenous introduction of acetylcholine didnt lead to any significant
changes of heart rate. Name this substance:
A. Propranolol
B.
C.
D.
E.
Adrenaline
Atropin sulfas*
Proserin
Salbutamol
350.
Blockade of this receptor system most likely associated with
Akathisia side effect of antipsychotic treatment:
A Muscarinic cholinergic
B Alpha adrenergic
C Dopamine*
D serotonin
E None of the above
351.
Hypotension due to antipsychotic medication associated with
effects on this receptor system
A Alpha –adrenergic*
B Dopamine
C Muscarinic cholinergic
D Serotonergic
E None - of the above
352.
Before the infiltration anesthesia was carried out, the test for
novocaine sensitivity was made to the patient. It was positive. Which of
the following drugs can be used for anesthesia in this case?
A Xycainum*
B Streptomycinum
C Cocainum
D Anaesthesinum
E Diсainum
353.
In the psychiatric hospital, during the long-term treatment,
symptoms of the Parkinson's disease appeared in the patient’s condition.
What drug was administered to the patient?
A Aminazinum *
B Mezapamum
C Sodium bromidum
D Lithium Carbonas
E Nialamidum
354.
The unconscious patient was delivered to the admission
department of the hospital. The patient’s skin was cold, pupils of the
eyes were narrowed, breathing was difficult, blood pressure was
decreased, the urinary bladder was full. The diagnosis was morphine
poisoning. What preparation should be used as antagonist?
A Naloxonum*
B Bemegridum
C Cytitonum
D Unithiolum
E Sodium thiosulfatum
355.
The patient, who complained of dry mouth, photophobia, sight
disturbance, dry skin, tachycardia etc., was delivered to the admission
department. The administered diagnosis was belladonna alkaloids
poisoning. Which drugs should be used?
A Proserinum*
B Diazepamum
C Pilocarpinum
D Armin
E Dipiroximum
356.
The patient was diagnosed with acute myocardial infarction,
which is accompanied by the persistent pain behind the breastbone. The
inefficiency of previously administered drugs allowed the doctor to
make neurolepanalgesia . What neuroleptic drugs are used for this type
of anesthesia?
A Droperidolum*
B Metaperasinum
C Haloperidolum
D Reserpine
E Aminazinum
357.
The condition of patient with hypotension was gradually
worsening. The patient complained of dizziness, weakness, and he took
some nonprescription ephedrine drugs tablets. However, some
improvement was observed only after the first use of the pill. What
phenomenon is caused by this action?
A Tachyphylaxis *
B Sensitization
C Idiosyncrasy
D Habituation
E Cumulation
358.
During the next attack of asthma, the patient inhaled medication,
known as bronchodilator or as the drug used in obstetric practice to
prevent miscarriages, with the help of the inhaler. What medical
preparation was used for the patient?
A Fenoterolum*
B Salbutamolum
C Adrenalini hydrochloridum
D Ephedrinum
E Theophyllinum
359.
The man in age of 36 with traumatic brain injury complained of
weakened breathing, threadlike pulse, absent reflexes. What is the most
appropriate route of Piracetam administration in this case?
A Intravenously *
B Subcutaneously.
C Orally.
D Rectally.
E Inhalation
360.
The woman 35 y.o. complained of the pain associated with
delayed first childbirth period. What is the best drug to decrease the
pain?
A Promedolum*
B Analginum
C Morphine hydrochloridum.
D Codeine phosphas
E Paracetamolum
361. The patient complained of dizziness, thirst, swallowing difficulties, poor
sight was asked to the doctor. He had his rapid breathing, dilated pupils,
general arousal, loquacity and the blood pressure was 110 /70 mm Hg and
the pulse was 110 per minute. The following symptoms may indicate at
the drug overdose?
A Atropine sulfas*
B Morphine hydrochloridum
C Ephedrinum
D Chlorpromazinum
E Caffeinum natrii benzoas
362. Lithium carbonate is the preferred treatment for:
A Typical rendogenous depression
B Schizophrenia
C Anxiety
D Bipolar disorder*
E Enuresis
363. Effective in treating both organophosphate and muscarine intoxication:
A Nicotinum
B Aceclidinum
C Atropinum sulfas *
D Pilocarpinum
E All of above
364. Most likely to reduce blood pressure by directly decreasing heart rate:
A Phentolaminum
B Propranololum *
C Nitroprusside sodium
D Phenylephrinum
E All of the above
365. Indicate Pilocarpine action:
A Dry mouth
B Pupillary dilation
C Increased gastrointestinal tone*
D Bronchiolar relaxation
E All of the above
366. Preganglionic fibers terminating on adrenal medullary chromaffin cells
release:
A Norepinephrinum
B Epinephrinum
C Acetylcholinum*
D Dopaminum
E Acedlidinum
367. Primary receptor type at autonomic ganglia:
A Adrenergic : beta 1
368.
369.
370.
371.
372.
373.
374.
B Adrenergic : beta 2
C Cholinergic : muscarinic
D Cholinergic : nicotinic*
E Dopaminergic : D. 1
Cholinergic receptor type that mediates the decrease in heart rate by
activating potassium channels:
A M1- muscarinic
B M2-muscarinic*
C M3-muscarinic
D Nicotinic
E All of the above
Phosphorylation of this enzyme is most likely to have an effect on
catecholamine biosynthesis:
A Phenylethanolamine N-methyltransferase
B Dopamine beta-hydroxylase
C MAO*
D Dopa decarboxylase
E All of the above
Drugs activating this receptor are used in treating asthma:
A Beta 1 adrenergic
B Muscarinic cholinergic
C Beta 2 adrenergic*
D Nicotinic cholinergic
E All of the above
Indicate which drug causes pupillary dilation with no effect on
accommodation:
A Pilocarpini hydrochloridum
B Phenoxybenzaminum
C Phentolaminum
D Atropini sulfas
E Neostigminum *
Prevents blood pressure reduction seen with isoproterenol (Isadrine):
A Propranololum *
B Phenylephrinum
C Atropini sulfas
D Phentolaminum
E Aceclidinum
Indicate action of salbutamolum:
A Bronchodilation*
B By I.V. injection only
C Decreases myocardial contractility
D Alpha adrenoceptor antagonist
E Significant heart rate increase
Immediate biosynthetic precursor of epinephrine:
A L-DOPA
B Isoproterenolum
C Doapminum
D Metaraminolum
E Norepinephrinum*
375. Therapeutic use of metaprololum:
A Renal vasodilator
B Positive inotrope in CHF
C Antihypertensive
D Antiarrhythmic drug*
E Bronchial asthma
376. Preganglionic fibers terminating on adrenal medullary chromaffin cells
release:
A Norepinephrinum
B Epinephrinum
C Acethylcholinum*
D Dopaminum
E Isoproterenolum
377. Primary receptor type at autonomic ganglia:
A Adrenergic : beta 1
B Adrenergic : beta 2
C Cholinergic : muscarinic
D Cholinergic : nicotinic*
E Dopaminergic : D1
378. Phosphorylation of this enzyme is most likely to have an effect on
catecholamine biosynthesis:
A Phenylethanolamine N-methyltransferase
B Dopamine beta-hydroxylase
C Tyrosine hydroxylase*
D Dopa decarboxylase
E All of the above
379. Effects of Epinephrinum:
A Limited effect on alpha receptors
B Increases heart rate, contributing to increase blood pressure*
C Epinephrine often reduces peripheral vascular resistance,
especially at high concentration
D Epinephrine tends to exhibit negative inotropic effects
E All of the above
380. Vasoconstrictive effects of epinephrinum:
A Alpha -1 adrenergic receptor-mediated affecting precapillary
resistance vessels of the skin, kidney, and mucosa
B Veins
C Both*
D Neither
E All of the above
381. Cardiac effects associated with epinephrinum:
A Positive chronotropic
B Positive inotropic
C Increased cardiac output
D Increased oxygen consumption
E All of the above*
382. Significant respiratory tract effects of epinephrinum:
A Beta -2 receptor mediated bronchoconstriction
B Alpha -1 receptor-mediated bronchodilation
C Beta -1 receptor-mediated bronchodilation
D Beta -2 receptor-mediated bronchodilation*
E All of the above
383. Toxicities/adverse reactions associated with sympathomimetics
A Angina
B Hypertension ; cerebral hemorrhage
C Cardiac arrhythmias
D Anxiety reactions
E All the above*
384. Drugs antagonize epinephrinum pressor effects:
A Phentolaminum *
B Isoproterenol
C Dopaminum
D Dobutaminum
E Atropini sulfas
385. Ventricular effects associated with epinephrinum administration:
A Increased automaticity
B Increased ectopic pacemaker activity
C Increased conduction philosophy
D Increased contractility
E All the above*
386. Primary neurotransmitter released by postganglionic neurons of the
autonomic sympathetic system:
A Epinephrinum
B Dopaminum
C Dobutaminum
D Norepinephrinum*
E Phenylephrinum
387. Decreased heart rate following norepinephrine infusion is most likely
due to:
A Direct norepinephrine activation of muscarinic receptors at the SA
node
B Heart rate cannot decrease following norepinephrine infusion
because norepinephrine activates beta-1 adrenergic receptors
C Activation of the baroreceptor system causing a reflex-mediated
decrease in heart rate*
D Peripheral vasodilation
E None of the above
388. Vascular effects of norepinephrinum:
A Significantly decreases glomerularl filtration rates
B Effective in treating variant angina
C Norepinephrine pressor effects blocked by prazosin*
D Increased blood flow to liver, kidney, and skeletal muscle
E All of the above
389. Immediate synthetic precursor of norepinephrinum:
A Epinephrinum
B Tyrosinum
C Tyrosini hydroxylase
D Dopaminum*
E Dopa
390. Low doses, this precursor of norepinephrine causes renovascular
dilation:
A Epinephrinum
B Dopa
C Dopaminum *
D Dobutaminum
E Nitroprussidum sodium
391. Significant therapeutic use for dopamine:
A Management of sleep cycles
B Treatment of Raynaud's phenomenon
C Treatment of cardiogenic/hypovolemic shock*
D Management of tachyarrhythmias
E All of the above
392. This drug has limited action at alpha-adrenergic receptors
A Phenylephrinum
B Phentolamine
C Norepinephrinum
D Isoproterenolum *
E Prazosinum
393. Adverse effects associated with isoproterenol administration:
A Palpitations
B Tachycardia
C Arrhythmias
D None of above
E All of above*
394. Simultaneous increases in myocardial contractility, glomerular filtration
rate, sodium excretion, urine output, and renal blood flow are associated
most likely with:
A Epinephrineum
B Isoproterenolum
C Phenylephrinum
D Dopaminum *
E Norepinephrinum
395. Clinical uses for sympathomimetic drugs:
A Hypovolemic shock caused by dehydration or blood loss
B Cardiogenic shock
C Cardiac output obstruction
D Loss of peripheral vascular tone
E All of the above*
396. Primary objective sympathomimetic drug use for management of shock:
397.
