The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
November 2004
Vol. 311, No. 2
Contents
PERSPECTIVES IN PHARMACOLOGY
Corticotropin-Releasing Factor in Brain: A Role in Activation,
Arousal, and Affect Regulation
Stephen C. Heinrichs and George F. Koob
ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Plasma Membrane Localization of Multidrug ResistanceYan Zhang, John D. Schuetz,
Associated Protein Homologs in Brain Capillary Endothelial
William F. Elmquist, and Donald W. Miller
Cells
The Role of Advanced Glycation in Reduced Organic Cation
Merlin C. Thomas, Christos Tikellis,
Transport Associated with Experimental Diabetes
Phillip Kantharidis, Wendy C. Burns, Mark
E. Cooper, and Josephine M. Forbes
427
449
456
Differential Multidrug Resistance-Associated Protein 1
through 6 Isoform Expression and Function in Human
Intestinal Epithelial Caco-2 Cells
Hannah M. Prime-Chapman,
Richard A. Fearn, Anne E. Cooper,
Vanessa Moore, and Barry H. Hirst
476
G-Adrenergic Blockade Affects Initial Drug Distribution Due
to Decreased Cardiac Output and Altered Blood Flow
Distribution
Michael J. Avrarn, Tom C. Krejrie, Thomas
K. Henthorn, and Claus U. Niemann
617
Pharmacokinetics of Novel Dipeptide Ester Prodrugs of
Acyclovir after Oral Administration: Intestinal Absorption and
Liver Metabolism
Banmeet S. Anand, Suresh Katragadda, and
Ashim K. Mitra
659
Estrogen Regulation of the Cytochrome P450 3A Subfamily in
Humans
Eric T. Williams, Malgorzata Leyk, Steven
A. Wrighton, Peter J. A. Davies, David S.
Loose, Gregory L. Shipley, and Henry W.
Strobel
728
Expression of Constitutive Androstane Receptor Splice
Variants- in Human Tissues and Their Functional
Consequences
Jatinder K. Lamba, Vishal Lamba,
Kazuto Yasuda, Yvonne S. Lin,
Mahfoud Assem, Emma Thompson,
Stephen Strom, and Erin Schuetz
811
Aron H. Lichtman, Donmienne Leung,
Christopher C. Shelton, Alan Saghatelian,
Christophe Hardouin, Dale L. Boger, and
Benjamin F. Cravatt
441
Alexander R. Kosowski and Sture Liljequist
560
BEHAVIORAL PHARMACOLOGY
Reversible Inhibitors of Fatty Acid Amide Hydrolase That
Promote Analgesia: Evidence for an Unprecedented
Combination of Potency and Selectivity
The NR2B-Selective W-Methyl-D-aspartate Receptor
Antagonist Ro 25-6981 [(±)-(R*,5*)-a-(4-HydroxyphenyI)-pmethyI-4-(phenyImethyl)-l-piperidine Propanol] Potentiates
the Effect of Nicotine on Locomotor Activity and Dopamine
Release in the Nucleus Accumbens
The Opioid Receptor Like-1 Receptor Agonist Ro 64-6198
(lS,3aS-8-2,3,3a,4,5,6-Hexahydro-m-phcnalen-l-yl-l-phenyll,3j8-triaza-spiro[4.51decan-4-onc) Produces a Discriminative
Stimulus in Rats Distinct from That of a jx, K, and 5 Opioid
Receptor Agonist Cue
Matthew D. Recker and Guy A. Higgins
652
Memantine Improves Spatial Learning in a Transgenic Mouse
Model of Alzheimer's Disease
Rimante Minkcviciene, Pradeep Banerjee,
and Heikki Tanila
677
Drug Discrimination in Methamphetamine-Trained Monkeys:
Effects of Monoamine Transporter Inhibitors
Paul W. Czoty, Chinnasamy R. Ramanathan,
Nicole H. Mutschler,
Alexandras Makriyannis, and Jack Bergman
720
Effect of the D3 Dopamine Receptor Partial Agonist BP897
