Hosam Mohamed-
viral uncoating inhibitors; influenza type A
Amantadine & Rimantadine
- class
- indication
-
fusion inhibitor/biomimetic peptide, HIV, binds viral gp41 displacing from cell
Enfuviritide
-class
-indication
-MOA
-
entry inhibitor; HIV; CCR5 antagonist- prevents entry of gp120
Maraviroc
-class
-indication
-MOA
-
Reverse Transcriptase
-enzyme for producing complementary DNA (cDNA) from RNA.
-associated with retroviruses (HIV)
-
incorporate nucleosides without 2' or 3' hydroxyl groups in DNA chain; causing chain termination
MOA for NRTIs?
-
inhibit reverse transcriptase enzyme
MOA for NNRTIs?
-
zidovudine, didanosine, zalcitabine, stavudine, abacavir
Which NRTIs are phosphorylated prior to incorporation?
-
c,d
Which NRTIs metabolism(s) include their oxidation to sulfoxide?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
-
abacavir
Which NRTI can cross the blood-brain barrier?
-
b
Which NRTI is a prodrug?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
-
b
Which NRTI is hydrolyzed to monophosphate?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
-
d
Which drugs are designed via structure-base drug design?
A) NRTI
B) HVC protease inhibitor
C) Endonuclease cap inhibitors
D) NNRTI
-
c
NNRTIs inhibit ______
a) fusion
b) entry
c) reverse transcriptase
d) RNA
-
c
Which NNRTI is active against resistant HIV?
a) Nevirapine
b) Delavirdine
c) Efavirenz
d) Etravirine
-
c,d
Which NNRTI is a second generation?
a) Nevirapine
b) Delavirdine
c) Rilpivirine
d) Etravirine
-
c
Which NNRTI was approved in 2011 and has a reduced-side effect profile?
a) Nevirapine
b) Delavirdine
c) Rilpivirine
d) Etravirine