398.
399.
400.
401.
402.
403.
A Increase myocardial contractility
B Decreased peripheral resistance
C Promote better renal perfusion
D Ensure adequate CNS perfusion*
E Improve coronary perfusion
Most likely to reduce myocardial performance in a damaged heart by
increasing afterload:
A Isoproterenolum
B Phenylephrinum *
C Low -dose dopaminum
D Low -dose epinephrinum
E All of the above
Receptor system most likely responsible for improved myocardial
contractility when dopamine is administered at low concentrations:
A Muscarinic cholinergic receptors
B Alpha adrenergic receptors
C Beta2 adrenergic receptors
D Dopamine receptors (D1)*
E Leukotriene receptors
Indicate a non-selective beta-adrenergic receptor blocker:
A Metoprololum
B Atenololum
C Timololum *
D Esmololum
E None of above
Beta-adrenergic receptor blockers: effects on the heart
A Increase heart rate
B Increased AV nodal refractory period*
C Increased contractility
D Increased myocardial oxygen demand
E Increased phase 4 depolarization
Mechanism(s) for propranolol-decreased amide local anesthetic
clearance:
A Decreased hepatic blood flow
B Inhibition of hepatic metabolism of local anesthetic
C Both*
D Neither
E All the above
Bradycardia hypotension, refractory to atropine sulfate, may occur
during anesthesia in pediatric and adult patients receiving this beta
adrenergic receptor antagonist:
A Nadololum
B Propranololum
C Esmololum
D Timololum *
E All the above
Choline ester most susceptible to hydrolysis by acetylcholinesterase:
404.
405.
406.
407.
408.
409.
410.
A Carbacholum
B Acetylcholinum*
C Methacholinum
D Pilocarpinum
E All the above
Indicate the direct effects associated with parasympathetic activation:
A Increase heart rate
B Decreased GI motility
C Decrease cardiac contractility
D Urinary retention
E All the above*
Location(s) of cholinergic synaptic sites:
A Neuromuscular junction
B Autonomic effector sites innervated by post-ganglionic
sympathetic fibers
C Some CNS synapses
D All of above*
E None of above
Indicate M,N cholinomimetic:
A Atropini sulfas
B Edrophonium
C Carbacholum*
D Acetylcholinum
E Ephedrinum
Rationale for prescribing anticholinesterase drugs to patients with
myasthenia gravis:
A Increase noradrenaline concentration
B Increase receptor number
C Increase amount of acetylcholine available of neuromuscular
junctions*
D Reduce receptor number
E All of the above
Effect(s) of muscarinic agonists on the gastrointestinal and urinary tracts:
A Increased intestinal peristalsis
B Increased tone
C Increased contraction amplitude
D Increase ureteral peristalsis
E All the above*
Rationale for prescribing anticholinesterase drugs to patients with
myasthenia gravis:
A Increase acetylcholine turnover
B Increase receptor number
C Increase amount of acetylcholine available of neuromuscular
junctions*
D Reduce choline reuptake
E All of the above
General clinical uses: anticholinesterases
A Antagonist -assisted reversal of neuromuscular blockade produced
by nondepolarizing neuromuscular-blocking drugs
B Myasthenia gravis management
C Glaucoma treatment
D Treatment of paralytic ileus and urinary bladder atony
E All of the above*
411. Factor(s) that may prevent or inhibit anticholinesterase-mediated
antagonism of neuromuscular-blockade:
A Hyperthermia
B Respiratory alkalosis
C Hyperkalemia
D Certain antibiotics*
E All of the above
412. Current primary therapeutic rationale for using anticholinergic
preoperative medication:
A Sedation
B Antisialagogue effects
C Prevetion of vagus irritation effects
D Neither
E All of the above*
413. Current primary therapeutic rationale for using anticholinergic
preoperative medication:
A Sedation
B Antisialagogue effects
C All of above*
D Neither
E Spasmolitic effect
414. Anticholinergic drug most likely to be used clinically to promote
bronchodilation:
A IV atropine
B Aerosolized atropine sulfas
C Aerosolized ipratropium bromide *
D Scopolaminum bromide
E All of the above
415. Adrenergic drug most likely to be used clinically to promote
bronchodilation:
A IV atropine
B Aerosolized salbutamol
C Aerosolized ipratropium bromide *
D None of above
E All of the above
416. Benzodiazepinum pharmacology is most closely linked to which
neurotransmitter system?
A Noradrenergic
B GABA system*
C Cholinergic
D Glycine system
417.
418.
419.
420.
421.
422.
423.
E All of the above
Atropin-like drugs pharmacology is most closely linked to which
neurotransmitter system?
A Noradrenergic
B GABA system
C Cholinergic*
D Glycine system
E All of the above
Most useful in reversing symptoms of benzodiazepine overdosage:
A Amphetaminum
B Buspironum
C Flumazenilum *
D Naltrexonum
E None
Most useful in reversing symptoms of morphine overdosage:
A Amphetaminum
B Buspironum
C Flumazenilum
D Naloxone*
E None
May be especially effective in treating anxiety associated with
nicotinum withdrawal:
A Meprobamatum
B Lobesilum *
C Both
D Neither
E All of the above
Which one of the following is an established clinical use of morphine?
A Management of generalized anxiety disorders
B Relief of pain associated with trauma*
C Pulmonary congestion
D Treatment of cough associated with use of ACE inhibitors
E Suppression of the ethanol withdrawal syndrome
Which one of the following is an established clinical use of morphine?
A Management of COPD
B Relief of pain associated with oncology*
C Pneumonia
D Treatment of cough associated with use of ACE inhibitors
E Suppression of the ethanol withdrawal syndrome
A patient known to be a heroin abuser comes to the ER with a painful
stab wound. The ER resident administers nalbuphine for the pain. Why
is this not a good idea?
A The patient is probably tolerant to nalbuphine.*
B The drug may precipitate a withdrawal state.
C Nalbuphine is a weaker analgesic than codeine.
D Vasodilating effects of nalbuphine increase blood loss.
E Nalbuphine is a strong receptor agonist.
424. Tricyclic antidepressants
A increase the antihypertensive effect of guanethidine
B anti-depressant effect*
C should not be used in patients with glaucoma
D may increase oral absorption of levodopa
E are sometimes used as antiarrhythmics
425. Which one of the following statements about lithium is correct?
A It causes symptoms of mild hyperthyroidism in up to 25% of
patients.
B Plasma levels are increased by a high-Na diet.
C Adverse effects include acne, polydipsia, and polyuria.
D Spina bifida is major concern in fetal development.
E Sedative actions calm manic patients within 24 h.*
426. A 29-year-old male patient is being treated with an antidepressant
drug, and his mood is improving. However, he complains of feeling
"jittery" and agitated at times, and if he takes his medication in the
afternoon he finds it difficult to get to sleep at night. He seems to have
lost weight during the 6 months that he has been taking the drug. He
has been warned not to take other drugs without consultation because
severe reactions have occurred with opioid analgesics, and with
dextromethorphan (in cough syrup). This patient is probably taking
A metaprololum
B chlorpromazine
C paroxetine*
D amitriptyline
E analginum
427. A patient has been diagnosed has having "long QT syndrome." Which
one of the following drugs used in the management of CNS dysfunction
is most likely to cause problems in this patient?
A Diazepamum*
B Ethosuximidum
C Fluoxetinum
D Propoxyphenum
E Thioridazinum
428. A 57-year-old patient, living at home, has severe pain due to a metastatic
carcinoma that is being managed with fentanyl, delivered transdermally
from a patch. He should also be taking, or at least have on hand
A apomorphinum
B Diazepamum
C loperamidum
D morphinum*
E naloxonum
429. A 30-year-old male patient is brought to the ER with the following
symptoms attributed to a drug overdose: ? HR and BP, mydriasis,
behavioral excitation, aggressiveness, paranoia, and hallucinations. Of
the following drugs, which one is most likely to be responsible for these
symptoms?
430.
431.
432.
433.
434.
435.
A Amphetaminum
B Ethanolum
C Fentanylum*
D Doxazosinum
E Marijuana
Vagal stimulation causes bradycardia, which can be blocked by
A atenololum
B atropii sulfas
C doxazosinum
D phenylephrinum
E propranololum*
Which one of the following effects is not caused by the ingestion of
mushrooms that contain pilocarpine?
A Bradycardia
B Bronchospasm
C Diarrhea
D Hypertension*
E Lacrimation
An increase in the cytosolic concentration of norepinephrine in
sympathetic nerve endings leads to
A activation of dopa decarboxylase
B increased release of norepinephrine
C inhibition of tyrosine hydroxylase
D stimulation of MAО*
E none of the above
Reflex tachycardia is most likely to occur after the systemic
administration of
A Fentanylum
B atenololum
C phenylephrinum
D propranololum*
E physostigminum
A 40-year-old male patient is being treated prophylactically with
propranolol. In terms of adverse effects of the drug, which of the
following is most likely to occur with use of this specific beta blocker?
A Bradycardia, mydriasis, sweating
B Bronchoconstriction, hyperglycemia, and hypotension
C Hypoglycemia, hyperlipidemia, and sedation*
D Micturition and rnydriasis
E Migraine headaches and AV block
A 45-year-old man has recently been the recipient of a heart transplant.
Which one of the following drugs is least likely to cause tachycardia in
this patient?
A Amphetaminum
B Dobutaminum
C Epinephrinum*
D Isoproterenol
E Norepinephrinum
436. Labetalol is an effective antihypertensive agent that, like propranolol, is
capable of blocking beta receptors. An important difference between the
two drugs is that labetalol
A
is a selective blocker of cardiac beta1 receptors
B
has intrinsic sympathomimetic activity*
C
is available only for intravenous use
D
has al receptor blocking actions
E
stimulates beta2 receptors in bronchioles
438.
hich of the following describes Aminazine influence on the cardiovascular system:
A. Decreasing of blood pressure*
B. Increasing of blood pressure
C. Tachycardia
D. Atrio-ventricular block
E. Cardiac arrest.
439.