[Af-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide]
on 1,-3,4-Dihydroxyphenylalanine-Induced Dyskinesias and
Parkinsonism in Squirrel Monkeys
Albert Hsu, Daniel M. Togasaki,
Erwan Bezard, Pierre Sokoloff,
J. William Langston, Donato A. Di Monte,
and Maryka Quit
770
Yves Rival, Aline Stennevin,
Laurence Puech, Anne Rouquette,
Claudie Cathala, Fabrice Lestienne,
Elisabeth Dupont-Passelaigue,
Jean-Francois Patoiseau, Thierry Wurch, and
Didier Junquero
Pal Pacber, Anne Vaslin, Rita BenkS,
Jon G. Mabley, Lucas Liaudet,
Gyorgy Hasko, Anita Marton, Sandor Batkai,
Mark Kollai, and Csaba Szabo
467
CARDIOVASCULAR
Human Adipocyte Fatty Acid-Binding Protein (aP2) Gene
Promoter-Driven Reporter Assay Discriminates Nonlipogenic
Peroxisome Proliferator-Activated Receptor y Ligands
A New, Potent Poly(ADP-ribosc) Polymerase Inhibitor
Improves Cardiac and Vascular Dysfunction Associated with
Advanced Aging
485
The Preparation and Characterization of Novel Peptide
Antagonists to Thrombin and Factor Vila and Activation of
Protease-Activated Receptor 1
Marvin T. Nieman, Mark Warnock,
Ahmed A. K. Hasan, Fakhri Mahdi,
Benedict R. Lucchesi, Nancy J. Brown,
Laine J. Murphey, and Alvin H. Schmaier
492
Role of Prostaglandins in Mediating Differences in Human
Internal Mammary and Radial Artery Relaxation Elicited by
Hypoxia
Sachin A. Gupte, Elias A. Zias,
Mohan R. Sarabu, and Michael S. Wolin
510
Perillyl Alcohol Is an Angiogenesis Inhibitor
Heleni Loutrari, Maria Hatziapostolou,
Vassoula Skouridou,
Evangelia Papadimitriou, Charis Roussos,
Fragiskos N. Kolisis, and
Andreas Papapetropoulos
568
Role of Protein Kinase CS in Endothelin-Induced Type I
Collagen Expression in Cardiac Myofibroblasts Isolated from
the Site of Myocardial Infarction
Vishnu Chintalgattu and Laxmansa C. Katwa
691
. Changes in Phospholipid Content and Myocardial CalciumIndependent Phospholipase A2 Activity during Chronic
Anthracycline Administration
Jane McHowat, Luther M. Swift,
Kimberly N. Crown, and
Narine A. Sarvazyan
736
The Role of Rho Kinase and Extracellular Regulated KinaseMitogen-Activated Protein Kinase in a 2-AdrenoceptorMediated Vasoconstriction in the Porcine Palmar Lateral Vein
Richard E. Roberts
742
Inhibitory Profile of SEA0400 [2-[4-[(2,5Difluorophenyl)methoxyjphenoxy]-5-ethoxyaniline] Assessed on
the Cardiac Na+-Ca2+ Exchanger, NCX1.1
Candace Lee, Neeraj S. Visen,
Naranjan S. Dhalla, Hoa Dinh Le, Michael
Isaac, Platon Choptiany, Gil Gross, Alexander
Omelchenko, Toshio Matsuda, Akemichi
Baba, Kenzo Takahashi, Mark Hnatowich,
and Larry V. Hryshko
748
Atsushi Fukunari, Ken Okamoto,
Takeshi Nishino, Bryan T. Eger, Emil F. Pai,
Miho Kamezawa, Ichimaro Yamada, and
Norihisa Kato
Alison J. Smith, Beth Oxley, Sallie Malpas,
Gopalan V. Pillai, and Peter B. Simpson
519
CELLULAR AND MOLECULAR
Y-700 [l-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-lffpyrazole-4-carboxylic Acid]: A Potent Xanthine
Oxidoreductase Inhibitor with Hepatic Excretion
Compounds Exhibiting Selective Efficacy for Different j3
Subunits of Human Recombinant y-Aminobutyric AcidA
Receptors
/V-Butyryl Glucosamine Increases Matrix Gene Expression by
Chondrocytes
'
■ .
■
.
