b
Which is the preferred agent in patients with good performance status?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
b,c
Which is dosed based off BSA?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
pre-hydrate with 1 L of NS prior to infusion, urine output >100ml for 1st 24 hrs, hold if SCr increases > 1.5
What must be done prior to Cisplatin dosing? (3)
b
Which can cause irritation that can lead to extravasation?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
a
Which is dosed based off AUC (Calvert Equation)?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
a
Which is best for patients with poor performance status?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
a
Which has a BBW for infusion-related reactions?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
c
Which should ONLY be used in patients with Non-Squamous Cell?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
c
Which can cause neutropenic sepsis?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
c
Which do we AVOID NSAIDS with?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
folic acid 7 days prior to first dose & 21 days after last dose; B12 every other cycle, 7 days prior to first dose
Prior to giving Pemetrexed, what should we give the patient? (2)
d
Which can cause flu-like symptoms?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
e
Which has a BBW for hepatic impairment?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
e
Which has a BBW for neutropenia?
a) carboplatin
b) cisplatin
c) pemetrexed
d) gemcitabine
e) docetaxel
f) paclitaxel
treat with dexamethasone BID x 3 days starting day before chemo
How can we combat Doxetaxel-induced Edema?
premedicate with steroids and antihistamines
How can we combat Doxetaxel-induced Hypersensitivity?
doxetaxel, pemetrexed, gemcitabine
Which chemo agents are used in patients with Squamous Cell Carcinoma?(3)
APAP
How do we treat Gemcitabine flu-symptoms?
hyper-sensitivity; hepatic impairment
Paclitaxel can cause ________ reactions and should be avoided in patients with __________.