Hosam Mohamed-
a
Which sulfa drug is used to treat bacterial vaginosis?
a) AVC
b) sulfacetamide sodium
c) sulfisoxazole
d) sulfisoxazole acetate
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b
Which sulfa drug is used to treat bacterial conjunctivitis?
a) AVC
b) sulfacetamide sodium
c) sulfisoxazole
d) sulfisoxazole acetate
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c
Which sulfa drug is used to treat UTI?
a) AVC
b) sulfacetamide sodium
c) sulfisoxazole
d) sulfisoxazole acetate
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c
Which sulfa drug is used to treat pediatric ear infections caused by Norcardia ?
a) AVC
b) sulfacetamide sodium
c) sulfisoxazole
d) sulfisoxazole acetate
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d
Which sulfa drug is used to treat H.flu ear infections?
a) AVC
b) sulfacetamide sodium
c) sulfisoxazole
d) sulfisoxazole acetate
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a
Which sulfa drug is used to treat minor UTI?
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d) sulfasalazine
e) sulfamethoxazole
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b,c
Which sulfa drug is used for the prevention of infection in wounds and burns?
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d)sulfasalazine
e) sulfamethoxazole
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c
Which sulfa drug can inhibit carbonic anyhydrase and lead to metabolic acidosis?
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d) sulfasalazine
e) sulfamethoxazole
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b
Which sulfa drug is especially active against Pseudomonas that may infect burn wounds?
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d)sulfasalazine
e) sulfamethoxazole
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d
Which sulfa drug is considered anti-inflammatory and inhibits prostaglandin synthesis in the GI tract? i.e. reduces diarrhea)
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d)sulfasalazine
e) sulfamethoxazole
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e
Which of the following sulfa drugs is used in conjunction with Trimethoprim?
a) sulfamethizole
b) silver sulfadiazine
c) mefenide acetate
d)sulfasalazine
e) sulfamethoxazole
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b
Sulfamethoxazole is _____.
a) cidal
b) static
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a
Trimethoprim is _____
a) cidal
b) static
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gm-: ear infection, h.flu, uti
SMX-TMP combination therapy is 1st line for?
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fungus
Pneumocystis Pneumonia is a ________.
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Pneumocystis Pneumonia
SMX is the DOC for ?
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displaces drugs from album; increasing their drug concentration except for cyclosporine
How does SMX affect drug concentrations of other drugs?
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certain bacteria lack enzymes to synthesize folate
What are the inherent bacterial resistance mechanisms for Sulfonamide?
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increased PAPA production, produce altered dihydropteroate, decreased permeability of sulfonamide into cell, MDR
What are the acquired bacterial resistance mechanisms for Sulfonamide?
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decreased permeability of trimethoprim into cell, increased production of dihydrofolate reductase, altered dihydrofolate reductase enzyme
What are the acquired bacterial resistance mechanisms for Trimethoprim?
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a
Which sulfa drug is used to treat Nocardiosis RTI and toxoplasmosis?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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a
Which sulfa drug can cause decreased carnitine levels that lead to mental changes?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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a
Which sulfa drug can cause leucopenia and anemia?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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b
Which drug is used as an alternate therapy in AIDS patients to treat Pneumocystis jiroveci pneumonia?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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c
Which drug is used in conjunction with Rifampin to treat Mycobacterium leprae?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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rash, fever, headache, photosensitivity, blood disorder
What are SE's associated with Dapsone?
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c
Antacids and H2 blockers decreased absorption of ________.
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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d,e
Which drug is a prodrug?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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d
Which drug possesses several mechanisms to slow down bacterial resistance?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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e
Which drug requires acidic urine pH? Commonly advised to drink Vit C & Cranberry Juice.
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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f
Which drug inhibits phosphoenolpyruvate transferase enzyme that catalyzes formation of diphosphate-N-acetylmuramic acid that is needed for cell wall formation?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
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d
Which drug is used to treat SMX-TMP/ FQ resistant E.coli?
a) sulfadiazine
b) trimetrexate glucuronate
c) dapsone
d) Nitrofurantoin
e) Methenamine
f) Fosfomycin tromethamine