CNS stimulant is:
A. Phenazepame
B. Sibazon
C. Sydnocarb*
D. Paracetamole
E. Morphine
440.
Which of the following is described as benzodiazepine with
hypnotic action?
A. Zopiclone
B. Phenobarbital
C. Nitrazepame*
D. Aethaminal sodium
E. Morphine
441.
The most common side effect of Anapriline:
A. Increasing of bronchial tone*
B. Arrhythmia
C. Increasing of arterial pressure
D. Dyspepsia
E. Increasing of temperature
442.
Which of the following is described as agent of ganglion blockers
group:
A. Enalaprile
B. Prazosine
C. Benzohexonium*
D. Dichlothiaside
E. Anapriline
443.
Which of the following drugs can cause insomnia?
A. Caffeine*
B. Diazepam
C. Aminazine
D. Valeriana
E. Sodium bromide
444.
A patient had to go through an operation. Doctors introduced him
Dithylinum (Listenone) and performed intubation. After the end of
operation and cessation of anesthesia the independent respiration wasn’t
restored. Which enzyme deficit prolongs the action of muscle relaxant?
A. Pseudocholinesterase*
B. Succinate dehydrogenase
C. Carboanhydrase
D. N-acetyltransferase
E. K-Na-adenosine triphosphatase
445.
What medicine is a drug of choice for epileptic status?
A. Ethosuximide
B. Sibazone*
C. Valproate sodium
D. Carbamazepine
E. Caffeine
446.
Side-effect of hypnotic agents from barbiturates group:
A. Excitation
B. Increase of blood pressure
C. Violation of structure of sleep*
D. Таchycardia
E. Bronchial spasm
447.
Which of the following agents is useful in the treatment of
endogenous depression?
A. Aminazine
B. Triftazine
C. Aethaperazine
D. Amitriptyline*
E. Droperidole
448.
M-сholinomimetiс used for glaucoma treatment is:
A. Ephedrine
B. Pilocarpine*
C. Proserine
D. Halazoline
E. Coffeine
449.
Which of the following agents should be taken for a stuffy, runny
nose?
A. Anapriline
B. Pilocarpine
C. Proserine
D. Halazoline*
E. Coffeine
450.
Which of the following is nonselective beta 1, 2. -adrenergic
agonist?
A. Codeine
B. Anapriline
C. Adrenaline
D. Isadrine*
E. Coffeine
451.
Psycho-motor stimulant is:
A. Phenazepame
B. Меzapame
C. Coffeine*
D. Nootropile
E. Haloperidole
452.
Parkinson-like syndrome is side effect of Aminazine, caused by
A. Blockade of M-cholinergic receptors
B. Blockade of alpha-adrenergic receptors
C. Blockade of dopamine receptors*
D. Hypersensitivity of dopamine receptors
E. Stimulation of nicotine receptors
453.
Which of the following anesthetics is most likely to produce
hepatotoxicity?
A. Aether
B. Isoflurane*
C. Natrii oxybutyras
D. Diazepam
E. Мorphine
454.
Atropine causes:
A. Decreasing of blood pressure
B. Bradycardia
C. Tachycardia*
D. Decreasing of intraocular pressure
E. Diarrhea
455.
Diazepam is used for treatment of:
A. Endogenous depression
B. Shock
C. Bipolar disorders
D. Epileptic status*
E. Myasthenia
456.
Selective alpha 1-adrenoblocker is:
A. Paracetamole
B. Prasozine*
C. Меsatone
D. Noradrenaline
E. Аtenolol
457.
Narcotic analgesic for neuroleptanalgesia is:
A. Моrphine
B. Promedole
C. Phentanyl*
D. Naloxon
E. Buprenorphine
458.
Which of the following therapeutic effects does Epinephrine, as an
adrenergic drug, produce?
A.
B.
C.
D.
E.
Urinary retention
Bronchial constriction
Increased heart rate and contractility*
Decreased heart rate and contractility
Decreased arterial pressure
459.
Beta-blockers may be used to treat hypertension and:
A. Chronic obstructive pulmonary disease (COPD)
B. Diarrhea
C. Heart block
D. Supraventricular tachyarrhythmias*
E. Ulcer disease
460.
Propranolol (Anapriline) is an effective:
A. Selective alpha-adrenergic antagonist
B. Nonselective beta-adrenergic antagonist*
C. Beta1-adrenergic antagonist
D. Beta2-adrenergic antagonist
E. Nonselective alpha-adrenergic antagonist
461.
When assessing a patient for adverse effects related to morphine,
which of the following would the physician NOT expect?
A. Decreased peristalsis
B. Diarrhea*
C. Delayed gastric emptying
D. Common bile duct spasm
E. Myosis
462.
When assessing for the most serious adverse reaction to narcotic
analgesic, the physician is careful to monitor the patient's:
A. Respiratory rate*
B. Temperature
C. Blood pressure
D. Mental status
E. Salivation
463.
Which of the following medications is used to treat a patient
suffering from acute intoxication by narcotic analgesics?
A. Naloxone*
B. Acetylcysteine
C. Methylprednisolone
D. Protamine sulfate
E. Atropine
464.
A patient admitted to the hospital with a diagnosis of pneumonia
asks the phycisian why she is receiving codeine when she does not have
any pain. His response is based on knowledge that codeine also has what
effect?
A. Immunostimulant
B. Anticough*
C. Expectorant
D. Immunosuppressant
E. Antiseptic
465.
Which of the following therapeutic effects do cholinergic
stimulants have?
A. Urinary bladder relaxation
B. Increased GI motility*
C. Mydriasis
D. Vasoconstriction
E. Spasmolytic
466.
Side effects to expect from anticholinergic (parasympatholytic)
agents, such as atropine, include all of the following EXCEPT:
A. Dilated pupils (mydriasis)
B. Urinary retention
C. Dry mouth
D. Diarrhea*
E. Tachycardia
467.
Scopolamine
A. has an atropinic effect*
B. an adrenergic agent
C. is a specific inhibitor of serotonin reuptake
D. is an inhibitor of monoamines oxidases
E. a nonsteroidal anti-inflammatory drug
468.
What is the mechanism of action of irritating substrances?
A. Axon-reflexes
B. Increase of vessel’s wall penetration
C. Distant action
D. Form albuminates
E. Cutano-visceral reflexes*
469.
A 40-year-old patient with bronchial asthma, who had an attack of
bronchospasm with manifestations of angina pectoris. What drug is the
most effective for the acute care?
A. Salbutamolum*
B. Adrenalini hydrochloridu
C. Ephedrini hydrochloridum
D. Atropini sulfa
E. Platyphyllini hydrotartras
470.
A 46-year-old patient with bronchial asthma was hospitalized. A
doctor prescribed drug to a patient. What is mechanism of action this
medicine?
A. effects on beta1 adrenergic receptors
B. effects on muscarinic cholinergic receptors
C. effects on beta2 adrenergic receptors*
D. effects on nicotinic cholinergic receptors
E. neither
471.
A 68-year-old man was admitted to an emergency hospital in
anaphylactic shock. From which of adrenoreceptors agonists is it
possible to expect the maximal therapeutic effect?
A. Adrenalini hydrochloridum*
B. Ephedrini hydrochloridum
C. Salbutamolum
D. Atenololum
E. Мorphine
472.
Group of drugs that produced paralysis vision accommodation?
A. М-cholinoblockers*
B. М-cholinomimetics
C. N-cholinomimetics
D. Adrenomimetics
E. Anticholinesterase agents
473.
To the patient with ulcer disease of stomach in the period of
increased acidity of gastric juice (in anamnesis is glaucoma) it is
necessary to prescribe a М-cholinoblocker. What agents must you
choose, taking into account attendant diseases?
A. Methacine*
B. Adrenaline
C. Atropine
D. Scopolamine
E. Mesatone
474.
Which of the mentioned drugs belongs to the cholinoblockers of
the selective action and is used at the complex ulcer therapy?
A. Gastrozepine*
B. Strophanthine
C. Proserine
D. Furosemide
E. Reserpine
475.
After a short-term operative intervention with the use of Dithyline,
for over 30 minutes a patient was noticed to have respiratory depression,
previous muscle tone hasn’t restored. What assistance is it necessary to
render to the patient?
A. Hemodialysis
B. Blood of plasma transfusion*
C. Hemosorption
D. Forsed diuresis
E. Peritoneal dialysis
476.
The drug of choice for treatment of anaphylactic shock is:
A. Noradrenaline
B. Naphthyzine
C. Isadrine
D. Adrenaline*
E. Anapriline
477.
Non- selective beta-adrenoblocker is:
A. Anaprilin*
B. Metoprolol
C. Аtenolol
D. Talinolol
E. Isadrine
478.
Main pharmacological effect of myorelaxants:
A.
B.
C.
D.
E.
Decline skeletal muscles tone*
Decline blood pressure
Increase blood pressure
Bradycardia
Bronchial spasm
479.
Selective alpha1-adrenoblocker:
A. Phentolamine
B. Prazosine*
C. Мesatone
D. Noradrenaline
E. Anapliline
480.
Adrenergic agent that is used for treatment of bronchial asthma
attack:
A. Мesatone
B. Noradrenaline
C. Galazoline
D. Salbutamole*
E. Anapliline
481.
The most common adverse effect of Anapriline is:
A. Tachycardia
B. Hypertension
C. Bronchial spasm*
D. Hyper tonus of skeletal muscles
E. Hypo tonus of skeletal muscles
482.
Main effect of ganglion- blockers is:
A. Decrease of vessels’ tone*
B. Increase of vessels’ tone
C. Decrease intraocular pressure
D. Analeptic action
E. Bronchial spasm
483.
Аdrenergic agonist, used for prophylaxis of premature labor:
A. Phenoterole*
B. Noradrenaline
C. Меsatone
D. Halazoline
E. Ephedrine
484.
What substance does N-cholinoreceptors have sensitivity to?
A. Nicotine*
B. Novocaine
C. Nalorphine
D. Nitroglycerine
E. Atropine
485.
What group of drugs used for the acute decreasing of blood
pressure?
A. Ganglioblockers*
B. Sympathomimetics
C. beta-adrenomimetics
D. alpha –adrenomimetics
E. Myorelaxants
486.
When solution of Amonii caustici is used?
A. Unconsciousness*
B. Antiseptic of wounds
C. Heavy metal salts poisoning
D. Instrument sterilisation
E. Superficial anaesthsia
487.
What is the prescription to the Dicainum usage?
