synergistic combination of two protein synthesis inhibitors bind to two different sites on the bacterial 50S ribosomal subunit
Synercid MOA?
semisynthetic
Synercid is a ______ compound.
dalfopristin
Which portion of Synercid acts at the early stage of protein formation?
quiniupristin
Which portion of Synercid acts at late stage protein formation (protein elongation)?
meningitis & endocarditis caused by enterococcus faecium; VREF
Synercid tx?
c
Which causes injection site pain?
a) Linezolid
b) tedizolid phosphate
c) Synercid
N&V, rash, diarrhea, athralgia
What are side effects associated with Synercid?
those metabolized by CYP450
What kind of drugs should be avoided when using Synercid?
mix with D5W; also wash; don't use saline
How do we administer Synercid?
agricultural use
_________ may be contributing to resistance.
ribosomal protection, acetyltransferase, efflux
What methods of resistance do bacteria exhibit against Streptogramins ? (3)
tab, suspension, iv
What are the dosage forms of Linezolid?
a
Linezolid is a ________ compound.
a) synthetic
b) natural
myelosuppression, thrombocytopenia, anemia, neutropenia, peripheral
What are SE's associated with Oxazolidinones?
cidal or static depends on dose; gm +
Oxazolidinones spectrum?
VRMRSA, VREF, CAP,
Oxazolidinones tx?
b
Which is a prodrug?
a) Linezolid
b) tedizolid phosphate
c) Synercid
complicated skin infection; nosocomial entero faecalis
Tedizolid Phosphate tx?
tablet/ iv
What is the dosage form of Tedizolid?
rRNA mutation decreases binding, ribosome protection, efflux
How do bacteria resist Oxazolidinones?
MRSA carriage, minor skin infections staph & strep
Mupirocin tx?
narrow spectrum; gm+ aerobes; gm- anaerobes
What is the spectrum for Mupirocin?