2023-04-24T23:37:54+03:00[Europe/Moscow] en true <p>a</p>, <p>b</p>, <p>c</p>, <p>large scale production is expensive; strict storage conditions/ shelf life</p>, <p>cocoa butter, synthetic fats, proprietary synthetic</p>, <p>glycero-gelatin, peg</p>, <p>emulsions, oil water mixture</p>, <p>b</p>, <p>cocoa butter</p>, <p>b</p>, <p>c</p>, <p>a</p>, <p>&lt;= 35</p>, <p>&gt; 36</p>, <p>b</p>, <p>Y, A, B', B</p>, <p>palm kernel oil, cottonseed oil</p>, <p>esterification, hydrogenation, fractionation</p>, <p>proprietary bases</p>, <p>Glycerinated gelatin</p>, <p>PEG</p>, <p>Water soluble bases</p>, <p>GG has slow dissolution and harder to prepare </p>, <p>water soluble bases; fatty bases</p>, <p>vaginal; urethral </p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>d</p>, <p>a</p>, <p>c</p>, <p>b</p>, <p>ss, aluminum, brass, plastic</p>, <p>b</p>, <p>d</p>, <p>b</p> flashcards
Suppositories

Suppositories

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  • a

    Which suppository has a cone or torpedo shape?

    a) rectal

    b) vaginal

    c) urethral

  • b

    Which suppository has globular/wedge-shaped?

    a) rectal

    b) vaginal

    c) urethral

  • c

    Which suppository has a thin pencil shape?

    a) rectal

    b) vaginal

    c) urethral

  • large scale production is expensive; strict storage conditions/ shelf life

    What are 2 disadvantages associated with suppository use?

  • cocoa butter, synthetic fats, proprietary synthetic

    What are our fatty base suppositories? (3)

  • glycero-gelatin, peg

    What are our soluble/water miscible suppositories? (2)

  • emulsions, oil water mixture

    What are our miscellaneous suppositories? (2)

  • b

    What is the most widely used base?

    a) synthetic fat

    b) cocoa butter

    c) proprietary synthetic

    d) glycero-gelatin

    e) emulsion

  • cocoa butter

    -naturally occurring triglyceride

    -innocuous, bland, non-irritating, non-reactive

  • b

    Which base is susceptible to oxidation or rancidity in the presence of unsaturated fatty acids?

    a) synthetic fat

    b) cocoa butter

    c) proprietary synthetic

    d) glycero-gelatin

    e) emulsion

  • c

    Which form of Coco butter crystallizes out of liquefied cocoa butter w/stirring?

    a)A form

    b) B' form

    c) B form

    d) Y form

  • a

    Which forms of Coco butter are obtained by suddenly cooling the melted cocoa butter to 0 degrees celsius?

    a)A form

    b) B' form

    c) B form

    d) Y form

  • <= 35

    Slow cooling =

  • > 36

    Rapid cooling =

  • b

    Which type of cooling can result in a suppository re-melting at room temperature?

    a) slow cooling

    b) rapid cooling

  • Y, A, B', B

    Order the suppository forms by melting temp. (lowest to highest)

  • palm kernel oil, cottonseed oil

    What are the common sources of Fatty bases? (2)

  • esterification, hydrogenation, fractionation

    What are the methods of modifying fatty bases? (3)

  • proprietary bases

    -consists of tryglycerides of saturated vegetable acids with varying proportions of partial esters.

    -e.g. Witepsol

  • Glycerinated gelatin

    -20% granular gelatin, 70% glycerin, 10% medication and minor excipients

  • PEG

    -polymers of ethylene oxide and water in various chain lengths and MWs (200-8000)

  • Water soluble bases

    -are chemically stable, miscible with water and mucous boundary layer

    -can increase aqueous boundary later volume

  • GG has slow dissolution and harder to prepare

    Why are PEG's preferred over Glycerinated gelatin?

  • water soluble bases; fatty bases

    Drug release is better in _____ than _______.

  • vaginal; urethral

    Water soluble/miscible bases are used more in _______ & _______ suppositories where longer localized action is desired.

  • a

    Fatty + Lipophilic drug =

    a) slow release

    b) rapid release

    c) moderate release

    d) moderate release (based on diffusion)

  • b

    Fatty + hydrophilic drug=

    a) slow release

    b) rapid release

    c) moderate release

    d) moderate release (based on diffusion)

  • c

    water soluble + lipophilic drug =

    a) slow release

    b) rapid release

    c) moderate release

    d) moderate release (based on diffusion)

  • d

    Water soluble + hydrophilic =

    a) slow release

    b) rapid release

    c) moderate release

    d) moderate release (based on diffusion)

  • a

    Which suppository preparation is used in extemporaneous compounding?

    a) hand rolling

    b) compression

    c) molds/fusion

  • c

    Which suppository preparation involves melting the base?

    a) hand rolling

    b) compression

    c) molds/fusion

  • b

    Which suppository preparation involves using force or friction to mix ingredients?

    a) hand rolling

    b) compression

    c) molds/fusion

  • ss, aluminum, brass, plastic

    What can molds be made of? (4)

  • b

    Which form of Coco butter changes slowly into stable form?

    a)A form

    b) B' form

    c) B form

    d) Y form

  • d

    Which form of Cocoa butter utilizes deep freeze?

    a)A form

    b) B' form

    c) B form

    d) Y form

  • b

    Which base should be coated in water upon insertion because of their hygroscopic nature?

    a) fatty base

    b) water soluble/miscible

    c) miscellaneous