The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
July 2007
Vol. 322, No. 1
Contents
BEHAVIORAL PHARMACOLOGY
Decrease in W-Methyl-D-aspartic Acid Receptor-NR2B Subunit
Levels by Intrathecal Short-Hairpin RNA Blocks Group I
Metabotropic Glutamate Receptor-Mediated Hyperalgesia
Antibodies to Nerve Growth Factor Reverse Established
Tactile Allodynia in Rodent Models of Neuropathic Pain
without Tolerance
Induction by Antipsychotics of "Win-Shift" in the Drug
Discrimination Paradigm
CARDIOVASCULAR
Direct Effects of Nicotine on Contractility of the Uterine
Artery in Pregnancy
Ca 2+-
Chronic Treatment with Carvedilol Improves
Dependent ATP Consumption in Triton X-Skinned Fiber
Preparations of Human Myocardium
Modulation of Sympathetic Activity by Tissue Plasminogen
Activator Is Independent of Plasminogen and Urokina.se
An in Vitro Study with an Ussing Chamber Showing That
Unfractionated Heparin Crosses Rat Gastric Mucosa
Bichoy H. Gabra, Fay K. Kessler, Joseph
K. Ritter, William L. Dewey, and Forrest L.
Smith
Kenneth D. Wild, Di Bian, Dawn Zhu,
James Davis, Anthony W. Bannon, Tie J.
Zhang, and Jean-Claude Louis
Francis Colpaert, Wouter Koek,
Mark Kleven, and Joel Besnard
DaLiao Xiao, Xiaohui Huang, Shumei Yanj
and Lubo Zhang
K. Brixius, R. Lu, B. Boelck, S. Grafweg,
F. Hoyer, C. Pott, U. Mehlhorn, W. Bloch,
and R. H. G. Schwinger
180
Ulrich Schaefer, Sandra Vorlova,
Takuji Machida, Jerry P. Melchor,
Sidney Strickland, and Roberto Levi
222
Bita Moazed and Linda M. Hiebert
265
tr2-Receptor Ligand-Mediated Inhibition of Inwardly
Rectifying K + Channels in the Heart
Biomarker Optimization to Track the Antithrombotic and
Hemostatic Effects of Clopidogret in Rats
William A. Schumacher, Jeffrey S.
Bostwick, Martin L. Ogletree, Anne B.
Stewart, Thomas E. Steinbacher, Ji Hua,
Laura A. Price, Pancras C. Wong, and
Robert P. Rehfuss
H] Neuroprotection by Small Molecule Activators of the Nerve
Growth Factor Receptor
282
288
Laurent Monassier, Boris Manoury,
Chlo6 Beilocq, Jacques Weissenburger,
Hugues Greney, Diane Zimmermann,
Jean-Daniel Ehrhardt, Patrice Jaillon,
Isabelle Baro, and Pascal Bousquet
CELLULAR AND MOLECULAR
Nicotine and Ethanol Activate Protein Kinase A
Synergistically via Gs /3y Subunits in Nucleus
Accumbens/Ventral Tegmental Cocultures: The Role of
Dopamine D,/D2 and Adenosine A2A Receptors
186
299
341
369
Yuichiro Inoue, Lina Yao, F.
Woodward Hopf, Peidong Fan, Zhan
Jiang, Antonello Bonci, and Ivan
Diamond
23
Bo Lin, Michael C. Pirrung, Liu Den|
Zhitao Li, Yufa Liu, and Nicholas J.
