Biol 427
1
Syllabus: Human Diversity and Population Genetics
C. D. Jones.
Basic Structure: Tuesday and Thursday 9:30 am- 10:45. Class will include lecture and
reading/discussion. One midterm and one final. Prerequisites: Biol 201 & 202
Lecture will introduce this subject and set up the questions that are discussed in the
paper(s) to be read. 1-3 papers or articles a week plus other assignments.
Week1:
Week2:
Week3:
Week4:
Week5:
Week6:
Week7
Introduction. Motivation and Questions
Coarse Overview and structure
Archaeology and Anthropology.
Question: Why are we the way we are?
Role is Human Health and Disease
Genetics Review
Populations and Genes
Statistical approach to genetics
Genetic variation
Hardy-Weinberg
Assumptions
Roles of environment, evolution, and genetics
Fst -- one method of testing neutrality versus selection
Admixture and structure
Population Genetics 2
Neutral Theory
Selection
Quantitative genetics and humans
Heritability
Mapping
Genomes
Basic concepts
Population Genomics
Evolutionary observations
Ancient genomes
Association Studies
Linkage
Association
GWAS
Trios vs Case Control
Prenatal screening
Midterm. (Start next section)
Makeup day :TBA
Students must have chosen the subjects for their presentations
9--27 – Exam
Designing GWAS
Biol 427
Week8:
Week9:
Week10:
Week11:
Week 12
Week 13:
Week 14:
Week 15:
2
Sampling
Genotyping
Analysis
Replication
Biases
Evolution and Humans
Genetics and Evolution
The Primates
The hominids
Admixture with Neanderthal
Language & Pair Bonding
World Language and Genetic Patterns
Role of natural selection and language
FOXP2
Pair Bonding
Human population structure
Consanguinous matings
Patterns of Human Migration
Migration and language
Implications for GWAS
Evolution and Human Disease: genetic disease
Return to pedigrees for Simple traits
Sickle cell, CF
Adaptation in humans?
Diseases of Modernity
Intersection of genetics, evolution and environment
Type 2 diabetes
Heart disease
Obesity
Metagenomics
Microbiomes
The ecology of the gut
Bacteria and their role in health
Genomics of the microbiomes
External diseases and human evolution
CF, Sickle cell
HIV
Misc Topics
Agriculture and Biotechnology
Catch --up
Review & Perspective on directions of human study