A. Superficial anaesthsia*
B. Conductive anaesthesia
C. Trunk anaesthesia
D. Infiltrative anaesthesia
E. Spinal anaesthesia
488.
To mark the usage of Vismuti nitras
A. Dermatitis, eczema*
B. Alkaloid poisoning
C. Heavy metal salts poisoning
D. Craks of rectum
E. Alcohol poisoning
489.
After operation of reposition of femur fracture with the using of
tubacurarine, breathing of patient did not resume. What is needed to
inject to sick for the removal of relaxation?
A. Proserine*
B. Platyphylline
C. Cyclodole
D. Atropine
E. Platyphylline
490.
A patient with an abcess was admitted to a surgical department for
operative treatment. During additional examination ventricular
premature beats were detected. What drug is the most expedient for
anesthesia in this case?
A. Aether pro narcosi
B. Phthorothanum
C. Atropine
D. Lidocainum
E. Ketaminum
491.
During an operative intervention with additional use of
Hygronium the patient’s arterial pressure has sharply decreased. What
groups of drugs can normalize arterial pressure in the given situation?
A. N-cholinomimetics
B. Beta-adrenergic blockers
C. Ganglionic blockers
D. M- cholinomimetics
E. Alpha-adrenoreceptors agonists*
492.
To mark the drug which is used for treatment of poisoning and
meteorism:
A.
B.
C.
D.
E.
Carbo activatus*
Taninum
Vismuti nitras
Argenti nitras
Solution of ammomii caustici
493.
What antiarrythmic agent has local anaesthetic activity?
A. Xycainum*
B. Novocainamidum
C. Verapamilum
D. Cordaronum
E. Aetmozinum
494.
To the patient with myocardial infarction which is complicated
ventrical arrhythmia. After the injection of antiarrhythmic drug with
local anaesthetic activity cardiac rhythm was normalized. What drug was
used?
A. Lidocainum*
B. Anaesthesinum
C. Verapamilum
D. Pananginum
E. Аnaprilinum
495.
A child has residual phenomena after poliomyelitis. What drug is
to be prescribed?
A. Pyroxicanum
B. Pentaminum
C. Analginum
D. Atropini sulfas
E. Galanthamini hydrobromidum*
496.
In the ophthalmologic department was hospitalized patient with
eye trauma. From the anamnesis it is known that he has hypersensitivity
to the sulfonamid agents. What local anaesthetic can be used in this
case?
A. Lidocainum*
B. Novocainum
C. Trimecainum
D. Dicainum
E. Anaesthesinum
497.
What is the mechanism of indirect-action cholinergic stimulants
action?
A. Blocks of cholinesterase*
B. Stimulates alpha-adrenoreceptors
C. Blocks of М-cholinoreceptors
D. Blocks of monoaminooxidase
E. Operates on serotonine receptors
498.
Patient entered the hospital neurological department with poststroke syndrome. What cholinergic medicine is the most expediently to
the patient?
A. Galantamine*
B.
C.
D.
E.
Atropine
Dipiroxim
Salbutamol
Aspirine
499.
Patient with the acute stomachache, vomiting, heavy breathing,
shortness of breath, was delivered to the intensive therapy department.
During examination of patient - skin moisture, hyper salivation, myosis,
bradycardia, muscular fascilation was noted. From the anamnesis it is
known, that patient – toxin abused person, used aerosols to insects as
abuse substance. What pharmacological group of agents the poisoning
substance belongs to?
A. N- cholinomimetic
B. М-choliniblockers
C. Myorelaxants
D. Ganglion-blockers
E. Anticholinesterase agents*
500.
To patient with signs of poisoning by phosphor organic substance
injected cholinesterase reactivators. Indicate a mechanism of action of
this group of drugs.
A. Dephosphorilation of cholinesterase with renewal of its activity*
B. Inactivation of cholinesterase
C. Block of cholinoreceptors
D. Activate of cholinoreceptors
E. Oppression of acetylcholine synthesis
501.
What is the mechanism of action of Proserine?
A. Blocks of cholinesterase*
B. Stimulates beta-adrenoreceptors
C. Blocks М-cholinoreceptors
D. Blocks monoaminooxidase
E. Acts on serotonin receptors
502.
To the patient with post-operation atony of intestine Proserine was
injected. What is the mechanism of drug’s action?
A. Antienzymic*
B. Receptor
C. Physical and chemical interreaction
D. Affect ionic channels of cellular membrane
E. Affect the transport systems of cellular membranes
503.
The woman of 63 years for renewal of functions of CNS after the
stroke of brain injections of Galantamine was recommended. What is
the mechanism of action of this drug?
A. Block of cholinesterase*
B. Block of MAO
C. Block of KOMT
D. Block of GABA-receptors.
E. Block of Кatalase
504.
Indirect cholinergic stimulants drugs have which of the following
therapeutic effect?
A.
B.
C.
D.
E.
Decreased GI motility
Increased GI motility*
Mydriasis
Vasoconstriction
Spasm reliving
505.
Contra-indication for M-cholinoblockers indication is:
A. Glaucoma*
B. Bronchial asthma
C. Ulcer disease
D. Kidney colic
E. Parkinson disease
506.
Having used eye drops a patient with glaucoma has developed
miosis and myopia, intraocular pressure has decreased. What group of
drugs causes such effect?
A. M-cholinergic blockers
B. M-cholinomimetics*
C. Alpha-adrenergic blockers
D. N-cholinomimetics
E. Ganglionic blockers
507.
A patient with manifestations of acute poisoning with morphine
has been taken to a resuscitation unit. What drug is it necessary to use as
antidote for gastric lavage.
A. Kalii permanganas*
B. Natrii hydrocarbonas
C. Furacilinum
D. Natrii chloridum
E. Acidum boricum
508.
A patient developed symptoms of medicinal parkinsonism after
psychosis treatment in a mental hospital. What drug had been used for
his treatment?
A. Lithii carbonas
B. Natrii bromidum
C. Aminazinum*
D. Furacilinum
E. Аnaprilinum
509.
What group of agents is used for the treatment of ulcer disease of
stomach and duodenum?
A. М-cholinoblockers*
B. N-cholinomimetics
C. Myorelaxants
D. Adrenomimetics
E. Anticholinesterase agents
510.
How М-cholinomimetics act?
A. Block of M-cholinoreceptors
B. Activate M-cholinoreceptors*
C. Inactivate of cholinesterase
D. Activate cholinesterase
E. Block cholinesterase
511.
What drug is used for dilatation of pupil when eye examination
has been made?
A. Atropine*
B. Proserine
C. Tubacurarine
D. Methacine
E. Pilocarpine
512.
Scopolamine hydrobromide have which of the following
therapeutic effect?
A. Air sick*
B. Reduce intraocular pressure
C. Atony of intestine
D. Arterial hypertension
E. Myorelaxation
513.
Group of medicines causes an accommodation spasm ?
A. Anticholinesterase agents*
B. М-cholinoblockers
C. N-cholinomimetics
D. Adrenomimetics
E. Sympatholitics
514.
A 25-year-old patient woman has a pain syndrome connected with
the delay of the first labor stage. What drug is necessary to be used for
relieving the pain?
A. Codeini phosphas
B. Analginum
C. Morphini hydrochloridum
D. Promedolum*
E. Paracetamolum
515.
The child, by chance, drank solution from the small bottle, which
his grandmother used for the treatment of glaucoma. The physician
prescribed atropine to the child. What is the mechanism of atropine
antidote action?
A. Influence on special receptors*
B. Co-operation with cellular metabolites
C. Physic-chemical
D. Antienzymic
E. Enzymic
516.
Patient complaints to dryness in the mouth, photophobia and
violation of vision was delivered to the hospital. The skin was
hyperemic, dry, pupils were dilate, tachycardia. Acute poisoning by
alkaloids of Belladonna was diagnosed. What medicine is the most
expediently to patient?
A. Proserine*
B. Aceclidine
C. Pilocarpine
D. Armine
E. Dipiroxime
517.
At 5 years old child was noted: moving excitation, delirium,
hoarse voice, dilated pupils which are not irresponsive on light, dry, hot,
hyperemic skin, tachycardia, tachypnoe. The indicated symptoms appear
in the child eating of Belladonna berries. Medicine of which
pharmacological group it is necessary to prescribe?
A. Anticholinesterase agents*
B. N-cholinolitics
C. N-cholinomimetics
D. M-cholinomimetics
E. Cholinesterase reactivates
518.
At adult man after consumption of food the Amanita muscaria
mushrooms the excitation, increased sweating, appeared the phenomena
of acute gastroenteritis, the pupils narrowed through 15-20 min was
noted. Then cramps, bradycardia, considerable general weakness,
somnolence, the collapse developed. The doctor immediately injected to
the sick patient antidote from the group:
A. М-cholinolitics*
B. N-cholinomimetics
C. N-cholinolitics
D. Anticholinesterase agents
E. Reactivators of cholinesterase
519.
The 6 years old child appear in the hospital with symptoms of
motive and linguistic excitation, dryness in mouth, bad swallowing,
hoarse voice. A skin was dry, hot. Pupils were extended, photophobia,
tachycardia. From anamnesis it is known, that child ate some berries of
dark-violet color. What toxic substance caused poisoning?
A. Atropine*
B. Pirenzepine
C. Pilocarpine
D. Platyphylline
E. Methacine
520.
Patient with the complaints to dryness in the mouth, photophobia
and violation of sight was delivered to the hospital. The skin was
hyperemic, dry, pupils were extended, tachycardia. After examination it
was diagnosed: poisoning by alkaloids of Belladona. What medicine is
the most expediently to patient?
A. Pilocarpine
B. Dipiroxime
C. Diazepam
D. Armine
E. Proserine*
521.
Tubocurarine chloride was applied to a patient under combined
narcosis as a muscle relaxant while performing the resection of the
stomach. What antagonist should be injected to the patient to restore
spontaneous breathing?
A. Proserinum*
B.
C.
D.
E.
Dithylinum
Cytitonum
Aethimizolum
Benzohexonium
522.
A 35-year-old male is hospitalized with signs of acute poisoning
with morphine. What antidote is necessary to be given to the patient?
A. Atropini sulfas
B. Naloxonum*
C. Proserinum
D. Lobelini hydrochloridum
E. Aethimizolum
523.
Analeptical remedy of reflective type from the N-cholinomimetics
group was given to the patient for restoration of breathing after
poisoning with carbon monoxide. What medicine was prescribed to the
patient?
