viral uncoating inhibitors; influenza type A
Amantadine & Rimantadine
- class
- indication
fusion inhibitor/biomimetic peptide, HIV, binds viral gp41 displacing from cell
Enfuviritide
-class
-indication
-MOA
entry inhibitor; HIV; CCR5 antagonist- prevents entry of gp120
Maraviroc
-class
-indication
-MOA
Reverse Transcriptase
-enzyme for producing complementary DNA (cDNA) from RNA.
-associated with retroviruses (HIV)
incorporate nucleosides without 2' or 3' hydroxyl groups in DNA chain; causing chain termination
MOA for NRTIs?
inhibit reverse transcriptase enzyme
MOA for NNRTIs?
zidovudine, didanosine, zalcitabine, stavudine, abacavir
Which NRTIs are phosphorylated prior to incorporation?
c,d
Which NRTIs metabolism(s) include their oxidation to sulfoxide?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
abacavir
Which NRTI can cross the blood-brain barrier?
b
Which NRTI is a prodrug?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
b
Which NRTI is hydrolyzed to monophosphate?
a) abacavir
b) tenofovir
c) lamivudine
d) emtricabine
d
Which drugs are designed via structure-base drug design?
A) NRTI
B) HVC protease inhibitor
C) Endonuclease cap inhibitors
D) NNRTI
c
NNRTIs inhibit ______
a) fusion
b) entry
c) reverse transcriptase
d) RNA
c
Which NNRTI is active against resistant HIV?
a) Nevirapine
b) Delavirdine
c) Efavirenz
d) Etravirine
c,d
Which NNRTI is a second generation?
a) Nevirapine
b) Delavirdine
c) Rilpivirine
d) Etravirine
c
Which NNRTI was approved in 2011 and has a reduced-side effect profile?
a) Nevirapine
b) Delavirdine
c) Rilpivirine
d) Etravirine