b
Which drug is 1st line for TB?
a) Azithromycin
b) Rifampin
c) streptomycin
d) Clarithromycin
c
Binds to 50s subunits & blocks translocation.
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
b
Binds to 30s subunits & causes codon misreading & polysome
destruction.
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
alanine racemase; L-ala to D-ala
Cycloserine inhibits __________, an enzyme, needed to convert _______ in
bacterial peptidoglycan; disrupting cell wall formation.
d
Which drug is used in combination with Isoniazid?
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
HIV + on protease inhibitors
When is Rifampin NOT used 1st line?
c
Which can cause P450 inhibition?
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
e
Which can induce P450s?
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
e
Which can cause flu-like symptoms due to missed doses?
a) fluoroquinolones
b) AG's
c) clarithromycin
d) Cycloserine
e) Ansamycins
b
If a patient has HIV, which do we give?
a) Rifampin
b) Rifabutin
c) Rifapentine
c
Which causes hyperuricemia?
a) Rifampin
b) Rifabutin
c) Rifapentine
c
Which has the most activity against TB?
a) Rifampin
b) Rifabutin
c) Rifapentine
myelosuppression
What is the most severe SE with Oxazolidinones?
MAO inhibitors
Which drugs do we avoid in combination with Oxazolidinones?
FQ's
-inhibits bacterial DNA replication through DNA gyrase and topoisomerase IV
tendinopathy
What is the black box warning for FQs?
Rifampin, isoniazid, pyrazinamide, ethambutol
Which drugs are first line for TB? (4)
ototoxicity, nephrotoxicity, peripheral neuropathy
AGs AE's? (3)
parenteral administration, high in SE's/toxicity, used for drug-resistant TB, contraindications
Why are some drugs 2nd or 3rd line agents? (4)
f; must always be used w isoniazid to prevent resistance
Cycloserine can be used as monotherapy. T/F?
ansamycins
-inhibits RNA transcription by inhibiting bacterial DNA-dependent RNA-
polymerase
TB; MAC
Rifapentine has more _______ activity, but less ______ activity than
Rifampin.
oxazolidinones
-inhibits bacterial protein synthesis by binding to A-site within 50s ribosomal
subunit and preventing the formation of 70s complex; inhibiting translation
children < 16, nursing/pregnant mothers
Who do we avoid using Fluoroquinolones in? (2)
Isoniazid (+pyridoxine) & rifampin
What is the preferred treatment course for TB? (3)