A. Lobeline hydrochloride*
B. Adrenalin hydrochloride
C. Atropine sulphate
D. Pentamin
E. Mesaton
524.
A patient with maniac-depressive psychosis demonstrates
inhibition of mental and impellent activity, agitation, depression. What
drug is it necessary to prescribe in order to relive pathological
depression?
A. Sydnocarbum
B. Amitriptylinum*
C. Coffeinum-natrii benzoas
D. Pyracetamum
E. Triphthazinum
525.
A child periodically experiences convulsive attacks with loss of
consciousness. A doctor diagnosed epilepsy. What drug is recommended
to this child?
A. Levodopum
B. Cyclodolum
C. Phenobarbitalum*
D. Atropini sulfas
E. Unithiolum
526.
A patient suffering from urolithiasis is hospitalized because of an
attack of renal colic. What emergency drug is to be prescribed in this
case?
A. Paracetamolum
B. Nitrazepamum
C. Pyracetamum
D. Promedolum*
E. Cyclodolum
527.
It is necessary to prescribe a patient a drug, which improves
memory and mental work in case of organic damages of the brain. What
drug should be prescribed?
A. Nitrazepamum
B. Pyracetamum*
C. Diazepamum
D. Hygronium
E. Coffeinum-natrii benzoas
528.
A patient with schizophrenia takes Aminazine. Which of the
pharmacodynamics effects is the basic one in this case?
A. Antipsychotic*
B. Hyperthermic
C. Antiinflammatory
D. Emetic
E. Antiagreggant
529.
Ganglioblockers drugs have which of the following therapeutic
effect?
A. Decrease blood pressure*
B. Increase blood pressure
C. Increase motility of intestine
D. Relaxation of muscles
E. Contraction of pupil
530.
What effects do exist in case of myorelaxants introduction?
A. Relaxation of skeletal muscles*
B. Contraction of pupil
C. Decreasing of intestine motility
D. Increasing of blood pressure
E. Decreasing of eye pressure
531.
Which of the following is NOT a side effect of the cholinoreceptor
blocker (Atropine)?
A. Increased pulse
B. Urinary retention*
C. Constipation
D. Mydriasis
E. Photophobia
532.
Which of the following is NOT a side effect of the Captopril?
A. Rash
B. Angioedema
C. Cough
D. Congestion*
E. Head pain
533.
Which of the following is NOT treated with Epinephrine?
A. Renal disease*
B. Asthma
C. Hypotension
D. Glaucoma
E. Shock
534.
Which of the following is NOT treated with (Ephedrine)?
A. Chronic obstructive pulmonary disease (COPD)*
B.
C.
D.
E.
Hypotension
Congestion
Incontinence
Bronchospasm
535.
Which of the following is NOT treated with Barbiturates?
A. Seizures
B. Hypotension*
C. Insomnia
D. Anxiety
E. Epilepsy
536.
What is the primary usage of beta-blockers agents?
A. Hypotension
B. Hypertension*
C. Diarrhea
D. Chest pain
E. Myasthenia gravis
537.
Indicate the location of beta –adrenoreceptors type:
A. Heart*
B. Glands
C. Smooth muscle
D. Endothelium
E. All of the above
538.
The symptoms of mushroom poisoning include all of the
following EXCEPT:
A. Salivation, lacrimation, nausea, vomiting
B. Dryness of mouth, hyperpyrexia, hallucination*
C. Headache, abdominal colic
D. Bradycardia, hypotension and shock
E. None of the above
539.
Which of the following direct-acting cholinomimetics has the
shortest duration of action?
A. Acetylcholine*
B. Proserinum
C. Galanthamini hydrobromidum
D. Pridostigmini bromidum
E. Cytitonum
540.
M-cholinimimetic agent is:
A. Carbacholinum
B. Pilocarpini hydrochloridum*
C. Cytitonum
D. Alloximum
E. Atropini sulfas
541.
Characteristics of Pilocarpine include all of the following
EXCEPT:
A. It is a tertiary amine alkaloid
B. It causes miosis and a decrease in intraocular pressure
C. Causes a decrease in secretory and motor activity of gut*
D. It is useful in the treatment of glaucoma
E. All of the above
542.
Which of the following cholinesterase inhibitors is irreversible?
A. Carbacholinum
B. Pilocarpini hydrochloridum
C. Proserinum
D. Phosphacolum*
E. Cytitonum
543.
In case of application of what group of drugs does the
accommodation paralysis arise up?
A. М-cholinoblockers*
B. М-cholinomimetics
C. N-cholinomimetics
D. Local anesthetics
E. Diuretics
544.
Proserinum increases all of the following effects EXCEPT:
A. Lacrimation
B. Bronchodilation*
C. Muscle twitching
D. Salivation
E. Bradycardia
545.
Which of the following cholinomimetics is commonly used in the
treatment of glaucoma?
A. Pilocarpini hydrochloridum*
B. Lobelini hydrochloridum
C. Carbocholinum
D. Atropini sulfas
E. Galanthamini hydrobromidum
546.
Which of the following cholinomimetic is most widely used for
paralytic ileus and atony of the urinary bladder?
A. Pilocarpini hydrochloridum
B. Lobelini hydrochloridum
C. Proserinum*
D. Atropini sulfas
E. Phosphacolum
547.
Chronic long-term therapy of myasthenia is usually accomplished
with:
A. Pilocarpini hydrochloridum
B. Lobelini hydrochloridum
C. Proserinum*
D. Atropini sulfas
E. Phosphacolum
548.
Which of the following cholinomimetics is a drug of choice for
reversing the effects of nondepolarizing neuromuscular relaxants?
A. Pilocarpini hydrochloridum
B. Lobelini hydrochloridum
C. Proserinum*
D. Atropini sulfas
E. Phosphacolum
549.
Indicate the reversible cholinesterase inhibitor, which penetrates
the blood-brain barrier:
A. Pilocarpini hydrochloridum
B. Proserinum
C. Carbocholinum
D. Atropini sulfas
E. Galanthamini hydrobromidum*
550.
Which of the following cholinomimetics is used in the treatment
of Atropine intoxication?
A. Pilocarpini hydrochloridum
B. Aceclidinum
C. Carbocholinum
D. Proserinum*
E. Phosphacolum
551.
The symptoms of excessive stimulation of muscarinic receptors
include all of the following EXCEPT:
A. Abdominal cramps, diarrhea
B. Increased salivation, excessive bronchial secretion
C. Miosis
D. Bradycardia
E. Weakness of all skeletal muscles*
552.
Which of the following drugs is used for acute toxic effects of Mcholinomimetics?
A. Atropini sulfas*
B. Proserinum
C. Galanthamini hydrobromidum
D. Carbocholinum
E. Proserinum
553.
The group of nicotinic receptor-blocking drugs consists of:
A. Ganglion-blockers
B. Atropine-similar drugs
C. Neuromuscular junction blockers
D. Anticholinesterases
E. Ganglion-blockers and Neuromuscular junction blockers*
554.
Which of the following drugs is both a muscarinic and nicotinic
blocker?
A. Atropini sulfas
B. Cyclodolum*
C. Galanthamini hydrobromidum
D. Phosphacolum
E. Pirilenum
555.
Indicate a muscarinic receptor-blocking drug:
A. Scopolamini hydrobromidum*
B. Proserinum
C. Galanthamini hydrobromidum
D. Phosphacolum
E. Pirilenum
556.
The effect of the drug on parasympathetic function declines
rapidly in all organs EXCEPT:
A. Eye*
B. Heart
C. Smooth muscle organs
D. Glands
E. All of the above
557.
The mechanism of Atropini sulfas action is:
A. Competitive ganglion blockade
B. Competitive muscarinic blockade*
C. Competitive neuromuscular blockade
D. Noncompetitive neuromuscular blockade
E. All of the above
558.
Which of the following antimuscarinic drugs is often effective in
preventing or reversing vestibular disturbances, especially motion
sickness?
A. Atropini sulfas
B. Scopolamini hydrobromidum*
C. Proserinum
D. Phosphacolum
E. Carbocholinum
559.
Atropini sulfas causes:
A. Miosis, a reduction in intraocular pressure and cyclospasm
B. Mydriasis, a rise in intraocular pressure and cycloplegia*
C. Miosis, a rise in intraocular pressure and cycloplegia
D. Mydriasis, a rise in intraocular pressure and cyclospasm
E. None of the above
560.
Patients complain on dry or “sandy” eyes when receiving large
doses of:
A. Atropini sulfas*
B. Proserinum
C. Phosphacolum
D. Carbocholinum
E. Galanthamini hydrobromidum
561.
Atropini sulfas causes:
A. Bradycardia, hypotension and bronchoconstriction
B. Mydriasis, tachycardia, little effect on blood pressure and
bronchodilation*
C. Decrease in contractile strength, conduction velocity through the
AV node
D. Tachycardia, hypertensive crisis and bronchodilation
E. None of the above
562.
Atropine is frequently used prior to administration of inhalant
anesthetics to reduce:
A. Muscle tone
B.
C.
D.
E.
Secretions*
Nausea and vomiting
All of the above
None of the above
563.
Atropine is now rarely used for the treatment of peptic ulcer
because of:
A. Slow gastric empting and prolongation of the exposure of the
ulcer bed to acid
B. Low efficiency and necessity of large doses
C. Adverse effects
D. All of the above*
E. None of the above
564.
Which of the following antimuscarinic drugs is a selective M1
blocker?
A. Atropini sulfas
B. Scopolamini hydrobromidum
C. Pirenzepinum*
D. Benzohexonium
E. Hygronium
565.
Atropini sulfas causes:
A. Spasmolitic activity*
B. Intestinal hypermotility
C. Stimulation of contraction in the gut
D. Stimulation of secretory activity
E. None of the above
566.
Which of the following drugs is useful in the treatment of uterine
spasms?
A. Proserinum
B. Phosphacolum
C. Carbocholinum
D. Atropini sulfas*
E. Galanthamini hydrobromidum
567.
The pharmacologic actions of Scopolamini hydrobromidum most
closely resemble those of:
A. Proserinum
B. Atropini sulfas*
C. Phosphacolum
D. Carbocholinum
E. Pilocarpini hydrochloridum
568.
Which of the following drugs is useful in the treatment of
Parkinson’s disease?
A. Amizylum*
B. Proserinum
C. Atropini sulfas
D. Phosphacolum
E. Benzohexonium
569.
Which of the following agents is used as an inhalation drug in
asthma?