G. Webster
59
Beryllium Induces Premature Senescence in Human
Fibrobtasts
Shannon S. A. Coates, Bruce E. Lehnert,
Sunil Sharma, Susan M. Kindell, and
Ronald K. Gary
70
Rasmus Jorgensen, Valentina Kubale,
Milka Vrecl, Thue W. Schwartz, and
Christian E. Elling
148
In Vitro Pharmacology of Clinically Used Central Nervous
System-Active Drugs as Inverse Hj Receptor Agonists
R. A. Bakker, M. W. Nicholas, T. T. Smith,
E. S. Burstein, U. Hacksell, H. Tirnmerman,
R. Leurs, M. R. Brann, and D. M. Weiner
172
Apomine Enhances the Antitumor Effects of Lovastatin on
Myeloma Cells by Down-Regulating 3-Hydroxy-3methylglutaryl-Coenzyme A Reductase
Anke J. Roelofs, Claire M. Edwards,
R. Graham G. Russell, F. Hal Ebetino,
Michael J. Rogers, and Philippa A. Hulley
228
UQ Oxyntomodulin Differentially Affects Glucagon-Like Peptide-1
Receptor /J-Arrestin Recruitment and Signaling through Ga s
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
Tumor Priming Enhances Delivery and Efficacy of
Nanomedicines
Combination Silencer RNA (siRNA) Targeting Bcl-2
Antagonizes siRNA against Thymidylate Synthase in Human
Tumor Cell Lines
ENDOCRINE AND DIABETES
Nateglinide and Mitiglinide, but Not Sulfonylureas, Induce
Insulin Secretion through a Mechanism Mediated by Calcium
Release from Endoplasmic Reticulum
Pharmacological Profile of the Thyroid Hormone Receptor
Antagonist NH3 in Rats
Dan Lu, M. Guillaume Wientjes, Ze Lu, and
Jessie L.-S. Au
Aleksandra A. Pandyra, Randal Berg,
Mark Vincent, and James Koropatnick
Conditional Deletion of Cytochrome P450 Oxidoreductase in the
Liver and Gastrointestinal Tract: A New Model for Studying
the Functions of the P450 System
Role of Transforming Growth Factor /3 in Rat Bladder
Smooth Muscle Cell Proliferation
Centrally Administered Nociceptin/Orphanin FQ (N/OFQ)
Evokes Bradycardia, Hypotension, and Diuresis in Mice via
Activation of Central N/OFQ Peptide Receptors
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
Neuroinflanimation and Behavioral Abnormalities after
Neonatal Terbutaline Treatment in Rats: Implications for
Autism
Attenuation of Ozone-Induced Airway Inflammation and
Hyper-Responsiveness by c-Jun NH2 Terminal Kinase
Inhibitor SP600125
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
[U Central Nervous System Drug Disposition: The Relationship
between in Situ Brain Permeability and Brain Free Fraction
Accelerated Urinary Excretion of Methylmercury following
Administration of Its Antidote W-Acetylcysteine Requires
Mrp2/Abcc2, the Apical Multidrug Resistance-Associated
Protein
123
Makoto Shigeto, Masashi Katsura,
1
Masafurai Matsuda, Seitaro Ohkuma, and
Kohei Kaku
Gary J. Grover, Celeste Dunn,
Ngoc-Ha Nguyen, Jamie Boulet, Gao Dong,
Jason Domogauer, Peter Barbounis, and
Thomas S. Scanlan
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Cisplatin-Induced Acute Renal Failure Is Associated with an
Increase in the Cytokines Interleukin (IL)-l/3, IL-18, IL-6, and
Neutrophil Infiltration in the Kidney
80
385
Sarah Faubel, Eli C. Lewis,
8
Leonid Reznikov, Danica Ljubanovic,
Thomas S. Hoke, Hilary Somerset,
Dong-Jin Oh, Lawrence Lu,
Christina L. Klein, Charles A. Dinarello, and
Charles L. Edelstein
Robert D. Finn, Aileen W. McLaren,
Dianne Carrie, Colin J. Henderson, and
C. Roland Wolf
40
Maurits M. Barendrecht,
Arthur C. M. Mulders, Henk van der Poel,
Maurice J. B. van den Hoff,
Martina Schmidt, and Martin C. Michel
117
Melissa A. Burmeister and
Daniel R. Kapusta
324
M. C. Zerrate, M. Pletnikov, S. L. Connors,
D. L. Vargas, F. J. Seidler,
A. W. Zimmerman, T. A. Slotkin, and
C. A. Pardo
16
Alison S. Williams, Razao Issa,
Sum Yee Leung, Puneeta Nath, Gregory D.
Ferguson, Brydon L. Bennett, Ian M.
