Tablets & Tablet Coating

-are dispersed in water prior to ingestion

-Prepared by compression of granular effervescent salts that release carbon dioxide in contact with water

What are the different compounds used in making effervescent mixtures? (3)

What kind of tablets dissolve slowly?

a) buccal

b) dispersible

c) effervescent

d) sublingual

What kind of tablets dissolve immediately to deliver rapid drug effects?

a) buccal

b) dispersible

c) effervescent

d) sublingual

Which kind of tablets use super-disintegrants to make it dissolve faster in liquid?

a) buccal

b) dispersible

c) effervescent

d) sublingual

Which kind of tablets are used for drugs that are destroyed by gastric juice or poorly absorbed in GI tract?

a) buccal

b) dispersible

c) effervescent

d) sublingual

-found in most chewable tablets; provides a good feeling in the mouth.

What are some chewable tablets?

Oral disintegrating tablets is mostly used in what kind of patients?

What are some properties of Good tablets? (5)

Tablet shape is determined by ______ and ______ of punch and die set.

Which method of tablet making CANNOT be used for potent drugs like Clonazepam?

a) wet granulation

b) direct compression

c) dry granulation

d) hot melt extrusion

Which method of tablet making is expensive & time consuming?

a) wet granulation

b) direct compression

c) dry granulation

d) hot melt extrusion

-Partial or complete separation of the top or bottom crowns of the tablet

-Separation of a tablet into two or more distinct layers

-Un-uniform distribution of color on a tablet, with light or dark spots appearing on surface

-The granules adhere to the die wall and punches.

-The tablet punches pick the contents of the tablet surface. Picking occurs on the letters, logos, and other designs of the punch face.

-Occurs in punches with engraving on the surface.

<25 degrees indicates _______ flow.

Active ingredient should lie between ___________ of the labeled value.

________ an acceptable hardness for an uncoated tablet.

-determines the tablet’s resistance to cracking, chipping and breaking during handling, packaging and shipping.

-water in beaker maintained at 37 +/- 2 degrees celsius

-shaft moves up and down at 29-32 cycles/min

-coated with a  polymer to form thin film around the surface. The release profile of drug from the dosage form depends on the nature of the  coating polymer.

What type of coating results in a "tablet within a tablet" or shell and core?

Hardness is a function of __________ and ____________.

What could be possible reasons as to why tablets vary in weight?

What are quality issues in coated tablets?

Why do quality issues in coated tablets occur?

What are disadvantages associated with sugar coating?

What difference in weight in the friability test is considered acceptable?