Group 37 – Arvin Soepriatna (Presenter), Chris Peng,
Blessan Sebastian
Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.
BME 401, Prof. Anastasio
10/28/2013
Need
 More efficient treatment process regarding drug
delivery with chemotherapeutic agents
 Currently no method to exclusively target tumors
 Chemotherapy side effects are serious
 Increased drug dosage without side-effects
 Shorter and more effective treatment time
Specific Design Requirements
Parameters
Specifications
Imaging Phantom Size
< 3x3 ft
Imaging Phantom Weight
≤ 30 lbs
Magnet Device Controller
< 3x3 ft
Magnetic Field Strength
<1T
Localization Duration
< 5 min
Imaging Depth
< 10 cm
Standard Operation Time
< 4 hrs
System Power Inlet
Standard 110V
Phantom Designs
• Blood Vessel
Phantom
• Box Obstacle
Course
• 3D Styrofoam Brain
Phantom
Magnetic Control Device
 Cartesian
 Conical
 Spherical
Advantages and Disadvantages
Imaging Technology Alternatives
 Positron Emission Tomography (PET)
 Measures γ-rays emission from radioactive tracer[1]
 Half-life of tracers[2]
 13N

~ 20 min.
18F ~ 110 min.
 Recent discoveries
 64Cu

~ 12.7 hours [3]
Nanoparticle conjugation
[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications
in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.
[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.
[3] Anderson, Carolyn J., Farrokh Dehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging
Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.
Imaging Technology Alternatives
 Single Photon Emission Computed Tomography
(SPECT)
 Similar to PET


γ-rays emission
Radioactive tracer
 Average half-lives ~6 hours[1]
 Difference from PET[2]


Lower resolution
High Noise
[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.
[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine
Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
Imaging Technology Alternatives
 Doppler Ultrasound
 Measures the time it takes for pulse signals to be
returned to the receiver from its generation.[1]
 High resolution images
 Problem:


Distortion through thick bones[2]
High signal to noise ratio
 Transcranial Ultrasound

Suboccipital Window [3]
[1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.
[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications
in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.
[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and
Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.
Imaging Technology Alternatives
 Spectral Computed Tomography (CT)
 Measures X-ray attenuation coefficient
 Utilizes photon counting detectors [1]


Broad spectrum info from X-ray
Lower dosage of X-ray
 High Resolution
[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral
CT Images. 2011. Web. 26 Oct. 2013.
Advantages and Disadvantages
[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their
Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.
[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine
Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
Chosen Design
 Magnetic Control Device: Conical Movement
 Imaging Technology: Transcranial Doppler Ultrasound
Phantom
 Styrofoam thickness: 3cm
 Model skull + brain
 IV tubing Diameter: 0.5 cm
 CSF = 0.7 – 1.0 mPa*s @37o C[1]
 Saline = 0.72 mPa*s[2]
 Pathway fixtures
 Plastic hooks
 Thin plastic cable wires
[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science
Business Media, 2011. p. 139. eBook.
[2] Kestin, Joseph, H. Ezzat Khalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys.
Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.
Conical Magnetic Control Device
 Joint modification of the machine made by Pulse
Therapeutics
 Motor specs for joints
 300 Watts
 Motor specs for rotating magnet
 Up to 300 RPM
Peak Voltage Output of Magnet
 Voltage measured using 3D magnetic transducer probe
Doppler Ultrasound
 Location of transducer
 Angle of incidence
 Properties of transducer
 For adults[1]

3-MHz transducers
 For pediatric

5-MHz transducers
[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and
Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.
Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.
Project Timeline
Team Organization
Team Member
Responsibilities
Chris Peng
Webpage, CAD Specialist, MATLAB
specialist
Arvin Soepriatna
Progress Presentation
Imaging Research, Experimental
Analysis
Blessan Sebastian
Final Presentation
Design Parameters and Safety, Phantom
Development