MCB 720 Reading List - Winter 2011
Frank Horodyski
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Chromatin
Lodish Ch. 6, pp. 215-217, 247-261
Ch. 7, pp. 299-307
Sarma. K. and Reinberg, D. (2005). Histone variants meet their match. Nature Reviews Mol.Cell
Biol. 6, 139-149.
Grewal, S.I.S., and Jia, S. (2007). Heterochromatin revisited. Nature Rev.Genetics 8, 35-46.
Zhou, V.W., Goren, A. and Bernstein, B.E. (2011). Charting histone modifications and the
functional organization of mammalian genomes. Nature Rev.Genetics 12, 7-18.
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Epigenetics
Lodish, Ch. 22, pp. 958-959, 982-983
Edwards, C.A. and Ferguson-Snith, A.C. (2007). Mechanisms regulating imprinted genes in
clusters. Curr.Opin.Cell Biol. 19, 281-289.
Straub, T. and Becker, P.B. (2007). Dosage compensation: the beginning and end of
generalization. Nature Rev.Genetics 8, 47-57.
Johnstone, S.E. and Baylin, S.B. (2010). Stress and the epigenetic landscape: a link to the
pathobiology of human diseases? Nature Rev.Genetics 11, 806-812..
Margueron, R. and Reinberg, D. (2010). Chromatin structure and the inheritance of epigenetic
information. Nature Rev.Genetics 11, 285-296.
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DNA Replication
Lodish Ch. 4, pp.111-118, 139-145
Ch. 6, pp. 261-265
Ch. 25, pp.1143-1145
Aladjem, M.I. (2007). Replication in context: dynamic regulation of DNA replication patterns in
metazoans. Nature Rev.Genetics 8, 588-600.
Kunkel, T.A. and Burgers, P.M. (2008). Dividing the workload at a eukaryotic replication fork.
Trends Cell Biol. 18, 521-527.
O’Sullivan,R.J. and Karlseder,J. (2010). Telomeres: protecting chromosomes against genome
instability. Nature Rev.Mol.Cell Biol. 11, 171-181
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Mutation-DNA Repair
Lodish Ch. 5, pp. 145-150
Ch. 25, pp.1139-1143
Lindahl, T. (1993). Instability and decay of the primary structure of DNA. Nature 362, 709-715.
Jiricny, J (2006). The multifasceted mismatch-repair system. Nature Reviews Mol.Cell Biol. 7,
335-346.
van Attikum,H. and Gasser, S.M. (2009). Crosstalk between histone modifications during the
DNA damage response. Trends Cell Biol. 19, 207-217.
Student presentation:
Kovtun, I.V., Liu, Y., Klundland, A., Wilson, S.H. and McMurray, C.T. (2007). OGG1 initiates
age-dependent CAG trinucleotide expansion in somatic cells. Nature 447, 447-452. (1)
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Posttranscriptional Gene Silencing
Lodish Ch. 8, pp. 347-351
Ch. 21, pp. 909-911
Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. and Sarnow, P, (2005). Modulation of
hepatitis C virus RNA abundance by a liver-specific microRNA. Science 309, 1577-1581.
Sarnow, P., Jopling, C.L., Norman, K.L., Schutz, S. and Wehner, K.A. (2006). MicroRNAs:
expression, avoidance, and subversion by vertebrate viruses. Nature Rev.Microbiol. 4, 651-659.
Filipowicz, W., Bhattacharyya, S.N. and Sonenberg, N. (2008). Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nature Rev.Genetics 9, 102114.
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Recombination and Transposition (student presentations)
Lodish Ch. 4, pp. 150-154
Ch. 6, pp. 226-236
Ch. 24, pp.1069-1076
Topics to be covered:
Mechanism of homologous recombination (2)
Role of RecA in DNA replication (3)
Immunoglobulin Gene Rearrangement (4)
Transposons and Mechanisms of Transposition (5)
LINE and SINEs (6)