2022-10-05T21:53:14+03:00[Europe/Moscow] en true <p>deficiency or excess of one metabolite, infestation of foreign organism, aberrant cell growth</p>, <p>blocks; increases</p>, <p>Chemotherapy</p>, <p>blocks; decreasing</p>, <p>Ideal inhibitor</p>, <p>Antimetabolites</p>, <p>selective toxicity</p>, <p>one that is essential for growth, but nonessential in humans</p>, <p>IC50</p>, <p>potency </p>, <p>Competitive inhibition</p> flashcards
Reversible Enzyme Inhibitors

Reversible Enzyme Inhibitors

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  • deficiency or excess of one metabolite, infestation of foreign organism, aberrant cell growth

    How are enzymes responsible for diseases?

  • blocks; increases

    Inhibition of an enzyme ______ the degradation of its substrate; therefore _________ its concentration

  • Chemotherapy

    -use of drugs to combat foreign organisms and aberrant cells

  • blocks; decreasing

    Inhibition of an enzyme ______ formation of the product; therefore _______ its concentration

  • Ideal inhibitor

    -totally specific for one target enzyme; rarely occurs, if at all

  • Antimetabolites

    -compounds that resemble essential metabolites, but inhibit metabolizing enzymes

  • selective toxicity

    The utilization of antimetabolites results in ______

  • one that is essential for growth, but nonessential in humans

    What is the ideal enzyme target ?

  • IC50

    the inhibitor concentration that produces 50% enzyme inhibition, is another common measurement of inhibition

  • potency

    What is IC50 used to measure?

  • Competitive inhibition

    -inhibitor competes with the substrate for the same binding site