Mark W. Poustie, John Carran,
Kevin McEleney, S. Jeffrey Dixon,
Tassos P. Anastassiades, and
Suzanne M. Bernier
601
610
Nobuhisa Tanaka, Takao Morita,
Akihiro Nezu, Akihiko Tanimura,
Itaru Mizoguchi, and Yosuke Tojyo
778
Barbara Tolloczko, Petra Turkewitsch,
Mustafa Al-Chalabi, and James G. Martin
787
Aarti N. Desai, Kelly M. Standifer, and
Douglas C. Eikenburg
794
Flavio F. Solca, Anke Baum, Elke Langkopf,
Georg Dahmann, Karl-Heinz Heider,
Frank Himmelsbach, and Jacques C. A.
van Meel
502
Bernd Kaina, Ute Miihihausen,
Andrea Piee-Staffa, Markus Christmann,
Regine Garcia Boy, Frank Rosch, and
Ralf Schirrmacher
585
Donald E. Mager, Darrell R. Abernethy,
Josephine M. Egan, and Dariush Elahi
830
Cesar Menor, Maria D. Fernandez-Moreno,
Jesus A. Fueyo, Oscar Escribano,
Tomas Olleros, Encarna Arriaza,
Carlos Cara, Michele Lorusso,
Marco Di Paola, Irene D. Roman, and
Luis G. Guijarro
668
Daniel Y. Hung, Gerhard A. Siebert,
Ping Chang, Yuri G. Anissimov, and
Michael S. Roberts
822
Kcrryn McCluskie, Mark A. Birrell,
Sissie Wong, and Maria G. Belvisi
625
A Cyclooxygenase Metabolite of Anandamide Causes
Inhibition of Interleukin-2 Secretion in Murine Splenocytes
Cheryl E. Rockwell and
Norbert E. Kaminski
683
Nicotine Activates Nuclear Factor of Activated T Cells c2
(NFATc2) and Prevents Cell Cycle Entry in T Cells
Ashley A. Frazer-Abel, Shairaz Baksh,
Susan P. Fosmire, Derail Willis,
Angela M. Pierce, Heather Meylemans,
Darwin S. Linthicum, Steven J. Burakoff,
Teresa Coons, Donald Bellgrau, and
Jaime F. Modiano
758
Shu-Cheng Chen, Tsui-Jung Chang, and
Fong-Sen Wu
529
Susan K. Sullivan, Robert E. Petroski,
Gail Verge, Raymond S. Gross,
Alan C. Foster, and Dimitri E. Grigoriadis
Alan C. Foster, Mary Ann Pelleymounter,
Mary Jane Cullen, Dacie Lewis,
Margaret Joppa, Ta Kung Chen,
Haig P. Bozigian, Raymond S. Gross, and
Kathleen R. Gogas
Smriti [yengar, Amy A. Webster,
Susan K. Hemrick-Luecke, Jimmy Yu Xu,
and Rosa Maria A. Simmons
537
Signaling Mechanisms Involved in Protease-Activated
Receptor-1-Mediated Interleukin-6 Production by Human
Gingival Fibroblasts
LY-294002 [2-(4-Morpholinyl)-8-phenyI-4//-l-benzopyran-4one] Affects Calcium Signaling in Airway Smooth Muscle
Cells Independently of Phosphoinositide 3-Kinase Inhibition
Simultaneous a2B- and /32-Adrenoceptor Activation Sensitizes
the «2n-Adrenoceptor for Agonist-Induced Down-Regulation
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
Inhibition of Epidermal Growth Factor Receptor Activity by
Two Pyrimidopyrimidine Derivatives
Inhibition of O6-Methylguanine-DNA Methyltransferase by
Glucose-Conjugated Inhibitors: Comparison with
Nonconjugated Inhibitors and Effect on Fotemustine and
Temozolomide-Induced Cell Death
ENDOCRINE AND REPRODUCTIVE
Exendin-4 Pharmacodynamics: Insights from the
Hyperglycemic Clamp Technique
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Azathioprine Acts upon Rat Hepatocyte Mitochondria and
Stress-Activated Protein Kinases Leading to Necrosis:
