2023-10-11T19:03:03+03:00[Europe/Moscow] en true <p>b</p>, <p>c</p>, <p>b</p>, <p>alanine racemase; L-ala to D-ala</p>, <p>d</p>, <p>HIV + on protease inhibitors</p>, <p>c</p>, <p>e</p>, <p>e</p>, <p>b</p>, <p>c</p>, <p>c</p>, <p>myelosuppression </p>, <p>MAO inhibitors </p>, <p>FQ's </p>, <p>tendinopathy </p>, <p>Rifampin, isoniazid, pyrazinamide, ethambutol </p>, <p>ototoxicity, nephrotoxicity, peripheral neuropathy </p>, <p>parenteral administration, high in SE's/toxicity, used for drug-resistant TB, contraindications </p>, <p>f; must always be used w isoniazid to prevent resistance </p>, <p>ansamycins </p>, <p>TB; MAC</p>, <p>oxazolidinones </p>, <p>children &lt; 16, nursing/pregnant mothers</p>, <p>Isoniazid (+pyridoxine) &amp; rifampin </p> flashcards
Tuberculosis Drugs (Nagle)

Tuberculosis Drugs (Nagle)

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  • b

    Which drug is 1st line for TB?

    a) Azithromycin

    b) Rifampin

    c) streptomycin

    d) Clarithromycin

  • c

    Binds to 50s subunits & blocks translocation.

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • b

    Binds to 30s subunits & causes codon misreading & polysome

    destruction.

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • alanine racemase; L-ala to D-ala

    Cycloserine inhibits __________, an enzyme, needed to convert _______ in

    bacterial peptidoglycan; disrupting cell wall formation.

  • d

    Which drug is used in combination with Isoniazid?

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • HIV + on protease inhibitors

    When is Rifampin NOT used 1st line?

  • c

    Which can cause P450 inhibition?

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • e

    Which can induce P450s?

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • e

    Which can cause flu-like symptoms due to missed doses?

    a) fluoroquinolones

    b) AG's

    c) clarithromycin

    d) Cycloserine

    e) Ansamycins

  • b

    If a patient has HIV, which do we give?

    a) Rifampin

    b) Rifabutin

    c) Rifapentine

  • c

    Which causes hyperuricemia?

    a) Rifampin

    b) Rifabutin

    c) Rifapentine

  • c

    Which has the most activity against TB?

    a) Rifampin

    b) Rifabutin

    c) Rifapentine

  • myelosuppression

    What is the most severe SE with Oxazolidinones?

  • MAO inhibitors

    Which drugs do we avoid in combination with Oxazolidinones?

  • FQ's

    -inhibits bacterial DNA replication through DNA gyrase and topoisomerase IV

  • tendinopathy

    What is the black box warning for FQs?

  • Rifampin, isoniazid, pyrazinamide, ethambutol

    Which drugs are first line for TB? (4)

  • ototoxicity, nephrotoxicity, peripheral neuropathy

    AGs AE's? (3)

  • parenteral administration, high in SE's/toxicity, used for drug-resistant TB, contraindications

    Why are some drugs 2nd or 3rd line agents? (4)

  • f; must always be used w isoniazid to prevent resistance

    Cycloserine can be used as monotherapy. T/F?

  • ansamycins

    -inhibits RNA transcription by inhibiting bacterial DNA-dependent RNA-

    polymerase

  • TB; MAC

    Rifapentine has more _______ activity, but less ______ activity than

    Rifampin.

  • oxazolidinones

    -inhibits bacterial protein synthesis by binding to A-site within 50s ribosomal

    subunit and preventing the formation of 70s complex; inhibiting translation

  • children < 16, nursing/pregnant mothers

    Who do we avoid using Fluoroquinolones in? (2)

  • Isoniazid (+pyridoxine) & rifampin

    What is the preferred treatment course for TB? (3)