Nuclear
-lipid soluble drug crosses cell membrane
-activates gene expression
-binds to specific regions of DNA
thyroid, androgen, glucocorticoid, estrogen
What are your types of nuclear receptors ?
RTKs
-receptors are transmembrane proteins with extracelluar binding domains and intracellular enzyme domains
Insulin- IR, EGFR, HER2
What are some types of RTKs?
Cytokine
- a large class of molecules, can pass a signaling event from extra- to intra-cellular
-external receptor can mediate phosphorylation events
IFNa/Br ; JAK/STAT
What are some types of cytokines?
cGMP
-Only active in a few cell types, i.e. intestinal mucosa and vascular smooth muscle
– Similar activity in those cells to cAMP
-Activated by guanylate cyclas
cAMP
– Most famous/common intracellular 2nd messenger
– Activated by adenylyl (or “adenylate”) cyclase (AC)
-Mediates hormonal responses, renal water conservation, calcium homeostasis, HR, production of hormones, smooth muscle relaxation and many, many more