2023-08-30T03:10:15+03:00[Europe/Moscow] en true <p>d</p>, <p>a</p>, <p>c</p>, <p>b</p>, <p>clonidine, methyldopa </p>, <p>first letter begins with O-Z</p>, <p>labetalol, carvedilol; vasodilation</p>, <p>-zosin suffix</p>, <p>agonizes the a-2 receptor, preventing release of NE; decreases catecholamine release in postganglionic fibers </p>, <p>replaces NE in vesicles; blocks conversion of L-DPOA to dopamine</p>, <p>decreases HR &amp; PR</p>, <p>peripheral vasoconstriction, bronchoconstriction, hypoglycemia </p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>d</p>, <p>e</p>, <p>decrease force of contraction, decrease HR by changing rhythm produced by SA node, slow AV conduction</p>, <p>antagonize B1 receptors on JGA; decreasing renin release</p>, <p>first letter begins with A-N; except nadolol</p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>d</p>, <p>e</p>, <p>bradycardia, bradyarrhythmias </p>, <p>worsening of pre-existing asthma</p>, <p> masked hypoglycemia</p>, <p>sedation, vivid dreams/nightmares, insomnia</p>, <p>Acebutolol, Pindolol</p>, <p>highly selective A-1 antagonist; relax arterial and venous smooth muscles; peripheral vasodilation </p>, <p>orthostatic hypotension</p>, <p>b</p>, <p>men with benign prostatic hyperplasia + hypertension</p>, <p>tachycardia, dizziness, flushing, headache, edema, nasal congestion</p>, <p>give at bedtime </p>, <p>b,c </p> flashcards
Sympatholytics

Sympatholytics

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  • d

    Which receptor causes smooth muscle bronchodilation?

    a) alpha 1

    b alpha 2

    c) beta 1

    d) beta 2

  • a

    Which receptor causes vascular, smooth muscle vasoconstriction?

    a) alpha 1

    b alpha 2

    c) beta 1

    d) beta 2

  • c

    Which receptor causes an increase in heart rate & contractile force?

    a) alpha 1

    b alpha 2

    c) beta 1

    d) beta 2

  • b

    Which receptor regulates NE in the Presynaptic terminal?

    a) alpha 1

    b alpha 2

    c) beta 1

    d) beta 2

  • clonidine, methyldopa

    What are the centrally-acting sympatholytics ? (2)

  • first letter begins with O-Z

    How can we tell our Non-selective beta blockers apart?

  • labetalol, carvedilol; vasodilation

    What are the mixed A&B blockers?(2) What does this cause?

  • -zosin suffix

    How can we identify alpha blockers?

  • agonizes the a-2 receptor, preventing release of NE; decreases catecholamine release in postganglionic fibers

    Clonidine MOA? (2)

  • replaces NE in vesicles; blocks conversion of L-DPOA to dopamine

    Methyldopa MOA?

  • decreases HR & PR

    How does Clonidine effect BP?

  • peripheral vasoconstriction, bronchoconstriction, hypoglycemia

    What are AE's of non-selective Beta blockers? (3)

  • a

    Which one has a High Lipid Solubility?

    a) Propranolol

    b) Nadolol

    c) Pindolol

    d) Labetalol

    e) Carvedilol

  • b

    Which one has the longest half-life (24 hours) ?

    a) Propranolol

    b) Nadolol

    c) Pindolol

    d) Labetalol

    e) Carvedilol

  • c

    Which one has intrinsic activity & not recommended?

    a) Proppranolol

    b) Nadolol

    c) Pindolol

    d) Labetalol

    e) Carvedilol

  • d

    Which one is is especially important for HTN in pregnancy?

    a) Proppranolol

    b) Nadolol

    c) Pindolol

    d) Labetalol

    e) Carvedilol

  • e

    Which one is important for HF & PAD because of its vasodilating effects?

    a) Proppranolol

    b) Nadolol

    c) Pindolol

    d) Labetalol

    e) Carvedilol

  • decrease force of contraction, decrease HR by changing rhythm produced by SA node, slow AV conduction

    How do Beta-blockers affect the heart? (3)

  • antagonize B1 receptors on JGA; decreasing renin release

    How do Beta-Blockers affect the kidney?

  • first letter begins with A-N; except nadolol

    How can we tell our B1 selective blockers apart?

  • a

    Which can cause angina pectoris?

    a) metoprolol

    b) atenolol

    c) acebutolol

    d) nebivolol

    e) Esmolol

  • c

    Which has intrinsic activity due to it being a partial agonist?

    a) metoprolol

    b) atenolol

    c) acebutolol

    d) nebivolol

    e) Esmolol

  • d

    Which is the most highly selective B1 blocker?

    a) metoprolol

    b) atenolol

    c) acebutolol

    d) nebivolol

    e) Esmolol

  • d

    Which one causes vasodilation and endothelial NO production?

    a) metoprolol

    b) atenolol

    c) acebutolol

    d) nebivolol

    e) Esmolol

  • e

    Which one has a very short half-life (10 min) ?

    a) metoprolol

    b) atenolol

    c) acebutolol

    d) nebivolol

    e) Esmolol

  • bradycardia, bradyarrhythmias

    What are CV AE's associated with Beta Blockers? (2)

  • worsening of pre-existing asthma

    What are Respiratory AE's associated with Beta Blockers?

  • masked hypoglycemia

    What are metabolic AE's associated with Beta blockers?

  • sedation, vivid dreams/nightmares, insomnia

    What are CNS AE's associated with Beta Blockers?

  • Acebutolol, Pindolol

    Which beta blockers are partial agonist? (2)

  • highly selective A-1 antagonist; relax arterial and venous smooth muscles; peripheral vasodilation

    A-1 blockers MOA?

  • orthostatic hypotension

    What is the MOST significant adverse effect of A-1 blockers?

  • b

    A-1 blockers can also relax the smooth muscle of what gland?

    a) hypothalamus

    b) prostate

    c) anal sphincter

    d) Thyroid

  • men with benign prostatic hyperplasia + hypertension

    When would we use a-1 blockers?

  • tachycardia, dizziness, flushing, headache, edema, nasal congestion

    AE's in A-1 blockers? (6)

  • give at bedtime

    How can we combat orthostasis in A1- antagonists?

  • b,c

    Which comes in an OROS-based dosage form?

    a) terazosin

    b) doxazosin

    c) prazosin

    d) alfuzosin