a
Which suppository has a cone or torpedo shape?
a) rectal
b) vaginal
c) urethral
b
Which suppository has globular/wedge-shaped?
a) rectal
b) vaginal
c) urethral
c
Which suppository has a thin pencil shape?
a) rectal
b) vaginal
c) urethral
large scale production is expensive; strict storage conditions/ shelf life
What are 2 disadvantages associated with suppository use?
cocoa butter, synthetic fats, proprietary synthetic
What are our fatty base suppositories? (3)
glycero-gelatin, peg
What are our soluble/water miscible suppositories? (2)
emulsions, oil water mixture
What are our miscellaneous suppositories? (2)
b
What is the most widely used base?
a) synthetic fat
b) cocoa butter
c) proprietary synthetic
d) glycero-gelatin
e) emulsion
cocoa butter
-naturally occurring triglyceride
-innocuous, bland, non-irritating, non-reactive
b
Which base is susceptible to oxidation or rancidity in the presence of unsaturated fatty acids?
a) synthetic fat
b) cocoa butter
c) proprietary synthetic
d) glycero-gelatin
e) emulsion
c
Which form of Coco butter crystallizes out of liquefied cocoa butter w/stirring?
a)A form
b) B' form
c) B form
d) Y form
a
Which forms of Coco butter are obtained by suddenly cooling the melted cocoa butter to 0 degrees celsius?
a)A form
b) B' form
c) B form
d) Y form
<= 35
Slow cooling =
> 36
Rapid cooling =
b
Which type of cooling can result in a suppository re-melting at room temperature?
a) slow cooling
b) rapid cooling
Y, A, B', B
Order the suppository forms by melting temp. (lowest to highest)
palm kernel oil, cottonseed oil
What are the common sources of Fatty bases? (2)
esterification, hydrogenation, fractionation
What are the methods of modifying fatty bases? (3)
proprietary bases
-consists of tryglycerides of saturated vegetable acids with varying proportions of partial esters.
-e.g. Witepsol
Glycerinated gelatin
-20% granular gelatin, 70% glycerin, 10% medication and minor excipients
PEG
-polymers of ethylene oxide and water in various chain lengths and MWs (200-8000)
Water soluble bases
-are chemically stable, miscible with water and mucous boundary layer
-can increase aqueous boundary later volume
GG has slow dissolution and harder to prepare
Why are PEG's preferred over Glycerinated gelatin?
water soluble bases; fatty bases
Drug release is better in _____ than _______.
vaginal; urethral
Water soluble/miscible bases are used more in _______ & _______ suppositories where longer localized action is desired.
a
Fatty + Lipophilic drug =
a) slow release
b) rapid release
c) moderate release
d) moderate release (based on diffusion)
b
Fatty + hydrophilic drug=
a) slow release
b) rapid release
c) moderate release
d) moderate release (based on diffusion)
c
water soluble + lipophilic drug =
a) slow release
b) rapid release
c) moderate release
d) moderate release (based on diffusion)
d
Water soluble + hydrophilic =
a) slow release
b) rapid release
c) moderate release
d) moderate release (based on diffusion)
a
Which suppository preparation is used in extemporaneous compounding?
a) hand rolling
b) compression
c) molds/fusion
c
Which suppository preparation involves melting the base?
a) hand rolling
b) compression
c) molds/fusion
b
Which suppository preparation involves using force or friction to mix ingredients?
a) hand rolling
b) compression
c) molds/fusion
ss, aluminum, brass, plastic
What can molds be made of? (4)
b
Which form of Coco butter changes slowly into stable form?
a)A form
b) B' form
c) B form
d) Y form
d
Which form of Cocoa butter utilizes deep freeze?
a)A form
b) B' form
c) B form
d) Y form
b
Which base should be coated in water upon insertion because of their hygroscopic nature?
a) fatty base
b) water soluble/miscible
c) miscellaneous