dispersible tablets
-are dispersed in water prior to ingestion
effervescent tablets
-Prepared by compression of granular effervescent salts that release carbon dioxide in contact with water
citric acid, tartaric acid, sodium bicarbonate
What are the different compounds used in making effervescent mixtures? (3)
a
What kind of tablets dissolve slowly?
a) buccal
b) dispersible
c) effervescent
d) sublingual
c,d
What kind of tablets dissolve immediately to deliver rapid drug effects?
a) buccal
b) dispersible
c) effervescent
d) sublingual
b
Which kind of tablets use super-disintegrants to make it dissolve faster in liquid?
a) buccal
b) dispersible
c) effervescent
d) sublingual
d
Which kind of tablets are used for drugs that are destroyed by gastric juice or poorly absorbed in GI tract?
a) buccal
b) dispersible
c) effervescent
d) sublingual
mannitol
-found in most chewable tablets; provides a good feeling in the mouth.
antacids, pediatric vitamins, anti-flatulent
What are some chewable tablets?
patients w difficulty swallowing; nausea & vomiting caused by chemo
Oral disintegrating tablets is mostly used in what kind of patients?
physical & chemical stability, esthetic appearance, bioavailable, content uniformity
What are some properties of Good tablets? (5)
shape; size
Tablet shape is determined by ______ and ______ of punch and die set.
b
Which method of tablet making CANNOT be used for potent drugs like Clonazepam?
a) wet granulation
b) direct compression
c) dry granulation
d) hot melt extrusion
a
Which method of tablet making is expensive & time consuming?
a) wet granulation
b) direct compression
c) dry granulation
d) hot melt extrusion
capping
-Partial or complete separation of the top or bottom crowns of the tablet
lamination
-Separation of a tablet into two or more distinct layers
mottling
-Un-uniform distribution of color on a tablet, with light or dark spots appearing on surface
sticking
-The granules adhere to the die wall and punches.
picking
-The tablet punches pick the contents of the tablet surface. Picking occurs on the letters, logos, and other designs of the punch face.
double impression
-Occurs in punches with engraving on the surface.
excellent
<25 degrees indicates _______ flow.
85-115%
Active ingredient should lie between ___________ of the labeled value.
4-6
________ an acceptable hardness for an uncoated tablet.
friability test
-determines the tablet’s resistance to cracking, chipping and breaking during handling, packaging and shipping.
tablet disintegration test
-water in beaker maintained at 37 +/- 2 degrees celsius
-shaft moves up and down at 29-32 cycles/min
film coating
-coated with a polymer to form thin film around the surface. The release profile of drug from the dosage form depends on the nature of the coating polymer.
compression coating
What type of coating results in a "tablet within a tablet" or shell and core?
compression force; amount of binding agent
Hardness is a function of __________ and ____________.
poor flow of granules; improper setting of die volume
What could be possible reasons as to why tablets vary in weight?
blistering, chipping, peeling, orange peel, sticking/picking
What are quality issues in coated tablets?
improper drying, formulation composition, processing issues
Why do quality issues in coated tablets occur?
time consuming; increase in size and weight of tablet
What are disadvantages associated with sugar coating?
less than 1%
What difference in weight in the friability test is considered acceptable?