Name the 4 different type of Receptors
Order the 4 receptors from fastest to slowest
Acetylcholine Agonists and Antagonists? (Nicotinic acetylcholine receptors)
Agonists:NICOTINE and LOBELINE
Antagonists:TUBOCURARINE, HEXAMETHONIUM and PANCURONIUM
How many similar proteins does each ligand gated ion channel receptor contain?
5 similar proteins (pentamer)
What regions do ligand gated ion channels span across?
-Extracellular
-Transmembrane
-Intracellular
Picture demonstrating the structure of LGICR
20 amino acids total
How does the LGICR open (binding)?
-Neurotransmitter acetylcholine will always bind to the a (alpha) subunits, in this case 2 AC binds
How many types of nicotine acetylcholine receptors are there?
2
Those found in skeletal muscle: N1 or Nm
And those found in the CNS (autonomic ganglia):N2 or Nn
Picture demonstrating nicotine type acetylcholine receptors
What is an EJP?
Excitatory junction potential
-A wave of depolarisation
What is Myasthenia gravis? What does it target? What occurs as a result? What receptors remain unaffected?
When the immune system mistakenly targets and attacks the acetylcholine receptors (AChR) on the muscle cells surfaces.
What agonist stimulates the Nicotinic cholinoceptor?
Acetylcholine
via depolarisation (Na/Ca influx)
What agonist stimulates 5HT3 Receptor?
5-HT
via depolarisation (Na/Ca influx)
What agonist stimulates GABA A Receptor?
Gamma-aminobutyric acid (GABA)
via hyperpolarisation (Chloride influx)
What agonist stimulates Glycine Receptor?
Glycine
via hyperpolarisation (Chloride influx)
Picture demonstrating the types of structure of LGICR
