2023-08-30T02:22:28+03:00[Europe/Moscow] en true <p>Thiazides </p>, <p>hypotension, hypokalemia, photosensitivity, hyponatremia, hyperglycemia </p>, <p>luminal side; hypokalemia due to the blockage on the luminal side; reabsorption instead happens on the basolateral membrane side</p>, <p>a</p>, <p>b</p>, <p>e</p>, <p>HCTZ, chlorthalidone, indapamide, metolazone, chlorothiazide</p>, <p>hyperkalemia, cardiac arrhythmia, menstrual abnormalities, gynecomastia, ED</p>, <p>to prevent hypokalemia/ maintain K+ balance</p>, <p>d</p>, <p>b</p>, <p>Spironolactone, Eplerenone , Amiloride, Triamterene </p>, <p>a,d</p>, <p>b,c </p>, <p>inhibits K+ excretion</p>, <p>a</p>, <p>a</p>, <p>d</p>, <p>mild hyperkalemia, GI</p>, <p>BP= CO x PR</p>, <p>an aldosterone antagonist that acts on the aldosterone receptors of the collecting duct and causes Na &amp; water excretion</p>, <p>a</p>, <p>H+ transporters; metabolic acidosis</p>, <p>luminal; na/ca++; interstitial; calcium reabsorption</p> flashcards
Thiazides and Potassium-Sparing Diuretics

Thiazides and Potassium-Sparing Diuretics

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  • Thiazides

    - inhibit Na+ reabsorption in distal convoluted tubule by blocking Na-Cl-Cotransporter (NCC).

  • hypotension, hypokalemia, photosensitivity, hyponatremia, hyperglycemia

    What are the Adverse Effects associated with Thiazide Diuretics? (5)

  • luminal side; hypokalemia due to the blockage on the luminal side; reabsorption instead happens on the basolateral membrane side

    Which side do Thiazide Diuretics enter? What can this cause?

  • a

    Which uses lower does i.e. most potent?

    a) hydrochlorothiazide (HCTZ)

    b) Chlorthalidone

    c) Indapamide

    d) Metolazone

    e) Chlorothiazide

  • b

    Which has a DOA or half-life of 50-60 hours?

    a) hydrochlorothiazide (HCTZ)

    b) Chlorthalidone

    c) Indapamide

    d) Metolazone

    e) Chlorothiazide

  • e

    Which one is not very lipophilic and requires IV dosing?

    a) hydrochlorothiazide (HCTZ)

    b) Chlorthalidone

    c) Indapamide

    d) Metolazone

    e) Chlorothiazide

  • HCTZ, chlorthalidone, indapamide, metolazone, chlorothiazide

    What are the Thiazide Diuretics? (5)

  • hyperkalemia, cardiac arrhythmia, menstrual abnormalities, gynecomastia, ED

    What are the AE's of Spironolactone? (5)

  • to prevent hypokalemia/ maintain K+ balance

    Why do we use Potassium-sparing diuretics?

  • d

    Where do Potassium-sparing diuretics act?

    a) loop of Henle

    b) Distal Convoluted Tubule

    c) Proximal Convoluted tubule

    d) Collecting duct/ tubule

  • b

    Where do Thiazide-Diuretics act?

    a) loop of Henle

    b) Distal Convoluted Tubule

    c) Proximal Convoluted tubule

    d) Collecting duct/ tubule

  • Spironolactone, Eplerenone , Amiloride, Triamterene

    What are the potassium-sparing diuretics? (4)

  • a,d

    Which Potassium-Sparing diuretics antagonize aldosterone receptors directly?

    a) Spironolactone

    b) Amiloride

    c) Triamterene

    d) Eplerenone

  • b,c

    Which Potassium-Sparing diuretics inhibit Na+ flux?

    a) Spironolactone

    b) Amiloride

    c) Triamterene

    d) Eplerenone

  • inhibits K+ excretion

    What does inhibiting Na+ flux do?

  • a

    Which is a Non-selective Aldosterone antagonist?

    a) Spironolactone

    b) Amiloride

    c) Triamterene

    d) Eplerenone

  • a

    Which one acts off target and antagonizes androgen receptors(sex steroids) ?

    a) Spironolactone

    b) Amiloride

    c) Triamterene

    d) Eplerenone

  • d

    Which one is metabolized by CYP3A4?

    a) Spironolactone

    b) Amiloride

    c) Triamterene

    d) Eplerenone

  • mild hyperkalemia, GI

    What are the AE of Eplerenone? (2)

  • BP= CO x PR

    What is the formula for Blood Pressure?

  • an aldosterone antagonist that acts on the aldosterone receptors of the collecting duct and causes Na & water excretion

    Spironolactone & Eplenerone MOA?

  • a

    Which Potassium-Sparing Diuretic is more selective?

    a) Eplerenone

    b) Spironolactone

  • H+ transporters; metabolic acidosis

    Potassium-sparing diuretics interfere with _______ in intercalated cells leading to ___________.

  • luminal; na/ca++; interstitial; calcium reabsorption

    Blocking Na+ entry from the ______ side enhances ______ exchange on the _______. Leading to _______.