Sodium channel blockers

2017-07-29T19:36:54+03:00[Europe/Moscow] en true Tetrodotoxin, Ajmaline, Lidocaine, Safinamide, Topiramate, Lorazepam, Quinidine, Saxitoxin, Procainamide, Pethidine, Primidone, Propafenone, Nefopam, Amitriptyline, Prajmaline, Moracizine, Ranolazine, PF-05089771, Raxatrigine, Funapide, Kavain, Butidrine, Norpropoxyphene, Ralfinamide, Evenamide, Irampanel, Zonisamide, Aprindine, Buprenorphine, Rufinamide, Phenytoin, Sparteine, Amiloride, Ethacizine, Ketamine, Tolperisone, Ketocaine, Orphenadrine, Methysticin, Lacosamide, Mexiletine, Flecainide, Propranolol, Disopyramide, Encainide, Lorcainide, Lorajmine, Bupropion/zonisamide, Coronaridine, Neosaxitoxin flashcards Sodium channel blockers
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  • Tetrodotoxin
    Tetrodotoxin (TTX) is a potent neurotoxin.
  • Ajmaline
    Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is class Ia antiarrhythmic agent.
  • Lidocaine
    Lidocaine, also known as xylocaine and lignocaine, is a medication used to numb tissue in a specific area and to treat ventricular tachycardia.
  • Safinamide
    Safinamide (INN; brand name Xadago) is a drug indicated for the treatment of Parkinson's disease with monoamine oxidase B inhibiting and other methods of action.
  • Topiramate
    Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug.
  • Lorazepam
    Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication.
  • Quinidine
    Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.
  • Saxitoxin
    Saxitoxin (STX) is a potent neurotoxin and the best-known paralytic shellfish toxin (PST).
  • Procainamide
    Procainamide is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias.
  • Pethidine
    Pethidine, also known as meperidine and Demerol, is a synthetic opioid pain medication of the phenylpiperidine class.
  • Primidone
    Primidone (INN, BAN, USP) is an anticonvulsant of the barbiturate class.
  • Propafenone
    Propafenone (/proʊˈpæfᵻnoʊn/ proh-PAF-i-nohn; brand name Rythmol SR or Rytmonorm) is a class 1C anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
  • Nefopam
    Nefopam (brand names: Acupan, Silentan, Nefadol and Ajan) is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class which was developed by Riker Laboratories in the 1960s.
  • Amitriptyline
    Amitriptyline, sold under the brand name Elavil among others, is a medicine used to treat a number of mental illnesses.
  • Prajmaline
    Prajmaline (Neo-gilurythmal) is a class Ia antiarrhythmic agent which has been available since the 1970s.
  • Moracizine
    Moracizine (INN) or moricizine (USAN) (trade name Ethmozine) is an antiarrhythmic of class IC.
  • Ranolazine
    Ranolazine, sold under the trade name Ranexa by Gilead Sciences, is a drug to treat angina that was first approved in 2006.
  • PF-05089771
    PF-05089771 is a selective, small-molecule Nav1.
  • Raxatrigine
    Raxatrigine (INN, USAN) (formerly CNV1014802, GSK-1014802) is a novel analgesic under development by Convergence Pharmaceuticals for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia (TGN).
  • Funapide
    Funapide (INN) (former developmental code names TV-45070 and XEN402) is a novel analgesic under development by Xenon Pharmaceuticals in partnership with Teva Pharmaceutical Industries for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain.
  • Kavain
    Kavain is the main kavalactone found mostly in the roots of the kava plant.
  • Butidrine
    Butidrine (INN) (brand names Betabloc, Butidrate, Recetan), or butedrine or butydrine, also known as hydrobutamine or idrobutamine, is a beta blocker related to pronethalol and propranolol that was developed in the 1960s.
  • Norpropoxyphene
    Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose.
  • Ralfinamide
    Ralfinamide (INN) (code names NW-1029, FCE-26742A, PNU-0154339E) is a multimodal drug which is under investigation by Newron Pharmaceuticals for the treatment of neuropathic pain and other pain conditions such as post-operative dental pain.
  • Evenamide
    Evenamide (INN) (developmental code names NW-3509, NW-3509A) is a selective voltage-gated sodium channel blocker, including (and not limited to) subtypes Nav1.
  • Irampanel
    Irampanel (INN, code name BIIR-561) is a drug which acts as a dual noncompetitive antagonist of the AMPA receptor and neuronal voltage-gated sodium channel blocker.
  • Zonisamide
    Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures; infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.
  • Aprindine
    Aprindine is a Class 1b antiarrhythmic agent.
  • Buprenorphine
    Buprenorphine is a semisynthetic opioid derivative of thebaine.
  • Rufinamide
    Rufinamide is an anticonvulsant medication.
  • Phenytoin
    Phenytoin, sold under the brand name Dilantin among others, is an anti-seizure medication.
  • Sparteine
    Sparteine is a class 1a antiarrhythmic agent; a sodium channel blocker.
  • Amiloride
    Amiloride, trade name Midamor, is a potassium-sparing diuretic first approved for use in 1967 (then known as MK-870).
  • Ethacizine
    Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine.
  • Ketamine
    Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.
  • Tolperisone
    Tolperisone, a piperidine derivative, is a centrally acting muscle relaxant.
  • Ketocaine
    Ketocaine (INN) (brand name Vericaina, former developmental code name Astra 2358 or A-2358) is an amino ether local anesthetic of the butyrophenone family used topically for pain relief which is marketed in Italy.
  • Orphenadrine
    Orphenadrine (sold under many brand names worldwide) is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.
  • Methysticin
    Methysticin is one of the six major kavalactones found in the kava plant.
  • Lacosamide
    Lacosamide (INN, formerly known as erlosamide, harkeroside, SPM 927, or ADD 234037) is a medication discovered by Dr.
  • Mexiletine
    Mexiletine (INN) (sold under the trade name Mexitil) is a non-selective voltage-gated sodium channel blocker which belongs to the Class IB anti-arrhythmic group of medicines.
  • Flecainide
    Flecainide acetate (/flɛˈkeɪnaɪd/ US dict: fle·kā′·nīd) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
  • Propranolol
    Propranolol is a medication of the beta blocker type.
  • Disopyramide
    Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia.
  • Encainide
    Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent.
  • Lorcainide
    Lorcainide (Lorcainide hydrochloride) is a Class 1c antiarrhythmic agent that is used to help restore normal heart rhythm and conduction in patients with premature ventricular contractions, ventricular tachycardiac [7] and Wolff-Parkinson-White syndrome.
  • Lorajmine
    Lorajmine (17-monochloroacetylajmaline) is a drug that is a potent sodium channel blocker (more specifically, a class Ia antiarrhythmic agent) that was used for treating arrhythmia.
  • Bupropion/zonisamide
    Bupropion/zonisamide (planned trade name Empatic) is an experimental drug combination for the treatment of obesity.
  • Coronaridine
    Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in Tabernanthe iboga and related species,including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.
  • Neosaxitoxin
    Neosaxitoxin (NSTX) is included, as other saxitoxin-analogs, in a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs).