Thiazides
- inhibit Na+ reabsorption in distal convoluted tubule by blocking Na-Cl-Cotransporter (NCC).
hypotension, hypokalemia, photosensitivity, hyponatremia, hyperglycemia
What are the Adverse Effects associated with Thiazide Diuretics? (5)
luminal side; hypokalemia due to the blockage on the luminal side; reabsorption instead happens on the basolateral membrane side
Which side do Thiazide Diuretics enter? What can this cause?
a
Which uses lower does i.e. most potent?
a) hydrochlorothiazide (HCTZ)
b) Chlorthalidone
c) Indapamide
d) Metolazone
e) Chlorothiazide
b
Which has a DOA or half-life of 50-60 hours?
a) hydrochlorothiazide (HCTZ)
b) Chlorthalidone
c) Indapamide
d) Metolazone
e) Chlorothiazide
e
Which one is not very lipophilic and requires IV dosing?
a) hydrochlorothiazide (HCTZ)
b) Chlorthalidone
c) Indapamide
d) Metolazone
e) Chlorothiazide
HCTZ, chlorthalidone, indapamide, metolazone, chlorothiazide
What are the Thiazide Diuretics? (5)
hyperkalemia, cardiac arrhythmia, menstrual abnormalities, gynecomastia, ED
What are the AE's of Spironolactone? (5)
to prevent hypokalemia/ maintain K+ balance
Why do we use Potassium-sparing diuretics?
d
Where do Potassium-sparing diuretics act?
a) loop of Henle
b) Distal Convoluted Tubule
c) Proximal Convoluted tubule
d) Collecting duct/ tubule
b
Where do Thiazide-Diuretics act?
a) loop of Henle
b) Distal Convoluted Tubule
c) Proximal Convoluted tubule
d) Collecting duct/ tubule
Spironolactone, Eplerenone , Amiloride, Triamterene
What are the potassium-sparing diuretics? (4)
a,d
Which Potassium-Sparing diuretics antagonize aldosterone receptors directly?
a) Spironolactone
b) Amiloride
c) Triamterene
d) Eplerenone
b,c
Which Potassium-Sparing diuretics inhibit Na+ flux?
a) Spironolactone
b) Amiloride
c) Triamterene
d) Eplerenone
inhibits K+ excretion
What does inhibiting Na+ flux do?
a
Which is a Non-selective Aldosterone antagonist?
a) Spironolactone
b) Amiloride
c) Triamterene
d) Eplerenone
a
Which one acts off target and antagonizes androgen receptors(sex steroids) ?
a) Spironolactone
b) Amiloride
c) Triamterene
d) Eplerenone
d
Which one is metabolized by CYP3A4?
a) Spironolactone
b) Amiloride
c) Triamterene
d) Eplerenone
mild hyperkalemia, GI
What are the AE of Eplerenone? (2)
BP= CO x PR
What is the formula for Blood Pressure?
an aldosterone antagonist that acts on the aldosterone receptors of the collecting duct and causes Na & water excretion
Spironolactone & Eplenerone MOA?
a
Which Potassium-Sparing Diuretic is more selective?
a) Eplerenone
b) Spironolactone
H+ transporters; metabolic acidosis
Potassium-sparing diuretics interfere with _______ in intercalated cells leading to ___________.
luminal; na/ca++; interstitial; calcium reabsorption
Blocking Na+ entry from the ______ side enhances ______ exchange on the _______. Leading to _______.