A. Atropini sulfas
B. Ipratropium bromidum*
C. Lobelini hydrochloridum
D. Amizylum
E. Galanthamini hydrobromidum
570.
Indicate an antimuscarinic drug, which is effective in the treatment
of mushroom poising:
A. Atropini sulfas*
B. Proserinum
C. Pilocarpini hydrochloridum
D. Carbocholinum
E. Aceclidinum
571.
Antimuscarinics are used in the treatment of the following
disorders EXCEPT:
A. Motion sickness
B. Glaucoma*
C. Hyperhidrosis
D. Asthma
E. Intestinal, renal and hepatic colic
572.
The Atropini sulfas poisoning includes all of the following
symptoms EXCEPT:
A. Mydriasis, cycloplegia
B. Hyperthermia, hot and flushed skin
C. Dry mouth
D. Agitation and delirium
E. Bradicardia, orthostatic hypotension*
573.
Contraindications to the use of antimuscarinic drugs are all of the
following EXCEPT:
A. Glaucoma
B. Myasthenia
C. Bronchial asthma*
D. Paralytic ileus and atony of the urinary bladder
E. All of the above
574.
The applications of the ganglion blockers have disappeared
because of all of the following reasons EXCEPT:
A. Orthostatic hypotension
B. Lack of selectivity
C. Homeostatic reflexes block
D. Respiratory depression*
E. None of the above
575.
Analeptical remedy of reflective type from the H-cholinomimetics
group was gi ven to the patient for restoration of breathing after
poisoning with carbon monoxide. What medicine was prescribed to the
patient?
A. Lobeline hydrochloride*
B. Adrenalin hydrochloride
C. Atropine sulphate
D. Pentamin
E. Mesaton
576.
At adult man after consumption of food the Amanita muscaria
mushrooms the excitation, increased sweating, appeared the phenomena
of acute gastroenteritis, the pupils narrowed through 15-20 min was
noted. Then cramps, bradycardia, considerable general weakness,
somnolence, the collapse developed. The doctor immediately injected to
the sick patient antidote from the group:
A. М-cholinolitics*
B. N-cholinomimetics
C. N-cholinolitics
D. Anticholinesterase agents
E. Antiagreggant agents
577.
Ganglion blocking drugs are used for the following emergencies
EXCEPT:
A. Hypertensive crises
B. Controlled hypotension
C. Cardiovascular collapse*
D. Pulmonary edema
E. Peripheral vascular spasms
578.
Agents that produce neuromuscular blockade act by inhibiting:
A. Interaction of acetylcholine with cholinergic receptors*
B. Release of acetylcholine from prejunctional membrane
C. Packaging of acetylcholine into synaptic vesicles
D. Reuptake of acetylcholine into the nerve ending
E. All of the above
579.
Indicate the long-acting neuromuscular blocking agent:
A. Tubocurarini chloridum*
B. Mellictinum
C. Dithylinum
D. Cyclodolum
E. Amizylum
580.
Which of the following neuromuscular blocking drugs is an
intermediate-duration muscle relaxant?
A. Tubocurarini chloridum
B. Mellictinum*
C. Dithylinum
D. Pipecuronium bromidum
E. Amizylum
581.
Which cholinergic blocking agent is contraindicated in patients
with glaucoma?
A. Proserinum
B. Atropini sulfas*
C. Aceclidinum
D. Pilocarpini hydrochloridum
E. Carbocholinum
582.
Butyrophenone derivative antipsychotic drug is:
A. Amizyl
B. Cyclodol
C. Chlozepidum
D. Haloperidol*
E. Atropini sulfas
583.
An example of an "atypical" antipsychotic agent:
A. Thioridazine
B. Haloperidole
C. Clozapine*
D. Mellictine
E. None of the above
584.
Antipsychotic drug with least extrapyramidal toxicity:
A. Aminazinum
B. Haloperidole
C. Clozapine*
D. Mellictine
E. None of the above
585.
Patient complaints to dizziness, nausea, salivation and spastic
stomachaches. He was delivered to the hospital. The diagnosis:
poisoning by the phosphor organic substance. What medicines must be
included to the complex therapy?
A. Atropine sulfate and Dipirоxim*
B. Tiosulfate sodium and Bemegridum
C. Tetacin-calcium and Unitiolum
D. Nalorphine hydrochloride and Bemegridum
E. Glucose and Bemegridum
586.
The woman of 63 years for renewal of functions of CNS after the
stroke of brain injections of Galantamine was recommended. What is the
mechanism of action of this drug?
A. Block of cholinesterase*
B. Block of MAO
C. Block of GABA-receptors
D. Block of Catalase
E. Block of COMT
587.
To patient with signs of poisoning by phosphor organic substance
injected cholinesterase reactivators. Indicate a mechanism of action of
this group of drugs:
A. Inactivation of cholinesterase
B. Block of cholinoreceptors
C. Activate of cholinoreceptors
D. Oppression of acetylcholine synthesis
E. Dephosphorilation of cholinesterase with renewal of its activity*
588.
Side-effects of Proserini include:
A. Hypertension
B. Increasing of the intra-eye pressure
C. Headache
D. Diarrhea*
E. Hypertension
589.
Scopolamine hydrobromide have which of the following
therapeutic effect?
A. Reduce intraocular pressure
B. Air sick*
C. Atony of intestine
D. Arterial hypertension
E. Myorelaxation
590.
What is indication of Cholinergic (parasympathomimetic) drugs?
A. Treating a postoperative patient who has bradycardia
B. Preventing salivation and sweating
C. Inhibiting muscular activity in the bladder
D. Treating a patient who has paresis and paralysis*
E. Hypertonia
591.
What is therapeutic indication of Phosphacolum?
A. The treatment of glaucoma*
B. Dislocation of lens
C. Myasthenia
D. At postoperative atone of intestine and of urinary bladder
E. Stop action on the eye of atropinum
592.
The patient with nephrolithiasis suffered from acute spastic pain.
Some narcotic analgesic, which hasn’t spasmogenic effect, was
introduced to the patient with atropin for the prevention of the pain
shock. What preparation was introduced to the patient?
A. Promedol*
B. Paracetamol
C. Haloperidol
D. Lobelini hydrochloride
E. Phosphacol
593.
The patient with unoperative gastric carcinoma was prescribed
promedol for pain syndrome reducing. In time decreasing anesthetic
effect, short length of action and acute increasing of pain by the whole
body were marked with the patient. The doctor explained that it was:
A. Promedol can accumulate
B. Psychic dependence
C. Addiction developing*
D. Tachyphylaxis appearing
E. None of the above
594.
After operation of reposition of femur fracture with the using of
tubacurarine, breathing of patient did not resume. What is needed to
inject to sick for the removal of relaxation?
A. Platyphylline
B. Proserine*
C. Cyclodole
D. Atropine
E. Acetylcholine
595.
At 42 years old woman, who carried an operation on kidney, after
anesthesia the phenomena of recuraresation developed and breathing
halted. It was used Dithyline as myorelaxant. What agent is most
expediently to use for renewal of muscles tonus?
A. Proserine
B. Blood plasma*
C. Caffeine
D. Galantamine hydrobromide
E. Atropine
596.
Side effects to expect from anticholinergic (parasympatholytic)
agents, such as atropine, include all of the following except:
A. Dilated pupils (mydriasis)
B. Urinary retention
C. Dry mouth
D. Diarrhea*
E. Paralysis of accommodation
597.
What agent is used in hypotensive conditions, rhinitis, for
prolongation of local anaesthetics action?
A. Proserinum
B. Hygronium
C. Mesatonum
D. Atropine sulfas
E. Methacinum
598.
What drug may cause bronchospasm, increase of intestinal motor
function and digestion glands secretion, dyspepsia, bradycardia,
intencification of ulcerative disease, retention of fluid in organism,
orthostatic collapse?
A. Lobelinum
B. Pilocarpini hydrochloridum
C. Anaprilinum
D. Octadinum*
E. Salbutamolum
599.
What preparation is used in case hypertension, ischemic heart
disease, angina pectoris, supraventricular and other arrhythmias,
glaucoma?
A. Salbutamolum
B. Anaprilinum*
C. Nitrozepamum
D. Adrenalini hydrochloridum
E. Octadinum
600.
What preparation is used in hypotensive conditions, anaphylactic
shock, hypoglycemic coma, in case of myocardial conductivity
disturbance, in heart arrest?
A. Metoprolol
B. Hygronium
C. Octadinum
D. Anaprilinum
E. Adrenalini hydrochloridum*
601.
A patient with bronchial asthma had been taking tablets which
caused insomnia, headache, increased blood pressure. What medicine
can cause such complications?
A. Anapriline
B. Ephedrine*
C. Nitrozepame
D. Lobeline
E. Salbutamole
602.
After Dithyline injection (1 mg/kg) long-term muscle paralysis has
been observed (for over 2 hours). What cure must be used for this
patient?
A. Adrenaline
B. Blood transfusion*
C. Proserine
D. Anaprilin
E. Salbutamole
603.
At 39 years old woman for the removal of high blood pressure
crisis the solution of Pentamine was injected. What is the mechanism of
medicine action?
A. Depression of N-cholinoreceptors*
B. Depression of М-cholinoreceptors
C. Stimulation of М-, Н-cholinoreceptors
D. Stimulation of N-cholinoreceptors
E. Stimulation of М-cholinoreceptors
604.
For the patient with the femur fracture, for reducing of sceletal
muscles tension during reposition of bone, it is necessary to prescribe
short acting myorelaxant.
A. Dithyline*
B. Anapriline
C. Tubacurarine
D. Atropine
E. Adrenaline
605.
The man appeared at the trauma department with diagnosis:
fracture of femur with displacement. For reposition of bone physician
used 10 ml of 2 % solution of Dithyline i/v, as a result protracted apnoe
and myorelaxation developed. Deficit of what enzyme caused such
pharmacogenetic enzymepatia?
A. Pseudocholinesterase*
B. Uridindiphosphoglucoronic transferase
C. Glucoso-6-phosphatdehydrogenase
D. Met-hemoglobinreductase
E. N-acetyltransferase
606.
The problem of skeletal muscle contraction exists at child after
poliomyelitis. What medicine is possible to prescribe?
A. Galantamine hydrobromide*
B. Platyphylline
C. Methacine
D. Atropine sulfate
E. Tubacurarine
607.
At the combine anesthesia at the patient, to whom the stomach
resection was carried out, was used the tubacurarine chloride as
myorelaxant. What agent-antagonist is necessary to use for renewal of
breathing?
