2023-03-13T21:05:51+03:00[Europe/Moscow] en true <p>d-lactate; d-alanine </p>, <p>resistant to vancomycin; must use other agents</p>, <p>no; MIC is too high; vancomycin has no effect</p>, <p>detergent </p>, <p>enhanced binding to lipid membrane, detergent-like effect on membranes, increases binding to precursor in Vancomycin resistant bacteria</p> flashcards
Protein synthesis & Vancomycin resistance

Protein synthesis & Vancomycin resistance

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  • d-lactate; d-alanine

    Van A-type resistance is due to expression of enzymes that modify cell wall precursor by substituting a terminal _______ for _______, reducing vancomycin binding affinity by 1000x.

  • resistant to vancomycin; must use other agents

    How do we treat Enterococcus faecium?

  • no; MIC is too high; vancomycin has no effect

    Can we treat Glycopeptide-intermediate resistant MRSA or Glycopeptide-resistant MRSA with vancomycin?

  • detergent

    Polar head group + lipid tail =

  • enhanced binding to lipid membrane, detergent-like effect on membranes, increases binding to precursor in Vancomycin resistant bacteria

    What are the advantages of using a Lipoglycopeptide vs. a Glycopeptide?