COURSE
BST 1
TITLE
2 2 Genetics
L T P Credits
4 0 1 5
COURSE OBJECTIVES : To acquaint students with the basic knowledge of Genetics .It would enable them to understand about evolutionary and various work done by the scientist to discover the basic hereditary mechanisms in life science.
COURSE CONTENTS :
Unit. No.
1
2
3
Description
DNA as Genetic material and Organization of Genomes
Griffith's transformation experiments, Hershey and Chase experiment, Structure of
DNA: Watson-Crick model, Chromosome structure and Morphology, Prokaryotic and eukaryotic chromosome, Nucleosome structure.
Classical Genetics
Phenomenon of dominance, Incomplete dominance, Codominance ; law of segregation
:mechanism of segregation, law of independent assortment.: Mendel's dihybrid cross,
Mechanism of independent assortment: Back cross and test cross
DNA replication:
Replication mechanism in Prokaryotes, Replication Mechanism in Eukaryotes
Gene transcription :
Transcription in prokaryotes and Eukaryotes. Types of RNA, Prokaryotic DNA
Transcription, DNA-RNA Complementarity, Prokaryotic RNA Polymerase,
Prokaryotic Initiation and Termination Signals for Transcription, Ribosomes and
Ribosomal RNA, Transfer RNA .
Eukaryotic DNA Transcription :
The Nucleolus in Eukaryotes, Differences Between Eukaryotic and Prokaryotic
Transcription, Promoters ,Caps and Tails, Introns ,RNA Editing .
Gene expression and Genetic code :
Information Transfer, Initiation Complex, Elongation, Termination, More on the
Ribosome, Signal Hypothesis, Protein-Folding Problem, Genetic Code, Triplet Nature of the Code, Breaking the Code, Wobble Hypothesis, Universality of the Genetic Code
Evolution of the Genetic Code
Population genetics:-
Hardy-Weinberg Equilibrium, Calculating Allelic Frequencies, Assumptions of Hardy-
Weinberg Equilibrium, Proof of Hardy-Weinberg Equilibrium, Generation Time
Testing for Fit to Hardy-Weinberg Equilibrium, Extensions of Hardy-Weinberg
Equilibrium, Multiple Alleles, Multiple Loci, Nonrandom Mating
Inbreeding.

Suggested Readings:
1.
Principles of Genetics, Seventh Edition, The McGraw−Hill Companies, 2011.
2.
Eldon John Gardner, Michael J. Simmons, D. Peter Snustad, Principles of Genetics, 8th
Ed; John Wiley & Sons.
3.
Current Perspectives in Genetics: Insights and Applications in Molecular, Classical, and
Human Genetics, 2000 Edition by Shelly Cummings, Paperback: 170 pages, Publisher:
Brooks Cole
4.
Concepts of Genetics (8th Edition) By William S. Klug Publisher: Pre.nti.ce Ha.ll
5.
Robert Schleif, Genetics and Molecular Biology, II nd
, The Johns Hopkins University
Press
Instructions for paper setter
The syllabus has been divided into three equal units. The paper setter is required to set Ten questions in all, three questions from each unit and a compulsory question consisting of five sub parts and based on the whole syllabus. The candidate will be required to attempt six questions including the compulsory question number no 1 and not more than two questions from each unit.