A. Cytotone
B. Dithyline
C. Proserine*
D. Ethymisole
E. Atropine sulfate
608.
The analeptic agent of reflex type from the N-cholinomimetics’
group injected to the patient with the purpose of renewal of breathing in
case of poisoning by the carbon monoxide. What agent was used in this
case?
A. Atropine sulfate
B. Adrenaline hydrochloride
C. Pentamine
D. Mesatone
E. Lobeline hydrochloride*
609.
An example of a cardioselective beta-blocker includes:
A. propranolol (Inderal)
B. nadolol (Corgard)
C. tenolol (Tenormin)*
D. timolol (Timoptic)
E. lidocaine (Xylocaine)
610.
Beta-blockers are used to treat which of the following disorders?
A. Hypertension
B. Bronchial asthma.
C. Hypotonia.
D. Insomnia
E. Chronic obstructive pulmonary disease (COPD)
611.
Cholinergic (parasympathomimetic) drugs have which of the
following therapeutic effects?
A. Urinary retention
B. Increased secretion of the bronchial, digestive and sweat gland*
C. Mydriasis
D. Vasoconstriction
E. Hypertonia
612.
Drugs of what group are used for controlled hypotension?
A. Ganglioblockers*
B. Sympatholitics
C. alpha-adrenoblockers
D. Antagonists of the calcium ions
E. Inhibitors of angiotensine-coversive enzyme
613.
Epinephrine, as an adrenergic (sympathomimetic) drug, produces
which of the following therapeutic effects?
A. Urinary retention
B. Bronchial constriction
C. Increased heart rate and contractility*
D. Decreased intestinal motility
E. Increased intestinal motility
614.
Nonselective beta-blockers may be used to treat hypertension and:
A. Chronic obstructive pulmonary disease (COPD)
B. Heart failure
C. Heart block
D. Supraventricular arrhythmia*
E. Bronchial asthma
615.
Side-effects of Hygronium include:
A. Diarrhea
B. Hypertension
C. Orthostatic hypotension*
D. Postoperative ischemic colitis
E. Headache
616.
Cytitone is used
A. For the removal of bronchospasm
B. For the medical treatment of intestine atony
C. For stimulating breathing in case of poisoning by the carbon
monoxide*
D. For the removal of attacks of angina pectoris
E. For the medical treatment of glaucoma
617.
Administration of an MAO inhibitor would most likely cause
changes in the CNS concentration of:
A. acetylcholine
B. histamine
C. norepinephrine*
D. serotonin
E. nitrazepam
618.
Antidepressant therapeutic effects may not be seen for two to four
weeks:
A. serotonin-specific reuptake inhibitors (SSRIs)
B. tricyclics antidepressants*
C. antiplatelets
D. both
E. neither
619.
After examining the patient was prescribed a remedy that is used
in case of neurosis or neurosis-like situation, hyper excitability and
irritability. What pharmacological group does this remedy belong to?
A. Analgetics
B. Anxiolytics*
C. Analeptics
D. Antipsychotics
E. CNS stimulants

620.
Antidepressant used for treatment of endogenous depressions
(schizophrenia, manic-depressive psychosis) is
A. Proserine
B. Caffeine
C. Amitriptyline*
D. Bemegride
E. Sibazone
621.
At the hands of nurse, working at the psychiatric unit during two
years symptoms of neurodermatitis appears. What drug can cause such
adverse effect?
A. Aminazine*
B. Morphine
C. Paracetamole
D. Atropine
E. Diazepame
The patient instead Aminazine (Chlorpromazine hydrochloride) was prescribed
another neuroleptic. What drug belongs to this group?
A Haloperidole*
B Phentanile
C Paracetamol
D Sibazone
E Morphine
622.
The typical complication, developing after long-term
administration of Aminazinum and other neuroleptics:
A. Euphoria
B. Increase of arterial pressure
C. Vomiting
D. Parkinsonism*
E. Bradycardia
623.
The typical complication, developing after prolonged usage of
Diazepamum and other tranquilizers:
A. Drug dependence*
B. Extrapyramidal disorders
C. Gastritis
D. Bronchial asthma
E. Arterial pressure increase
624.
Primary agent used in chronic management of mania in bipolar
disorder:
A. paracetamol
B. lithium*
C. valproic acid (Depakene, Depakote)
D. imipramine (Tofranil)
E. phentanile
625.
Primary use of fluoxetine (Prozac):
A. treating obsessive-compulsive disorder
B. management of morbid obesity
C. treating endogenous depression*
D. management of alcohol withdrawal
E. treating anxiety
626.
Therapeutic uses of lithium salts:
A. Prophylaxis and treatment of bipolar disorders (manic-depressive
disorder)*
B. Asthenia
C. Insomnia
D. Cardiac arrhythmia
E. Epilepsy
627.
An atypical antipsychotic medication useful for treatment of
schizophrenia is:
A. Closapine*
B. Morphine
C. Paracetamole
D. Haloperidole
E. Diazepame
628.
Basic difference of neuroleptics from tranquilizers:
A. Anticonvulsant properties
B. Antipsychotic effect*
C. Do not affect the vegetative nervous system
D. Do not intensify the action of anesthesia drugs
E. Cause tachyphylaxis
629.
Caffeine action caused by excitation of brain stem centers:
A. Tranquilizer
B. Improvement of memory
C. Breathing stimulation*
D. Mental and physical capacity increase
E. Tachycardia
630.
Caffeine is
A. Analeptic and antidepressant
B. Analeptic and psychomotor stimulant*
C. Antidepressant and psychomotor stimulant
D. Antidepressant and nootropic
E. Analeptic and nootropic
631.
Mechanism of antipsychotic action of neuroleptics is:
A. Blockade of cholinoreceptors in CNS
B. Blockade of dopamine D2-receptors in CNS*
C. Blockade of adenosine receptors in CNS
D. Blockade of histamine receptors in CNS
E. Activating of GABA-receptors in CNS
632.
Neuroleptics are administered for:
A. Psychoses*
B. Neuroses
C. Hyperkinesis
D. Collapse
E. Parkinson’s disease
633.
Pyracetam nootropic activity reveals in
A. Delirium and hallucinations
B. Fear
C. Improvement of studying and memory*
D. Fatigue
E. Depression
634.
Prolonged administration of tranquilizers is limited due to their
ability to cause:
A. Drug dependence*
B. Myorelaxation of central genesis
C. Intensifying of analgesics action
D. Somnolent effect
E. Anticonvulsant effect
635.
Sulfocamphocainum is used:
A. For medulla centers activation*
B. For endogenous depression
C. For rheumatism
D. For arterial hypertension
E. For tachyarrhythmias
636.
The main complications after neuroleptics administration:
A. Extrapyramidal disorders*
B. Arterial pressure increase
C. Bradycardia
D. Drug dependence
E. Euphoria
637.
The drug which after long-term administration causes
phenomenon of bromism:
A. Sodium bromide*
B. Sodium hydrocarbonate
C. Sodium sulfate
D. Sodium citrate
E. Atropine
638.
The effect of Diazepamum
A. Anxyolitic*
B. Antipsychotic
C. Antivomiting
D. Hypothermal
E. M-cholinoblocking
639.
The excitation of benzodiazepine receptors is accompanied with:
A. Anxiolytic effect*
B. Antipsychotic effect
C. Antivomiting effect
D. Arterial pressure increase
E. Arterial pressure decrease
640.
The mechanism of action of sodium bromide
A. Excitation of M-cholinoreceptors in the brain
B. Intensifying processes of depression in the brain*
C. Intensifying processes of excitation in CNS
D. Blockade of the histamine receptors in CNS
E. Blockade of dopamine receptors in CNS
641.
The physician monitors a patient taking an antipsychotic
medication for side effects, including:
A. Hyper salivation
B. Hypetension
C. Diarrhea
D. Extrapyramidal syndrome*
E. Cramps
642.
The symptoms of bromism (side effect of long-term bromides
administration):
A. *Acne rashes, somnolence, rhino rhea*
B. Excitation of CNS, dryness of mucous membranes
C. Constipation, stomach-ache
D. Tachycardia, insomnia
E. Nausea, vomiting
643.
Side effects to expect from anticholinergic (parasympatholytic)
agents, such as atropine, include all of the following except:
A. Dilated pupils (mydriasis)
B. Urinary retention
C. Dry mouth
D. Paralysis of accommodation
E. Decreasing of intra-eye pressure*
644.
The analeptic agent of reflex type from the N-cholinomimetics’
group injected to the patient with the purpose of renewal of breathing in
case of poisoning by the carbon monoxide. What agent was used in this
case?
A. Atropine sulfate
B. Adrenaline hydrochloride
C. Pentamine
D. Mesatone
E. Lobeline hydrochloride*
645.
What agent is used in hypotensive conditions, rhinitis, for
prolongation of local anaesthetics action?
A. Proserinum
B. Hygronium
C. Anaesthesinum
D. Mesatonum*
E. Atropine sulfate
646.
What agent may block postsynaptic N-cholinoreceptors of the
sympathetic and parasympathetic ganglion, adrenal medulla and carotid
zone?
A. N-cholinomimetics
B. Ganglioblockers*
C. M-N- cholinomimetics
D. M-cholinoblockers
E. Adrenomimetics
647.
A man, 36 years old, with a craniocerebral trauma has diminished breath
sound, thread pulse, reflexes are absent. What route of the administration of
pyracetame is the most appropriate in this case?
A. Rectal
B. Subcutaneous
C. Peroral
D. Intravenous*
E. Inhalation
648.
A 35-year-old female patient suffering from ischemic heart disease has
been prescribed Propranolol. But having found a concomitant disease, the
doctor decided to replace this drug by Atenolol. What disease was found by the
doctor?
A. Cholecystitis
B. Arterial hypertension
C. Duodenal ulcer
D. Myasthenia
E. Bronchial asthma*
649.
Clinical usage of narcotic analgetics:
A. Relieves dyspnea in CH
B. Reduces pulmonary edema and pain in myocardial infarction
C. Reduces preoperative pain
D. None of above
E. All of above *
650.
As aspirin depresses cyclooxygenas activity as he has antiinflammative
action. What biology active substance level will decrease in such case?
A. Iodothyronines
B. Cathecholamines
C. Leukotrienes
D. Prostaglandins*
E. Biogenic amines
651.
