insulin r&b specific binding site on tyrosine kinase receptor(RTK) on liver/muscle CSM, causes 2 receptor polypeptides to undergo conformational change & dimerise >

dimerisation activates tyrosine kinase region of each polypeptide; each tyrosine kinase phosphorylates tyrosines of other polypeptide >

activated RTK recognised by specific relay proteins, pass signal on, leads to activation of glycogen synthase >

glycogen synthase catalyses glucose -> glycogen conversion(glycogenesis) >

any 1:

insulin also stimulates increase in rate of respiration using glucose as respiratory substrate, broken down & oxidised to CO₂, H₂O ;

increase in plasma membrane permeability of target cells to glucose, increase rate of uptake of glucose from blood by most body cells ;

glucose -> fats conversion for storage in adipose cells/tissues

Spell: H2 Biology 19 - Cell signalling