2023-11-24T00:29:20+03:00[Europe/Moscow] en true <p>Name the 4 different type of Receptors</p>, <p>Order the 4 receptors from fastest to slowest</p>, <p>Acetylcholine Agonists and Antagonists? (Nicotinic acetylcholine receptors)</p>, <p>How many similar proteins does each ligand gated ion channel receptor contain?</p>, <p>What regions do ligand gated ion channels span across?</p>, <p>Picture demonstrating the structure of LGICR</p>, <p>How does the LGICR open (binding)?</p>, <p>How many types of nicotine acetylcholine receptors are there?</p>, <p>Picture demonstrating nicotine type acetylcholine receptors</p>, <p>What is an EJP?</p>, <p>What is Myasthenia gravis? What does it target? What occurs as a result? What receptors remain unaffected?</p>, <p>What agonist stimulates the Nicotinic cholinoceptor?</p>, <p>What agonist stimulates 5HT3 Receptor?</p>, <p>What agonist stimulates GABA A Receptor?</p>, <p>What agonist stimulates Glycine Receptor?</p>, <p>Picture demonstrating the types of structure of LGICR</p> flashcards
Receptor Mechanisms I (Pharmacology)

Receptor Mechanisms I (Pharmacology)

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  • Name the 4 different type of Receptors

  • Order the 4 receptors from fastest to slowest

  • Acetylcholine Agonists and Antagonists? (Nicotinic acetylcholine receptors)

    Agonists:NICOTINE and LOBELINE

    Antagonists:TUBOCURARINE, HEXAMETHONIUM and PANCURONIUM

  • How many similar proteins does each ligand gated ion channel receptor contain?

    5 similar proteins (pentamer)

  • What regions do ligand gated ion channels span across?

    -Extracellular

    -Transmembrane

    -Intracellular

  • Picture demonstrating the structure of LGICR

    20 amino acids total

    20 amino acids total

  • How does the LGICR open (binding)?

    -Neurotransmitter acetylcholine will always bind to the a (alpha) subunits, in this case 2 AC binds

    -Neurotransmitter acetylcholine will always bind to the a (alpha) subunits, in this case 2 AC binds

  • How many types of nicotine acetylcholine receptors are there?

    2

    Those found in skeletal muscle: N1 or Nm

    And those found in the CNS (autonomic ganglia):N2 or Nn

  • Picture demonstrating nicotine type acetylcholine receptors

  • What is an EJP?

    Excitatory junction potential

    -A wave of depolarisation

  • What is Myasthenia gravis? What does it target? What occurs as a result? What receptors remain unaffected?

    When the immune system mistakenly targets and attacks the acetylcholine receptors (AChR) on the muscle cells surfaces.

    When the immune system mistakenly targets and attacks the acetylcholine receptors (AChR) on the muscle cells surfaces.

  • What agonist stimulates the Nicotinic cholinoceptor?

    Acetylcholine

    via depolarisation (Na/Ca influx)

  • What agonist stimulates 5HT3 Receptor?

    5-HTvia depolarisation (Na/Ca influx)

    5-HT

    via depolarisation (Na/Ca influx)

  • What agonist stimulates GABA A Receptor?

    Gamma-aminobutyric acid (GABA)via hyperpolarisation (Chloride influx)

    Gamma-aminobutyric acid (GABA)

    via hyperpolarisation (Chloride influx)

  • What agonist stimulates Glycine Receptor?

    Glycine

    via hyperpolarisation (Chloride influx)

  • Picture demonstrating the types of structure of LGICR