MICR 424/524 Medical and Veterinary Virology
Spring-2012
Internet Course.
Course Format:
On-line Lecture and Individual Study
Credits.
3 credits
Required Texts:. Viruses and human disease by Strauss et al. (AP Elsevier,
2nd edition),
Auxiliary Suggested References:
1) Fields Virology – 2nd and 5th editions
2) Virology – 3rd edition (Levy, Fraenkel-Conrat, Owens)
3) Veterinary Virology – 3rd edition (Fenner et al)
4) Medical Virology – 3rd edition (White and Fenner)
Course URL- https://d2l.sdbor.edu/
MICR-492/592-S03D-2012SP Tp-Virology-Chase
https://d2l.sdbor.edu/d2l/lp/homepage/home.d2l?ou=342978
Instructor
Dr. Christopher Chase
Office:
ADRDL Rm 125
Tel:
605-688-5652
E-mail:
Christopher_Chase@sdstate.edu
Office Hours: By appointment
Contact Information: I prefer e-mail contact, and check it frequently. Please use my
SDSU and not the d2l site. This provides us with a record of your communication, and
you with a guarantee that I received it (I reply to all e-mails). Due to my extensive travel
schedule, all communications will be via my SDSU email account. All emails will be
answered within 24 to 48 hours. Any technical issues can be addressed to John Howard
via his SDSU email account (john.howard@sdstate.edu).
Course Objectives.
1. The goal of this course is to provide students with an in-depth knowledge
on virus characterization, structure, and replication and on molecular pathogenesis of
viral diseases in human and animals.
2. Introduce graduate level students to grant writing.
3. Develop and apply concepts and terminology.
4. Reinforce skills in critical thinking and communication.
A piece of advice. Virology is in integrated subject. What we start with is what we end
with. We often look at the same topic from several angles, which are often scattered
among several chapters of the textbook. It is your responsibility to learn the material in
the textbook, under the guidance of the instructors. While we will not cover all the
material in the book, we will cover material from each individual chapter. There is
therefore a large amount of new vocabulary and processes to learn. Nevertheless, it is
important to understand that material covered in this course builds upon a pre-existing
knowledge of basic molecular biology, microbiology, and chemistry. Use the book,
especially the index, to look up material prior to lecture. It will take a significant portion
of your time to make sure you have topics organized. While it is important to know
proper names and terms for things we discuss, if you think in terms of processes the
material will be much easier to understand.
Grading Scheme (Undergraduate):
Term Tests (3)
90 points (30 points/each)
Final Exam
60 points
Total
150 points
60% - 20% Each
40%
100%
Grading Scheme (Graduate)
Term Tests (3)
Grant Assignment
Final Exam
Total
60% - 20% Each
10%
30%
100%
90 points (30 points/each)
15 points
45 points (60 questions)
150 points
Exams will be taken on-line. All exams will be timed and will be 50 minutes. The Final
exam will be 120 minutes.
In general, grading for this course will be firm, based on the following standards:

90.0 – 100.0% = A

80.0 – 89.9% = B

70.0 – 79.9% = C

60.0 – 69.9% = D

0.0 - 59.9% = F
Practice Exams and Assignments: Practice exams are available to download. Online selfcheck practice assignments will not be used.
Term Tests will be multiple choice or true-false. Each test will consist of approximately
30 multiple choice, best-answer questions..
Final Exam: Similar in format to the term tests, with 60 questions total. Material will be
largely based upon lecture material covered during the last 25% of the course, but will
require a comprehensive understanding of concepts covered in the first 75% of the
course.
Research proposal (Graduate students only):
Pick a virology related topic, and it may be related to the virus in your thesis work but
should be a different approach or an extension of your thesis works. The proposal should
consist of a project summary, objectives, background and significance, research design
and methods and references. Additional guidelines will be provided. The proposal is
limited to10 pages maximum. Grant topics are due on March 2, 2012. The grant due
on April 27, 2012 by 5 PM. You will lose 5 points for each day that the grant is late.
ADA statement: Students are entitled to “reasonable accommodation” under the
provisions of the Americans with Disabilities Act. Those in need of such accommodation
should notify the instructor and make appropriate arrangements with the SDSU Office of
Disabilities Services, Wintrode Student Success Center (SWSC) 110, 688-4504 or 6884032.
Freedom in learning:
Students are responsible for learning the content of any course of study in which they are
enrolled. Under Board of Regents and University policy, student academic performance
shall be evaluated solely on an academic basis and students should be free to take
reasoned exception to the data or views offered in any course of study. Students who
believe that an academic evaluation is unrelated to academic standards but is related
instead to judgment of their personal opinion or conduct should first contact the instructor
of the course. If the student remains unsatisfied, the student may contact the department
head and/or dean of the college, which (sic) offers the class to initiate a review of the
evaluation.
Class Schedule
Lecture # Topic
1
Overview of viruses
2
Overview of virus structure & assembly
3
Virus-cell interacction-replication strategies
4
Virus structure and assembly
5
Virological methods
6
Subviral agents
7
Picornaviridae
8
Rhabdoviridae
9
Review
Exam #1 Must be completed by 5PM on
Monday February 6. 2012
10
Coronaviridae
11
Togaviridae
12
Flaviviridae
13
Orthomyxoviridae
14
Paramyxoviridae
15
Filoviridae
16
Bunyaviridae, Arenaviridae
17
Reoviridae
18
Review
Exam #2 Must be completed by 5PM on Friday,
March 2, 2012
Chapter*
1
1
1
2
9
3
4
3
3
3
4
4
4
4
5
19
20
21
22
23
24
25
26
27
28
29
Retroviridae 1
6
Lentivirus HIV-1
6
Lentivirus HIV-1
6
Hepadnaviridae
6
Poxviridae
7
Herpesviridae 1
7
Herpesviridae 2
7
Adenoviridae
7
Papillomaviridae
7
Parvoviridae
7
Review
Exam #3 Must be completed by 5PM on
Monday, April 2, 2012
Lecture # Topic
Chapter
30
Viral Interference and Interferon
31
Viral Pathogenesis (viral counterdefenses)
10
32
Viral Transformation and Oncoviruses
33
Viral Immunity 1 (host defense)
10
34
Viral Immunity 2 (host defense)
10
35
Prevention and control of virus infection
36
Emerginf viruses/virus evolution
8
37
Viral vectors and gene therapy
11
38
Review
39
Final Exam Must completed by 5PM on Friday,
May 4, 2012
*Numbers refer to chapters in Viruses and human disease by Strauss et al. (AP
Elsevier,2nd edition),