2022-10-16T20:38:57+03:00[Europe/Moscow] en true <p>Nuclear</p>, <p>thyroid, androgen, glucocorticoid, estrogen</p>, <p>RTKs</p>, <p>Insulin- IR, EGFR, HER2</p>, <p>Cytokine</p>, <p>IFNa/Br ; JAK/STAT</p>, <p>cGMP</p>, <p>cAMP</p> flashcards
Receptor types

Receptor types

Customize
collection saved
Share
Long Term Learning Spaced Repetition
Add to Long Term Learning Desk
Fast learning Repeat this set of flashcards
Preview Test Spell
Play
Match
Review

  • Nuclear

    -lipid soluble drug crosses cell membrane

    -activates gene expression

    -binds to specific regions of DNA

  • thyroid, androgen, glucocorticoid, estrogen

    What are your types of nuclear receptors ?

  • RTKs

    -receptors are transmembrane proteins with extracelluar binding domains and intracellular enzyme domains

  • Insulin- IR, EGFR, HER2

    What are some types of RTKs?

  • Cytokine

    - a large class of molecules, can pass a signaling event from extra- to intra-cellular

    -external receptor can mediate phosphorylation events

  • IFNa/Br ; JAK/STAT

    What are some types of cytokines?

  • cGMP

    -Only active in a few cell types, i.e. intestinal mucosa and vascular smooth muscle

    – Similar activity in those cells to cAMP

    -Activated by guanylate cyclas

  • cAMP

    – Most famous/common intracellular 2nd messenger

    – Activated by adenylyl (or “adenylate”) cyclase (AC)

    -Mediates hormonal responses, renal water conservation, calcium homeostasis, HR, production of hormones, smooth muscle relaxation and many, many more