Protective Role of /V-Acetyl-L-cysteine
Disposition Kinetics of Propranolol Isomers in the Perfused
Rat Liver
INFLAMMATION AND IMMUNOPHARMACOLOGY
Nitric Oxide as a Noninvasive Biomarker of
Lipopolysaccharide-Induced Airway Inflammation: Possible
Role in Lung Neutrophilia
NEUROPHARMACOLOGY
Competitive Inhibition of the Capsaicin Receptor-Mediated
Current by Dehydroepiandrosterone in Rat Dorsal Root
Ganglion Neurons
Characterization of the Interaction of Indiplon, a Novel
Pyrazolopyrimidine Sedative-Hypnotic, with the GABAA
Receptor
In Vivo Pharmacological Characterization of Indiplon, a
Novel Pyrazolopyrimidine Sedative-Hypnotic
Efficacy of Duloxetine, a Potent And Balanced SerotoninNorepinephrine Reuptake Inhibitor in Persistent Pain Models
in Rats
Bupropion (Zyban, Wellbutrin) Inhibits Nicotine-Induced
Viral Reactivation in Herpes Simplex Virus Type 1 Latent
Rabbits
Marvin E. Myles, Ann M. Azcuy,
Ngoc T. Nguyen, Eric R. Reisch,
Steven A. Barker, Hilary W. Thompson, and
James M. Hill
547
576
640
Ro 64-6198 [(lS,3aS)-8-(2,3,3a,4,5,6-Hexahydro-lff-phenalen-lyl)-l-phenyl-l,3,8-triaza-spiro[4.5]decan-4-one] Acts
Differently from Nociceptin/Orphanin FQ in Rat
Periaqueductal Gray Slices
Lih-Chu Chiou, Kuang-Chieh Chuang,
Juergen Wichmann, and Geo Adam
645
Serotonin1B Receptors in the Ventral Tegmental Area
Modulate Cocaine-Induced Increases in Nucleus Accumbens
Dopamine Levels
L. E. O'Dell and L. H. Parsons
711
The Role of 5-Hydroxytryptamine3 Receptors in the Vagal
Afferent Activation-Induced Inhibition of the First Cervical
Dorsal Horn Spinal Neurons Projected from Tooth Pulp in the
Rat
Takeshi Tanimoto, Mamoru Takeda,
Tosbimi Nishikawa, and Shigeji Matsumoto
803
Endogenous u-Serine Is Involved in Induction of Neuronal
Death by A'-Methyl-D-aspartate and Simulated Ischemia in
Rat Cerebrocortical Slices
Hiroshi Katsuki, Mild Nonaka,
Hisashi Shirakawa, Toshiaki Kume, and
Akinori Akaike
836
The Bile Acid Tauroursodeoxycholic Acid Modulates
Phosphorylation and Translocation of Bad via
Phosphatidylinositol 3-Kinase in Glutamate-Induced Apoptosis
of Rat Cortical Neurons
Rui E. Castro, Susana Sola, Rita M. Ramalho,
Clifford J. Steer, and Cecilia M. P. Rodrigues
845
Naoya Matsunaga, Naomi Nakamura,
Noriyo Yoneda, Tian Qin,
Hideyuki Terazono, Hideto To,
Shun Higuchi, and Shigehiro Ohdo
594
Jean-Claude Lavoie, Therese Rouleau, and
Philippe Chessex
634
Maria F. M. Braga, Edna F. R. Pereira,
Arpad Mike, and Edson X. Albuquerque
700
Andrea C. Simmonds, Burhan I. Ghanayem,
Ashish Sharma, Christopher A. Reilly,
Brandie Millen, Garold S. Yost, and
Poh-Gek Forkert
853
TOXICOLOGY
Influence of Feeding Schedule on 24-h Rhythm of
Hepatotoxicity Induced by Acetaminophen in Mice
Interaction between Ascorbate and Light-Exposed Riboflavin
Induces Lung Remodeling
Pb2+ via Protein Kinase C Inhibits Nicotinic Cholinergic
Modulation of Synaptic Transmission in the Hippocampus
ERRATUM
Correction to "Bioactivation of 1,1-Dichloroethylene by
CYP2E1 and CYP2F2 in Murine Lung"