The 4th Asian Biomaterials Congress
Cell-Adhesion Surface Modification by Cold Plasma Polymerization of
Isopropanol or Acetic Acid Films
1
Liao Shu Chuan1, Wei-Yu Chen2, Ko-Shao Chen3*
Center Thin Film Technologic and Applications, Ming Chi University of Technology, New
Taipei city, Taiwan
2
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
3
Department of Materials Engineering, Tatung University, Taipei
*kschen@ttu.edu.tw
This study depositing plasma films on the surface to improve hydrophilic quality and
biocompatibility modified polymeric substrates, confers surface property change and cells
adhesion. Using Isopropanol (IPA) and acetic acid (AA) as monomers, then fibroblastic cells,
caco2 cells and embryonic stem (ES) cells for test there cells adhesion. The IPA or AA
plasma polymerization film maintained stability on a hydrophilic surface for long-term aging.
As a result, after IPA or AA plasma treated substrates surface water contact angle change
from hydrophobic drop to hydrophilic, The results of Electron Spectroscopy for Chemical
Analysis (ESCA) show for acetic acid film, three peaks corresponding to the C-C group
(285.0eV), C-O group (286.6eV), and C=O group (288.7eV) were observed.
This indicated that appropriate IPA or AA plasma treatment could increase the polar
components on the surface of substrates to improve the hydrophilicity. In addition, the
biocompatibility test demonstrated that cells adhesion on the IPA or AA plasma-treated
polymeric substrates is better than the untreated.
Keywords: Cell-Adhesion/ Surface Modification/ Cold Plasma Polymerization/Isopropanol /Acetic
Acid Films