Supplementary Table 1. Distribution of the minor alleles of either rs2066844 or
rs2066847 in 85 children with SBTx from whom the discovery cohort of 60 Caucasian
children was derived. Wild type=common allele of NOD2 SNPs, Mutant=minor alleles of
either NOD2 SNP.
Table 1
Recipient
N=85
Wild-type(n=68)
Mutant(n=17)
p-value
Rejector : Non-Rejector
42:26
14:3
NS
Gender: M : F
37:31
8:9
NS
Age at Tx, years (Mean±SD)
5.4±0.6
5±1.5
NS
Race: Caucasians: African
Americans: Hispanics: Others
46:15:6:1
14:3:0:0
Diagnosis
Gastroschisis
11
8
0.019
Hirschsprung's disease
7
0
NS
Necrotizing enterocolitis
6
3
NS
Pseudo-obstruction
7
0
NS
Jejunal Atresia
7
2
NS
Microvillous inclusion
3
0
NS
Tufting enteropathy
4
0
NS
Volvulus
19
3
NS
Trauma
3
0
NS
Others
1
1
NS
Tx Type: aSBTx
31
3
NS
SBTx with Liver (LSBTx)
37
14
NS
Children with any NOD2 mutation
17/85
1
Supplementary Table 2: Causes of graft loss and death for 85 children from whom
the discovery cohort of 60 Caucasian children was derived. These 85 children include 51
with LSBTx, and 34 with isolated SBTx.
LSBTx (n=51)
Causes of Death
Deaths
Causes of Graft Loss
Grafts lost
Sepsis
3 Chronic Rejection
2
End Stage Mitochondrial
Complex Disease
1 Acute Rejection
2
Intraventricular
Hemorrhage
1 Sepsis
2
Total Deaths
n=5 (9.8%)
Acute Rejection and
Chronic Rejection
1
End Stage Mitochondrial
Complex Disease
1
Intraventricular
Hemorrhage
1
Total Graft Loss
n=9 (17.6%)
Isolated SBTx (n=34)
Sepsis
1 Chronic Rejection
6
GVHD+ Sepsis
1 PTLD
3
Acute Renal Failure
1 GVHD+ Sepsis
1
Total Deaths
n=3 (8.8%)
ARF
1
Technical
1
Total Graft Loss
n=12
(35.3%)
2
Supplementary Table 3. Linear regression analysis statistics for 41 rATG induced
Caucasians from the discovery cohort who received either LSBTx (N=24) oriIsolated
SBTx (N=17).
Early Rejection
N = 24
(LSBTx, N=24)
coefficients
p-value
Age at Tx
0.500
0.037
Gender
-0.250
rs2066844
0.500
Early Rejection
N = 17
(isolated SBTx, N=17)
coefficients
p-value
Age at
Tx
0.214
0.622
0.137
Gender
0.143
0.622
0.017
SNP 8
0.286
0.622
3