2023-10-20T03:09:27+03:00[Europe/Moscow] en true <p>b</p>, <p>b,c</p>, <p>pre-hydrate with 1 L of NS prior to infusion, urine output &gt;100ml for 1st 24 hrs, hold if SCr increases &gt; 1.5</p>, <p>b</p>, <p>a</p>, <p>a</p>, <p>a</p>, <p>c</p>, <p>c</p>, <p>c</p>, <p>folic acid 7 days prior to first dose &amp; 21 days after last dose; B12 every other cycle, 7 days prior to first dose</p>, <p>d</p>, <p>e</p>, <p>e</p>, <p>treat with dexamethasone BID x 3 days starting day before chemo</p>, <p>premedicate with steroids and antihistamines </p>, <p>doxetaxel, pemetrexed, gemcitabine</p>, <p>APAP</p>, <p>hyper-sensitivity; hepatic impairment</p> flashcards
Therapeutics NSCLC (Chemotherapy)

Therapeutics NSCLC (Chemotherapy)

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  • b

    Which is the preferred agent in patients with good performance status?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • b,c

    Which is dosed based off BSA?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • pre-hydrate with 1 L of NS prior to infusion, urine output >100ml for 1st 24 hrs, hold if SCr increases > 1.5

    What must be done prior to Cisplatin dosing? (3)

  • b

    Which can cause irritation that can lead to extravasation?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • a

    Which is dosed based off AUC (Calvert Equation)?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • a

    Which is best for patients with poor performance status?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • a

    Which has a BBW for infusion-related reactions?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • c

    Which should ONLY be used in patients with Non-Squamous Cell?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • c

    Which can cause neutropenic sepsis?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • c

    Which do we AVOID NSAIDS with?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • folic acid 7 days prior to first dose & 21 days after last dose; B12 every other cycle, 7 days prior to first dose

    Prior to giving Pemetrexed, what should we give the patient? (2)

  • d

    Which can cause flu-like symptoms?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • e

    Which has a BBW for hepatic impairment?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • e

    Which has a BBW for neutropenia?

    a) carboplatin

    b) cisplatin

    c) pemetrexed

    d) gemcitabine

    e) docetaxel

    f) paclitaxel

  • treat with dexamethasone BID x 3 days starting day before chemo

    How can we combat Doxetaxel-induced Edema?

  • premedicate with steroids and antihistamines

    How can we combat Doxetaxel-induced Hypersensitivity?

  • doxetaxel, pemetrexed, gemcitabine

    Which chemo agents are used in patients with Squamous Cell Carcinoma?(3)

  • APAP

    How do we treat Gemcitabine flu-symptoms?

  • hyper-sensitivity; hepatic impairment

    Paclitaxel can cause ________ reactions and should be avoided in patients with __________.