2023-03-19T05:24:33+03:00[Europe/Moscow] en true <p>synergistic combination of two protein synthesis inhibitors bind to two different sites on the bacterial 50S ribosomal subunit</p>, <p>semisynthetic</p>, <p>dalfopristin</p>, <p>quiniupristin </p>, <p>meningitis &amp; endocarditis caused by enterococcus faecium; VREF</p>, <p>c</p>, <p>N&amp;V, rash, diarrhea, athralgia</p>, <p>those metabolized by CYP450</p>, <p>mix with D5W; also wash; don't use saline</p>, <p>agricultural use</p>, <p>ribosomal protection, acetyltransferase, efflux</p>, <p>tab, suspension, iv</p>, <p>a</p>, <p>myelosuppression, thrombocytopenia, anemia, neutropenia, peripheral </p>, <p>cidal or static depends on dose; gm + </p>, <p>VRMRSA, VREF, CAP, </p>, <p>b</p>, <p>complicated skin infection; nosocomial entero faecalis </p>, <p>tablet/ iv</p>, <p>rRNA mutation decreases binding, ribosome protection, efflux</p>, <p>MRSA carriage, minor skin infections staph &amp; strep</p>, <p>narrow spectrum; gm+ aerobes; gm- anaerobes </p> flashcards
Streptogramins & Oxazolidinones

Streptogramins & Oxazolidinones

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  • synergistic combination of two protein synthesis inhibitors bind to two different sites on the bacterial 50S ribosomal subunit

    Synercid MOA?

  • semisynthetic

    Synercid is a ______ compound.

  • dalfopristin

    Which portion of Synercid acts at the early stage of protein formation?

  • quiniupristin

    Which portion of Synercid acts at late stage protein formation (protein elongation)?

  • meningitis & endocarditis caused by enterococcus faecium; VREF

    Synercid tx?

  • c

    Which causes injection site pain?

    a) Linezolid

    b) tedizolid phosphate

    c) Synercid

  • N&V, rash, diarrhea, athralgia

    What are side effects associated with Synercid?

  • those metabolized by CYP450

    What kind of drugs should be avoided when using Synercid?

  • mix with D5W; also wash; don't use saline

    How do we administer Synercid?

  • agricultural use

    _________ may be contributing to resistance.

  • ribosomal protection, acetyltransferase, efflux

    What methods of resistance do bacteria exhibit against Streptogramins ? (3)

  • tab, suspension, iv

    What are the dosage forms of Linezolid?

  • a

    Linezolid is a ________ compound.

    a) synthetic

    b) natural

  • myelosuppression, thrombocytopenia, anemia, neutropenia, peripheral

    What are SE's associated with Oxazolidinones?

  • cidal or static depends on dose; gm +

    Oxazolidinones spectrum?

  • VRMRSA, VREF, CAP,

    Oxazolidinones tx?

  • b

    Which is a prodrug?

    a) Linezolid

    b) tedizolid phosphate

    c) Synercid

  • complicated skin infection; nosocomial entero faecalis

    Tedizolid Phosphate tx?

  • tablet/ iv

    What is the dosage form of Tedizolid?

  • rRNA mutation decreases binding, ribosome protection, efflux

    How do bacteria resist Oxazolidinones?

  • MRSA carriage, minor skin infections staph & strep

    Mupirocin tx?

  • narrow spectrum; gm+ aerobes; gm- anaerobes

    What is the spectrum for Mupirocin?