Adcock, and Kian Fan Chung
351
Scott G. Summerfield, Kevin Read,
David J. Begley, Tanja Obradovic,
Ismael J. Hidalgo, Sara Coggon,
Ann V. Lewis, Rod A. Porter, and
Phil Jeffrey
Michael S. Madejczyk, David A. Aremu,
Tracey A, Simmons-Willis,
Thomas W. Clarkson, and
Nazzareno Ballatori
205
378
Rifaximin Is a Gut-Specific Human Pregnane X Receptor
Activator
Xiaochao Ma, Yatrik M. Shah,
Grace L. Guo, Ting Wang,
Kristopher W. Krausz, Jeffrey R. Idle, and
Frank J. Gonzalez
391
Doxorubicin Degradation in Cardiomyocytes
Pierantonio Menna, Emanuela Salvatorelli,
and Giorgio Minotti
408
Eric C. Peterson, Melinda Gunnell,
Yingni Che, Robyn L. Goforth,
F. Ivy Carroll, Ralph Henry, Huimin Liu,
and S. Michael Owens
30
Competitive Antagonism between the Nicotinic Allosteric
Potentiating Ligand Galantamine and Kynurenic Acid at al*
Nicotinic Receptors
Cristiane Lopes, Edna F. R. Pereira,
Hui-Qiu Wu, Puranik Pumshottamachar,
Vincent Njar, Robert Schwarcz, and Edson
X. Albuquerque
48
In Vivo Effect of Venlafaxine on Locus Coeruleus Neurons:
Role of Opioid, a2-Adrenergic, and 5-HydroxytryptamineIA
Receptors
Esther Berrocoso and Juan Antonio Mico
101
Olanzapine Increases RGS7 Protein Expression via
Stimulation of the Janus Tyrosine Kinase-Signal Transducer
and Activator of Transcription Signaling Cascade
Rakesh K. Singh, Ju Shi,
Bozena W. Zemaitaitis, and Nancy A. Muma
133
Region-Specific Overexpression of P-glycoprotein at the
Blood-Brain Barrier Affects Brain Uptake of Phenytoin in
Epileptic Rats
E. A. van Vliet, R. van Schaik,
P. M. Edelbroek, R. A. Voskuyl, S. Redeker, E.
Aronica, W. J. Wadraan, and J. A. Gorter
141
Selectivity of S- and K-Opioid Ligands Depends on the Route
of Central Administration in Mice
Flufenamic Acid Bi-Directionally Modulates the Transient
Outward K+ Current in Rat Cerebellar Granule Cells
Mary M. Lunzer and Philip S. Portoghese
166
Zheng-Ge Zhao, Man Zhang, Xi-Min Zeng,
Xiao-Wei Fei, Lin-Yun Liu,
Zhi-Hong Zhang, Yan-Ai Mei
195
Pharmacological Effects of Ephedrine Alkaloids on Human
ffj- and «3-Adrenergic Receptor Subtypes
Guoyi Ma, Supriya A. Bavadekar,
Yolande M. Davis, Shilpa G. Lalchandani,
Rangaswamy Nagmani, Brian T. Schaneberg,
Ikhlas A. Khan, and Dennis R. Feller
214
The Fatty Acid Amide Hydrolase Inhibitor URB597
(Cyclohexylcarbamic Acid 3'-Carbamoylbiphenyl-3-yl Ester)
Reduces Neuropathic Pain after Oral Administration in Mice
Roberto Russo, Jesse LoVerme,
Giovanna La Rana, Timothy R. Compton,
Jeff Parrott, Andrea Duranti, Andrea Tontini,
Marco Mor, Giorgio Tarzia,
Antonio Calignano, and Daniele Piomelli
236
Behavioral Cross-Tolerance between Repeated Intracerebellar
Nicotine and Acute A9-Tetrahydrocannabinol-Induced
Cerebellar Ataxia: Role of Cerebellar Nitric Oxide
Aaron D. Smith and M. Saeed Dar
243
A Novel Family of Potent Negative Allosteric Modulators of
Group II Metabotropic Glutamate Receptors
Kamondanai Hemstapat, Herve Da Costa,