The patient with unoperative gastric carcinoma was prescribed promedol
for pain syndrome reducing. In time decreasing anesthetic effect, short length
of action and acute increasing of pain by the whole body were marked with the
patient. The doctor explained that it was:
A. Addiction developing*
B. Tachyphylaxis appearing
C. Psychic dependence
D. Promedol can accumulate
E. Decreased resorption of promedol in renal tubule
652.
The doctor notes lithium on a patient's drug history upon admission. The
doctor would suspect that this patient suffers from:
A. Obsessive-compulsive disorder
B. Absence seizures
C. Bipolar disorder*
D. Paranoid schizophrenia
E. None answer is correct
653.
Characteristics of lithium toxicity:
A. remor
B. diabetes insipidus
C. all of the above *
D. hypothyroidism
E. changes in the electrocardiogram
654.
Indicate the mechanism of action of Imizine:
A. Blockade of monoaminoxidase(MAO)
B. Activation of noradrenaline
C. Blockade of neuronal reuptake of serotonin and noradrenaline*
D. Blockade of GABA-receptors
E. Stimulation of adenosine receptors
655.
Neuroleptic which rarely causes Parkinson syndrome due to its Mcholinoblocking activity
A. Aminazine
B. Rezerpine
C. Haloperidolum
D. Clozapinum*
E. Anaprilin
656.
What neuroleptic used for neuroleptanalgesia:
A. Aminazine
B. Triftazine
C. Rezerpine
D. Haloperidole
E. Droperidole*
657.
The excitation of benzodiazepine receptors is accompanied with:
A. Anxiolytic effect*
B. Antipsychotic effect
C. Antivomiting effect
D. Arterial pressure increase
E. Arterial pressure decrease
658.
At 5 years old child next symptoms were set by doctor: moving
exitation, delirium, hoarse voice, dilated pupils which are not irresponsive on
light, dry, hot, hyperemic skin, tachycardia, tachypnoe. The indicated
symptoms arose up after consumption by child of berries of Belladona. Drugs
of what numerated pharmacological groups of medicines is necessary to
prescribe?
A. N-cholinomimetics
B. N-cholinolitics
C. Anticholinesterase agents*
D. M-cholinomimetics
E. Reactivators of cholinesterase
659.
At the child next symptoms were noted: moving exitation, delirium,
hoarse voice, dilated pupils which are not irresponsive on light, dry, hot,
hyperemic skin, tachycardia, tachypnoe. The indicated symptoms arose up
after consumption by child of berries of Belladona. Drugs of What numerated
pharmacological groups of medicines is necessary to prescribe?
A. N-cholinolitics
B. N-cholinomimetics
C. Anticholinesterase agents*
D. M-cholinomimetics
E. Reactivators of cholinesterase
660.
What group of agents does belong Ipratropium bromide to?
A. Adrenoblockers
B. М-cholinomimetics
C. N-cholinomimetics
D. М-cholinoblockers*
E. Anticholinesterase agents
661.
What group of agents is used for the ulcerous illness of stomach and
duodenum bowel?
A. N-cholinomimetics
B. М-cholinoblockers*
C. Myorelaxants
D. Adrenomimetics
E. Anticholinesterase agents
662.
A 49-year-old man who poisoned himself with mercury dichloride was
taken to the admission room in grave condition. What antidote should be
immediately introduced?
A. Unithiol*
B. Dipiroxim
C. Atropine
D. Nalorphine
E. Isonitrosine
663.
A 45-year-old woman with red and itchy eczematoid dermatitis visits
your office. She had a dental procedure one day earlier with administration of a
local anesthetic. There were no otherfindings, although she indicated that she
had a history of allergic reactions. Which of the following drugs is most likely
involved?
A. Procaine*
B. Cocaine
C. Lidocaine
D. Bupivacaine
E. Etidocaine
664.
A 55-year-old patient with continuing ventricular arrhythmias was
admitted to the hospital. The patient is taking timolol drops for glaucoma, daily
insulin injections for diabetes mellitus, and an ACE inhibitor for hypertension.
You have decided to use phenytoin instead of procai-namide. What is the
reason?
A. The anticholinergic effect of procainamide would aggravate glaucoma*
B. The local anesthetic effect of procainamide would potentiate diabetes
C. The hypertensive effects of procainamide would aggravate the
hypertension
D. The local anesthetic effect of procainamide would aggravate the
hypertension
E. The cholinergic effects of procainamide would aggravate the diabetes
665.
A patient has got a spasm of smooth muscles of bronchi. Activators of
what membrane cytoreceptors are phisiologi-cally reasoned to stop an attack?
A. β-adrenoreceptors*
B. α-аdrenoreceptors
C. α-andβ-аdrenoreceptors
D. Н-cholinoreceptors
E. М-cholinoreceptors
666.
Analeptical remedy of reflective type from the H-cholinomimetics group
was given to the patient for restoration of breathing after poisoning with carbon
monoxide. What medicine was prescribed to the patient?
A. Lobeline hydrochloride*
B. Atropine sulphate
C. Adrenalin hydrochloride
D. Mesaton
E. Pentamin
667.
To anaesthetize the surgical treatment of burn surface, a patient was
intravenously injected a medication for short-acting narcosis. 1 minute later the
patient being under anaesthesia showed increased blood pressure, tachycardia,
increased tone of skeletal muscles; reflexes remained. After recovering from
anaesthesia the patient had disorientation and visual hallucinations. What
medication was the patient injected?
A. Ketamine*
B. Sombrevin
C. Diethyl ether
D. Thiopental sodium
E. Nitrous oxide
668.
Desulfiram is widely used in medical practice to prevent alcocholism. It
inhibits aldehyde dehydrogenase. Increased level of what metabolite causes
aversion to alcochol?
A. Acetaldehyde*
B. Ethanol
C. Malonyl aldehyde
D. Propionic aldehyde
E. Methanol
669.
A patient had to go through an operation. Doctors introduced him dithylinum (listenone) and performed intubation. After the end of operati-on and
cessation of anesthesia the independent respiration wasn’t restored. Which
enzyme deficit prolongs the action of muscle relaxant?
A. Pseudocholinesterase*
B. Succinate dehydrogenase
C. Carbanhydrase
D. N-acetyltransferase
E. K-Na-adenosine triphosphatase
670.
63 y.o. man with collapse symptoms was delivered to the emergency
hospital. A doctor chose noradrenaline in order to prevent hypotension. What is
the action mechanism of this medication?
A. Activation ofα1-adrenoreceptors*
B. Activation of serotonin receptors
C. Activation of β-adrenoreceptors
D. Activation of dopamine receptors
E. Block of M-cholinoreceptors
671.
A patient with II stage hypertensi-on has been taking one of hypotensive
medications for the purpose of treatment. After a time arterial pressure
decreased, but the patient started complaining of flaccidity, sleepiness,
indifference. A bitlater he felt stomach pain. He was di-agnosed with ulcer.
What hypotensive medication has the patient been taking?
A. Reserpine*
B. Dibazole
C. Furosemide
D. Verapamil
E. Captopril
672.
What is the influence of cholinesterase inhibitors on myoparalytic action
of antidepolarizative myorelaxants?
A Strengthen
B Lengthen
C Lessen
D Shorten*
E No effect
673.
What drug can remove bronchial spasm?
A Anaprilinum
B Ephedrini hydrochloridum*
C Noradrenalini hydrotartras
D Naphthysinum
E Prasosinum
674.
What effect is observed after using ganglion blockers ?
A Increasing of blood pressure
B Decreasing of blood pressure*
C Increasing of peristaltic
D Increasing of secretion of digestive glands
E Miosis
675.
What is the indication of usage of Melictinum:
A Intubation of trachea
B Acute pain of different origin
C Muscle relaxation during surgical operation*
D Hypertension
E Tetanus
676.
Indication for atropini sulfas usage.
A Hypoacide gastritis
B Increasing of intraophtalmic pressure
C Intoxication with antycholynaesterase substances*
D Intestinal atonia
E Hyperglycemia
677.
What cause therapeutic effect of levodopa on Parkinson disease?
A Stimulation of cholinergic processes in CNS
B Inhibition of cholinergic processes in CNS
C Stimulation of dophaminergic processes in CNS*
D Inhibition dophaminergic processes in CNS
E Activation of the brain cortex
678.
What drugs are used for potentiate of therapeutic effects and decreasing
of side effects of Levodopa?
A Cholinesterase inhibitors
B Inhibitors of monoaminooxidase
C Inhibitors of peripheral DOPA decarboxylase*
D Reactivates of cholinesterase
E M-cholinomimetics
679.
To determine the characteristic feature of narcotic analgesics:
A Eliminated only pains, which are caused by inflammation
B Eliminates pains by any origin*
C Have anti-inflammatory action
D Does not cause drug dependence and habit
E Increased breathing volume
680.
What main indication for using of narcotic analgesics?
A Headache
B Neuralgia
C Pain on malignant tumours*
D Muscle, joint pains on inflammation
E Rheumatic pains
681.
Note the peculiarity of codeinum action
A Has a good analgesic activity
B Depress the central sections of cough reflex
C Peripherally depress cough reflex*
D Cause addiction and medical dependency
E Is used for treatment of inflamation
682.
To indicate the peculiarity of novocainamidum:
A It is used only parentally
B Decrease arterial pressure*
C Increase arterial pressure
D Doesn’t influence on arterial pressure
E It is used only orally
683.
To note the antiarrithmic drugs from the membrane stabilization group.
A Lidocainum*
B Atropinum
C Izadrinum
D Ephedrinum
E Difeninum
684.
To note the side effect, which can be observed during the using of
anaprilinum.
A
B
C
D
E
Constipation
Evidence tachycardia
Increasing of atrio-ventricular conduction
Hypertension
Increasing of bronchial tone*
685.
The correct statement about antihypertesive action of captoprilum is:
A Activate renin excretion in kidneys
B Inhibiting the angiotensinconverting enzyme*
C Blocking the angiotensine receptors
D Blocking the sympatic nodules
E Blocking -adrenoreceptors
686.
Note the correct statement about apomorphyni hydrochloridum
A Direct stimulate influence on vomiting center*
B Activate the chemo-receptors of vomiting start-zone in medulla
oblongata
C Reflector excitement of vomiting center from activation of mucous
receptors in stomach
D Does not cause he vomiting
E Is used for treatment of ulcer disease
687.
A patient who suffers from insomnia caused by emotional disorder was
prescribed a hypnoticdrug with tranquillizing effect. What hypnotic was
prescribed?
A Nitrazepam*
B Phenobarbital
C Chloral hydrate
D Sodium ethaminal
E Bromisoval