d
Which receptor causes smooth muscle bronchodilation?
a) alpha 1
b alpha 2
c) beta 1
d) beta 2
a
Which receptor causes vascular, smooth muscle vasoconstriction?
a) alpha 1
b alpha 2
c) beta 1
d) beta 2
c
Which receptor causes an increase in heart rate & contractile force?
a) alpha 1
b alpha 2
c) beta 1
d) beta 2
b
Which receptor regulates NE in the Presynaptic terminal?
a) alpha 1
b alpha 2
c) beta 1
d) beta 2
clonidine, methyldopa
What are the centrally-acting sympatholytics ? (2)
first letter begins with O-Z
How can we tell our Non-selective beta blockers apart?
labetalol, carvedilol; vasodilation
What are the mixed A&B blockers?(2) What does this cause?
-zosin suffix
How can we identify alpha blockers?
agonizes the a-2 receptor, preventing release of NE; decreases catecholamine release in postganglionic fibers
Clonidine MOA? (2)
replaces NE in vesicles; blocks conversion of L-DPOA to dopamine
Methyldopa MOA?
decreases HR & PR
How does Clonidine effect BP?
peripheral vasoconstriction, bronchoconstriction, hypoglycemia
What are AE's of non-selective Beta blockers? (3)
a
Which one has a High Lipid Solubility?
a) Propranolol
b) Nadolol
c) Pindolol
d) Labetalol
e) Carvedilol
b
Which one has the longest half-life (24 hours) ?
a) Propranolol
b) Nadolol
c) Pindolol
d) Labetalol
e) Carvedilol
c
Which one has intrinsic activity & not recommended?
a) Proppranolol
b) Nadolol
c) Pindolol
d) Labetalol
e) Carvedilol
d
Which one is is especially important for HTN in pregnancy?
a) Proppranolol
b) Nadolol
c) Pindolol
d) Labetalol
e) Carvedilol
e
Which one is important for HF & PAD because of its vasodilating effects?
a) Proppranolol
b) Nadolol
c) Pindolol
d) Labetalol
e) Carvedilol
decrease force of contraction, decrease HR by changing rhythm produced by SA node, slow AV conduction
How do Beta-blockers affect the heart? (3)
antagonize B1 receptors on JGA; decreasing renin release
How do Beta-Blockers affect the kidney?
first letter begins with A-N; except nadolol
How can we tell our B1 selective blockers apart?
a
Which can cause angina pectoris?
a) metoprolol
b) atenolol
c) acebutolol
d) nebivolol
e) Esmolol
c
Which has intrinsic activity due to it being a partial agonist?
a) metoprolol
b) atenolol
c) acebutolol
d) nebivolol
e) Esmolol
d
Which is the most highly selective B1 blocker?
a) metoprolol
b) atenolol
c) acebutolol
d) nebivolol
e) Esmolol
d
Which one causes vasodilation and endothelial NO production?
a) metoprolol
b) atenolol
c) acebutolol
d) nebivolol
e) Esmolol
e
Which one has a very short half-life (10 min) ?
a) metoprolol
b) atenolol
c) acebutolol
d) nebivolol
e) Esmolol
bradycardia, bradyarrhythmias
What are CV AE's associated with Beta Blockers? (2)
worsening of pre-existing asthma
What are Respiratory AE's associated with Beta Blockers?
masked hypoglycemia
What are metabolic AE's associated with Beta blockers?
sedation, vivid dreams/nightmares, insomnia
What are CNS AE's associated with Beta Blockers?
Acebutolol, Pindolol
Which beta blockers are partial agonist? (2)
highly selective A-1 antagonist; relax arterial and venous smooth muscles; peripheral vasodilation
A-1 blockers MOA?
orthostatic hypotension
What is the MOST significant adverse effect of A-1 blockers?
b
A-1 blockers can also relax the smooth muscle of what gland?
a) hypothalamus
b) prostate
c) anal sphincter
d) Thyroid
men with benign prostatic hyperplasia + hypertension
When would we use a-1 blockers?
tachycardia, dizziness, flushing, headache, edema, nasal congestion
AE's in A-1 blockers? (6)
give at bedtime
How can we combat orthostasis in A1- antagonists?
b,c
Which comes in an OROS-based dosage form?
a) terazosin
b) doxazosin
c) prazosin
d) alfuzosin