Yi Nong, Ashley E. Brady, Qingwei Luo,
Colleen M. Niswender, Gilles D. Tamagnan,
and P. Jeffrey Conn
254
Edaravone (3-Methyl-l-phenyl-2-pyrazolin-5-one), a Radical
Scavenger, Prevents l-Methyl-4-phenyl-1,2,3,6tetrahydropyridine-Induced Neurotoxicity in the Substantia
Nigra but Not the Striatum
Toshiyuki Kawasaki, Kotaro Ishihara,
Yukio Ago, Akemichi Baba, and
Toshio Matsuda
274
Chronic Nicotine Differentially Regulates a6- and 03Containing Nicotinic Cholinergic Receptors in Rat Brain
David C. Perry, Danyan Mao,
Allison B. Gold, J. Michael Mclntosh, John
C. Pezzullo, and Kenneth J. Kellar
E. Machova, J. Jakubik, E. E. El-Fakahany,
and V. Dolezal
306
NEUROPHARMACOLOGY
Using Hapten Design to Discover Therapeutic Monoclonal
Antibodies for Treating Methamphetamine Abuse
Wash-Resistantly Bound Xanomeline Inhibits Acetylcholine
Release by Persistent Activation of Presynaptic M 2 and M4
Muscarinic Receptors in Rat Brain
316
Rapid Stimulation of Presynaptic Serotonin Transport by A 3
Adenosine Receptors
Chong-Bin Zhu, Jennifer A. Steiner,
Jaclyn L. Munn, Lynette C. Daws, William
A. Hewlett, and Randy D. Blakely
332
Tolerance to the Antinociceptive and Antiexudative Effects of
Morphine in a Murine Model of Peripheral Inflammation
Victor Fernandez-Duefias, Olga Pol,
Paula Garcia-Nogales, Laura Hernandez,
Eulalia Planas, and Margarita M. Puig
D. Kota, B. R. Martin, S. E. Robinson, and
M. I. Damaj
360
Nicotine Dependence and Reward Differ between Adolescent
and Adult Male Mice
399
TOXICOLOGY
[s] Proteomic Analysis of Alternative Protein Tyrosine
Phosphorylation in 1,2-Dichlorovinyl-Cysteine-Induced
Cytotoxicity in Primary Cultured Rat Renal Proximal
Tubular Cells
Reversal of Lead-Induced Neuronal Apoptosis by Chelation
Treatment in Rats: Role of Reactive Oxygen Species and
Intracellular Ca2+
Apoptosis in Microencapsulated Juvenile Rabbit Chondrocytes
Induced by Ofloxacin: Role Played by 0,-Integrin Receptor
LETTERS TO THE EDITOR
Comments on "Cannabimimetic Properties of Ajulemic Acid"
, Marjo de Graauw, Sylvia Le
Devedec,
Ine Tijdens, Mirjam B. Smeets,
Andre M. Deelder, and Bob van de Water
108
Swaran J. S. Flora, Geetu Saxena, and
Ashish Mehta
155
Zhi-guo Sheng, Shuangqing Peng, Changyong Wang, Hong-bo Li, Ravindra K.
Hajela, Yim-ei Wang, Qian-qian Li, Mi-feng
Liu, Yan-sheng Dong, and Gang Han
Matthias Karst
420
Comments on "Anti-Influenza Prodrug Oseltamivir Is
Activated by Carboxylesterase Human Carboxylesterase 1,
and the Activation Is Inhibited by Antiplatelet Agent
Clopidogrel"
Stephen Fowler, Sian M. Lennon, Gerhard
Hoffmann, and Craig R. Rayner
422
Response to Comments on "Anti-Influenza Prodrug
Oseltamivir Is Activated by Carboxylesterase Human
Carboxylesterase 1, and the Activation Is Inhibited by
Antiplatelet Agent Clopidogrel"
Deshi Shi, Jian Yang, Dongfang Yang,
Edward L. LeCluyse, Chris Black, Li You,
Fatemeh Akhlaghi, and Bingfang Yan
424