2023-11-24T16:50:45+03:00[Europe/Moscow] en true <p>How many different proteins make up the G-Protein coupled receptor?</p>, <p>What is the abbreviation for G-Protein Coupled Receptors?</p>, <p>What are other names for GPCRS? And why are they called this?</p>, <p>How many different GCPRS are there on the Human genome?</p>, <p>What is the structure of the GCPRS?</p>, <p>Cell signalling is caused by what in GPCRS?</p>, <p>Specific Enzyme signalling is determined how in GPCRS?</p>, <p>What forms of the alpha subunit are there?</p>, <p>What do each of the alpha forms stimulate?</p>, <p>How are GPCRS activated?</p>, <p>Picture summary of the G-protein activation and termination</p>, <p>What the series of reactions that occurs after GPCR binds with adenylate cyclase?</p>, <p>What do the Gq and G11 alpha subunits do?</p>, <p>What the series of reactions that occurs after GPCRs Gq/G11 subunits have been activated? (9)</p>, <p>General summary of the different a (alpha) subunits </p>, <p>What a subunit does the different Muscarinic and Adrenergic receptors stimulate? What increases/decreases? And what happens after that?</p>, <p>What do the Receptors are stimulated by the Gas and Gai subunits?</p>, <p>General summary of the receptor responses from increased cAMP</p> flashcards
Receptor Mechanisms II (Pharmacology)

Receptor Mechanisms II (Pharmacology)

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  • How many different proteins make up the G-Protein coupled receptor?

    1

  • What is the abbreviation for G-Protein Coupled Receptors?

    GPCRS

  • What are other names for GPCRS? And why are they called this?

    Heptahelical Receptor and 7TM receptor

    Why?

    Because the amino acid chain goes in and out of the membrane, 7 times

  • How many different GCPRS are there on the Human genome?

    830 and they are the major target of pharmaceutical developed treatment

  • What is the structure of the GCPRS?

    GTP bound to ford GDP

    GTP bound to ford GDP

  • Cell signalling is caused by what in GPCRS?

    By the separation of the a (alpha) and b (beta) subunits

  • Specific Enzyme signalling is determined how in GPCRS?

    Enzyme signalling is determined by the different forms of the a (alpha) subunit

  • What forms of the alpha subunit are there?

    4 forms:

    as- (stimulation)

    ai- (inhibition)

    aq-

    a12/13-

  • What do each of the alpha forms stimulate?

    (Adenylyl is another name for Adenylate)

    (Adenylyl is another name for Adenylate)

  • How are GPCRS activated?

    Via binding of an agonist

  • Picture summary of the G-protein activation and termination

  • What the series of reactions that occurs after GPCR binds with adenylate cyclase?

    Adenylate cyclase converts ATP into cAMP,cAMP will activate a kinase (Kinases put phosphate groups onto targets), which allows long-lasting cellular effects. cAMP levels are broken down by phosphodiesterases

    Adenylate cyclase converts ATP into cAMP,

    cAMP will activate a kinase (Kinases put phosphate groups onto targets), which allows long-lasting cellular effects. cAMP levels are broken down by phosphodiesterases

  • What do the Gq and G11 alpha subunits do?

    Increase phospholipase C activity

  • What the series of reactions that occurs after GPCRs Gq/G11 subunits have been activated? (9)

    1)Agonist binds2)Affinity of the a subunit for GTP goes up3)Causes a dissociation of the b and y subunits (they stay in the lipid phase)4)The activated Gq a subunit leads to the activation of PLC-b (Phospholipase C (beta)5)Which interacts with PIP26)PLC-b cleaves the inositol group of PIP2, which converts it to IP37)Which leads DAG (diacylglycerol) to remain in the cellular membrane8)IP3 will bind to its own receptor found in intracellular calcium stores9)DAG will usually stay in the cellular membrane but can activate its own protein kinases

    1)Agonist binds

    2)Affinity of the a subunit for GTP goes up

    3)Causes a dissociation of the b and y subunits (they stay in the lipid phase)

    4)The activated Gq a subunit leads to the activation of PLC-b (Phospholipase C (beta)

    5)Which interacts with PIP2

    6)PLC-b cleaves the inositol group of PIP2, which converts it to IP3

    7)Which leads DAG (diacylglycerol) to remain in the cellular membrane

    8)IP3 will bind to its own receptor found in intracellular calcium stores

    9)DAG will usually stay in the cellular membrane but can activate its own protein kinases

  • General summary of the different a (alpha) subunits

  • What a subunit does the different Muscarinic and Adrenergic receptors stimulate? What increases/decreases? And what happens after that?

  • What do the Receptors are stimulated by the Gas and Gai subunits?

  • General summary of the receptor responses from increased cAMP