Flashcards: Protein synthesis & Vancomycin resistance
d-lactate; d-alanine
Van A-type resistance is due to expression of enzymes that modify cell wall precursor by substituting a terminal _______ for _______, reducing vancomycin binding affinity by 1000x.
resistant to vancomycin; must use other agents
How do we treat Enterococcus faecium?
no; MIC is too high; vancomycin has no effect
Can we treat Glycopeptide-intermediate resistant MRSA or Glycopeptide-resistant MRSA with vancomycin?
detergent
Polar head group + lipid tail =
enhanced binding to lipid membrane, detergent-like effect on membranes, increases binding to precursor in Vancomycin resistant bacteria
What are the advantages of using a Lipoglycopeptide vs. a Glycopeptide?